Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 18, 2010, Pages 5398-5401

  Li, Songpei ^a   Li, Wei ^a   Wang, Yinghua ^b   Asada, Yoshihisa ^c   Koike, Kazuo ^a  

^a TOHO UNIVERSITY   (Japan)

^b Ningxia Institute for Drug Control   (China)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Flavonoids; Glycyrrhiza uralensis; Protein tyrosine phosphatase 1B

Indexed keywords

APIGENIN; BENZOFURAN DERIVATIVE; CYCLOGLYCYRRHISOFLAVONE; CYCLOLICOCOUMARONE; FLAVONOID; GLISOFLAVONE; GLYCYBENZOFURAN; GLYCYCOUMARIN; GLYCYRRHISOFLAVONE; HYDROXYL GROUP; ISOGLYCYCOUMARIN; ISOKAEMPFERIDE; ISOLIQUIRITIGENIN; LICOCOUMARONE; LICOFLAVONE A; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG ACTIVITY; DRUG ISOLATION; DRUG STRUCTURE; GLYCYRRHIZA URALENSIS; HETERONUCLEAR MULTIPLE QUANTUM COHERENCE; IC 50; IN VITRO STUDY; KINETICS; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PLANT ROOT; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

DIABETES MELLITUS, TYPE 2; FLAVONOIDS; GLYCYRRHIZA URALENSIS; HUMANS; INHIBITORY CONCENTRATION 50; PLANT EXTRACTS; PLANT ROOTS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; STRUCTURE-ACTIVITY RELATIONSHIP;

GLYCYRRHIZA URALENSIS;

EID: 77956173930     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.07.110     Document Type: Article

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24. PTP1B (human, recombinant) was purchased from Enzo Life Sciences, Inc. A mixture consisting of 2 mM p-NPP and 0.05 μg PTP1B in a buffer containing 0.06 M citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA, and 1 mM dithiothreitol (DTT) with or without a tested compound solution (prepared in the above buffer solution containing 3% DMSO), was incubated at 37 °C for 30 min. The reaction was terminated by adding 20 μL of 10 M NaOH. The reaction mixture was blended by a microplate mixer for 5 min and the amount of produced p-nitrophenol was tested by measuring the absorbance at 405 nm. The blank was measured in the same way except adding buffer solution instead of the enzyme.