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Volumn 22, Issue 7, 2012, Pages 347-354

Landscapes and archipelagos: Spatial organization of gene regulation in vertebrates

Author keywords

Chromatin loops; Enhancers; Genome organization; Long range regulation; Transcription

Indexed keywords

CHROMATIN; DEVELOPMENTAL GENE; DNA MODIFICATION; ENHANCER REGION; GENE CONTROL; GENE LOCUS; GENE TECHNOLOGY; GENETIC TRANSCRIPTION; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; VERTEBRATE;

EID: 84862755561     PISSN: 09628924     EISSN: 18793088     Source Type: Journal    
DOI: 10.1016/j.tcb.2012.04.003     Document Type: Review
Times cited : (34)

References (93)
  • 1
    • 33750352462 scopus 로고    scopus 로고
    • Transcriptional regulatory elements in the human genome
    • Maston G.A., et al. Transcriptional regulatory elements in the human genome. Annu. Rev. Genomics Hum. Genet. 2006, 7:29-59.
    • (2006) Annu. Rev. Genomics Hum. Genet. , vol.7 , pp. 29-59
    • Maston, G.A.1
  • 2
    • 3042696502 scopus 로고    scopus 로고
    • Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression
    • Zuniga A., et al. Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression. Genes Dev. 2004, 18:1553-1564.
    • (2004) Genes Dev. , vol.18 , pp. 1553-1564
    • Zuniga, A.1
  • 3
    • 0042810698 scopus 로고    scopus 로고
    • A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly
    • Lettice L.A., et al. A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly. Hum. Mol. Genet. 2003, 12:1725-1735.
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 1725-1735
    • Lettice, L.A.1
  • 5
    • 39049155994 scopus 로고    scopus 로고
    • Long-range control of gene expression. Preface
    • Hill R.E., van Heyningen V. Long-range control of gene expression. Preface. Adv. Genet. 2008, 61:xiii-xv.
    • (2008) Adv. Genet. , vol.61
    • Hill, R.E.1    van Heyningen, V.2
  • 6
    • 39049130281 scopus 로고    scopus 로고
    • Global control regions and regulatory landscapes in vertebrate development and evolution
    • Spitz F., Duboule D. Global control regions and regulatory landscapes in vertebrate development and evolution. Adv. Genet. 2008, 61:175-205.
    • (2008) Adv. Genet. , vol.61 , pp. 175-205
    • Spitz, F.1    Duboule, D.2
  • 7
    • 0038613098 scopus 로고    scopus 로고
    • A global control region defines a chromosomal regulatory landscape containing the HoxD cluster
    • Spitz F., et al. A global control region defines a chromosomal regulatory landscape containing the HoxD cluster. Cell 2003, 113:405-417.
    • (2003) Cell , vol.113 , pp. 405-417
    • Spitz, F.1
  • 8
    • 79953162491 scopus 로고    scopus 로고
    • Gene expression in time and space: additive vs hierarchical organization of cis-regulatory regions
    • Maeda R.K., Karch F. Gene expression in time and space: additive vs hierarchical organization of cis-regulatory regions. Curr. Opin. Genet. Dev. 2011, 21:187-193.
    • (2011) Curr. Opin. Genet. Dev. , vol.21 , pp. 187-193
    • Maeda, R.K.1    Karch, F.2
  • 9
    • 34547819351 scopus 로고    scopus 로고
    • The rise and fall of Hox gene clusters
    • Duboule D. The rise and fall of Hox gene clusters. Development 2007, 134:2549-2560.
    • (2007) Development , vol.134 , pp. 2549-2560
    • Duboule, D.1
  • 10
    • 1542563409 scopus 로고    scopus 로고
    • Initial sequencing and comparative analysis of the mouse genome
    • Waterston R.H., et al. Initial sequencing and comparative analysis of the mouse genome. Nature 2002, 420:520-562.
    • (2002) Nature , vol.420 , pp. 520-562
    • Waterston, R.H.1
  • 11
    • 2042437650 scopus 로고    scopus 로고
    • Initial sequencing and analysis of the human genome
    • Lander E.S., et al. Initial sequencing and analysis of the human genome. Nature 2001, 409:860-921.
