메뉴 건너뛰기




Volumn 18, Issue 5, 2007, Pages 681-685

Assessment of osteoclast number and function: Application in the development of new and improved treatment modalities for bone diseases

Author keywords

CTX I; Osteoclast number; Resorption; TRAcP; TRAP 5b

Indexed keywords

AMINO TERMINAL TELOPEPTIDE; AZD 0530; BIOLOGICAL MARKER; BISPHOSPHONIC ACID DERIVATIVE; CARBOXY TERMINAL TELOPEPTIDE; CATHEPSIN K; CHLORIDE CHANNEL BLOCKING AGENT; DENOSUMAB; ESTROGEN; NS 3696; OSTEOCLAST DIFFERENTIATION FACTOR ANTIBODY; PHOSPHATASE; PROTEIN ANTIBODY; PROTEIN TYROSINE KINASE INHIBITOR; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TARTRATE RESISTANT ACID PHOSPHATASE 5B; UNCLASSIFIED DRUG;

EID: 34047185276     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-006-0286-8     Document Type: Article
Times cited : (120)

References (45)
  • 1
    • 2942523836 scopus 로고    scopus 로고
    • Anatomy and biology of bone matrix and cellular elements
    • American Society for Bone and Mineral Research, Washington, pp
    • Baron R (2003) Anatomy and biology of bone matrix and cellular elements. Primer on the metabolic bone diseases and disorders of mineral metabolism. American Society for Bone and Mineral Research, Washington, pp 1-8
    • (2003) Primer on the metabolic bone diseases and disorders of mineral metabolism , pp. 1-8
    • Baron, R.1
  • 2
    • 0027418922 scopus 로고
    • Hormones in the coupling of bone resorption and formation
    • Martin TJ (1993) Hormones in the coupling of bone resorption and formation. Osteoporos Int 3(Suppl 1):121-125
    • (1993) Osteoporos Int , vol.3 , Issue.SUPPL. 1 , pp. 121-125
    • Martin, T.J.1
  • 3
    • 4243742304 scopus 로고    scopus 로고
    • Estrogen and bone metabolism
    • Vaananen HK, Harkonen PL (1996) Estrogen and bone metabolism. Maturitas 23 Suppl:S65-S69
    • (1996) Maturitas , vol.23 , Issue.SUPPL.
    • Vaananen, H.K.1    Harkonen, P.L.2
  • 4
    • 0034455103 scopus 로고    scopus 로고
    • Birth and death of bone cells: Basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis
    • Manolagas SC (2000) Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev 21:115-137
    • (2000) Endocr Rev , vol.21 , pp. 115-137
    • Manolagas, S.C.1
  • 5
    • 0034284550 scopus 로고    scopus 로고
    • Therapeutic approaches to bone diseases
    • Rodan GA, Martin TJ (2000) Therapeutic approaches to bone diseases. Science 289:1508-1514
    • (2000) Science , vol.289 , pp. 1508-1514
    • Rodan, G.A.1    Martin, T.J.2
  • 6
    • 0343517092 scopus 로고    scopus 로고
    • Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: The OFELY study
    • Garnero P, Sornay-Rendu E, Claustrat B et al (2000) Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: the OFELY study. J Bone Miner Res 15:1526-1536
    • (2000) J Bone Miner Res , vol.15 , pp. 1526-1536
    • Garnero, P.1    Sornay-Rendu, E.2    Claustrat, B.3
  • 7
    • 0033306407 scopus 로고    scopus 로고
    • Monitoring of alendronate treatment and prediction of effect on bone mass by biochemical markers in the early postmenopausal intervention cohort study
    • Ravn P, Hosking D, Thompson D et al (1999) Monitoring of alendronate treatment and prediction of effect on bone mass by biochemical markers in the early postmenopausal intervention cohort study. J Clin Endocrinol Metab 84:2363-2368
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 2363-2368
    • Ravn, P.1    Hosking, D.2    Thompson, D.3
  • 8
    • 0033105942 scopus 로고    scopus 로고
    • Biochemical markers can predict the response in bone mass during alendronate treatment in early postmenopausal women. Alendronate Osteoporosis Prevention Study Group
    • Ravn P, Clemmesen B, Christiansen C (1999) Biochemical markers can predict the response in bone mass during alendronate treatment in early postmenopausal women. Alendronate Osteoporosis Prevention Study Group. Bone 24:237-244
    • (1999) Bone , vol.24 , pp. 237-244
    • Ravn, P.1    Clemmesen, B.2    Christiansen, C.3
  • 9
    • 22144485121 scopus 로고    scopus 로고
    • Soluble cathepsin K: A novel marker for the prediction of nontraumatic fractures?
