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Volumn 81, Issue 6, 2012, Pages 811-819

Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CYCLINE; SMALL INTERFERING RNA;

EID: 84861428331     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.112.077735     Document Type: Article
Times cited : (76)

References (48)
  • 3
    • 0031933285 scopus 로고    scopus 로고
    • In vitro and in vivo evidence suggesting a role for iron in cisplatin- induced nephrotoxicity
    • DOI 10.1046/j.1523-1755.1998.00767.x
    • Baliga R, Zhang Z, Baliga M, Ueda N, and Shah SV (1998) In vitro and in vivo evidence suggesting a role for iron in cisplatin-induced nephrotoxicity. Kidney Int 53:394-401. (Pubitemid 28097855)
    • (1998) Kidney International , vol.53 , Issue.2 , pp. 394-401
    • Baliga, R.1    Zhang, Z.2    Baliga, M.3    Ueda, N.4    Shah, S.V.5
  • 4
    • 3042588011 scopus 로고    scopus 로고
    • Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex
    • DOI 10.1038/nature02585
    • Bowman GD, O'Donnell M, and Kuriyan J (2004) Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex. Nature 429:724-730. (Pubitemid 38833117)
    • (2004) Nature , vol.429 , Issue.6993 , pp. 724-730
    • Bowman, G.D.1    O'Donnell, M.2    Kuriyan, J.3
  • 5
    • 0018849930 scopus 로고
    • A search for differential polypeptide synthesis throughout the cell cycle of HeLa cells
    • Bravo R and Celis JE (1980) A search for differential polypeptide synthesis throughout the cell cycle of HeLa cells. J Cell Biol 84:795-802. (Pubitemid 10122239)
    • (1980) Journal of Cell Biology , vol.84 , Issue.3 , pp. 795-802
    • Bravo, R.1    Celis, J.E.2
  • 6
    • 0023579723 scopus 로고
    • Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: Association with DNA replication sites
    • Bravo R and Macdonald-Bravo H (1987) Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites. J Cell Biol 105:1549-1554. (Pubitemid 18023377)
    • (1987) Journal of Cell Biology , vol.105 , Issue.4 , pp. 1549-1554
    • Bravo, R.1    Macdonald-Bravo, H.2
  • 8
    • 0028302333 scopus 로고
    • A qualitative and quantitative protein database approach identifies individual and groups of functionally related proteins that are differentially regulated in simian virus 40 (SV40) transformed human keratinocytes: An overview of the functional changes associated with the transformed phenotype
    • Celis JE and Olsen E (1994) A qualitative and quantitative protein database approach identifies individual and groups of functionally related proteins that are differentially regulated in simian virus 40 (SV40) transformed human keratinocytes: an overview of the functional changes associated with the transformed phenotype. Electrophoresis 15:309-344. (Pubitemid 24151835)
    • (1994) Electrophoresis , vol.15 , Issue.3-4 , pp. 309-344
    • Celis, J.E.1    Olsen, E.2
  • 10
    • 0025878186 scopus 로고
    • In vitro model for intrinsic drug resistance: Effects of protein kinase C activators on the chemosensitivity of cultured human colon cancer cells
    • Dong ZY, Ward NE, Fan D, Gupta KP, and O'Brian CA (1991) In vitro model for intrinsic drug resistance: effects of protein kinase C activators on the chemosensitivity of cultured human colon cancer cells. Mol Pharmacol 39:563-569.
    • (1991) Mol Pharmacol , vol.39 , pp. 563-569
    • Dong, Z.Y.1    Ward, N.E.2    Fan, D.3    Gupta, K.P.4    O'Brian, C.A.5
  • 11
    • 48749132702 scopus 로고    scopus 로고
    • Molecular and histological markers in urothelial carcinomas of the upper urinary tract
    • Eltz S, Comperat E, Cussenot O, and Rouprêt M (2008) Molecular and histological markers in urothelial carcinomas of the upper urinary tract. BJU Int 102:532-535.
