Effects of phosphodiesterase 3,4,5 inhibitors on hepatocyte cAMP levels, glycogenolysis, gluconeogenesis and susceptibility to a mitochondrial toxin

Molecular and Cellular Biochemistry

Volumn 252, Issue 1-2, 2003, Pages 205-211

  Abdollahi, Mohammad ^a   Chan, Tom S ^a   Subrahmanyam, Vangala ^b   O'Brien, Peter J ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b PURDUE PHARMA L P   (United States)

Author keywords

cAMP; cGMP; Gluconeogenesis; Glycogenolysis; Hepatocytes; Phosphodiesterase inhibitors

Indexed keywords

3 (3 CYCLOPENTYLOXY 4 METHOXYBENZYL) 6 ETHYLAMINO 8 ISOPROPYL 3H PURINE; 4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; 4 [2 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL] 2 PHENYLETHYL]PYRIDINE; ALANINE; AMRINONE; CYANIDE; CYCLIC AMP; CYCLIC GMP PHOSPHODIESTERASE; CYTOTOXIN; DIPYRIDAMOLE; FRUCTOSE; GLUCAGON; GLUCOSE; ISOBUTYLMETHYLXANTHINE; ISOLIQUIRITIGENIN; LACTIC ACID; MILRINONE; PAPAVERINE; PHOSPHODIESTERASE INHIBITOR; PYRUVIC ACID; ROLIPRAM; SILDENAFIL; THEOPHYLLINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ISOLATION; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DIET RESTRICTION; DRUG EFFICACY; DRUG SELECTIVITY; GLUCONEOGENESIS; GLYCOGENOLYSIS; INCUBATION TIME; LIVER CELL; MALE; MITOCHONDRION; NONHUMAN; RAT; STATISTICAL SIGNIFICANCE;

ALANINE; ANIMALS; CYCLIC AMP; FRUCTOSE; GLUCONEOGENESIS; HEPATOCYTES; LIVER GLYCOGEN; MALE; MITOCHONDRIA, LIVER; PHOSPHODIESTERASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; TOXINS, BIOLOGICAL;

ANIMALIA;

EID: 0141505057     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1025568714217     Document Type: Article

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