Programming of the lung in early life by bacterial infections predisposes to chronic respiratory disease

Clinical Obstetrics and Gynecology

Volumn 56, Issue 3, 2013, Pages 566-576

  Starkey, Malcolm R ^a   Nguyen, Duc H ^a   Kim, Richard Y ^a   Nair, Prema M ^a   Brown, Alexandra C ^a   Essifie, Ama Tawiah ^a   Horvat, Jay C ^a   Hansbro, Philip M ^a  

^a UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

asthma; chronic respiratory disease; COPD; early life; infection; therapy

Indexed keywords

ANRUKINZUMAB; BACTERIAL VACCINE; IMA 026; IMMUNOGLOBULIN G1 ANTIBODY; LEBRIKIZUMAB; UNCLASSIFIED DRUG;

ARTICLE; ASTHMA; ASYMPTOMATIC INFECTION; BACTERIAL INFECTION; BACTERIAL MENINGITIS; BACTERIAL PNEUMONIA; CHILDHOOD DISEASE; CHLAMYDIA TRACHOMATIS; CHLAMYDIASIS; CHRONIC LUNG DISEASE; CHRONIC RESPIRATORY TRACT DISEASE; COMMUNITY ACQUIRED PNEUMONIA; DISEASE PREDISPOSITION; HAEMOPHILUS INFLUENZAE; HUMAN; LUNG STRUCTURE; NONHUMAN; STREPTOCOCCUS PNEUMONIAE; VACCINATION; WHEEZING;

ASTHMA; BACTERIAL INFECTIONS; CHLAMYDIA INFECTIONS; CHLAMYDIA TRACHOMATIS; CHLAMYDOPHILA PNEUMONIAE; HAEMOPHILUS INFECTIONS; HAEMOPHILUS INFLUENZAE; HUMANS; IMMUNOLOGIC FACTORS; INTERLEUKIN-13; LUNG; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY TRACT INFECTIONS; STREPTOCOCCAL INFECTIONS; STREPTOCOCCAL VACCINES; STREPTOCOCCUS PNEUMONIAE; TOLL-LIKE RECEPTOR 2;

EID: 84882452828     PISSN: 00099201     EISSN: 15325520     Source Type: Journal    
DOI: 10.1097/GRF.0b013e3182993a0c     Document Type: Article

References (73)

