The IRE1α-XBP1 pathway positively regulates parathyroid hormone (PTH)/PTH-related peptide receptor expression and is involved in PTH-induced osteoclastogenesis

Journal of Biological Chemistry

Volumn 288, Issue 3, 2013, Pages 1691-1695

  Tohmonda, Takahide ^a   Yoda, Masaki ^a   Mizuochi, Hiroshi ^a   Morioka, Hideo ^a   Matsumoto, Morio ^a   Urano, Fumihiko ^b   Toyama, Yoshiaki ^a   Horiuchi, Keisuke ^a  

^a KEIO UNIVERSITY   (Japan)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EMBRYONIC FIBROBLASTS; ENDOPLASMIC RETICULUM STRESS; ER STRESS; GENE SILENCING; IN-VITRO; MOUSE EMBRYONIC FIBROBLASTS; OSTEOBLAST DIFFERENTIATION; OSTEOCLAST FORMATION; OSTEOCLASTOGENESIS; PARATHYROID HORMONES; PEPTIDE RECEPTOR; POTENTIAL BINDING SITES; PRIMARY OSTEOBLASTS; PROMOTER REGION; PROTEIN SYNTHESIS; UNFOLDED PROTEIN RESPONSE;

CELL CULTURE; CELL MEMBRANES; FIBROBLASTS; GENETIC ENGINEERING; PEPTIDES; SENSORS; STRESS MEASUREMENT; TRANSCRIPTION; TRANSCRIPTION FACTORS;

OSTEOBLASTS;

BONE MORPHOGENETIC PROTEIN 2; INOSITOL REQUIRING PROTEIN 1ALPHA; OSTEOCLAST DIFFERENTIATION FACTOR; PARATHYROID HORMONE; PARATHYROID HORMONE RELATED PROTEIN RECEPTOR; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ARTICLE; BINDING SITE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; FIBROBLAST; GENE SILENCING; IN VITRO STUDY; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BINDING SITES; BONE MORPHOGENETIC PROTEIN 2; CELL DIFFERENTIATION; CELLS, CULTURED; DNA-BINDING PROTEINS; EMBRYO, MAMMALIAN; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; FIBROBLASTS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MICE; OSTEOBLASTS; PARATHYROID HORMONE; PARATHYROID HORMONE-RELATED PROTEIN; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; RANK LIGAND; RECEPTOR, PARATHYROID HORMONE, TYPE 1; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; UNFOLDED PROTEIN RESPONSE;

EID: 84872724391     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C112.424606     Document Type: Article

References (26)