    • Holzer G, Noske H, Lang T (2005) Soluble cathepsin K: a novel marker for the prediction of nontraumatic fractures? J Lab Clin Med 146:13-17
    • (2005) J Lab Clin Med , vol.146 , pp. 13-17
    • Holzer, G.1    Noske, H.2    Lang, T.3
  • 10
    • 0031875640 scopus 로고    scopus 로고
    • Application of a new serum assay for type I collagen cross-linked N-telopeptides: Assessment of diurnal changes in bone turnover with and without alendronate treatment
    • Gertz BJ, Clemens JD, Holland SD et al (1998) Application of a new serum assay for type I collagen cross-linked N-telopeptides: assessment of diurnal changes in bone turnover with and without alendronate treatment. Calcif Tissue Int 63:102-106
    • (1998) Calcif Tissue Int , vol.63 , pp. 102-106
    • Gertz, B.J.1    Clemens, J.D.2    Holland, S.D.3
  • 11
    • 0032952132 scopus 로고    scopus 로고
    • Novel serum markers of bone resorption: Clinical assessment and comparison with established urinary indices
    • Woitge HW, Pecherstorfer M, Li Y (1999) Novel serum markers of bone resorption: clinical assessment and comparison with established urinary indices. J Bone Miner Res 14:792-801
    • (1999) J Bone Miner Res , vol.14 , pp. 792-801
    • Woitge, H.W.1    Pecherstorfer, M.2    Li, Y.3
  • 12
    • 0034083361 scopus 로고    scopus 로고
    • Serum crosslaps for monitoring the response in individuals undergoing antiresorptive therapy
    • Christgau S, Bitsch-Jensen O, Hanover BN et al (2000) Serum crosslaps for monitoring the response in individuals undergoing antiresorptive therapy. Bone 26:505-511
    • (2000) Bone , vol.26 , pp. 505-511
    • Christgau, S.1    Bitsch-Jensen, O.2    Hanover, B.N.3
  • 13
    • 0034047217 scopus 로고    scopus 로고
    • Tartrate-resistant acid phosphatase 5b: A novel serum marker of bone resorption
    • Halleen JM, Alatalo SL, Suominen H et al (2000) Tartrate-resistant acid phosphatase 5b: a novel serum marker of bone resorption. J Bone Miner Res 15:1337-1345
    • (2000) J Bone Miner Res , vol.15 , pp. 1337-1345
    • Halleen, J.M.1    Alatalo, S.L.2    Suominen, H.3
  • 14
    • 33746434437 scopus 로고    scopus 로고
    • Secretion of tartrate-resistant acid phosphatase by osteoclasts correlates with resorptive behavior
    • Kirstein B, Chambers TJ, Fuller K (2006) Secretion of tartrate-resistant acid phosphatase by osteoclasts correlates with resorptive behavior. J Cell Biochem 98:1085-1094
    • (2006) J Cell Biochem , vol.98 , pp. 1085-1094
    • Kirstein, B.1    Chambers, T.J.2    Fuller, K.3
  • 15
    • 12344279757 scopus 로고    scopus 로고
    • The chloride channel inhibitor n53736 prevents bone resorption in ovariectomized rats without changing bone formation
    • Schaller S, Henriksen K, Sveigaard C et al (2004) The chloride channel inhibitor n53736 prevents bone resorption in ovariectomized rats without changing bone formation. J Bone Miner Res 19:1144-1153
    • (2004) J Bone Miner Res , vol.19 , pp. 1144-1153
    • Schaller, S.1    Henriksen, K.2    Sveigaard, C.3
  • 16
    • 19944432718 scopus 로고    scopus 로고
    • Acidification of the osteoclastic resorption compartment provides insight into the coupling of bone formation to bone resorption