    • (2008) BJU Int , vol.102 , pp. 532-535
    • Eltz, S.1    Comperat, E.2    Cussenot, O.3    Rouprêt, M.4
  • 12
    • 0030592544 scopus 로고    scopus 로고
    • Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA
    • DOI 10.1016/S0092-8674(00)81347-1
    • Gulbis JM, Kelman Z, Hurwitz J, O'Donnell M, and Kuriyan J (1996) Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA. Cell 87:297-306. (Pubitemid 26359007)
    • (1996) Cell , vol.87 , Issue.2 , pp. 297-306
    • Gulbis, J.M.1    Kelman, Z.2    Hurwitz, J.3    O'Donnell, M.4    Kuriyan, J.5
  • 13
    • 67449126645 scopus 로고    scopus 로고
    • The iron chelator Dp44mT does not protect myocytes against doxorubicin
    • Hasinoff BB and Patel D (2009) The iron chelator Dp44mT does not protect myocytes against doxorubicin. J Inorg Biochem 103:1093-1101.
    • (2009) J Inorg Biochem , vol.103 , pp. 1093-1101
    • Hasinoff, B.B.1    Patel, D.2
  • 17
    • 0033120419 scopus 로고    scopus 로고
    • The prognostic significance of proliferation-associated nucleolar protein p120 expression in prostate adenocarcinoma: A comparison with cyclins A and B1, Ki-67, proliferating cell nuclear antigen, and p34(cdc2)
    • DOI 10.1002/(SICI)1097-0142(19990401)85:7<1569::AID-CNCR19>3.0. CO;2-M
    • Kallakury BV, Sheehan CE, Rhee SJ, Fisher HA, Kaufman RP Jr, Rifkin MD, and Ross JS (1999) The prognostic significance of proliferation-associated nucleolar protein p120 expression in prostate adenocarcinoma: a comparison with cyclins A and B1, Ki-67, proliferating cell nuclear antigen, and p34cdc2. Cancer 85:1569-1576. (Pubitemid 29152830)
    • (1999) Cancer , vol.85 , Issue.7 , pp. 1569-1576
    • Kallakury, B.V.S.1    Sheehan, C.E.2    Rhee, S.J.3    Fisher, H.A.G.4    Kaufman Jr., R.P.5    Rifkin, M.D.6    Ross, J.S.7
  • 19
    • 0029163487 scopus 로고
    • Structural and functional similarities of prokaryotic and eukaryotic DNA polymerase sliding clamps
    • Kelman Z and O'Donnell M (1995) Structural and functional similarities of prokaryotic and eukaryotic DNA polymerase sliding clamps. Nucleic Acids Res 23:3613-3620.
    • (1995) Nucleic Acids Res , vol.23 , pp. 3613-3620
    • Kelman, Z.1    O'Donnell, M.2
  • 20
    • 0027159054 scopus 로고
    • The immunogenic properties of drug-resistant murine tumor cells do not correlate with expression of the MDR phenotype
    • Killion JJ, Radinsky R, Dong Z, Fishbeck R, Whitworth P, and Fidler IJ (1993) The immunogenic properties of drug-resistant murine tumor cells do not correlate with expression of the MDR phenotype. Cancer Immunol Immunother 36:381-386. (Pubitemid 23146825)
    • (1993) Cancer Immunology Immunotherapy , vol.36 , Issue.6 , pp. 381-386
    • Killion, J.J.1    Radinsky, R.2    Dong, Z.3    Fishbeck, R.4    Whitworth, P.5    Fidler, I.J.6
  • 21
    • 58149352656 scopus 로고    scopus 로고
    • Lys-110 is essential for targeting PCNA to replication and repair foci, and the K110A mutant activates apoptosis
    • Kim BJ and Lee H (2008) Lys-110 is essential for targeting PCNA to replication and repair foci, and the K110A mutant activates apoptosis. Biol Cell 100:675-686.
    • (2008) Biol Cell , vol.100 , pp. 675-686
    • Kim, B.J.1    Lee, H.2
  • 24
    • 0029063745 scopus 로고
    • Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1
    • Luo Y, Hurwitz J, and Massagué J (1995) Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1. Nature 375:159-161.
    • (1995) Nature , vol.375 , pp. 159-161
    • Luo, Y.1    Hurwitz, J.2    Massagué, J.3
  • 25
    • 0041885325 scopus 로고    scopus 로고
    • Proliferating cell nuclear antigen (PCNA): A dancer with many partners
    • DOI 10.1242/jcs.00653
    • Maga G and Hubscher U (2003) Proliferating cell nuclear antigen (PCNA): a dancer with many partners. J Cell Sci 116:3051-3060. (Pubitemid 37038954)
    • (2003) Journal of Cell Science , vol.116 , Issue.15 , pp. 3051-3060
    • Maga, G.1    Hubscher, U.2
  • 27
    • 77957244799 scopus 로고    scopus 로고
    • Membrane transport and intracellular sequestration of novel thiosemicarbazone chelators for the treatment of cancer
    • Merlot AM, Pantarat N, Lovejoy DB, Kalinowski DS, and Richardson DR (2010) Membrane transport and intracellular sequestration of novel thiosemicarbazone chelators for the treatment of cancer. Mol Pharmacol 78:675-684.
