Protective Effects of SKF-96365, a Non-Specific Inhibitor of SOCE, against MPP+-Induced Cytotoxicity in PC12 Cells: Potential Role of Homer1

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Chen, Tao ^a,b   Zhu, Jie ^a   Zhang, Chi ^a   Huo, Kai ^a   Fei, Zhou ^a   Jiang, Xiao Fan ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b The 123th Hospital of PLA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (4 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPOXY]ETHYL] 1H IMIDAZOLE; LACTATE DEHYDROGENASE; PROTEIN HOMER 1;

ANIMAL CELL; ARTICLE; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENDOPLASMIC RETICULUM; ENZYME RELEASE; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; UPREGULATION;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; CALCIUM; CARRIER PROTEINS; CELL DEATH; HUMANS; IMIDAZOLES; NEURONS; NEUROPROTECTIVE AGENTS; PC12 CELLS; RATS;

EID: 84873161845     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0055601     Document Type: Article

References (44)

1. Jellinger KA, (2001) The pathology of Parkinson's disease. Adv Neurol 86: 55-72.
2. Braak H, Del Tredici K, Rub U, de Vos RA, Jansen Steur EN, et al. (2003) Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 24: 197-211.
3. Fahn S, Sulzer D, (2004) Neurodegeneration and neuroprotection in Parkinson disease. NeuroRx 1: 139-154.
4. Schapira AH, Olanow CW, (2004) Neuroprotection in Parkinson disease: mysteries, myths, and misconceptions. JAMA 291: 358-364.
5. Ritz B, Rhodes SL, Qian L, Schernhammer E, Olsen JH, et al. (2010) L-type calcium channel blockers and Parkinson disease in Denmark. Ann Neurol 67: 600-606.
6. Ilijic E, Guzman JN, Surmeier DJ, (2011) The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease. Neurobiol Dis 43: 364-371.
7. Becker C, Jick SS, Meier CR, (2008) Use of antihypertensives and the risk of Parkinson disease. Neurology 70: 1438-1444.
8. Brandt SK, Weatherly ME, Ware L, Linn DM, Linn CL, (2011) Calcium preconditioning triggers neuroprotection in retinal ganglion cells. Neuroscience 172: 387-397.
9. Wilhelmus MM, van der Pol SM, Jansen Q, Witte ME, van der Valk P, et al. (2011) Association of Parkinson disease-related protein PINK1 with Alzheimer disease and multiple sclerosis brain lesions. Free Radic Biol Med 50: 469-476.
10. Surmeier DJ, Guzman JN, Sanchez-Padilla J, Schumacker PT, (2011) The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson's disease. Neuroscience 198: 221-231.
11. Parekh AB, Putney JW Jr, (2005) Store-operated calcium channels. Physiol Rev 85: 757-810.
12. Peng L, Men X, Zhang W, Wang H, Xu S, et al. (2011) Dynamin-related protein 1 is implicated in endoplasmic reticulum stress-induced pancreatic beta-cell apoptosis. Int J Mol Med 28: 161-169.
13. Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, et al. (1997) Homer: a protein that selectively binds metabotropic glutamate receptors. Nature 386: 284-288.
14. Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, et al. (1998) Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron 21: 717-726.
15. Xiao B, Tu JC, Worley PF, (2000) Homer: a link between neural activity and glutamate receptor function. Curr Opin Neurobiol 10: 370-374.
16. Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, et al. (2003) Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell 114: 777-789.
17. Luo P, Zhao Y, Li D, Chen T, Li S, et al. (2012) Protective effect of Homer 1a on tumor necrosis factor-alpha with cycloheximide-induced apoptosis is mediated by mitogen-activated protein kinase pathways. Apoptosis.
18. Chen T, Fei F, Jiang XF, Zhang L, Qu Y, et al. (2012) Down-regulation of Homer1b/c attenuates glutamate-mediated excitotoxicity through endoplasmic reticulum and mitochondria pathways in rat cortical neurons. Free Radic Biol Med 52: 208-217.
19. Dorsey ER, Constantinescu R, Thompson JP, Biglan KM, Holloway RG, et al. (2007) Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. Neurology 68: 384-386.
20. Lo Bianco C, Schneider BL, Bauer M, Sajadi A, Brice A, et al. (2004) Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease. Proc Natl Acad Sci U S A 101: 17510-17515.
