Isoliquiritigenin 2′-methyl ether induces growth inhibition and apoptosis in oral cancer cells via heme oxygenase-1

Toxicology in Vitro

Volumn 24, Issue 3, 2010, Pages 776-782

  Lee, Young Man ^a   Jeong, Gil Saeng ^a   Lim, Hyun Dae ^a   An, Ren Bo ^b   Kim, Youn Chul ^a   Kim, Eun Cheol ^a  

^a Wonkwang University   (South Korea)

^b YANBIAN UNIVERSITY   (China)

Author keywords

Apoptosis; Heme oxygenase 1; Isoliquiritigenin 2 methyl ether; Oral cancer cell

Indexed keywords

ANTINEOPLASTIC AGENT; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOLIQUIRITIGENIN 2' METHYL ETHER; MITOGEN ACTIVATED PROTEIN KINASE; PROTOPORPHYRIN TIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; CHALCONE; DRUG DERIVATIVE; ENZYME INHIBITOR; ISOLIQUIRITIGENIN 2'-METHYL ETHER; P21 ACTIVATED KINASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CAESALPINIA; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOUTH CANCER; PRIMARY TUMOR; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; UPREGULATION; CELL PROLIFERATION; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUTH TUMOR; OXIDATIVE STRESS; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE; ULTRASTRUCTURE; WESTERN BLOTTING;

CAESALPINIA SAPPAN;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CHALCONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; HEME OXYGENASE-1; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; MOUTH NEOPLASMS; NF-KAPPA B; OXIDATIVE STRESS; P21-ACTIVATED KINASES; PHOSPHORYLATION;

EID: 77649180814     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2009.12.024     Document Type: Article

References (39)

