An accessory to the 'Trinity': SR-As are essential pathogen sensors of extracellular dsRNA, mediating entry and leading to subsequent type I IFN responses

PLoS Pathogens

Volumn 6, Issue 3, 2010, Pages

  DeWitte Orr, Stephanie J ^a   Collins, Susan E ^a   Bauer, Carla M T ^a   Bowdish, Dawn M ^a   Mossman, Karen L ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CELL SURFACE RECEPTOR; CYTOKINE; DOUBLE STRANDED RNA; INTERFERON; MELANOMA DIFFERENTIATION ASSOCIATED PROTEIN 5; NUCLEIC ACID; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PATTERN RECOGNITION RECEPTOR; POLYINOSINIC POLYCYTIDYLIC ACID; RETINOIC ACID INDUCIBLE PROTEIN I; SCAVENGER RECEPTOR A; TOLL LIKE RECEPTOR 3; UNCLASSIFIED DRUG; TLR3 PROTEIN, MOUSE; VIRUS RNA;

ANIMAL CELL; ARTICLE; CELL SPECIFICITY; CELL SURFACE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOLYSIS; EMBRYO; EXTRACELLULAR SPACE; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VIVO STUDY; INHIBITION KINETICS; INNATE IMMUNITY; MACROPHAGE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN SECRETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA BINDING; RNA TRANSPORT; SIGNAL TRANSDUCTION; VESICULAR STOMATITIS VIRUS; VIRUS IMMUNITY; WILD TYPE; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL LINE; CYTOLOGY; GENE SILENCING; GENETICS; IMMUNOLOGY; METABOLISM; MONOCYTE; MOUSE MUTANT; VIRUS INFECTION;

MURINAE; MUS;

ANIMALS; CELL LINE; EXTRACELLULAR SPACE; FIBROBLASTS; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTERFERON TYPE I; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOCYTES; RNA, DOUBLE-STRANDED; RNA, VIRAL; SCAVENGER RECEPTORS, CLASS A; TOLL-LIKE RECEPTOR 3; VIRUS DISEASES;

EID: 77950412066     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000829     Document Type: Article

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