Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci

Human Molecular Genetics

Volumn 24, Issue 6, 2015, Pages 1791-1800

  He, Meian ^a   Xu, Min ^b,c   Zhang, Ben ^e   Liang, Jun ^f   Chen, Peng ^g   Lee, Jong Young ⁱ   Johnson, Todd A ^j   Li, Huaixing ^k   Yang, Xiaobo ^l,m   Dai, Juncheng ⁿ   Liang, Liming ^b   Gui, Lixuan ^a   Qi, Qibin ^b   Huang, Jinyan ^b   Li, Yanping ^b   Adair, Linda S ^o   Aung, Tin ^q   Cai, Qiuyin ^e   Cheng, Ching Yu ^g,q,r   Cho, Myeong Chan ⁱ   Cho, Yoon Shin ⁱ   Chu, Minjie ⁿ   Cui, Bin ^c   Gao, Yu Tang ^d   Go, Min Jin ⁱ   Gu, Dongfeng ^s   Gu, Weiqiong ^c   Guo, Huan ^a   Hao, Yongchen ^s   Hong, Jie ^c   Hu, Zhibin ⁿ   Hu, Yanling ^m   Huang, Jianfeng ^s   Hwang, Joo Yeon ⁱ   Ikram, Mohammad Kamran ^g,q,u,v   Jin, Guangfu ⁿ   Kang, Dae Hee ^w   Khor, Chiea Chuen ^g,x   Kim, Bong Jo ⁱ   Kim, Hung Tae ⁱ   Kubo, Michiaki ^j   Lee, Jeannette ^g   Lee, Juyoung ⁱ   Lee, Nanette R ^y   Li, Ruoying ^h   Li, Jun ^a   Liu, JianJun ^g,x   Longe, Jirong ^e   Lu, Wei ^z   Lu, Xiangfeng ^s   Miao, Xiaoping ^a   Okada, Yukinori ^j   Ong, Rick Twee Hee ^g   Qiu, Gaokun ^a   Seielstad, Mark ^g   Sim, Xueling ^g,aa   Song, Huaidong ^d   Takeuchi, Fumihiko ^ab   Tanaka, Toshihiro ^j   Taylor, Phil R ^ac   Wang, Laiyuan ^s   Wang, Weiqing ^c   Wang, Yiqin ^k   Wu, Chen ^t   Wu, Ying ^p   Xiang, Yong Bing ^d   Yamamoto, Ken ^ad   Yang, Handong ^ae   Liao, Ming ^l   Yokota, Mitsuhiro ^af   Young, Terri ^r,ag   Zhang, Xiaomin ^a   Kato, Norihiro ^ab   Wang, Qing K ^ah   Zheng, Wei ^e   Hu, Frank B ^b   Lin, Dongxin ^t   Shen, Hongbing ⁿ   Teo, Yik Ying ^g,x   Mo, Zengnan ^l   Wong, Tien Yin ^g,q   Lin, Xu ^k   Mohlke, Karen L ^p   Ning, Guang ^c   Tsunoda, Tatsuhiko ^j   Han, Bok Ghee ⁱ   Shu, Xiao Ou ^e   Tai, E Shyong ^g,h,r   Wu, Tangchun ^a   Qi, Lu ^b   more..

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c BEIJING HOSPITAL   (China)

^d SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^e VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^f XUZHOU CENTRAL HOSPITAL   (China)

^g NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^h Dept Medicine Endocrinol Diabet   (Singapore)

ⁱ Korea National Institute of Health   (South Korea)

^j RIKEN   (Japan)

^k Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^l First Affiliated Hospital   (China)

^m GUANGXI MEDICAL UNIVERSITY   (China)

ⁿ NANJING MEDICAL UNIVERSITY   (China)

^o IL   (United States)

^p UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^q SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^r DUKE NUS MEDICAL SCHOOL   (Singapore)

^s FUWAI HOSPITAL   (China)

^t CANCER HOSPITAL   (China)

^u ERASMUS MEDICAL CENTER   (Netherlands)

^v NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^w Seoul National University   (South Korea)

^x GENOME INSTITUTE OF SINGAPORE   (Singapore)

^y UNIVERSITY OF SAN CARLOS   (Philippines)