1. Masoli M, Fabian D, Holt S, et al. Global Initiative for Asthma ProgramThe global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy. 2004;59: 469-478.
2. Maddox L, Schwartz DA. The pathophysiology of asthma. Annu Rev Med. 2002;53:477-498.
3. Cohn L, Elias JA, Chupp GL. Asthma: mechanisms of disease persistence and progression. Annu Rev Immunol. 2004;22:789-815.
4. Barlow JL, Bellosi A, Hardman CS, et al. Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity. J Allergy Clin Immunol. 2012; 129:e191-194.
5. Chang YJ, Kim HY, Albacker LA, et al. Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity. Nat Immunol. 2011;12:631-638.
6. Kim HY, Chang YJ, Subramanian S, et al. Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity. J Allergy Clin Immunol. 2012; 129:216-227. e211-216.
7. O'Byrne PM, Inman MD. Airway hyperresponsiveness. Chest. 2003;123:411S-416S.
8. Piippo-Savolainen E, Remes S, Kannisto S, et al. Early predictors for adult asthma and lung function abnormalities in infants hospitalized for bronchiolitis: a prospective 18-to 20-year follow-up. Allergy Asthma Proc. 2006;27:341-349.
9. von Mutius E. Paediatric origins of adult lung disease. Thorax. 2001;56:153-157.
10. Sears MR, Greene JM, Willan AR, et al. A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med. 2003;349:1414-1422.
11. Hansbro PM, Beagley KW, Horvat JC, et al. Role of atypical bacterial infection of the lung in predisposition/protection of asthma. Pharmacol Ther. 2004;101:193-210.
12. Burri PH. Fetal and postnatal development of the lung. Annu Rev Physiol. 1984;46:617-628.
13. Horvat JC, Starkey MR, Kim RY, et al. Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology. J Allergy Clin Immunol. 2010;125:617-625. 625 e611-625 e616.
14. Jupelli M, Murthy AK, Chaganty BK, et al. Neonatal chlamydial pneumonia induces altered respiratory structure and function lasting into adult life. Lab Invest. 2011;91:1530-1539.
15. Butler J, Caro CG, Alcala R, et al. Physiological factors affecting airway resistance in normal subjects and in patients with obstructive respiratory disease. J Clin Invest. 1960;39:584-591.
16. Bartlett NW, McLean GR, Chang YS, et al. Genetics and epidemiology: asthma and infection. Curr Opin Allergy Clin Immunol. 2009;9:395-400.
17. Guilbert TW, Denlinger LC. Role of infection in the development and exacerbation of asthma. Expert Rev Respir Med. 2010;4:71-83.
18. Beem MO, Saxon EM. Respiratory-tract colonization and a distinctive pneumonia syndrome in infants infected with Chlamydia trachomatis. N Engl J Med. 1977;296:306-310.
19. Mardh PA, Helin I, Bobeck S, et al. Colonisation of pregnant and puerperal women and neonates with Chlamydia trachomatis. Br J Vener Dis. 1980;56:96-100.
20. Hammerschlag MR. Pneumonia due to Chlamydia pneumoniae in children: epidemiology, diagnosis, and treatment. Pediatr Pulmonol. 2003;36: 384-390.
21. Darville T. Chlamydia trachomatis infections in neonates and young children. Semin Pediatr Infect Dis. 2005;16:235-244.
22. Heggie AD, Lumicao GG, Stuart LA, et al. Chlamydia trachomatis infection in mothers and infants. A prospective study. Am J Dis Child. 1981; 135:507-511.
23. Hammerschlag MR, Anderka M, Semine DZ, et al. Prospective study of maternal and infantile infection with Chlamydia trachomatis. Pediatrics. 1979;64:142-148.
24. Numazaki K, Chiba S, Kogawa K, et al. Chronic respiratory disease in premature infants caused by Chlamydia trachomatis. J Clin Pathol. 1986;39: 84-88.
25. Alexander ER, Harrison HR. Role of Chlamydia trachomatis in perinatal infection. Rev Infect Dis. 1983;5:713-719.
26. Harrison HR, Taussig LM, Fulginiti VA. Chlamydia trachomatis and chronic respiratory disease in childhood. Pediatr Infect Dis. 1982;1:29-33.
27. Bavastrelli M, MidullaM, Rossi D, et al. Chlamydia trachomatis infection in children with wheezing simulating asthma. Lancet. 1992;339:1174.