1. Alam J., and Cook J.L. Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway. Current Pharmaceutical Design 9 (2003) 2499-2511
2. Boldt S., Weidle U.H., and Kolch W. The role of MAPK pathways in the action of chemotherapeutic drugs. Carcinogenesis 23 (2002) 1831-1838
3. Cardinali M.H., Pietraszkiewicz J.F., and Robbins K.C. Tyrosine phosphorylation as a marker for aberrantly regulated growth-promoting pathways in cell lines derived from head and neck malignancies. International Journal of Cancer 61 (1995) 98-103
4. Chen G.G., Liu Z.M., Vlantis A.C., Tse G.M., Leung B.C., and van Hasselt C.A. Heme oxygenase-1 protects against apoptosis induced by tumor necrosis factor-alpha and cycloheximide in papillary thyroid carcinoma cells. Journal of Cellular Biochemistry 92 (2004) 1246-1256
5. Choi A.M., and Alam J. Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury. American Journal of Respiratory Cell and Molecular Biology 15 (1996) 9-19
6. Chung H.Y., Jung Y.M., Shin D.H., Lee J.Y., Oh M.Y., Kim H.J., Jang K.S., Jeon S.J., Son K.H., and Kon G. Anticancer effects of wogonin in both estrogen receptor-positive and -negative human breast cancer cell lines in vitro and in nude mice xenografts. International Journal of Cancer 122 (2007) 816-822
7. Dandrea T., Hellmold H., Jonsson C., Zhivotovsky B., Hofer T., Wärngård L., and Cotgreave I. The transcriptosomal response of human A549 lung cells to a hydrogen peroxide-generating system: relationship to DNA damage, cell cycle arrest, and caspase activation. Free Radical Biology & Medicine 36 (2004) 881-896
8. Dennery P.A., Sridhar K.J., Lee C.S., Wong H.E., Shokoohi V., Rodgers P.A., and Spitz D.R. Heme oxygenase-mediated resistance to oxygen toxicity in hamster fibroblasts. The Journal of Biological Chemistry 1272 (1997) 14937-14942
9. Dennery P.A., Sridhar K.J., Lee C.S., Wong H.E., Shokoohi V., Rodgers P.A., and Spitz D.R. Heme oxygenase-mediated resistance to oxygen toxicity in hamster fibroblasts. The Journal of Biological Chemistry 272 (1997) 14937-14942
10. Fujieda S., Inuzuka M., Tanaka N., Sunaga H., Fan G.K., Ito T., Sugimoto C., Tsuzuki H., and Saito H. Expression of p27 is associated with Bax expression and spontaneous apoptosis in oral and oropharyngeal carcinoma. International Journal of Cancer 84 (1999) 315-320
11. Goodman A.I., Choudhury M., da Silva J.L., Schwartzman M.L., and Abraham N.G. Overexpression of the heme oxygenase gene in renal cell carcinoma. Proceedings of the Society for Experimental Biology and Medicine 214 (1997) 54-61
12. Grossman D., Kim P.J., Schechner J.S., and Altieri D.C. Inhibition of melanoma tumor growth in vivo by surviving targeting. Proc Natl Acad Sci USA**** 98 (2001) 635-640
13. Inoue J., Gohda J., Akiyama T., and Semba K. NF-κB activation in development and progression of cancer. Cancer Science 98 (2007) 268-274
14. Ishii T., Itoh K., Takahashi S., Sato H., Yanagawa T., Katoh Y., Bannai S., and Yamamoto M. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. The Journal of Biological Chemistry 275 (2000) 16023-16029
15. Jeong G.S., Lee D.S., Kwon T.O., Lee H.S., An R.B., and Kim Y.C. Cytoprotective constituents of the heartwood of Caesalpinia sappan on glutamate-induced oxidative damage in HT22 cells. Biological & Pharmaceutical Bulletin 32 (2009) 945-949
16. Juan S.H., Cheng T.H., Lin H.C., Chu Y.L., and Lee W.S. Mechanism of concentration-dependent induction of heme oxygenase-1 by resveratrol in human aortic smooth muscle cells. Biochemical Pharmacology 69 (2005) 41-48
17. Juan S.H., Lee T.S., Tseng K.W., Liou J.Y., Shyue S.K., Wu K.K., and Chau L.Y. Adenovirus-mediated heme oxygenase-1 gene transfer inhibits the development of atherosclerosis in apolipoprotein E-deficient mice. Circulation 104 (2001) 1519-1525
18. Kang S.A., Park H.J., Kim M.J., Lee S.Y., Han S.W., and Leem K.H. Citri reticulatae viride pericarpium extract induced apoptosis in SNU-C4, human colon cancer cells. Journal of Ethnopharmacology 97 (2005) 231-235
19. Kim E.C., Hwang Y.S., Lee H.J., Lee S.K., Park M.H., Jeon B.H., and Jeon C.D. Caesalpinia sappan induces cell death by increasing the expression of p53 and P21Waf1/CIP1 in head and neck cancer cells. The American Journal of Chinese Medicine 33 (2005) 405-414