    • (2001) Nature , vol.409 , pp. 860-921
    • Lander, E.S.1
  • 12
    • 0034708480 scopus 로고    scopus 로고
    • The genome sequence of Drosophila melanogaster
    • Adams M.D., et al. The genome sequence of Drosophila melanogaster. Science 2000, 287:2185-2195.
    • (2000) Science , vol.287 , pp. 2185-2195
    • Adams, M.D.1
  • 13
    • 0032509302 scopus 로고    scopus 로고
    • Sequencing Consortium, Genome sequence of the nematode C. elegans: a platform for investigating biology
    • C. elegans Sequencing Consortium (1998) Genome sequence of the nematode C. elegans: a platform for investigating biology. Science 282, 2012-2018.
    • (1998) Science , vol.282 , pp. 2012-2018
    • Elegans, C.1
  • 14
    • 34250305146 scopus 로고    scopus 로고
    • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
    • ENCODE Project Consortium
    • ENCODE Project Consortium Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 2007, 447:799-816.
    • (2007) Nature , vol.447 , pp. 799-816
  • 15
    • 65549104157 scopus 로고    scopus 로고
    • Histone modifications at human enhancers reflect global cell-type-specific gene expression
    • Heintzman N., et al. Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature 2009, 459:108-112.
    • (2009) Nature , vol.459 , pp. 108-112
    • Heintzman, N.1
  • 16
    • 77957932111 scopus 로고    scopus 로고
    • Genomics tools for unraveling chromosome architecture
    • van Steensel B., Dekker J. Genomics tools for unraveling chromosome architecture. Nat. Biotechnol. 2010, 28:1089-1095.
    • (2010) Nat. Biotechnol. , vol.28 , pp. 1089-1095
    • van Steensel, B.1    Dekker, J.2
  • 17
    • 33751316959 scopus 로고    scopus 로고
    • In vivo enhancer analysis of human conserved non-coding sequences
    • Pennacchio L.A., et al. In vivo enhancer analysis of human conserved non-coding sequences. Nature 2006, 444:499-502.
    • (2006) Nature , vol.444 , pp. 499-502
    • Pennacchio, L.A.1
  • 18
    • 38649123306 scopus 로고    scopus 로고
    • Ultraconservation identifies a small subset of extremely constrained developmental enhancers
    • Visel A., et al. Ultraconservation identifies a small subset of extremely constrained developmental enhancers. Nat. Genet. 2008, 40:158-160.
    • (2008) Nat. Genet. , vol.40 , pp. 158-160
    • Visel, A.1
  • 19
    • 77956641239 scopus 로고    scopus 로고
    • ChIP-Seq identification of weakly conserved heart enhancers
    • Blow M.J., et al. ChIP-Seq identification of weakly conserved heart enhancers. Nat. Genet. 2010, 42:806-810.
    • (2010) Nat. Genet. , vol.42 , pp. 806-810
    • Blow, M.J.1
  • 20
    • 39049147650 scopus 로고    scopus 로고
    • Metrics of sequence constraint overlook regulatory sequences in an exhaustive analysis at phox2b
    • McGaughey D.M., et al. Metrics of sequence constraint overlook regulatory sequences in an exhaustive analysis at phox2b. Genome Res. 2008, 18:252-260.
    • (2008) Genome Res. , vol.18 , pp. 252-260
    • McGaughey, D.M.1
  • 21
    • 79551655285 scopus 로고    scopus 로고
    • Functional and mechanistic diversity of distal transcription enhancers
    • Bulger M., Groudine M. Functional and mechanistic diversity of distal transcription enhancers. Cell 2011, 144:327-339.
    • (2011) Cell , vol.144 , pp. 327-339
    • Bulger, M.1    Groudine, M.2
  • 22
    • 33847334699 scopus 로고    scopus 로고
    • Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome
    • Heintzman N.D., et al. Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat. Genet. 2007, 39:311-318.
    • (2007) Nat. Genet. , vol.39 , pp. 311-318
    • Heintzman, N.D.1
  • 23
    • 60149091656 scopus 로고    scopus 로고
    • ChIP-seq accurately predicts tissue-specific activity of enhancers
    • Visel A., et al. ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature 2009, 457:854-858.
