Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region

Structure

Volumn 23, Issue 7, 2015, Pages 1227-1235

  Xu, Xiang ^a,b   Choi, Sung Hee ^a,b   Hu, Tiancen ^c   Tiyanont, Kittichoat ^a,b   Habets, Roger ^d   Groot, Arjan J ^d   Vooijs, Marc ^d   Aster, Jon C ^e   Chopra, Rajiv ^c   Fryer, Christy ^c   Blacklow, Stephen C ^a,b,e  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^d MAASTRICHT UNIVERSITY   (Netherlands)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ASPARAGINE; CYSTEINE; GLUTAMIC ACID; GLUTAMINE; HYDROGEN; IMMUNOGLOBULIN G; N ACETYLGLUCOSAMINE; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; NOTCH3 RECEPTOR; NOTCH RECEPTOR; NOTCH3 PROTEIN, HUMAN; PROTEIN BINDING;

ARTICLE; AUTOREGULATION; CELL SURFACE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIMERIZATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HYDROGEN BOND; IMMUNOFLUORESCENCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; REPORTER GENE; SEDIMENTATION; SEQUENCE ALIGNMENT; SURFACE PROPERTY; U2OS CELL LINE; X RAY CRYSTALLOGRAPHY; CHEMISTRY; GENETICS; HEK293 CELL LINE; METABOLISM; MISSENSE MUTATION; MOLECULAR MODEL; PROTEIN DOMAIN; PROTEIN MULTIMERIZATION; TUMOR CELL LINE;

CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; PROTEOLYSIS; RECEPTOR, NOTCH3; RECEPTORS, NOTCH;

EID: 84936847287     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2015.05.001     Document Type: Article

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