Osteo-transcriptomics of human mesenchymal stem cells: Accelerated gene expression and osteoblast differentiation induced by vitamin D reveals c-MYC as an enhancer of BMP2-induced osteogenesis

Bone

Volumn 46, Issue 3, 2010, Pages 613-627

  Piek, Ester ^a   Sleumer, Laura S ^a   van Someren, Eugene P ^a   Heuver, Leonie ^a   de Haan, Jorn R ^b   de Grijs, Ingrid ^a   Gilissen, Christian ^c   Hendriks, José M ^a   van Ravestein van Os, Roselinde I ^d   Bauerschmidt, Susanne ^d   Dechering, Koen J ^a,d   van Zoelen, Everardus J ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

C MYC; Human mesenchymal stem cells; Microarray; Osteogenesis; Vitamin D

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; CALCITRIOL; COLECALCIFEROL; DEXAMETHASONE; MYC PROTEIN; VITAMIN D; MYC PROTEIN, HUMAN;

ARTICLE; BINDING SITE; BONE DEVELOPMENT; BONE MINERALIZATION; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; OSTEOBLAST; PROMOTER REGION; TRANSCRIPTOMICS; BIOSYNTHESIS; CELL CULTURE; COMPARATIVE STUDY; CYTOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; MESENCHYMAL STROMA CELL; METABOLISM; PHYSIOLOGY; PROCEDURES; UPREGULATION;

BONE MORPHOGENETIC PROTEIN 2; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; CELLS, CULTURED; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; MESENCHYMAL STEM CELLS; OSTEOBLASTS; OSTEOGENESIS; PROTO-ONCOGENE PROTEINS C-MYC; UP-REGULATION; VITAMIN D; MESENCHYMAL STROMAL CELLS;

EID: 77649181800     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.10.024     Document Type: Article

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