    • (2009) Nature , vol.457 , pp. 854-858
    • Visel, A.1
  • 24
    • 80555156095 scopus 로고    scopus 로고
    • SAGA and ATAC histone acetyl transferase complexes regulate distinct sets of genes and ATAC defines a class of p300-independent enhancers
    • Krebs A.R., et al. SAGA and ATAC histone acetyl transferase complexes regulate distinct sets of genes and ATAC defines a class of p300-independent enhancers. Mol. Cell 2011, 44:410-423.
    • (2011) Mol. Cell , vol.44 , pp. 410-423
    • Krebs, A.R.1
  • 25
    • 78650758676 scopus 로고    scopus 로고
    • Histone H3K27ac separates active from poised enhancers and predicts developmental state
    • Creyghton M.P., et al. Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:21931-21936.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 21931-21936
    • Creyghton, M.P.1
  • 26
    • 79951516056 scopus 로고    scopus 로고
    • A unique chromatin signature uncovers early developmental enhancers in humans
    • Rada-Iglesias A., et al. A unique chromatin signature uncovers early developmental enhancers in humans. Nature 2011, 470:279-283.
    • (2011) Nature , vol.470 , pp. 279-283
    • Rada-Iglesias, A.1
  • 27
    • 77952367798 scopus 로고    scopus 로고
    • Widespread transcription at neuronal activity-regulated enhancers
    • Kim T.-K., et al. Widespread transcription at neuronal activity-regulated enhancers. Nature 2010, 465:182-187.
    • (2010) Nature , vol.465 , pp. 182-187
    • Kim, T.-K.1
  • 28
    • 77952908743 scopus 로고    scopus 로고
    • A large fraction of extragenic RNA pol II transcription sites overlap enhancers
    • De Santa F., et al. A large fraction of extragenic RNA pol II transcription sites overlap enhancers. PLoS Biol. 2010, 8:e1000384.
    • (2010) PLoS Biol. , vol.8
    • De Santa, F.1
  • 29
    • 34548697503 scopus 로고    scopus 로고
    • Deletion of ultraconserved elements yields viable mice
    • Ahituv N., et al. Deletion of ultraconserved elements yields viable mice. PLoS Biol. 2007, 5:e234.
    • (2007) PLoS Biol. , vol.5
    • Ahituv, N.1
  • 30
    • 58149463874 scopus 로고    scopus 로고
    • Chromosomal dynamics at the Shh locus: limb bud-specific differential regulation of competence and active transcription
    • Amano T., et al. Chromosomal dynamics at the Shh locus: limb bud-specific differential regulation of competence and active transcription. Dev. Cell 2009, 16:47-57.
    • (2009) Dev. Cell , vol.16 , pp. 47-57
    • Amano, T.1
  • 31
    • 58149333734 scopus 로고    scopus 로고
    • Long-range chromosomal interactions and gene regulation
    • Miele A., Dekker J. Long-range chromosomal interactions and gene regulation. Mol. Biosyst. 2008, 4:1046-1057.
    • (2008) Mol. Biosyst. , vol.4 , pp. 1046-1057
    • Miele, A.1    Dekker, J.2
  • 32
    • 70349873824 scopus 로고    scopus 로고
    • Comprehensive mapping of long-range interactions reveals folding principles of the human genome
    • Lieberman-Aiden E., et al. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science 2009, 326:289-293.
    • (2009) Science , vol.326 , pp. 289-293
    • Lieberman-Aiden, E.1
  • 33
    • 70449103609 scopus 로고    scopus 로고
    • An oestrogen-receptor-alpha-bound human chromatin interactome
    • Fullwood M.J., et al. An oestrogen-receptor-alpha-bound human chromatin interactome. Nature 2009, 462:58-64.
    • (2009) Nature , vol.462 , pp. 58-64
    • Fullwood, M.J.1
  • 34
    • 33750212321 scopus 로고    scopus 로고
    • Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C)
    • Simonis M., et al. Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C). Nat. Genet. 2006, 38:1348-1354.
    • (2006) Nat. Genet. , vol.38 , pp. 1348-1354
    • Simonis, M.1
  • 35
    • 79959952919 scopus 로고    scopus 로고
    • The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA
    • Splinter E., et al. The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA. Genes Dev. 2011, 25:1371-1383.
    • (2011) Genes Dev. , vol.25 , pp. 1371-1383
    • Splinter, E.1
  • 36
    • 78650994865 scopus 로고    scopus 로고
    • The three-dimensional folding of the α-globin gene domain reveals formation of chromatin globules
    • Baù D., et al. The three-dimensional folding of the α-globin gene domain reveals formation of chromatin globules. Nat. Struct. Mol. Biol. 2011, 18:107-114.
