Mutations in LRRK2 potentiate age-related impairment of autophagic flux

Molecular Neurodegeneration

Volumn 10, Issue 1, 2015, Pages

  Saha, Shamol ^a   Ash, Peter E A ^a   Gowda, Vivek ^a   Liu, Liqun ^a   Shirihai, Orian ^a   Wolozin, Benjamin ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Autophagy; C. elegans; Imaging; LC3; LRRK2; synuclein

Indexed keywords

ALPHA SYNUCLEIN; CHIMERIC PROTEIN; LEUCINE RICH REPEAT KINASE 2; LGG1 PROTEIN; UNCLASSIFIED DRUG; GREEN FLUORESCENT PROTEIN; LRRK2 PROTEIN, HUMAN; PHOTOPROTEIN; PROTEIN SERINE THREONINE KINASE; RED FLUORESCENT PROTEIN;

ARTICLE; AUTOPHAGOSOME; CAENORHABDITIS ELEGANS; CELL AGING; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; GENE EXPRESSION; LIFESPAN; LYSOSOME; MACROAUTOPHAGY; MUTATION; NERVE CELL DEGENERATION; NONHUMAN; PROTEIN PROTEIN INTERACTION; WILD TYPE; AGING; AMINO ACID SUBSTITUTION; ANIMAL; AUTOPHAGY; COMPARATIVE STUDY; GENETICS; HUMAN; METABOLISM; MISSENSE MUTATION; PHAGOSOME; PHYSIOLOGY; POINT MUTATION; TRANSGENIC ANIMAL;

CAENORHABDITIS ELEGANS;

AGING; ALPHA-SYNUCLEIN; AMINO ACID SUBSTITUTION; ANIMALS; ANIMALS, GENETICALLY MODIFIED; AUTOPHAGY; CAENORHABDITIS ELEGANS; DOPAMINERGIC NEURONS; GREEN FLUORESCENT PROTEINS; HUMANS; LEUCINE-RICH REPEAT SERINE-THREONINE PROTEIN KINASE-2; LUMINESCENT PROTEINS; LYSOSOMES; MUTATION, MISSENSE; PHAGOSOMES; POINT MUTATION; PROTEIN-SERINE-THREONINE KINASES;

EID: 84936867402     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/s13024-015-0022-y     Document Type: Article

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