21. Dawson TM, Dawson VL, (2003) Molecular pathways of neurodegeneration in Parkinson's disease. Science 302: 819-822.
22. Gomez-Lazaro M, Bonekamp NA, Galindo MF, Jordan J, Schrader M, (2008) 6-Hydroxydopamine (6-OHDA) induces Drp1-dependent mitochondrial fragmentation in SH-SY5Y cells. Free Radic Biol Med 44: 1960-1969.
23. Takashima A, Koike T, (1985) Relationship between dopamine content and its secretion in PC12 cells as a function of cell growth. Biochim Biophys Acta 847: 101-107.
24. Panariello F, Perruolo G, Cassese A, Giacco F, Botta G, et al. (2012) Clozapine impairs insulin action by up-regulating Akt phosphorylation and Ped/Pea-15 protein abundance. J Cell Physiol 227: 1485-1492.
25. Krieglstein K, Suter-Crazzolara C, Fischer WH, Unsicker K, (1995) TGF-beta superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity. EMBO J 14: 736-742.
26. Soldner F, Weller M, Haid S, Beinroth S, Miller SW, et al. (1999) MPP+ inhibits proliferation of PC12 cells by a p21(WAF1/Cip1)-dependent pathway and induces cell death in cells lacking p21(WAF1/Cip1). Exp Cell Res 250: 75-85.
27. Sethi K, (2008) Levodopa unresponsive symptoms in Parkinson disease. Mov Disord 23 Suppl 3: S521-533.
28. Weiner WJ, Reich SG, (2008) Agonist or levodopa for Parkinson disease?: ultimately, it doesn't matter; neither is good enough. Neurology 71: 470-471.
29. Merritt JE, Armstrong WP, Benham CD, Hallam TJ, Jacob R, et al. (1990) SK&F 96365, a novel inhibitor of receptor-mediated calcium entry. Biochem J 271: 515-522.
30. Ramsey IS, Delling M, Clapham DE, (2006) An introduction to TRP channels. Annu Rev Physiol 68: 619-647.
31. Ding J, Zhang JR, Wang Y, Li CL, Lu D, et al. (2012) Effects of a non-selective TRPC channel blocker, SKF-96365, on melittin-induced spontaneous persistent nociception and inflammatory pain hypersensitivity. Neurosci Bull 28: 173-181.
32. Okada T, Shimizu S, Wakamori M, Maeda A, Kurosaki T, et al. (1998) Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain. J Biol Chem 273: 10279-10287.
33. Zhu X, Jiang M, Birnbaumer L, (1998) Receptor-activated Ca2+ influx via human Trp3 stably expressed in human embryonic kidney (HEK)293 cells. Evidence for a non-capacitative Ca2+ entry. J Biol Chem 273: 133-142.
34. Wang GX, Poo MM, (2005) Requirement of TRPC channels in netrin-1-induced chemotropic turning of nerve growth cones. Nature 434: 898-904.
35. Singh A, Hildebrand ME, Garcia E, Snutch TP, (2010) The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels. Br J Pharmacol 160: 1464-1475.
36. Ango F, Robbe D, Tu JC, Xiao B, Worley PF, et al. (2002) Homer-dependent cell surface expression of metabotropic glutamate receptor type 5 in neurons. Mol Cell Neurosci 20: 323-329.
37. Shin DM, Dehoff M, Luo X, Kang SH, Tu J, et al. (2003) Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCbeta GAP activities. J Cell Biol 162: 293-303.
38. Sato M, Suzuki K, Nakanishi S, (2001) NMDA receptor stimulation and brain-derived neurotrophic factor upregulate homer 1a mRNA via the mitogen-activated protein kinase cascade in cultured cerebellar granule cells. J Neurosci 21: 3797-3805.
39. Wang Y, Fei Z, Ma YH, Liu WB, Zhu J, et al. (2012) VEGF upregulates Homer 1a gene expression via the mitogen-activated protein kinase cascade in cultured cortex neurons. Neurosci Lett 515: 44-49.
40. Ross WN, (1989) Changes in intracellular calcium during neuron activity. Annu Rev Physiol 51: 491-506.
41. Cali T, Ottolini D, Brini M, (2011) Mitochondria, calcium, and endoplasmic reticulum stress in Parkinson's disease. Biofactors 37: 228-240.
42. Mekahli D, Bultynck G, Parys JB, De Smedt H, Missiaen L, (2011) Endoplasmic-reticulum calcium depletion and disease. Cold Spring Harb Perspect Biol 3.
43. Harper JL, Camerini-Otero CS, Li AH, Kim SA, Jacobson KA, et al. (2003) Dihydropyridines as inhibitors of capacitative calcium entry in leukemic HL-60 cells. Biochem Pharmacol 65: 329-338.
44. Szikra T, Barabas P, Bartoletti TM, Huang W, Akopian A, et al. (2009) Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels. PLoS One 4: e6723.