Bacterial Sliding Clamp Inhibitors that Mimic the Sequential Binding Mechanism of Endogenous Linear Motifs

Journal of Medicinal Chemistry

Volumn 58, Issue 11, 2015, Pages 4693-4702

  Yin, Zhou ^a   Whittell, Louise R ^a   Wang, Yao ^a   Jergic, Slobodan ^a   Ma, Cong ^b   Lewis, Peter J ^b   Dixon, Nicholas E ^a   Beck, Jennifer L ^a   Kelso, Michael J ^a   Oakley, Aaron J ^a  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL DNA; BACTERIAL SLIDING CLAMP INHIBITOR; DNA POLYMERASE; UNCLASSIFIED DRUG; CARBAZOLE DERIVATIVE; DNA DIRECTED DNA POLYMERASE; ESCHERICHIA COLI PROTEIN; PROTEIN BINDING;

ALKYLATION; AMIDATION; ARTICLE; CONFORMATIONAL TRANSITION; CONSENSUS SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIASTEREOISOMER; DISSOCIATION CONSTANT; DNA BINDING; DNA REPLICATION; DRUG CONFORMATION; DRUG MECHANISM; DRUG PROTEIN BINDING; ENANTIOMER; ESCHERICHIA COLI; FLUORESCENCE POLARIZATION; HYDROGEN BOND; IC50; IN VITRO STUDY; ISOTHERMAL TITRATION CALORIMETRY; LIPOPHILICITY; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN PROTEIN INTERACTION; SEQUENCE ALIGNMENT; STEREOCHEMISTRY; X RAY CRYSTALLOGRAPHY; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOLECULAR MIMICRY; PROTEIN MOTIF; STRUCTURE ACTIVITY RELATION; SURFACE PROPERTY; THERMODYNAMICS;

AMINO ACID MOTIFS; BINDING SITES; CARBAZOLES; CRYSTALLOGRAPHY, X-RAY; DNA REPLICATION; DNA, BACTERIAL; DNA-DIRECTED DNA POLYMERASE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FLUORESCENCE POLARIZATION; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PROPERTIES; THERMODYNAMICS;

EID: 84935872619     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00232     Document Type: Article

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