^z SHANGHAI MUNICIPAL CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^aa UNIVERSITY OF MICHIGAN   (United States)

^ab NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^ac NATIONAL CANCER INSTITUTE   (United States)

^ad KYUSHU UNIVERSITY   (Japan)

^ae HUBEI UNIVERSITY OF MEDICINE   (China)

^af AICHI GAKUIN UNIVERSITY   (Japan)

^ag DUKE UNIVERSITY EYE CENTER   (United States)

^ah HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE 1; CCN PROTEIN; CCND1 PROTEIN; CRIM1 PROTEIN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 10; DNM2 PROTEIN; EXTL3 PROTEIN; HCG22 PROTEIN; INTERLEUKIN ENHANCER BINDING FACTOR 3; KDM6B PROTEIN; MYC PROTEIN; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 14; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 9; PAN2 PROTEIN; PROTEIN P107; PROTEIN TYROSINE PHOSPHATASE; SODIUM PHOSPHATE COTRANSPORTER 2; SOMATOMEDIN C; SONIC HEDGEHOG PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UBD PROTEIN; UNCLASSIFIED DRUG; ZNF638 PROTEIN;

ADULT; ADULT HEIGHT; ARTICLE; BODY HEIGHT; EAST ASIAN; EUROPEAN; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ALGORITHM; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; PRIORITY JOURNAL; SEX DIFFERENCE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; ADOLESCENT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CAUCASIAN; FAR EAST; FEMALE; GENETICS; GENOME-WIDE ASSOCIATION STUDY; MALE; META ANALYSIS; METABOLISM; MIDDLE AGED; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ASIAN CONTINENTAL ANCESTRY GROUP; BODY HEIGHT; EUROPEAN CONTINENTAL ANCESTRY GROUP; FAR EAST; FEMALE; GENE FREQUENCY; GENETIC LOCI; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; METABOLIC NETWORKS AND PATHWAYS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN TYROSINE PHOSPHATASES; YOUNG ADULT;

EID: 84936073085     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddu583     Document Type: Article

References (43)

