Cutting edge: IL-5 primes Th2 cytokine-producing capacity in eosinophils through a STAT5-dependent mechanism

Journal of Immunology

Volumn 173, Issue 5, 2004, Pages 2918-2922

  Zhu, Yuechun ^a   Chen, Luqiu ^a   Huang, Zan ^a   Alkan, Serhan ^a   Bunting, Kevin D ^b,c   Wen, Renren ^d   Wang, Demin ^d   Huang, Hua ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b AMERICAN RED CROSS   (United States)

^c GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 13; INTERLEUKIN 25; INTERLEUKIN 4; INTERLEUKIN 5; STAT5 PROTEIN; UNCLASSIFIED DRUG;

ALLERGY; ANIMAL CELL; ARTICLE; ASTHMA; BONE MARROW CELL; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; EOSINOPHIL; MOUSE; NONHUMAN; PARASITOSIS; PRIORITY JOURNAL; PROTEIN FUNCTION; STEM CELL; TH2 CELL;

EID: 4344641107     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.5.2918     Document Type: Article

References (18)

1. Wills-Karp, M. 1999. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu. Rev. Immunol. 17:255.
2. Klion, A. D., and T. B. Nutman. 2004. The role of eosinophils in host defense against helminth parasites. J. Allergy Clin. Immunol. 113:30.
3. Rothenberg, M. E. 1998. Eosinophilia. N. Engl. J. Med. 338:1592.
4. Wardlaw, A. J., R. Moqbel, and A. B. Kay. 1995. Eosinophils: biology and role in disease. Adv. Immunol. 60:151.
5. Shinkai, K., M. Mohrs, and R. M. Locksley. 2002. Helper T cells regulate type-2 innate immunity in vivo. Nature 420:825.
6. Chen, L., K. A. Grabowski, J. P. Xin, J. Coleman, Z. Huang, B. Espiritu, S. Alkan, H. B. Xie, Y. Zhu, F. A. White, et al. 2004. IL-4 induces differentiation and expansion of Th2 cytokine-producing eosinophils. J. Immunol. 172:2059.
7. Adachi, T., and R. Alam. 1998. The mechanism of IL-5 signal transduction. Am. J. Physiol. 2175:C623.
8. Sato, S., T. Katagiri, S. Takaki, Y. Kikuchi, Y. Hitoshi, S. Yonehara, S. Tsukada, D. Kitamura, T. Watanabe, O. Witte, et al. 1994. IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases. J. Exp. Med. 180:2101.
9. Ogata, N., Y. Kikuchi, T. Kouro, M. Tomonaga, and K. Takatsu. 1997. The activation of the JAK2/STAT5 pathway is commonly involved in signaling through the human IL-5 receptor. Int. Arch. Allergy Immunol. 114(Suppl. 1):24.
10. Liu, X., G. W. Robinson, F. Gouilleux, B. Groner, and L. Hennighausen. 1995. Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Proc. Natl. Acad. Sci. USA 92:8831.
11. Teglund, S., C. McKay, E. Schuetz, J. M. van Deursen, D. Stravopodis, D. Wang, M. Brown, S. Bodner, G. Grosveld, and J. N. Ihle. 1998. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 93:841.
12. Bunting, K. D., H. L. Bradley, T. S. Hawley, R. Moriggl, B. P. Sorrentino, and J. N. Ihle. 2002. Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5. Blood 99:479.
13. Hu-Li, J., C. Pannetier, L. Guo, M. Lohning, H. Gu, C. Watson, M. Assenmacher, A. Radbruch, and W. E. Paul. 2001. Regulation of expression of IL-4 alleles: analysis using a chimeric GFP/IL-4 gene. Immunity 14:1.
14. Zhang, Y., R. Apilado, J. Coleman, S. Ben-Sasson, S. Tsang, J. Hu-Li, W. E. Paul, and H. Huang. 2001. Interferon γ stabilizes the T helper cell type 1 phenotype. J. Exp. Med. 194:165.
15. Murphy, K. M., and S. L. Reiner. 2002. The lineage decisions of helper T cells. Nat. Rev. Immunol. 2:933.
16. Lin, J. X., and W. J. Leonard. 2000. The role of Stat5a and Stat5b in signaling by IL-2 family cytokines. Oncogene 19:2566.
17. Yang, L., X.-F. Qin, D. Baltimore, and L. Van Parijs. 2002. Generation of functional antigen-specific T cells in defined genetic backgrounds by retrovirus-mediated expression of TCR cDNAs in hematopoietic precursor cells. Proc. Natl. Acad. Sci. USA 99:6204.
18. Zhu, J., J. Cote-Sierra, L. Guo, and W. E. Paul. 2003. Stat5 activation plays a critical role in Th2 differentiation. Immunity 19:739.