    • (2010) Mol Pharmacol , vol.78 , pp. 675-684
    • Merlot, A.M.1    Pantarat, N.2    Lovejoy, D.B.3    Kalinowski, D.S.4    Richardson, D.R.5
  • 28
    • 33745231691 scopus 로고    scopus 로고
    • Clinical validity of proliferating cell nuclear antigen as an objective marker for evaluating biologic features in patients with untreated prostate cancer
    • DOI 10.1111/j.1442-2042.2006.01400.x
    • Miyamoto S, Ito K, Kurokawa K, Suzuki K, Suzuki K, and Yamanaka H (2006) Clinical validity of proliferating cell nuclear antigen as an objective marker for evaluating biologic features in patients with untreated prostate cancer. Int J Urol 13:767-772. (Pubitemid 43926770)
    • (2006) International Journal of Urology , vol.13 , Issue.6 , pp. 767-772
    • Miyamoto, S.1    Ito, K.2    Kurokawa, K.3    Suzuki, K.4    Suzuki, K.5    Yamanaka, H.6
  • 29
    • 34249066085 scopus 로고    scopus 로고
    • PCNA, the Maestro of the Replication Fork
    • DOI 10.1016/j.cell.2007.05.003, PII S0092867407005946
    • Moldovan GL, Pfander B, and Jentsch S (2007) PCNA, the maestro of the replication fork. Cell 129:665-679. (Pubitemid 46802385)
    • (2007) Cell , vol.129 , Issue.4 , pp. 665-679
    • Moldovan, G.-L.1    Pfander, B.2    Jentsch, S.3
  • 30
    • 11144219969 scopus 로고    scopus 로고
    • Proliferating cell nuclear antigen (PCNA) and MIB 1: Markers of locally advanced and biologically aggressive prostate cancer
    • Mulligan JM, Mai KT, Parks W, and Gerridzen RG (1997) Proliferating cell nuclear antigen (PCNA) and MIB 1: Markers of locally advanced and biologically aggressive prostate cancer. Can J Urol 4:422-425.
    • (1997) Can J Urol , vol.4 , pp. 422-425
    • Mulligan, J.M.1    Mai, K.T.2    Parks, W.3    Gerridzen, R.G.4
  • 31
    • 0030910012 scopus 로고    scopus 로고
    • Assessment of the Alamar Blue assay for cellular growth and viability in vitro
    • DOI 10.1016/S0022-1759(97)00043-4, PII S0022175997000434
    • Nakayama GR, Caton MC, Nova MP, and Parandoosh Z (1997) Assessment of the Alamar Blue assay for cellular growth and viability in vitro. J Immunol Methods 204:205-208. (Pubitemid 27262014)
    • (1997) Journal of Immunological Methods , vol.204 , Issue.2 , pp. 205-208
    • Nakayama, G.R.1    Caton, M.C.2    Nova, M.P.3    Parandoosh, Z.4
  • 32
    • 57349184695 scopus 로고    scopus 로고
    • Proliferating cell nuclear antigen: A proteomics view
    • Naryzhny SN (2008) Proliferating cell nuclear antigen: a proteomics view. Cell Mol Life Sci 65:3789-3808.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 3789-3808
    • Naryzhny, S.N.1
  • 33
    • 34948861204 scopus 로고    scopus 로고
    • Characterization of proliferating cell nuclear antigen (PCNA) isoforms in normal and cancer cells: There is no cancer-associated form of PCNA
    • DOI 10.1016/j.febslet.2007.09.022, PII S0014579307010046
    • Naryzhny SN and Lee H (2007) Characterization of proliferating cell nuclear antigen (PCNA) isoforms in normal and cancer cells: there is no cancer-associated form of PCNA. FEBS Lett 581:4917-4920. (Pubitemid 47531762)
    • (2007) FEBS Letters , vol.581 , Issue.25 , pp. 4917-4920
    • Naryzhny, S.N.1    Lee, H.2
  • 34
    • 17144365007 scopus 로고    scopus 로고
    • Proliferating cell nuclear antigen (PCNA) may function as a double homotrimer complex in the mammalian cell
    • Naryzhny SN, Zhao H, and Lee H (2005) Proliferating cell nuclear antigen (PCNA) may function as a double homotrimer complex in the mammalian cell. J Biol Chem 280:13888-13894.