1. Perola, M., Sammalisto, S., Hiekkalinna, T., Martin, N.G., Visscher, P.M., Montgomery, G.W., Benyamin, B., Harris, J.R., Boomsma, D., Willemsen, G. et al. (2007) Combined genome scans for body stature in 6, 602 European twins: evidence for common Caucasian loci. PLoS Genet., 3, e97.
2. Carmichael, C.M. and McGue, M. (1995) A cross-sectional examination of height, weight, and body mass index in adult twins. J. Gerontol. A Biol. Sci. Med. Sci., 50, B237-B244.
3. Kabat, G.C., Heo, M., Kamensky, V., Miller, A.B. and Rohan, T.E. (2013) Adult height in relation to risk of cancer in a cohort of Canadian women. Int. J. Cancer, 132, 1125-1132.
4. Green, J., Cairns, B.J., Casabonne, D., Wright, F.L., Reeves, G. and Beral, V. (2011) Height and cancer incidence in the Million Women Study: prospective cohort, and meta-analysis of prospective studies of height and total cancer risk. Lancet Oncol., 12, 785-794.
5. Shimizu, Y., Imano, H., Ohira, T., Kitamura, A., Kiyama, M., Okada, T., Ishikawa, Y., Shimamoto, T., Yamagishi, K., Tanigawa, T. et al. (2013) Adult height and body mass index in relation to risk of total stroke and its subtypes: the circulatory risk in communities study. J. Stroke Cerebrovasc. Dis., 23, 667-674.
6. Rosenberg, M.A., Patton, K.K., Sotoodehnia, N., Karas, M.G., Kizer, J.R., Zimetbaum, P.J., Chang, J.D., Siscovick, D., Gottdiener, J.S., Kronmal, R.A. et al. (2012) The impact of height on the risk of atrial fibrillation: the Cardiovascular Health Study. Eur. Heart J., 33, 2709-2717.
7. Tripaldi, R., Stuppia, L. and Alberti, S. (2013) Human height genes and cancer. Biochim. Biophys. Acta, 1836, 27-e41.
8. Lango Allen, H., Estrada, K., Lettre, G., Berndt, S.I., Weedon, M.N., Rivadeneira, F., Willer, C.J., Jackson, A.U., Vedantam, S., Raychaudhuri, S. et al. (2010) Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature, 467, 832-838.
9. Marigorta, U.M. and Navarro, A. (2013) High trans-ethnic replicability of GWAS results implies common causal variants. PLoS Genet., 9, e1003566.
10. Kim, J.-J., Lee, H.-I., Park, T., Kim, K., Lee, J.-E., Cho, N.H., Shin, C., Cho, Y.S., Lee, J.-Y., Han, B.-G. et al. (2009) Identification of 15 loci influencing height in a Korean population. J. Hum. Genet., 55, 27-31.
11. Okada, Y., Kamatani, Y., Takahashi, A., Matsuda, K., Hosono, N., Ohmiya, H., Daigo, Y., Yamamoto, K., Kubo, M., Nakamura, Y. et al. (2010) A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. Hum. Mol. Genet., 19, 2303-2312.
12. Lei, S.-F., Yang, T.-L., Tan, L.-J., Chen, X.-D., Guo, Y., Guo, Y.-F., Zhang, L., Liu, X.-G., Yan, H., Pan, F. et al. (2008) Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci. Hum. Genet., 125, 1-9.
13. Yang, J., Ferreira, T., Morris, A.P., Medland, S.E., Madden, P.A., Heath, A.C., Martin, N.G., Montgomery, G.W., Weedon, M.N., Loos, R.J. et al. (2012) Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat. Genet., 44, 369-375, S361-S363.
14. Wang, K., Li, M. and Bucan, M. (2007) Pathway-based approaches for analysis of genomewide association studies. Am. J. Hum. Genet., 81, 1278-1283.
15. Segre, A.V., Groop, L., Mootha, V.K., Daly, M.J. and Altshuler, D. (2010) Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits. PLoS Genet., 6, e1001058.
16. Clemmons, D.R. (2007) Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer. Nat. Rev. Drug Discov., 6, 821-833.
17. Kemp, S.F. (2009) Insulin-like growth factor-I deficiency in children with growth hormone insensitivity: current and future treatment options. BioDrugs, 23, 155-163.
18. The International HapMap Consortium. (2003) The International HapMap Project. Nature, 426, 789-796.
19. Tartaglia, M., Mehler, E.L., Goldberg, R., Zampino, G., Brunner, H.G., Kremer, H., van der Burgt, I., Crosby, A.H., Ion, A., Jeffery, S. et al. (2001) Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. Nat. Genet., 29, 465-468.
20. Noonan, J.A. (1968) Hypertelorism with Turner phenotype. A new syndrome with associated congenital heart disease. Am. J. Dis. Child, 116, 373-380.
21. Tartaglia, M., Niemeyer, C.M., Fragale, A., Song, X., Buechner, J., Jung, A., Hahlen, K., Hasle, H., Licht, J.D. and Gelb, B.D. (2003) Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Nat. Genet., 34, 148-150.
22. Schaeffer, L., Gohlke, H., Muller, M., Heid, I.M., Palmer, L.J., Kompauer, I., Demmelmair, H., Illig, T., Koletzko, B. and Heinrich, J. (2006) Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Hum. Mol. Genet., 15, 1745-1756.