    • (2011) Nat. Struct. Mol. Biol. , vol.18 , pp. 107-114
    • Baù, D.1
  • 37
    • 67649766870 scopus 로고    scopus 로고
    • Transcription factories: gene expression in unions?
    • Sutherland H., Bickmore W.A. Transcription factories: gene expression in unions?. Nat. Rev. Genet. 2009, 10:457-466.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 457-466
    • Sutherland, H.1    Bickmore, W.A.2
  • 38
    • 79957803199 scopus 로고    scopus 로고
    • Nuclear organization: taking a position on gene expression
    • Geyer P.K., et al. Nuclear organization: taking a position on gene expression. Curr. Opin. Cell Biol. 2011, 23:354-359.
    • (2011) Curr. Opin. Cell Biol. , vol.23 , pp. 354-359
    • Geyer, P.K.1
  • 39
    • 78651514974 scopus 로고    scopus 로고
    • Polycomb-dependent regulatory contacts between distant Hox loci in Drosophila
    • Bantignies F., et al. Polycomb-dependent regulatory contacts between distant Hox loci in Drosophila. Cell 2011, 144:214-226.
    • (2011) Cell , vol.144 , pp. 214-226
    • Bantignies, F.1
  • 40
    • 80054110441 scopus 로고    scopus 로고
    • The dynamic architecture of Hox gene clusters
    • Noordermeer D., et al. The dynamic architecture of Hox gene clusters. Science 2011, 334:222-225.
    • (2011) Science , vol.334 , pp. 222-225
    • Noordermeer, D.1
  • 41
    • 84862908850 scopus 로고    scopus 로고
    • Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation
    • Li G., et al. Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation. Cell 2012, 148:84-98.
    • (2012) Cell , vol.148 , pp. 84-98
    • Li, G.1
  • 42
    • 73349090560 scopus 로고    scopus 로고
    • Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells
    • Schoenfelder S., et al. Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells. Nat. Genet. 2010, 42:53-61.
    • (2010) Nat. Genet. , vol.42 , pp. 53-61
    • Schoenfelder, S.1
  • 43
    • 39049092286 scopus 로고    scopus 로고
    • Beta-globin regulation and long-range interactions
    • Palstra R.J., et al. Beta-globin regulation and long-range interactions. Adv. Genet. 2008, 61:107-142.
    • (2008) Adv. Genet. , vol.61 , pp. 107-142
    • Palstra, R.J.1
  • 44
    • 0141730403 scopus 로고    scopus 로고
    • The beta-globin nuclear compartment in development and erythroid differentiation
    • Palstra R.-J., et al. The beta-globin nuclear compartment in development and erythroid differentiation. Nat. Genet. 2003, 35:190-194.
    • (2003) Nat. Genet. , vol.35 , pp. 190-194
    • Palstra, R.-J.1
  • 45
    • 0036923833 scopus 로고    scopus 로고
    • Looping and interaction between hypersensitive sites in the active beta-globin locus
    • Tolhuis B., et al. Looping and interaction between hypersensitive sites in the active beta-globin locus. Mol. Cell 2002, 10:1453-1465.
    • (2002) Mol. Cell , vol.10 , pp. 1453-1465
    • Tolhuis, B.1
  • 46
    • 34247272882 scopus 로고    scopus 로고
    • Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression
    • Vernimmen D., et al. Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression. EMBO J. 2007, 26:2041-2051.
    • (2007) EMBO J. , vol.26 , pp. 2041-2051
    • Vernimmen, D.1
  • 47
    • 76049125820 scopus 로고    scopus 로고
    • Chromosome looping at the human alpha-globin locus is mediated via the major upstream regulatory element (HS-40)
    • Vernimmen D., et al. Chromosome looping at the human alpha-globin locus is mediated via the major upstream regulatory element (HS-40). Blood 2009, 114:4253-4260.
    • (2009) Blood , vol.114 , pp. 4253-4260
    • Vernimmen, D.1
  • 48
    • 79960980390 scopus 로고    scopus 로고
    • Variegated gene expression caused by cell-specific long-range DNA interactions
    • Noordermeer D., et al. Variegated gene expression caused by cell-specific long-range DNA interactions. Nat. Cell Biol. 2011, 13:944-951.