28. Webley WC, Tilahun Y, Lay K, et al. Occurrence of Chlamydia trachomatis and Chlamydia pneumoniae in paediatric respiratory infections. Eur Respir J. 2009;33:360-367.
29. Hammerschlag MR. Chlamydia trachomatis and Chlamydia pneumoniae infections in children and adolescents. Pediatr Rev. 2004;25:43-51.
30. Grayston JT, Campbell LA, Kuo CC, et al.Anew respiratory tract pathogen: Chlamydia pneumoniae strain TWAR. J Infect Dis. 1990;161: 618-625.
31. Teig N, Anders A, Schmidt C, et al. Chlamydophila pneumoniae and Mycoplasma pneumoniae in respiratory specimens of children with chronic lung diseases. Thorax. 2005;60:962-966.
32. Webley WC, Salva PS, Andrzejewski C, et al. The bronchial lavage of pediatric patients with asthma contains infectious Chlamydia. Am J Respir Crit Care Med. 2005;171:1083-1088.
33. Hahn DL, Schure A, Patel K, et al. Chlamydia pneumoniae-specific IgE is prevalent in asthma and is associated with disease severity. PLoS One. 2012;7:e35945.
34. Zaitsu M. The development of asthma in wheezing infants with Chlamydia pneumoniae infection. J Asthma. 2007;44:565-568.
35. Moxon ER,Murphy TF. Haemophilus influenzae. In: Mandell G, Bennett J, Dolin R eds. Principles and Practice of Infectious Diseases. New York: Churchill Livingstone; 2000: 2369-2378.
36. Ladhani SN, Ramsay M, Slack MP. The impact of Haemophilus influenzae serotype B resurgence on the epidemiology of childhood invasive Haemophilus influenzae disease in England and Wales. Pediatr Infect Dis J. 2011;30:893-895.
37. Ladhani S, Slack MP, Heath PT, et al. Invasive Haemophilus influenzae Disease, Europe, 1996-2006. Emerg Infect Dis. 2010;16:455-463.
38. van Wessel K, Rodenburg GD, Veenhoven RH, et al. Nontypeable Haemophilus influenzae invasive disease in The Netherlands: a retrospective surveillance study 2001-2008. Clin Infect Dis. 2011;53:e1-e7.
39. MacNeil JR, Cohn AC, Farley M, et al. Current epidemiology and trends in invasive Haemophilus influenzae disease-United States, 1989-2008. Clin Infect Dis. 2011;53:1230-1236.
40. O'Brien KL, Wolfson LJ, Watt JP, et al. Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates. Lancet. 2009;374:893-902.
41. Bisgaard H, Hermansen MN, Buchvald F, et al. Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med. 2007;357: 1487-1495.
42. De Schutter I, De Wachter E, Crokaert F, et al. Microbiology of bronchoalveolar lavage fluid in children with acute nonresponding or recurrent community-acquired pneumonia: identification of nontypeable Haemophilus influenzae as a major pathogen. Clin Infect Dis. 2011;52:1437-1444.
43. De Schutter I, Dreesman A, Soetens O, et al. In young children, persistent wheezing is associated with bronchial bacterial infection: a retrospective analysis. BMC Pediatr. 2012;12:83.
44. Horvat JC, Beagley KW, Wade MA, et al. Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease. Am J Respir Crit Care Med. 2007;176:556-564.
45. Starkey MR, Kim RY, Beckett EL, et al. Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice. PLoS One. 2012;7:e42588.
46. Starkey MR, Essilfie AT, Horvat JC, et al. Constitutive production of IL-13 promotes early-life Chlamydia respiratory infection and allergic airway disease. Mucosal Immunol. 2013;6:569-579.
47. Asquith KL, Horvat JC, Kaiko GE, et al. Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts. PLoS Pathog. 2011;7:e1001339.
48. Kaiko GE, Phipps S, Hickey DK, et al. Chlamydia muridarum infection subverts dendritic cell function to promote Th2 immunity and airways hyperreactivity. J Immunol. 2008;180:2225-2232.
49. Beckett EL, Phipps S, Starkey MR, et al. TLR2, but not TLR4, is required for effective host defence against Chlamydia respiratory tract infection in early life. PLoS One. 2012;7:e39460.
50. O'Connell CM, AbdelRahman YM, Green E, et al. Toll-like receptor 2 activation by Chlamydia trachomatis is plasmid dependent, and plasmidresponsive chromosomal loci are coordinately regulated in response to glucose limitation by C. trachomatis but not by C. muridarum. Infect Immun. 2011;79:1044-1056.