    • (2005) J Biol Chem , vol.280 , pp. 13888-13894
    • Naryzhny, S.N.1    Zhao, H.2    Lee, H.3
  • 35
    • 70149088980 scopus 로고    scopus 로고
    • Repair activities of human 8-oxoguanine DNA glycosylase are stimulated by the interaction with human checkpoint sensor Rad9-Rad1-Hus1 complex
    • Park MJ, Park JH, Hahm SH, Ko SI, Lee YR, Chung JH, Sohn SY, Cho Y, Kang LW, and Han YS (2009) Repair activities of human 8-oxoguanine DNA glycosylase are stimulated by the interaction with human checkpoint sensor Rad9-Rad1-Hus1 complex. DNA repair 8:1190-1200.
    • (2009) DNA Repair , vol.8 , pp. 1190-1200
    • Park, M.J.1    Park, J.H.2    Hahm, S.H.3    Ko, S.I.4    Lee, Y.R.5    Chung, J.H.6    Sohn, S.Y.7    Cho, Y.8    Kang, L.W.9    Han, Y.S.10
  • 36
    • 59149089078 scopus 로고    scopus 로고
    • The iron chelator Dp44mT causes DNA damage and selective inhibition of topoisomerase IIalpha in breast cancer cells
    • Rao VA, Klein SR, Agama KK, Toyoda E, Adachi N, Pommier Y, and Shacter EB (2009) The iron chelator Dp44mT causes DNA damage and selective inhibition of topoisomerase IIalpha in breast cancer cells. Cancer Res 69:948-957.
    • (2009) Cancer Res , vol.69 , pp. 948-957
    • Rao, V.A.1    Klein, S.R.2    Agama, K.K.3    Toyoda, E.4    Adachi, N.5    Pommier, Y.6    Shacter, E.B.7
  • 37
    • 0030894798 scopus 로고    scopus 로고
    • The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents II: The mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1- naphthylaldehyde benzoyl hydrazone
    • Richardson DR and Milnes K (1997) The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents II: the mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1-naphthylaldehyde benzoyl hydrazone. Blood 89:3025-3038. (Pubitemid 27172591)
    • (1997) Blood , vol.89 , Issue.8 , pp. 3025-3038
    • Richardson, D.R.1    Milnes, K.2
  • 38
    • 0028063364 scopus 로고
    • Inhibition of gastric cancer cell proliferation by antisense oligonucleotides targeting the messenger RNA encoding proliferating cell nuclear antigen
    • Sakakura C, Hagiwara A, Tsujimoto H, Ozaki K, Sakakibara T, Oyama T, Ogaki M, and Takahashi T (1994) Inhibition of gastric cancer cell proliferation by antisense oligonucleotides targeting the messenger RNA encoding proliferating cell nuclear antigen. Br J Cancer 70:1060-1066. (Pubitemid 24358939)
    • (1994) British Journal of Cancer , vol.70 , Issue.6 , pp. 1060-1066
    • Sakakura, C.1    Hagiwara, A.2    Tsujimoto, H.3    Ozaki, K.4    Sakakibara, T.5    Oyama, T.6    Ogaki, M.7    Takahashi, T.8
  • 39
    • 0029661817 scopus 로고    scopus 로고
    • P21(waf1/cip1) protein associates with the detergent-insoluble form of PCNA concomitantly with disassembly of PCNA at nucleotide excision repair sites
    • Savio M, Stivala LA, Scovassi AI, Bianchi L, and Prosperi E (1996) p21waf1/cip1 protein associates with the detergent-insoluble form of PCNA concomitantly with disassembly of PCNA at nucleotide excision repair sites. Oncogene 13:1591-1598. (Pubitemid 26377489)
    • (1996) Oncogene , vol.13 , Issue.8 , pp. 1591-1598
    • Savio, M.1    Stivala, L.A.2    Scovassi, A.I.3    Bianchi, L.4    Prosperi, E.5
  • 40
    • 34547949985 scopus 로고    scopus 로고
    • A conserved physical and functional interaction between the cell cycle checkpoint clamp loader and DNA ligase I of eukaryotes
    • DOI 10.1074/jbc.M703774200
    • Song W, Levin DS, Varkey J, Post S, Bermudez VP, Hurwitz J, and Tomkinson AE (2007) A conserved physical and functional interaction between the cell cycle checkpoint clamp loader and DNA ligase I of eukaryotes. J Biol Chem 282:22721-22730. (Pubitemid 47267306)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.31 , pp. 22721-22730
    • Song, W.1    Levin, D.S.2    Varkey, J.3    Post, S.4    Bermudez, V.P.5    Hurwitz, J.6    Tomkinson, A.E.7
  • 41
    • 67650617710 scopus 로고    scopus 로고
    • The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps, PCNA and hRad9-hRad1-hHus1
    • Song W, Pascal JM, Ellenberger T, and Tomkinson AE (2009) The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps, PCNA and hRad9-hRad1-hHus1. DNA Repair (Amst) 8:912-919.
