Macyranones: Structure, Biosynthesis, and Binding Mode of an Unprecedented Epoxyketone that Targets the 20S Proteasome

Journal of the American Chemical Society

Volumn 137, Issue 25, 2015, Pages 8121-8130

  Keller, Lena ^a,b   Plaza, Alberto ^a,b,f   Dubiella, Christian ^e   Groll, Michael ^e   Kaiser, Marcel ^c,d   Müller, Rolf ^a,b  

^a SAARLAND UNIVERSITY   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d UNIVERSITY OF BASEL   (Switzerland)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^f FRAUNHOFER INSTITUTE FOR MOLECULAR BIOLOGY AND APPLIED ECOLOGY IME   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BINS; BIOCHEMISTRY; BIOSYNTHESIS; CRYSTALLOGRAPHY; GENES; KETONES; SCAFFOLDS;

AMIDE BOND FORMATION; BIOSYNTHETIC GENE CLUSTER; DRUG DISCOVERY PROCESS; INHIBITORY EFFECT; IRREVERSIBLE BINDING; LEISHMANIA DONOVANI; PHYLOGENETIC ANALYSIS; TRYPANOSOMA BRUCEI;

X RAY CRYSTALLOGRAPHY;

ACYL COENZYME A DEHYDROGENASE; AMIDE; ANTINEOPLASTIC AGENT; ANTIPARASITIC AGENT; CHYMOTRYPSIN; EPOXOMICIN; EPOXYKETONE; KETONE; MACYRANONE A; MACYRANONE B; MACYRANONE C; MACYRANONE D; MACYRANONE DERIVATIVE; MACYRANONE E; MACYRANONE F; PROTEASOME; PROTEASOME INHIBITOR; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; PEPTIDE;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BACTERIUM; BINDING AFFINITY; BIOSYNTHESIS; CANCER INHIBITION; CHEMICAL BINDING; CONTROLLED STUDY; CYSTOBACTER FUSCUS; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GENE CLUSTER; GENE DISRUPTION; HUMAN; HUMAN CELL; IC50; LEISHMANIA DONOVANI; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYLOGENY; RAT; SCREENING TEST; STRUCTURE ANALYSIS; TRYPANOSOMA BRUCEI RHODESIENSE; X RAY CRYSTALLOGRAPHY; YEAST; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; GENETICS; METABOLISM; MULTIGENE FAMILY; MYXOCOCCALES; NUCLEAR MAGNETIC RESONANCE;

ANTI-INFECTIVE AGENTS; BIOSYNTHETIC PATHWAYS; CHROMATOGRAPHY, LIQUID; DRUG DISCOVERY; HUMANS; MASS SPECTROMETRY; MODELS, MOLECULAR; MULTIGENE FAMILY; MYXOCOCCALES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES; PHYLOGENY; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS;

EID: 84935047429     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b03833     Document Type: Article

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