51. Darville T, O'Neill JM, Andrews CW Jr, et al. Toll-like receptor-2, but not Toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infection. J Immunol. 2003;171:6187-6197.
52. Essilfie AT, Simpson JL, Dunkley ML, et al. Combined Haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma. Thorax. 2012;67:588-599.
53. Essilfie AT, Simpson JL, Horvat JC, et al. Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease. PLoS Pathog. 2011;7:e1002244.
54. Shuto T, Imasato A, Jono H, et al. Glucocorticoids synergistically enhance nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via a negative cross-talk with p38MAP kinase. J Biol Chem. 2002;277:17263-17270.
55. Shuto T, Xu H, Wang B, et al. Activation of NFkappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha/beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells. Proc Natl Acad Sci USA. 2001;98:8774-8779.
56. Lugade AA, Bogner PN, Murphy TF, et al. The role of TLR2 and bacterial lipoprotein in enhancing airway inflammation and immunity. Front Immunol. 2011;2:10.
57. Bogaert D, Weinberger D, Thompson C, et al. Impaired innate and adaptive immunity to Streptococcus pneumoniae and its effect on colonization in an infant mouse model. Infect Immun. 2009;77: 1613-1622.
58. Garvy BA, Harmsen AG. The importance of neutrophils in resistance to pneumococcal pneumonia in adult and neonatal mice. Inflammation. 1996;20:499-512.
59. Zhang Z, Clarke TB, Weiser JN. Cellular effectors mediating Th17-dependent clearance of pneumococcal colonization in mice. J Clin Invest. 2009;119:1899-1909.
60. Letiembre M, Echchannaoui H, Bachmann P, et al. Toll-like receptor 2 deficiency delays pneumococcal phagocytosis and impairs oxidative killing by granulocytes. Infect Immun. 2005;73: 8397-8401.
61. Gauvreau GM, Boulet LP, Cockcroft DW, et al. Effects of interleukin-13 blockade on allergeninduced airway responses in mild atopic asthma. Am J Respir Crit Care Med. 2011;183:1007-1014.
62. Hansbro PM, Scott GV, Essilfie AT, et al. Th2 cytokine antagonists: potential treatments for severe asthma. Expert Opin Investig Drugs. 2013;22:49-69.
63. Song CH, Lee JK. Lebrikizumab treatment in adults with asthma. N Engl J Med. 2011;365: 2433author reply 2433-2434.
64. Basith S, Manavalan B, Lee G, et al. Toll-like receptor modulators: a patent review (2006-2010). Expert Opin Ther Pat. 2011;21:927-944.
65. Galluzzi L, Vacchelli E, Eggermont A, et al. Trial watch: experimental Toll-like receptor agonists for cancer therapy. Oncoimmunology. 2012;1:699-716.
66. Simons MP, O'Donnell MA, Griffith TS. Role of neutrophils in BCG immunotherapy for bladder cancer. Urol Oncol. 2008;26:341-345.
67. Murata M. Activation of Toll-like receptor 2 by a novel preparation of cell wall skeleton from Mycobacterium bovis BCG Tokyo (SMP-105) sufficiently enhances immune responses against tumors. Cancer Science. 2008;99:1435-1440.
68. Thorburn AN, Hansbro PM. Harnessing regulatory T cells to suppress asthma: from potential to therapy. Am J Respir Cell Mol Biol. 2010;43: 511-519.
69. Preston JA, Thornburn NA, Starkey MR, et al. Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells. Eur Respir J. 2011;37:53-64.
70. Preston JA, Essilfie AT, Horvat JC, et al. Inhibition of allergic airways disease by immunomodulatory therapy with whole killed Streptococcus pneumoniae. Vaccine. 2007;25:8154-8162.
71. Thorburn AN, O'Sullivan BJ, Thomas R, et al. Pneumococcal conjugate vaccine-induced regulatory T cells suppress the development of allergic airways disease. Thorax. 2010;65:1053-1060.
72. Thorburn AN, Foster PS, Gibson PG, et al. Components of Streptococcus pneumoniae suppress allergic airways disease and NKT cells by inducing regulatory T cells. J Immunol. 2012;188: 4611-4620.
73. Fung KY, Mangan NE, Cumming H, et al. Interferon-E is a novel, innate cytokine that protects the reproductive tract from viral and bacterial infection. Science. 2013;339: 1088-1092.