    • (2009) DNA Repair (Amst) , vol.8 , pp. 912-919
    • Song, W.1    Pascal, J.M.2    Ellenberger, T.3    Tomkinson, A.E.4
  • 43
    • 48849096940 scopus 로고    scopus 로고
    • Proliferation markers and survival in early breast cancer: A systematic review and meta-analysis of 85 studies in 32,825 patients
    • Stuart-Harris R, Caldas C, Pinder SE, and Pharoah P (2008) Proliferation markers and survival in early breast cancer: a systematic review and meta-analysis of 85 studies in 32,825 patients. Breast 17:323-334.
    • (2008) Breast , vol.17 , pp. 323-334
    • Stuart-Harris, R.1    Caldas, C.2    Pinder, S.E.3    Pharoah, P.4
  • 44
    • 0031663505 scopus 로고    scopus 로고
    • The DNA replication fork in eukaryotic cells
    • DOI 10.1146/annurev.biochem.67.1.721
    • Waga S and Stillman B (1998) The DNA replication fork in eukaryotic cells. Ann Rev Biochem 67:721-751. (Pubitemid 28411143)
    • (1998) Annual Review of Biochemistry , vol.67 , pp. 721-751
    • Waga, S.1    Stillman, B.2
  • 45
    • 68949137117 scopus 로고    scopus 로고
    • Structure and functional implications of the human rad9-hus1-rad1 cell cycle checkpoint complex
    • Xu M, Bai L, Gong Y, Xie W, Hang H, and Jiang T (2009) Structure and functional implications of the human rad9-hus1-rad1 cell cycle checkpoint complex. J Biol Chem 284:20457-20461.
    • (2009) J Biol Chem , vol.284 , pp. 20457-20461
    • Xu, M.1    Bai, L.2    Gong, Y.3    Xie, W.4    Hang, H.5    Jiang, T.6
  • 46
    • 0036491750 scopus 로고    scopus 로고
    • [In vitro experiment of inhibiting cell proliferation on human esophageal squamous cell cancer T]. Tn cell line by proliferating cell nuclear antigen antisense oligodeoxynucleotide
    • Yang L, Ye SD, Feng LG, Wang JS, and Zhai W (2002) [In vitro experiment of inhibiting cell proliferation on human esophageal squamous cell cancer T]. Tn cell line by proliferating cell nuclear antigen antisense oligodeoxynucleotide. Ai Zheng 21:276-280.
    • (2002) Ai Zheng , vol.21 , pp. 276-280
    • Yang, L.1    Ye, S.D.2    Feng, L.G.3    Wang, J.S.4    Zhai, W.5
  • 47
    • 0036718371 scopus 로고    scopus 로고
    • Tumor-infiltrating macrophages are involved in suppressing growth and metastasis of human prostate cancer cells by INF-beta gene therapy in nude mice
    • Zhang F, Lu W, and Dong Z (2002) Tumor-infiltrating macrophages are involved in suppressing growth and metastasis of human prostate cancer cells by INF-beta gene therapy in nude mice. Clin Cancer Res 8:2942-2951. (Pubitemid 35025743)
    • (2002) Clinical Cancer Research , vol.8 , Issue.9 , pp. 2942-2951
    • Zhang, F.1    Lu, W.2    Dong, Z.3


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