    • Karsdal MA, Henriksen K, Sorensen MG et al (2005) Acidification of the osteoclastic resorption compartment provides insight into the coupling of bone formation to bone resorption. Am J Pathol 166:467-476
    • (2005) Am J Pathol , vol.166 , pp. 467-476
    • Karsdal, M.A.1    Henriksen, K.2    Sorensen, M.G.3
  • 17
    • 26844499571 scopus 로고    scopus 로고
    • Cells of the osteoclast lineage as mediators of the anabolic actions of parathyroid hormone in bone
    • Koh AJ, Demiralp B, Neiva KG et al (2005) Cells of the osteoclast lineage as mediators of the anabolic actions of parathyroid hormone in bone. Endocrinology 146:4584-4596
    • (2005) Endocrinology , vol.146 , pp. 4584-4596
    • Koh, A.J.1    Demiralp, B.2    Neiva, K.G.3
  • 18
    • 13244267455 scopus 로고    scopus 로고
    • Osteoclast-derived activity in the coupling of bone formation to resorption
    • Martin TJ, Sims NA (2005) Osteoclast-derived activity in the coupling of bone formation to resorption. Trends Mol Med 11:76-81
    • (2005) Trends Mol Med , vol.11 , pp. 76-81
    • Martin, T.J.1    Sims, N.A.2
  • 19
    • 23944461952 scopus 로고    scopus 로고
    • Mechanism of action of bisphosphonates
    • Reszka AA, Rodan GA (2003) Mechanism of action of bisphosphonates. Curr Osteoporos Rep 1:45-52
    • (2003) Curr Osteoporos Rep , vol.1 , pp. 45-52
    • Reszka, A.A.1    Rodan, G.A.2
  • 20
    • 25444449013 scopus 로고    scopus 로고
    • Serum TRACP 5b Is a useful marker for monitoring alendronate treatment: Comparison with other markers of bone turnover
    • Nenonen A, Cheng S, Ivaska KK et al (2005) Serum TRACP 5b Is a useful marker for monitoring alendronate treatment: comparison with other markers of bone turnover. J Bone Miner Res 20:1804-1812
    • (2005) J Bone Miner Res , vol.20 , pp. 1804-1812
    • Nenonen, A.1    Cheng, S.2    Ivaska, K.K.3
  • 21
    • 33344469853 scopus 로고    scopus 로고
    • Denosumab in postmenopausal women with low bone mineral density
    • McClung MR, Lewiecki EM, Cohen SB et al (2006) Denosumab in postmenopausal women with low bone mineral density. N Engl J Med 354:821-831
    • (2006) N Engl J Med , vol.354 , pp. 821-831
    • McClung, M.R.1    Lewiecki, E.M.2    Cohen, S.B.3
  • 22
    • 33750513412 scopus 로고    scopus 로고
    • Osteoprotegerin as a potential therapy for osteoporosis
    • Hamdy NA (2006) Osteoprotegerin as a potential therapy for osteoporosis. Curr Rheumatol Rep 8:50-54
    • (2006) Curr Rheumatol Rep , vol.8 , pp. 50-54
    • Hamdy, N.A.1
  • 23
    • 0942300651 scopus 로고    scopus 로고
    • Clinical performance of immunoreactive tartrate-resistant acid phosphatase isoform 5b as a marker of bone resorption
    • Hannon RA, Clowes JA, Eagleton AC et al (2004) Clinical performance of immunoreactive tartrate-resistant acid phosphatase isoform 5b as a marker of bone resorption. Bone 34:187-194
    • (2004) Bone , vol.34 , pp. 187-194
    • Hannon, R.A.1    Clowes, J.A.2    Eagleton, A.C.3
  • 24
    • 24044482954 scopus 로고    scopus 로고
    • Serum tartrate-resistant acid phosphatase 5b in monitoring bisphosphonate treatment with clodronate: A comparison with urinary N-terminal telopeptide of type I collagen and serum type I procollagen amino-terminal propeptide