23. Tanaka, T., Shen, J., Abecasis, G.R., Kisialiou, A., Ordovas, J.M., Guralnik, J.M., Singleton, A., Bandinelli, S., Cherubini, A., Arnett, D. et al. (2009) Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study. PLoS Genet., 5, e1000338.
24. Demirkan, A., van Duijn, C.M., Ugocsai, P., Isaacs, A., Pramstaller, P.P., Liebisch, G., Wilson, J.F., Johansson, A., Rudan, I., Aulchenko, Y.S. et al. (2012) Genome-wide association study identifies novel loci associated with circulating phosphoand sphingolipid concentrations. PLoS Genet., 8, e1002490.
25. Kwak, J.H., Paik, J.K., Kim, O.Y., Jang, Y., Lee, S.H., Ordovas, J.M. and Lee, J.H. (2011) FADS gene polymorphisms in Koreans: association with omega6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery disease. Atherosclerosis, 214, 94-100.
26. Waterworth, D.M., Ricketts, S.L., Song, K., Chen, L., Zhao, J.H., Ripatti, S., Aulchenko, Y.S., Zhang, W., Yuan, X., Lim, N. et al. (2010) Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler. Thromb. Vasc. Biol., 30, 2264-2276.
27. Chambers, J.C., Zhang, W., Sehmi, J., Li, X., Wass, M.N., Van der Harst, P., Holm, H., Sanna, S., Kavousi, M., Baumeister, S.E. et al. (2011) Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat. Genet., 43, 1131-1138.
28. Weedon, M.N., Lango, H., Lindgren, C.M., Wallace, C., Evans, D.M., Mangino, M., Freathy, R.M., Perry, J.R., Stevens, S., Hall, A.S. et al. (2008) Genome-wide association analysis identifies 20 loci that influence adult height. Nat. Genet., 40, 575-583.
29. Lettre, G., Jackson, A.U., Gieger, C., Schumacher, F.R., Berndt, S.I., Sanna, S., Eyheramendy, S., Voight, B.F., Butler, J.L., Guiducci, C. et al. (2008) Identification of ten loci associated with height highlights new biological pathways in human growth. Nat. Genet., 40, 584-591.
30. Sokol, S.Y. (1999) Wnt signaling and dorso-ventral axis specification in vertebrates. Curr. Opin. Genet. Dev., 9, 405-410.
31. Zhou, Z.Q., Shung, C.Y., Ota, S., Akiyama, H., Keene, D.R. and Hurlin, P.J. (2011) Sequential and coordinated actions of c-Myc and N-Myc control appendicular skeletal development. PLoS ONE, 6, e18795.
32. Kung, A.W., Xiao, S.M., Cherny, S., Li, G.H., Gao, Y., Tso, G., Lau, K.S., Luk, K.D., Liu, J.M., Cui, B. et al. (2010) Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies. Am. J. Hum. Genet., 86, 229-239.
33. Piek, E., Sleumer, L.S., van Someren, E.P., Heuver, L., de Haan, J.R., de Grijs, I., Gilissen, C., Hendriks, J.M., van Ravestein-van Os, R.I., Bauerschmidt, S. et al. (2010) Osteo-transcriptomics of human mesenchymal stem cells: accelerated gene expression and osteoblast differentiation induced by vitamin D reveals c-MYC as an enhancer of BMP2-induced osteogenesis. Bone, 46, 613-627.
34. Wood, A.R., Esko, T., Yang, J., Vedantam, S., Pers, T.H., Gustafsson, S., Chu, A.Y., Estrada, K., Luan, J., Kutalik, Z. et al. (2014) Defining the role of common variation in the genomic and biological architecture of adult human height. Nat. Genet., 46, 1173-1186.
35. Li, Y., Willer, C., Sanna, S. and Abecasis, G. (2009) Genotype imputation. Annu. Rev. Genomics Hum. Genet., 10, 387-406.
36. Marchini, J., Howie, B., Myers, S., McVean, G. and Donnelly, P. (2007) A new multipoint method for genome-wide association studies by imputation of genotypes. Nat. Genet., 39, 906-913.
37. Browning, B.L. and Browning, S.R. (2009) A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals. Am. J. Hum. Genet., 84, 210-223.
38. Cochran, W.G. (1954) The combination of estimates from different experiments. Biometrics, 10, 101-129.
39. Higgins, J.P. and Thompson, S.G. (2002) Quantifying heterogeneity in a meta-analysis. Stat. Med., 21, 1539-1558.
40. Devlin, B. and Roeder, K. (1999) Genomic control for association studies. Biometrics, 55, 997-1004.
41. Park, J.H., Wacholder, S., Gail, M.H., Peters, U., Jacobs, K.B., Chanock, S.J. and Chatterjee, N. (2010) Estimation of effect size distribution from genome-wide association studies and implications for future discoveries. Nat. Genet., 42, 570-575.
42. Raychaudhuri, S., Plenge, R.M., Rossin, E.J., Ng, A.C., Purcell, S. M., Sklar, P., Scolnick, E.M., Xavier, R.J., Altshuler, D. and Daly, M.J. (2009) Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet., 5, e1000534.
43. Faul, F., Erdfelder, E., Lang, A.G. and Buchner, A. (2007) G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav. Res. Methods, 39, 175-191.