1. Ron, D., and Walter, P. (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 8, 519-529 (Pubitemid 46985379)
2. Xu, C., Bailly-Maitre, B., and Reed, J. C. (2005) Endoplasmic reticulum stress: cell life and death decisions. J. Clin. Invest. 115, 2656-2664 (Pubitemid 41434389)
3. Hetz, C., and Glimcher, L. H. (2009) Fine-tuning of the unfolded protein response: Assembling the IRE1α interactome. Mol. Cell 35, 551-561
4. Hetz, C. (2012) The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat. Rev. Mol. Cell Biol. 13, 89-102
5. Tohmonda, T., Miyauchi, Y., Ghosh, R., Yoda, M., Uchikawa, S., Takito, J., Morioka, H., Nakamura, M., Iwawaki, T., Chiba, K., Toyama, Y., Urano, F., and Horiuchi, K. (2011) The IRE1α-XBP1 pathway is essential for osteoblast differentiation through promoting transcription of Osterix. EMBO Rep. 12, 451-457
6. Sha, H., He, Y., Chen, H., Wang, C., Zenno, A., Shi, H., Yang, X., Zhang, X., and Qi, L. (2009) The IRE1α-XBP1 pathway of the unfolded protein response is required for adipogenesis. Cell Metab. 9, 556-564
7. Han, D., Lerner, A. G., Vande Walle, L., Upton, J. P., Xu, W., Hagen, A., Backes, B. J., Oakes, S. A., and Papa, F. R. (2009) IRE1α kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell 138, 562-575
8. Acosta-Alvear, D., Zhou, Y., Blais, A., Tsikitis, M., Lents, N. H., Arias, C., Lennon, C. J., Kluger, Y., and Dynlacht, B. D. (2007) XBP1 controls diverse cell type-and condition-specific transcriptional regulatory networks. Mol. Cell 27, 53-66 (Pubitemid 46991391)
9. Martinon, F., Chen, X., Lee, A. H., and Glimcher, L. H. (2010) TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat. Immunol. 11, 411-418
10. Wu, J., and Kaufman, R. J. (2006) From acute ER stress to physiological roles of the unfolded protein response. Cell Death Differ. 13, 374-384
11. Murakami, T., Saito, A., Hino, S., Kondo, S., Kanemoto, S., Chihara, K., Sekiya, H., Tsumagari, K., Ochiai, K., Yoshinaga, K., Saitoh, M., Nishimura, R., Yoneda, T., Kou, I., Furuichi, T., Ikegawa, S., Ikawa, M., Okabe, M., Wanaka, A., and Imaizumi, K. (2009) Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation. Nat. Cell Biol. 11, 1205-1211
12. Zhang, P., McGrath, B., Li, S., Frank, A., Zambito, F., Reinert, J., Gannon, M., Ma, K., McNaughton, K., and Cavener, D. R. (2002) The PERK eukaryotic initiation factor 2α kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol. Cell. Biol. 22, 3864-3874 (Pubitemid 34525227)
13. Saito, A., Ochiai, K., Kondo, S., Tsumagari, K., Murakami, T., Cavener, D. R., and Imaizumi, K. (2011) Endoplasmic reticulum stress response mediated by the PERK-eIF2α-ATF4 pathway is involved in osteoblast differentiation induced by BMP2. J. Biol. Chem. 286, 4809-4818
14. Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., and de Crombrugghe, B. (2002) The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108, 17-29 (Pubitemid 34137009)
15. Urano, F., Bertolotti, A., and Ron, D. (2000) IRE1 and efferent signaling from the endoplasmic reticulum. J. Cell Sci. 113, 3697-3702
16. Urano, F., Wang, X., Bertolotti, A., Zhang, Y., Chung, P., Harding, H. P., and Ron, D. (2000) Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287, 664-666 (Pubitemid 30070916)
17. Reimold, A. M., Etkin, A., Clauss, I., Perkins, A., Friend, D. S., Zhang, J., Horton, H. F., Scott, A., Orkin, S. H., Byrne, M. C., Grusby, M. J., and Glimcher, L. H. (2000) An essential role in liver development for transcription factor XBP-1. Genes Dev. 14, 152-157 (Pubitemid 30070980)
18. Jüppner, H., Abou-Samra, A. B., Freeman, M., Kong, X. F., Schipani, E., Richards, J., Kolakowski, L. F., Jr., Hock, J., Potts, J. T., Jr., Kronenberg, H. M., et al. (1991) A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254, 1024-1026 (Pubitemid 21917436)
19. McCauley, L. K., and Martin, T. J. (2012) Twenty-five years of PTHrP progress: from cancer hormone to multifunctional cytokine. J. Bone Miner. Res. 27, 1231-1239
20. Datta, N. S., and Abou-Samra, A. B. (2009) PTH and PTHrP signaling in osteoblasts. Cell. Signal. 21, 1245-1254
21. Guise, T. A., Yin, J. J., Taylor, S. D., Kumagai, Y., Dallas, M., Boyce, B. F., Yoneda, T., and Mundy, G. R. (1996) Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. J. Clin. Invest. 98, 1544-1549 (Pubitemid 26327863)
22. Mundy, G. R. (2002) Metastasis to bone: causes, consequences, and therapeutic opportunities. Nat. Rev. Cancer 2, 584-593 (Pubitemid 37328925)
23. Papandreou, I., Denko, N. C., Olson, M., Van Melckebeke, H., Lust, S., Tam, A., Solow-Cordero, D. E., Bouley, D. M., Offner, F., Niwa, M., and Koong, A. C. (2011) Identification of an Ire1α endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood 117, 1311-1314
24. Kitamura, T., Koshino, Y., Shibata, F., Oki, T., Nakajima, H., Nosaka, T., and Kumagai, H. (2003) Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics. Exp. Hematol. 31, 1007-1014 (Pubitemid 37329742)
25. McCuaig, K. A., Lee, H. S., Clarke, J. C., Assar, H., Horsford, J., and White, J. H. (1995) Parathyroid hormone/parathyroid hormone related peptide receptor gene transcripts are expressed from tissue-specific and ubiquitous promoters. Nucleic Acids Res. 23, 1948-1955
26. Oikawa, D., Akai, R., and Iwawaki, T. (2010) Positive contribution of the IRE1α-XBP1 pathway to placental expression of CEA family genes. FEBS Lett. 584, 1066-1070