The pro-domains of neurotrophins, including BDNF, are linked to Alzheimer's disease through a toxic synergy with Aβ

Human Molecular Genetics

Volumn 24, Issue 14, 2015, Pages 3929-3938

  Lim, Jung Yeon ^a   Reighard, Charles P ^a   Crowther, Damian C ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MEDIMMUNE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; BRAIN DERIVED NEUROTROPHIC FACTOR; INSECT PROTEIN; MESSENGER RNA; NEUROTROPHIN; NEUROTROPHIN 1; NEUROTROPHIN RECEPTOR P75; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN; DROSOPHILA PROTEIN; GENETIC MARKER; NERVE GROWTH FACTOR; NEUROTROPHIN 1, DROSOPHILA; PEPTIDE FRAGMENT;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; DROSOPHILA; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MALE; MIDDLE AGED; NEUROBLASTOMA CELL LINE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; VERY ELDERLY; WESTERN BLOTTING; ANIMAL; BRAIN; CELL SURVIVAL; GENETIC MARKER; GENETICS; METABOLISM; TUMOR CELL LINE;

MAMMALIA;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL LINE, TUMOR; CELL SURVIVAL; DROSOPHILA; DROSOPHILA PROTEINS; FEMALE; GENETIC MARKERS; HUMANS; MALE; MIDDLE AGED; NERVE GROWTH FACTORS; PEPTIDE FRAGMENTS; PROTEIN INTERACTION MAPS; RECEPTOR, TRKB; UP-REGULATION;

EID: 84936769308     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddv130     Document Type: Article

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