20. Kweon M.H., Adhami V.M., Lee J.S., and Mukhtar H. Constitutive overexpression of Nrf2-dependent heme oxygenase-1 in A549 cells contributes to resistance to apoptosis induced by epigallocatechin 3-gallate. The Journal of Biological Chemistry 281 (2006) 33761-33772
21. Lee J., Lee B.U., Lee S.K., Lee H.J., Cho N.P., Yoon J.H., Choi H.R., Lee S.K., and Kim E.C. Expression of heme oxygenase-1 in oral epithelial dysplasias. International Journal of Oral and Maxillofacial Surgery 37 (2008) 287-292
22. Lee J., Lee H.J., Park J.D., Lee S.K., Lee S.I., Lim H.D., Lee Y.M., Yun Y.G., Jeon B.H., Ree I.S., Jun C.D., Lee S.K., and Kim E.C. Anti-cancer activity of highly purified sulfur in immortalized and malignant human oral keratinocytes. Toxicology In Vitro 22 (2008) 87-95
23. Lee P.J., Alam J., Wiegand G.W., and Choi A.M. Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia. Proceedings of the National Academy of Sciences USA 93 (1996) 10393-10398
24. Lee S.K., Park D.Y., Lee H.J., Lee J., Choi M.K., Jeon B.H., Jun C.D., Lee S.K., and Kim E.C. Functional interaction between nitric oxide-induced iron homeostasis and heme oxygenase-1 in immortalized and malignant oral keratinocytes. Cancer Letters 249 (2007) 283-293
25. Lee S.K., Lee J., Lee S.I., Bae W.J., Lee Y.M., Park J.S., Lee S.K., Park S.J., Min S.K., and Kim E.C. N-guanyl-1,7,-diamineoheptane, an inhibitor of deoxyhypusine synthase, suppresses differentiation and induces apoptosis via mitochondrial and AMPK pathways in immortalized and malignant human oral keratinocytes. Journal of Oral Pathology and Medicine 38 (2009) 792-800
26. Lin C.C., Chiang L.L., Lin C.H., Shih C.H., Liao Y.T., Hsu M.J., and Chen B.C. Transforming growth factor-β1 stimulates heme oxygenase-1 expression via the PI3K/Akt and NF-κB pathways in human lung epithelial cells. European Journal of Pharmacology 560 (2007) 101-109
27. Maines M.D. Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. The FASEB Journal 10 (1988) 2557-2568
28. Maines M.D., and Abrahamsson P.A. Expression of heme oxygenase-1 (HSP32) inhuman prostate: normal, hyperplastic, and tumor tissue distribution. Urology 47 (1996) 727-733
29. Nagai M., Nagumo S., Lee S.M., Eguchi I., and Kawai K.I. Protosappanin A novel biphenyl compound from Sappan lignum. Chemical & Pharmaceutical Bulletin 34 (1986) 1-6
30. Panka D.J., Atkins M.B., and Mier J.W. Targeting the mitogen activated protein kinase pathway in the treatment of malignant melanoma. Clinical Cancer Research 12 (2006) 2371-2375
31. Poss K.D., and Tonegawa S. Reduced stress defense in heme oxygenase 1-deficient cells. Proceedings of the National Academy of Sciences USA 94 (1997) 10925-10930
32. Saitoh T., Sskashita S., Nakata H., Shimokawa T., Kinjo J.E., Yamahara J., Yamasaki M., and Nohara T. 3-Benzylchroman derivatives related to brazilin from Sappan lignum. Chemical & Pharmaceutical Bulletin 34 (1986) 2506-2511
33. Schliephake H. Prognostic relevance of molecular markers of oral cancer - a review. International Journal of Oral and Maxillofacial Surgery 32 (2003) 233-245
34. Shimokawa T., Kinjo J.E., Yamahara J., Yamasaki M., and Nohara T. Two novel compounds from Caesalpinia sappan L. Chemical & Pharmaceutical Bulletin 33 (1985) 3545-3547
35. Squires M.S., Hudson E.A., Howells L., Sale S., Houghton C.E., Jones J.L., Fox L.H., Dickens M., Prigent S.A., and Manson M.M. Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells. Biochemical Pharmacology 65 (2003) 361-376
36. Stadheim T.A., Xiao H., and Eastman A. Inhibition of extracellular signal-regulated kinase (ERK) mediates cell cycle phase independent apoptosis in vinblastine-treated ML-1 cells. Cancer Research 61 (2001) 1533-1540
37. Taille C., El-Benna J., Lanone S., Dang M.C., Ogier-Denis E., Aubier M., and Boczkowski J. Induction of heme oxygenase-1 inhibits NAD(P)H oxidase activity by down-regulating cytochrome b558 expression via the reduction of heme availability. The Journal of Biological Chemistry 279 (2004) 28681-28688
38. Tanaka S., Akaike T., Fang J., Beppu T., Ogawa M., Tamura F., Miyamoto Y., and Maeda H. Antiapoptotic effect of haem oxygenase-1 induced by nitric oxide in experimental solid tumour. British Journal of Cancer 88 (2003) 902-909
39. Xie Y.W., Ming D.S., Xu H.X., Dong H., and But P.P. Vasorelaxing effects of Caesalpinia sappan involvement of endogenous nitric oxide. Life Sciences 67 (2000) 1913-1918