    • Tahtela R, Seppanen J, Laitinen K et al (2005) Serum tartrate-resistant acid phosphatase 5b in monitoring bisphosphonate treatment with clodronate: a comparison with urinary N-terminal telopeptide of type I collagen and serum type I procollagen amino-terminal propeptide. Osteoporos Int 16:1109-1116
    • (2005) Osteoporos Int , vol.16 , pp. 1109-1116
    • Tahtela, R.1    Seppanen, J.2    Laitinen, K.3
  • 25
    • 2342527672 scopus 로고    scopus 로고
    • The effect of raloxifene on markers of bone turnover in older women living in long-term care facilities
    • Hansdottir H, Franzson L, Prestwood K et al (2004) The effect of raloxifene on markers of bone turnover in older women living in long-term care facilities. J Am Geriatr Soc 52:779-783
    • (2004) J Am Geriatr Soc , vol.52 , pp. 779-783
    • Hansdottir, H.1    Franzson, L.2    Prestwood, K.3
  • 26
    • 34948846777 scopus 로고    scopus 로고
    • The effect of AZ0530, a highly selective SRC inhibitor, on bone turnover in healthy males
    • Abstract nb OC042
    • Hannon RA, Clack G, Gallager N et al (2005) The effect of AZ0530, a highly selective SRC inhibitor, on bone turnover in healthy males. European Calcified Tissue Society Conference 2005 [Abstract nb OC042]
    • (2005) European Calcified Tissue Society Conference
    • Hannon, R.A.1    Clack, G.2    Gallager, N.3
  • 27
    • 0004971274 scopus 로고    scopus 로고
    • Pharmacologic Effects of a Single Treatment with Osteoprotegerin (OPG) on Bone Remodeling and Bone Density in Normal Rats
    • abstract 1132
    • Capparelli C, Morony S, Warmington KS et al (2000) Pharmacologic Effects of a Single Treatment with Osteoprotegerin (OPG) on Bone Remodeling and Bone Density in Normal Rats. J Bone Miner Res 15 [Suppl 1], abstract 1132
    • (2000) J Bone Miner Res , vol.15 , Issue.SUPPL. 1
    • Capparelli, C.1    Morony, S.2    Warmington, K.S.3
  • 28
    • 34047102271 scopus 로고    scopus 로고
    • RANKL Inhibition with AMG 162, a Fully Human MAb, Causes Sustained Suppression of Bone Resorption and Increased BMD in Knockin Mice Expressing Humanized RANKL
    • abstract SU304
    • Kostenuik P, Warmington KS, Grisanti M et al (2005) RANKL Inhibition with AMG 162, a Fully Human MAb, Causes Sustained Suppression of Bone Resorption and Increased BMD in Knockin Mice Expressing Humanized RANKL. J Bone Miner Res 20 [Suppl 1], abstract SU304
    • (2005) J Bone Miner Res , vol.20 , Issue.SUPPL. 1
    • Kostenuik, P.1    Warmington, K.S.2    Grisanti, M.3
  • 29
    • 0242581709 scopus 로고    scopus 로고
    • Transforming growth factor-beta controls human osteoclastogenesis through the p38 MAPK and regulation of RANK expression
    • Karsdal MA, Hjorth P, Henriksen K et al (2003) Transforming growth factor-beta controls human osteoclastogenesis through the p38 MAPK and regulation of RANK expression. J Biol Chem 278:44975-44987
    • (2003) J Biol Chem , vol.278 , pp. 44975-44987
    • Karsdal, M.A.1    Hjorth, P.2    Henriksen, K.3
  • 30
    • 1942533447 scopus 로고    scopus 로고
    • Characterization of osteoclasts from patients harboring a G215R mutation in ClC-7 causing Autosomal Dominant Osteopetrosis type II (ADOII)