    • (2011) Nat. Cell Biol. , vol.13 , pp. 944-951
    • Noordermeer, D.1
  • 49
    • 33645073400 scopus 로고    scopus 로고
    • A functional screen for sonic hedgehog regulatory elements across a 1 Mb interval identifies long-range ventral forebrain enhancers
    • Jeong Y., et al. A functional screen for sonic hedgehog regulatory elements across a 1 Mb interval identifies long-range ventral forebrain enhancers. Development 2006, 133:761-772.
    • (2006) Development , vol.133 , pp. 761-772
    • Jeong, Y.1
  • 50
    • 68549123708 scopus 로고    scopus 로고
    • A cluster of three long-range enhancers directs regional Shh expression in the epithelial linings
    • Sagai T., et al. A cluster of three long-range enhancers directs regional Shh expression in the epithelial linings. Development 2009, 136:1665-1674.
    • (2009) Development , vol.136 , pp. 1665-1674
    • Sagai, T.1
  • 51
    • 14844341770 scopus 로고    scopus 로고
    • Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb
    • Sagai T., et al. Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb. Development 2005, 132:797-803.
    • (2005) Development , vol.132 , pp. 797-803
    • Sagai, T.1
  • 52
    • 0038115063 scopus 로고    scopus 로고
    • Organizing axes in time and space; 25 years of colinear tinkering
    • Kmita M., Duboule D. Organizing axes in time and space; 25 years of colinear tinkering. Science 2003, 301:331-333.
    • (2003) Science , vol.301 , pp. 331-333
    • Kmita, M.1    Duboule, D.2
  • 53
    • 2442695407 scopus 로고    scopus 로고
    • Chromatin decondensation and nuclear reorganization of the HoxB locus upon induction of transcription
    • Chambeyron S., Bickmore W.A. Chromatin decondensation and nuclear reorganization of the HoxB locus upon induction of transcription. Genes Dev. 2004, 18:1119-1130.
    • (2004) Genes Dev. , vol.18 , pp. 1119-1130
    • Chambeyron, S.1    Bickmore, W.A.2
  • 54
    • 77955647352 scopus 로고    scopus 로고
    • The three-dimensional architecture of Hox cluster silencing
    • Ferraiuolo M.A., et al. The three-dimensional architecture of Hox cluster silencing. Nucleic Acids Res. 2010, 38:7472-7484.
    • (2010) Nucleic Acids Res. , vol.38 , pp. 7472-7484
    • Ferraiuolo, M.A.1
  • 55
    • 81855227640 scopus 로고    scopus 로고
    • A regulatory archipelago controls hox genes transcription in digits
    • Montavon T., et al. A regulatory archipelago controls hox genes transcription in digits. Cell 2011, 147:1132-1145.
    • (2011) Cell , vol.147 , pp. 1132-1145
    • Montavon, T.1
  • 56
    • 79953748673 scopus 로고    scopus 로고
    • A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression
    • Wang K.C., et al. A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Nature 2011, 472:120-124.
    • (2011) Nature , vol.472 , pp. 120-124
    • Wang, K.C.1
  • 57
    • 80755169506 scopus 로고    scopus 로고
    • A genetic approach to the transcriptional regulation of Hox gene clusters
    • Tschopp P., Duboule D. A genetic approach to the transcriptional regulation of Hox gene clusters. Annu. Rev. Genet. 2011, 45:145-166.
    • (2011) Annu. Rev. Genet. , vol.45 , pp. 145-166
    • Tschopp, P.1    Duboule, D.2
  • 58
    • 34249943590 scopus 로고    scopus 로고
    • Transgenic analysis of Hoxd gene regulation during digit development
    • Gonzalez F., et al. Transgenic analysis of Hoxd gene regulation during digit development. Dev. Biol. 2007, 306:847-859.
    • (2007) Dev. Biol. , vol.306 , pp. 847-859
    • Gonzalez, F.1
  • 59
    • 77954960062 scopus 로고    scopus 로고
    • Phenotypic robustness conferred by apparently redundant transcriptional enhancers
    • Frankel N., et al. Phenotypic robustness conferred by apparently redundant transcriptional enhancers. Nature 2010, 466:490-493.
