Necroptosis interfaces with MOMP and the MPTP in mediating cell death

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Karch, Jason ^a   Kanisicak, Onur ^a   Brody, Matthew J ^a   Sargent, Michelle A ^a   Michael, Demetria M ^a   Molkentin, Jeffery D ^a,b  

^a UNIVERSITY OF CINCINNATI   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COFILIN 1; CYCLOPHILIN D; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; MIXED LINEAGE KINASE; MIXED LINEAGE KINASE KINASE DOMAIN LIKE PROTEIN; PROTEIN BAK; PROTEIN BAX; PROTEIN MCL 1; UNCLASSIFIED DRUG; BAK1 PROTEIN, MOUSE; BAX PROTEIN, MOUSE; BCL2 PROTEIN, MOUSE; CARRIER PROTEIN; CYCLOPHILIN; PROTEIN BCL 2; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK3 PROTEIN, MOUSE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWNSTREAM PROCESSING; ENZYME INHIBITION; FIBROBLAST; IN VIVO STUDY; MALE; MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION; MITOCHONDRIAL PERMEABILITY; MOUSE; NECROPTOSIS; NONHUMAN; OLIGOMERIZATION; PROTEIN EXPRESSION; ANIMAL; C57BL MOUSE; GENETICS; METABOLISM; MITOCHONDRION; PATHOLOGY;

MUS;

ANIMALS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CYCLOPHILINS; FIBROBLASTS; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES;

EID: 84936805413     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0130520     Document Type: Article

References (29)