    • Henriksen K, Gram J, Schaller S et al (2004) Characterization of osteoclasts from patients harboring a G215R mutation in ClC-7 causing Autosomal Dominant Osteopetrosis type II (ADOII). Am J Pathol 164:1537-1545
    • (2004) Am J Pathol , vol.164 , pp. 1537-1545
    • Henriksen, K.1    Gram, J.2    Schaller, S.3
  • 31
    • 0027752423 scopus 로고
    • Ultrastructural investigations of bone resorptive cells in two types of autosomal dominant osteopetrosis
    • Bollerslev J, Marks SC Jr, Pockwinse S et al (1993) Ultrastructural investigations of bone resorptive cells in two types of autosomal dominant osteopetrosis. Bone 14:865-869
    • (1993) Bone , vol.14 , pp. 865-869
    • Bollerslev, J.1    Marks Jr, S.C.2    Pockwinse, S.3
  • 32
    • 2142810972 scopus 로고    scopus 로고
    • Osteoclast-derived serum tartrate-resistant acid phosphatase 5b in Albers-Schonberg disease (type II autosomal dominant osteopetrosis)
    • Alatalo SL, Ivaska KK, Waguespack SG et al (2004) Osteoclast-derived serum tartrate-resistant acid phosphatase 5b in Albers-Schonberg disease (type II autosomal dominant osteopetrosis). Clin Chem 50:883-890
    • (2004) Clin Chem , vol.50 , pp. 883-890
    • Alatalo, S.L.1    Ivaska, K.K.2    Waguespack, S.G.3
  • 33
    • 33645789497 scopus 로고    scopus 로고
    • Clinical, genetic and cellular analysis of forty-nine osteopetrotic patients: Implications for diagnosis and treatment
    • Del Fattore A, Peruzzi B, Rucci N et al (2005) Clinical, genetic and cellular analysis of forty-nine osteopetrotic patients: implications for diagnosis and treatment. J Med Genet 43:315-325
    • (2005) J Med Genet , vol.43 , pp. 315-325
    • Del Fattore, A.1    Peruzzi, B.2    Rucci, N.3
  • 34
    • 0026531796 scopus 로고
    • Marked diurnal variation in urinary excretion of pyridinium cross-links in premenopausal women
    • Schlemmer A, Hassager C, Jensen SB et al (1992) Marked diurnal variation in urinary excretion of pyridinium cross-links in premenopausal women. J Clin Endocrinol Metab 74:476-480
    • (1992) J Clin Endocrinol Metab , vol.74 , pp. 476-480
    • Schlemmer, A.1    Hassager, C.2    Jensen, S.B.3
  • 35
    • 0036309083 scopus 로고    scopus 로고
    • Circadian variation in the serum concentration of C-terminal telopeptide of type I collagen (serum CTx): Effects of gender, age, menopausal status, posture, daylight, serum cortisol, and fasting
    • Qvist P, Christgau S, Pedersen BJ et al (2002) Circadian variation in the serum concentration of C-terminal telopeptide of type I collagen (serum CTx): effects of gender, age, menopausal status, posture, daylight, serum cortisol, and fasting. Bone 31:57-61
    • (2002) Bone , vol.31 , pp. 57-61
    • Qvist, P.1    Christgau, S.2    Pedersen, B.J.3
  • 37
    • 0023796303 scopus 로고
    • Bone cell populations and histomorphometric correlates to function
    • Simmons DJ, Menton DN, Russell JE et al (1988) Bone cell populations and histomorphometric correlates to function. Anat Rec 222:228-236
    • (1988) Anat Rec , vol.222 , pp. 228-236
    • Simmons, D.J.1    Menton, D.N.2    Russell, J.E.3
  • 38
    • 0038199622 scopus 로고    scopus 로고
    • Tartrate-resistant acid phosphatase 5B is a specific and sensitive marker of bone resorption