    • (2010) Nature , vol.466 , pp. 490-493
    • Frankel, N.1
  • 60
    • 79959825697 scopus 로고    scopus 로고
    • Morphological evolution caused by many subtle-effect substitutions in regulatory DNA
    • Frankel N., et al. Morphological evolution caused by many subtle-effect substitutions in regulatory DNA. Nature 2011, 474:598-603.
    • (2011) Nature , vol.474 , pp. 598-603
    • Frankel, N.1
  • 61
    • 51149097760 scopus 로고    scopus 로고
    • Shadow enhancers as a source of evolutionary novelty
    • Hong J.-W., et al. Shadow enhancers as a source of evolutionary novelty. Science 2008, 321:1314.
    • (2008) Science , vol.321 , pp. 1314
    • Hong, J.-W.1
  • 62
    • 77956521381 scopus 로고    scopus 로고
    • Shadow enhancers foster robustness of Drosophila gastrulation
    • Perry M.W., et al. Shadow enhancers foster robustness of Drosophila gastrulation. Curr. Biol. 2010, 20:1562-1567.
    • (2010) Curr. Biol. , vol.20 , pp. 1562-1567
    • Perry, M.W.1
  • 63
    • 12744261452 scopus 로고    scopus 로고
    • Evolution and functional classification of vertebrate gene deserts
    • Ovcharenko I., et al. Evolution and functional classification of vertebrate gene deserts. Genome Res. 2005, 15:137-145.
    • (2005) Genome Res. , vol.15 , pp. 137-145
    • Ovcharenko, I.1
  • 64
    • 34248153777 scopus 로고    scopus 로고
    • Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates
    • Kikuta H., et al. Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates. Genome Res. 2007, 17:545-555.
    • (2007) Genome Res. , vol.17 , pp. 545-555
    • Kikuta, H.1
  • 65
    • 61349104285 scopus 로고    scopus 로고
    • Highly conserved non-coding elements on either side of SOX9 associated with Pierre Robin sequence
    • Benko S., et al. Highly conserved non-coding elements on either side of SOX9 associated with Pierre Robin sequence. Nat. Genet. 2009, 41:359-364.
    • (2009) Nat. Genet. , vol.41 , pp. 359-364
    • Benko, S.1
  • 66
    • 68149180869 scopus 로고    scopus 로고
    • A transposon-based chromosomal engineering method to survey a large cis-regulatory landscape in mice
    • Kokubu C., et al. A transposon-based chromosomal engineering method to survey a large cis-regulatory landscape in mice. Nat. Genet. 2009, 41:946-952.
    • (2009) Nat. Genet. , vol.41 , pp. 946-952
    • Kokubu, C.1
  • 67
    • 60549097668 scopus 로고    scopus 로고
    • Systematic human/zebrafish comparative identification of cis-regulatory activity around vertebrate developmental transcription factor genes
    • Navratilova P., et al. Systematic human/zebrafish comparative identification of cis-regulatory activity around vertebrate developmental transcription factor genes. Dev. Biol. 2009, 327:526-540.
    • (2009) Dev. Biol. , vol.327 , pp. 526-540
    • Navratilova, P.1
  • 68
    • 0142084743 scopus 로고    scopus 로고
    • Scanning human gene deserts for long-range enhancers
    • Nobrega M.A., et al. Scanning human gene deserts for long-range enhancers. Science 2003, 302:413.
    • (2003) Science , vol.302 , pp. 413
    • Nobrega, M.A.1
  • 69
    • 79955859947 scopus 로고    scopus 로고
    • An evolutionarily conserved three-dimensional structure in the vertebrate Irx clusters facilitates enhancer sharing and coregulation
    • Tena J.J., et al. An evolutionarily conserved three-dimensional structure in the vertebrate Irx clusters facilitates enhancer sharing and coregulation. Nat. Commun. 2011, 2:310.
    • (2011) Nat. Commun. , vol.2 , pp. 310
    • Tena, J.J.1
  • 70
    • 33744475085 scopus 로고    scopus 로고
    • A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter
    • De Gobbi M., et al. A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter. Science 2006, 312:1215-1217.