1. Green DR, Kroemer G. The Pathophysiology of Mitochondrial Cell Death. Science. 2004; 305(5684):626-9. doi: 10.1126/science.1099320 PMID: 15286356
2. Halestrap AP. What is the mitochondrial permeability transition pore? J Mol Cell Cardiol. 2009; 46(6): 821-31. Epub 2009/03/07. doi: 10.1016/j.yjmcc.2009.02.021 PMID: 19265700.
3. Baines CP, Kaiser RA, Purcell NH, Blair NS, Osinska H, Hambleton MA, et al. Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature. 2005; 434(7033): 658-62. Epub 2005/04/01. doi: 10.1038/nature03434 PMID: 15800627.
4. Nakagawa T, Shimizu S, Watanabe T, Yamaguchi O, Otsu K, Yamagata H, et al. Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature. 2005; 434(7033):652-8. Epub 2005/04/01. doi: 10.1038/nature03317 PMID: 15800626.
5. Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science. 2001; 292(5517):727-30. Epub 2001/04/28. doi: 10.1126/science.1059108 PMID: 11326099; PubMed Central PMCID: PMC3049805.
6. Karch J, Kwong JQ, Burr AR, Sargent MA, Elrod JW, Peixoto PM, et al. Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice. Elife. 2013; 2. doi: ARTN e00772. doi: 10.7554/eLife.00772. ISI:000328625400001.
7. Karch J, Molkentin JD. Regulated Necrotic Cell Death The Passive Aggressive Side of Bax and Bak. Circ Res. 2015; 116(11):1800-9. PMID: 25999420
8. Irrinki KM, Mallilankaraman K, Thapa RJ, Chandramoorthy HC, Smith FJ, Jog NR, et al. Requirement of FADD, NEMO, and BAX/BAK for Aberrant Mitochondrial Function in Tumor Necrosis Factor Alpha-Induced Necrosis. Mol Cell Biol. 2011; 31(18):3745-58. doi: 10.1128/mcb.05303-11 PMID: 21746883
9. Tischner D, Manzl C, Soratroi C, Villunger A, Krumschnabel G. Necrosis-like death can engage multiple pro-apoptotic Bcl-2 protein family members. Apoptosis. 2012; 17(11):1197-209. doi: 10.1007/s10495-012-0756-8 PMID: 22971741
10. Kroemer G, Galluzzi L, Vandenabeele P, Abrams J, Alnemri ES, Baehrecke EH, et al. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ. 2008; 16(1):3-11. doi: 10.1038/cdd.2008.150 PMID: 18846107
11. Lin Y, Devin A, Rodriguez Y, Liu Z-g. Cleavage of the death domain kinase RIP by Caspase-8 prompts TNF-induced apoptosis. Genes Dev. 1999; 13(19):2514-26. PMID: 10521396
12. Cho Y, Challa S, Moquin D, Genga R, Ray TD, Guildford M, et al. Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation. Cell. 2009; 137(6):1112-23. doi: 10.1016/j.cell.2009.05.037 PMID: 19524513
13. He S, Wang L, Miao L, Wang T, Du F, Zhao L, et al. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-α. Cell. 2009; 137(6):1100-11. doi: 10.1016/j.cell.2009.05.021 PMID: 19524512
14. Sun L, Wang H, Wang Z, He S, Chen S, Liao D, et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell. 2012; 148(1):213-27.
15. Wu J, Huang Z, Ren J, Zhang Z, He P, Li Y, et al. Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis. Cell Res. 2013; 23(8):994-1006. doi: 10.1038/cr.2013.91 PMID: 23835476
16. Marshall KD, Baines CP. Necroptosis: is there a role for mitochondria? Frontiers in physiology. 2014; 5.
17. Lim S, Davidson S, Mocanu M, Yellon D, Smith C. The cardioprotective effect of necrostatin requires the cyclophilin-D component of the mitochondrial permeability transition pore. Cardiovasc Drugs Ther. 2007; 21(6):467-9. PMID: 17965927
18. Tait SW, Oberst A, Quarato G, Milasta S, Haller M, Wang R, et al. Widespread mitochondrial depletion via mitophagy does not compromise necroptosis. Cell reports. 2013; 5(4):878-85. doi: 10.1016/j.celrep.2013.10.034 PMID: 24268776
19. Linkermann A, Bra¨sen JH, Darding M, Jin MK, Sanz AB, Heller J-O, et al. Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury. Proceedings of the National Academy of Sciences. 2013; 110(29):12024-9. doi: 10.1073/pnas.1305538110 PMID: 23818611
20. Chua BT, Volbracht C, Tan KO, Li R, Victor CY, Li P. Mitochondrial translocation of cofilin is an early step in apoptosis induction. Nature cell biology. 2003; 5(12):1083-9. PMID: 14634665
21. Wabnitz G, Goursot C, Jahraus B, Kirchgessner H, Hellwig A, Klemke M, et al. Mitochondrial translocation of oxidized cofilin induces caspase-independent necrotic-like programmed cell death of T cells. Cell death & disease. 2010; 1(7):e58.
22. Klamt F, Zdanov S, Levine RL, Pariser A, Zhang Y, Zhang B, et al. Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin. Nature Cell Biology. 2009; 11(10):1241-6. doi: 10.1038/ncb1968 PMID: 19734890
23. Perciavalle RM, Stewart DP, Koss B, Lynch J, Milasta S, Bathina M, et al. Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration. Nature cell biology. 2012; 14(6):575-83. doi: 10.1038/ncb2488 PMID: 22544066
24. Kim H, Tu HC, Ren D, Takeuchi O, Jeffers JR, Zambetti GP, et al. Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis. Mol Cell. 2009; 36(3):487-99. Epub 2009/11/18. doi: 10.1016/j.molcel.2009.09.030 PMID: 19917256; PubMed Central PMCID: PMC3163439.
25. Hoppins S, Edlich F, Cleland MM, Banerjee S, McCaffery JM, Youle RJ, et al. The soluble form of Bax regulates mitochondrial fusion via MFN2 homotypic complexes. Mol Cell. 2011; 41(2):150-60. Epub 2011/01/25. doi: 10.1016/j.molcel.2010.11.030 PMID: 21255726; PubMed Central PMCID: PMC3072068.
26. Li L, Chen Y, Doan J, Murray J, Molkentin JD, Liu Q. A TAK1 Signaling Pathway Critically Regulates Myocardial Survival and Remodeling. Circulation. 2014:CIRCULATIONAHA. 114.011195.
27. Vercammen D, Beyaert R, Denecker G, Goossens V, Van Loo G, Declercq W, et al. Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. The Journal of experimental medicine. 1998; 187(9):1477-85. PMID: 9565639
28. Kaiser WJ, Upton JW, Long AB, Livingston-Rosanoff D, Daley-Bauer LP, Hakem R, et al. RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature. 2011; 471(7338):368-72. doi: http://www.nature.com/nature/journal/v471/n7338/abs/10.1038-nature09857-unlocked.html#supplementary-information. doi: 10.1038/nature09857 PMID: 21368762
29. De Marchi U, Basso E, Szabò I, Zoratti M. Electrophysiological characterization of the Cyclophilin D-deleted mitochondrial permeability transition pore. Mol Membr Biol. 2006; 23(6):521-30. PMID: 17127624