    • Halleen JM (2003) Tartrate-resistant acid phosphatase 5B is a specific and sensitive marker of bone resorption. Anticancer Res 23:1027-1029
    • (2003) Anticancer Res , vol.23 , pp. 1027-1029
    • Halleen, J.M.1
  • 39
    • 0842304432 scopus 로고    scopus 로고
    • Discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of c-Src
    • Ple PA, Green TP, Hennequin LF et al (2004) Discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of c-Src. J Med Chem 47:871-887
    • (2004) J Med Chem , vol.47 , pp. 871-887
    • Ple, P.A.1    Green, T.P.2    Hennequin, L.F.3
  • 40
    • 32644460848 scopus 로고    scopus 로고
    • Serum cathepsin K concentrations reflect osteoclastic activity in women with postmenopausal osteoporosis and patients with Paget's disease
    • Meier C, Meinhardt U, Greenfield JR et al (2006) Serum cathepsin K concentrations reflect osteoclastic activity in women with postmenopausal osteoporosis and patients with Paget's disease. Clin Lab 52:1-10
    • (2006) Clin Lab , vol.52 , pp. 1-10
    • Meier, C.1    Meinhardt, U.2    Greenfield, J.R.3
  • 41
    • 23344448604 scopus 로고    scopus 로고
    • Proteolytic excision of a repressive loop domain in tartrate-resistant acid phosphatase by cathepsin K in osteoclasts
    • Ljusberg J, Wang Y, Lang P et al (2005) Proteolytic excision of a repressive loop domain in tartrate-resistant acid phosphatase by cathepsin K in osteoclasts. J Biol Chem 280:28370-28381
    • (2005) J Biol Chem , vol.280 , pp. 28370-28381
    • Ljusberg, J.1    Wang, Y.2    Lang, P.3
  • 42
    • 39249084294 scopus 로고    scopus 로고
    • The Ratio of Osteoclast Activity/Osteoclast Number (CTX/TRACP 5b) Improves the Interpretation of the Effects of Anti-Resorptive Treatments in Human Osteclast Cultures
    • abstract SU290
    • Rissanen J, Suutari S, Ylonen S et al (2005) The Ratio of Osteoclast Activity/Osteoclast Number (CTX/TRACP 5b) Improves the Interpretation of the Effects of Anti-Resorptive Treatments in Human Osteclast Cultures. J Bone Miner Res 20 [Suppl 1], abstract SU290
    • (2005) J Bone Miner Res , vol.20 , Issue.SUPPL. 1
    • Rissanen, J.1    Suutari, S.2    Ylonen, S.3
  • 43
    • 0141796739 scopus 로고    scopus 로고
    • The effects of parathyroid hormone, alendronate, or both in men with osteoporosis
    • Finkelstein JS, Hayes A, Hunzelman JL et al (2003) The effects of parathyroid hormone, alendronate, or both in men with osteoporosis. N Engl J Med 349:1216-1226
    • (2003) N Engl J Med , vol.349 , pp. 1216-1226
    • Finkelstein, J.S.1    Hayes, A.2    Hunzelman, J.L.3
  • 44
    • 0141684971 scopus 로고    scopus 로고
    • The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis
    • Black DM, Greenspan SL, Ensrud KE et al (2003) The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N Engl J Med 349:1207-1215
    • (2003) N Engl J Med , vol.349 , pp. 1207-1215
    • Black, D.M.1    Greenspan, S.L.2    Ensrud, K.E.3
  • 45
    • 0141527583 scopus 로고    scopus 로고
    • Is the paradigm shifting?
    • Heaney RP (2003) Is the paradigm shifting? Bone 33:457-465
    • (2003) Bone , vol.33 , pp. 457-465
    • Heaney, R.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.