    • (2006) Science , vol.312 , pp. 1215-1217
    • De Gobbi, M.1
  • 71
    • 76049106672 scopus 로고    scopus 로고
    • Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition
    • Lower K.M., et al. Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:21771-21776.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 21771-21776
    • Lower, K.M.1
  • 72
    • 79953176250 scopus 로고    scopus 로고
    • Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor
    • Ruf S., et al. Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor. Nat. Genet. 2011, 43:379-386.
    • (2011) Nat. Genet. , vol.43 , pp. 379-386
    • Ruf, S.1
  • 73
    • 70249088327 scopus 로고    scopus 로고
    • Genomic views of distant-acting enhancers
    • Visel A., et al. Genomic views of distant-acting enhancers. Nature 2009, 461:199-205.
    • (2009) Nature , vol.461 , pp. 199-205
    • Visel, A.1
  • 74
    • 70349611559 scopus 로고    scopus 로고
    • Cis-ruption mechanisms: disruption of cis-regulatory control as a cause of human genetic disease
    • Kleinjan D.-J., Coutinho P. Cis-ruption mechanisms: disruption of cis-regulatory control as a cause of human genetic disease. Brief. Funct. Genomics Proteomics 2009, 8:317-332.
    • (2009) Brief. Funct. Genomics Proteomics , vol.8 , pp. 317-332
    • Kleinjan, D.-J.1    Coutinho, P.2
  • 75
    • 55049108856 scopus 로고    scopus 로고
    • Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein
    • Jeong Y., et al. Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein. Nat. Genet. 2008, 40:1348-1353.
    • (2008) Nat. Genet. , vol.40 , pp. 1348-1353
    • Jeong, Y.1
  • 76
    • 79951473520 scopus 로고    scopus 로고
    • 9p21 DNA variants associated with coronary artery disease impair interferon-gamma signalling response
    • Harismendy O., et al. 9p21 DNA variants associated with coronary artery disease impair interferon-gamma signalling response. Nature 2011, 470:264-268.
    • (2011) Nature , vol.470 , pp. 264-268
    • Harismendy, O.1
  • 77
    • 77956295666 scopus 로고    scopus 로고
    • An 8q24 gene desert variant associated with prostate cancer risk confers differential in vivo activity to a MYC enhancer
    • Wasserman N.F., et al. An 8q24 gene desert variant associated with prostate cancer risk confers differential in vivo activity to a MYC enhancer. Genome Res. 2010, 20:1191-1197.
    • (2010) Genome Res. , vol.20 , pp. 1191-1197
    • Wasserman, N.F.1
  • 78
    • 77953098883 scopus 로고    scopus 로고
    • 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC
    • Ahmadiyeh N., et al. 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:9742-9746.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 9742-9746
    • Ahmadiyeh, N.1
  • 79
    • 68149180901 scopus 로고    scopus 로고
    • The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer
    • Pomerantz M.M., et al. The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. Nat. Genet. 2009, 41:882-884.
    • (2009) Nat. Genet. , vol.41 , pp. 882-884
    • Pomerantz, M.M.1
  • 80
    • 77649263411 scopus 로고    scopus 로고
    • Long-range enhancers on 8q24 regulate c-Myc
    • Sotelo J., et al. Long-range enhancers on 8q24 regulate c-Myc. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:3001-3005.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 3001-3005
    • Sotelo, J.1
  • 81
    • 77951759477 scopus 로고    scopus 로고
    • Genotype-phenotype correlation in eight new patients with a deletion encompassing 2q31.1
    • Mitter D., et al. Genotype-phenotype correlation in eight new patients with a deletion encompassing 2q31.1. Am. J. Med. Genet. 2010, 152A:1213-1224.
    • (2010) Am. J. Med. Genet. , vol.152 A , pp. 1213-1224
    • Mitter, D.1
  • 82
    • 32944464214 scopus 로고    scopus 로고
    • Breakpoints around the HOXD cluster result in various limb malformations
    • Dlugaszewska B., et al. Breakpoints around the HOXD cluster result in various limb malformations. J. Med. Genet. 2006, 43:111-118.
    • (2006) J. Med. Genet. , vol.43 , pp. 111-118
    • Dlugaszewska, B.1
  • 83
    • 33750350276 scopus 로고    scopus 로고
    • Long-range downstream enhancers are essential for Pax6 expression
    • Kleinjan D.A., et al. Long-range downstream enhancers are essential for Pax6 expression. Dev. Biol. 2006, 299:563-581.
