Investigating the Interaction Pattern and Structural Elements of a Drug-Polymer Complex at the Molecular Level

Molecular Pharmaceutics

Volumn 12, Issue 7, 2015, Pages 2459-2468

  Nie, Haichen ^a   Mo, Huaping ^a   Zhang, Mingtao ^a   Song, Yang ^a   Fang, Ke ^a   Taylor, Lynne S ^a   Li, Tonglei ^a   Byrn, Stephen R ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

amorphous solid dispersion; clofazimine; drug loading capacity; drug polymer interactions; ionic interaction; solution NMR

Indexed keywords

CARBOXYLIC ACID; CHLOROFORM; CLOFAZIMINE; HYDROXYPROPYLMETHYLCELLULOSE PHTHALATE; POLYMER; DRUG CARRIER; LEPROSTATIC AGENT; METHYLCELLULOSE; SOLVENT;

ARTICLE; DISPERSION; DRUG FORMULATION; EVAPORATION; MOLECULAR INTERACTION; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; QUANTUM CHEMISTRY; ULTRAVIOLET SPECTROSCOPY; ANALOGS AND DERIVATIVES; CHEMISTRY; DRUG STABILITY; MEDICINAL CHEMISTRY; PROCEDURES; SOLUBILITY;

CHEMISTRY, PHARMACEUTICAL; CLOFAZIMINE; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; LEPROSTATIC AGENTS; METHYLCELLULOSE; POLYMERS; SOLUBILITY; SOLVENTS;

EID: 84936776405     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.5b00162     Document Type: Article

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