Endoplasmic reticulum stress response and bone loss in experimental periodontitis in mice

Journal of Periodontal Research

Volumn 50, Issue 4, 2015, Pages 500-508

  Yamada, H ^a   Nakajima, T ^a   Domon, H ^a   Honda, T ^a   Yamazaki, K ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

Author keywords

Endoplasmic reticulum stress; Osteoclast; Periodontitis; Porphyromonas gingivalis

Indexed keywords

4-PHENYLBUTYRIC ACID; ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ARYLBUTYRIC ACID DERIVATIVE; AUTACOID; CATHEPSIN K; CHAPERONE; CTSK PROTEIN, MOUSE; CYTOKINE; OSTEOCLAST DIFFERENTIATION FACTOR; TNFSF11 PROTEIN, MOUSE;

ALVEOLAR BONE LOSS; ANIMAL; BONE MARROW CELL; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; ENDOPLASMIC RETICULUM STRESS; GINGIVA; INBRED MOUSE STRAIN; MACROPHAGE; MALE; MICROBIOLOGY; MOUSE; OSTEOCLAST; PATHOLOGY; PERIODONTITIS; PHYSIOLOGY; PORPHYROMONAS GINGIVALIS; UNFOLDED PROTEIN RESPONSE;

ALVEOLAR BONE LOSS; ANIMALS; BONE MARROW CELLS; CATHEPSIN K; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM STRESS; GINGIVA; INFLAMMATION MEDIATORS; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MOLECULAR CHAPERONES; OSTEOCLASTS; PERIODONTITIS; PHENYLBUTYRATES; PORPHYROMONAS GINGIVALIS; RANK LIGAND; TARTRATE-RESISTANT ACID PHOSPHATASE; UNFOLDED PROTEIN RESPONSE;

EID: 84935726395     PISSN: 00223484     EISSN: 16000765     Source Type: Journal    
DOI: 10.1111/jre.12232     Document Type: Article

References (30)

1. Domon H, Takahashi N, Honda T et al. Up-regulation of the endoplasmic reticulum stress-response in periodontal disease. Clin Chim Acta 2009;401:134-140.
2. Zhang K, Kaufman RJ. From endoplasmic-reticulum stress to the inflammatory response. Nature 2008;454:455-462.
3. Bernales S, Papa FR, Walter P. Intracellular signaling by the unfolded protein response. Annu Rev Cell Dev Biol 2006;22:487-508.
4. Hotamisligil GS, Erbay E. Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol 2008;8:923-934.
5. Wang K, Niu J, Kim H, Kolattukudy PE. Osteoclast precursor differentiation by MCPIP via oxidative stress, endoplasmic reticulum stress, and autophagy. J Mol Cell Biol 2011;3:360-368.
6. Baker PJ, Evans RT, Roopenian DC. Oral infection with Porphyromonas gingivalis and induced alveolar bone loss in immunocompetent and severe combined immunodeficient mice. Arch Oral Biol 1994;39:1035-1040.
7. Maekawa T, Takahashi N, Tabeta K et al. Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile. PLoS ONE 2011;6:e20240.
8. Zode GS, Kuehn MH, Nishimura DY et al. Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma. J Clin Invest 2011;121:3542-3553.
9. -ΔΔCt method. Methods 2001;25:402-408.
10. Sulniute R, Lindh T, Wilczynska M, Li J, Ny T. Plasmin is essential in preventing periodontitis in mice. Am J Pathol 2011;179:819-828.
11. Ha J, Choi HS, Lee Y, Kwon HJ, Song YW, Kim HH. CXC chemokine ligand 2 induced by receptor activator of NF-κB ligand enhances osteoclastogenesis. J Immunol 2010;184:4717-4724.
12. Bonapace G, Waheed A, Shah GN, Sly WS. Chemical chaperones protect from effects of apoptosis-inducing mutation in carbonic anhydrase IV identified in retinitis pigmentosa 17. Proc Natl Acad Sci USA 2004;101:12300-12305.
13. + T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice. Infect Immun 1999;67:2804-2809.
14. Kang HL, Benzer S, Min KT. Life extension in Drosophila by feeding a drug. Proc Natl Acad Sci USA 2002;99:838-843.
15. Hamamura K, Tanjung N, Yokota H. Suppression of osteoclastogenesis through phosphorylation of eukaryotic translation initiation factor 2 alpha. J Bone Miner Metab 2013;31:618-628.
16. Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 2007;8:519-529.
17. Tohmonda T, Yoda M, Mizuochi H et al. The IRE1α-XBP1 pathway positively regulates parathyroid hormone (PTH)/PTH-related peptide receptor expression and is involved in PTH-induced osteoclastogenesis. J Biol Chem 2013;288:1691-1695.
18. Henriksen K, Tanko LB, Qvist P, Delmas PD, Christiansen C, Karsdal MA. Assessment of osteoclast number and function: application in the development of new and improved treatment modalities for bone diseases. Osteoporos Int 2007;18:681-685.
19. Darnay BG, Ni J, Moore PA, Aggarwal BB. Activation of NF-κB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-κB-inducing kinase. Identification of a novel TRAF6 interaction motif. J Biol Chem 1999;274:7724-7731.
20. Boyce BF. Advances in osteoclast biology reveal potential new drug targets and new roles for osteoclasts. J Bone Miner Res 2013;28:711-722.
21. Hu P, Han Z, Couvillon AD, Kaufman RJ, Exton JH. Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1α-mediated NF-κB activation and down-regulation of TRAF2 expression. Mol Cell Biol 2006;26:3071-3084.
22. Urano F, Wang X, Bertolotti A et al. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 2000;287:664-666.
23. Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010;140:900-917.
24. Özcan U, Yilmaz E, Özcan L et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006;313:1137-1140.
25. Saito T, Shimazaki Y. Metabolic disorders related to obesity and periodontal disease. Periodontol 2000 2007;43:254-266.
26. Blasco-Baque V, Serino M, Vergnes JN et al. High-fat diet induces periodontitis in mice through lipopolysaccharides (LPS) receptor signaling: protective action of estrogens. PLoS ONE 2012;7:e48220.
27. Arimatsu K, Yamada H, Miyazawa H et al. Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota. Sci Rep 2014;4:4828.
28. Nakajima T, Yamazaki K. Periodontal disease and risk of atherosclerotic coronary heart disease. Odontology 2009;97:84-91.
29. Lalla E, Papapanou PN. Diabetes mellitus and periodontitis: a tale of two common interrelated diseases. Nat Rev Endocrinol 2011;7:738-748.
30. Merquiol E, Uzi D, Mueller T et al. HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response. PLoS ONE 2011;6:e24660.