    • (2006) Dev. Biol. , vol.299 , pp. 563-581
    • Kleinjan, D.A.1
  • 84
    • 84855261984 scopus 로고    scopus 로고
    • DNaseI hypersensitivity and ultraconservation reveal novel, interdependent long-range enhancers at the complex Pax6 cis-regulatory region
    • McBride D.J., et al. DNaseI hypersensitivity and ultraconservation reveal novel, interdependent long-range enhancers at the complex Pax6 cis-regulatory region. PLoS ONE 2011, 6:e28616.
    • (2011) PLoS ONE , vol.6
    • McBride, D.J.1
  • 85
    • 45249110444 scopus 로고    scopus 로고
    • A microduplication of the long range SHH limb regulator (ZRS) is associated with triphalangeal thumb-polysyndactyly syndrome
    • Klopocki E., et al. A microduplication of the long range SHH limb regulator (ZRS) is associated with triphalangeal thumb-polysyndactyly syndrome. J. Med. Genet. 2008, 45:370-375.
    • (2008) J. Med. Genet. , vol.45 , pp. 370-375
    • Klopocki, E.1
  • 86
    • 84856009018 scopus 로고    scopus 로고
    • Disruption of a long distance regulatory region upstream of SOX9 in isolated disorders of sex development
    • Benko S., et al. Disruption of a long distance regulatory region upstream of SOX9 in isolated disorders of sex development. J. Med. Genet. 2011, 48:825-830.
    • (2011) J. Med. Genet. , vol.48 , pp. 825-830
    • Benko, S.1
  • 87
    • 68149169945 scopus 로고    scopus 로고
    • Duplications of noncoding elements 5' of SOX9 are associated with brachydactyly-anonychia
    • Kurth I., et al. Duplications of noncoding elements 5' of SOX9 are associated with brachydactyly-anonychia. Nat. Genet. 2009, 41:862-863.
    • (2009) Nat. Genet. , vol.41 , pp. 862-863
    • Kurth, I.1
  • 88
    • 84856747483 scopus 로고    scopus 로고
    • Three-dimensional folding and functional organization principles of the Drosophila genome
    • Sexton T., et al. Three-dimensional folding and functional organization principles of the Drosophila genome. Cell 2012, 148:458-472.
    • (2012) Cell , vol.148 , pp. 458-472
    • Sexton, T.1
  • 89
    • 82955163171 scopus 로고    scopus 로고
    • Fluorescence in situ hybridization with high-complexity repeat-free oligonucleotide probes generated by massively parallel synthesis
    • Boyle S., et al. Fluorescence in situ hybridization with high-complexity repeat-free oligonucleotide probes generated by massively parallel synthesis. Chromosome Res. 2011, 19:901-909.
    • (2011) Chromosome Res. , vol.19 , pp. 901-909
    • Boyle, S.1
  • 90
    • 77957139539 scopus 로고    scopus 로고
    • Mediator and cohesin connect gene expression and chromatin architecture
    • Kagey M.H., et al. Mediator and cohesin connect gene expression and chromatin architecture. Nature 2010, 467:430-435.
    • (2010) Nature , vol.467 , pp. 430-435
    • Kagey, M.H.1
  • 91
    • 65649123756 scopus 로고    scopus 로고
    • Architectural roles of multiple chromatin insulators at the human apolipoprotein gene cluster
    • Mishiro T., et al. Architectural roles of multiple chromatin insulators at the human apolipoprotein gene cluster. EMBO J. 2009, 28:1234-1245.
    • (2009) EMBO J. , vol.28 , pp. 1234-1245
    • Mishiro, T.1
  • 92
    • 80052815461 scopus 로고    scopus 로고
    • Noncoding RNAs and enhancers: complications of a long-distance relationship
    • Orom U.A., Shiekhattar R. Noncoding RNAs and enhancers: complications of a long-distance relationship. Trends Genet. 2011, 27:433-439.
    • (2011) Trends Genet. , vol.27 , pp. 433-439
    • Orom, U.A.1    Shiekhattar, R.2
  • 93
    • 70349312354 scopus 로고    scopus 로고
    • ChIP-seq: advantages and challenges of a maturing technology
    • Park P.J. ChIP-seq: advantages and challenges of a maturing technology. Nat. Rev. Genet. 2009, 10:669-680.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 669-680
    • Park, P.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.