In vitro and in vivo ocular safety and eye surface permanence determination by direct and Magnetic Resonance Imaging of ion-sensitive hydrogels based on gellan gum and kappa-carrageenan

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 94, Issue , 2015, Pages 342-351

  Fernández Ferreiro, Anxo ^a,b,d   González Barcia, Miguel ^b,d   Gil Martínez, María ^c   Vieites Prado, Alba ^d   Lema, Isabel ^a,d   Argibay, Barbara ^d   Blanco Méndez, José ^a   Lamas, Maria Jesus ^b,d   Otero Espinar, Francisco Javier ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b Pharmacy Department   (Spain)

^c Instituto Oftalmológico Gómez Ulla   (Spain)

^d Santiago University Clinical Hospital   (Spain)

Author keywords

Gellan gum; Het Cam; In situ gelling system; In vivo ocular surface permanence; Ion activated ophthalmic hydrogel; Kappa carrageenan; Magnetic Resonance Imaging; Ocular toxicity; Polysaccharides; Real Time Cell Analyzer System

Indexed keywords

BIOPOLYMER; CARRAGEENAN; GELLAN; BACTERIAL POLYSACCHARIDE; HYDROGEL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MEDIATED CYTOTOXICITY; CORNEA EDEMA; CORNEA THICKNESS; CORNEA ULCER; CYTOTOXICITY; EVALUATION STUDY; EX VIVO STUDY; EYE IRRITATION; EYE REDNESS; EYE SURFACE PERMANENCE; EYE TOXICITY; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; INTRAOCULAR DRUG ADMINISTRATION; ION EXCHANGE; LACRIMAL FLUID; MALE; MOUSE; MUCOADHESION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHASE TRANSITION; PHYSICAL PARAMETERS; SURFACE PROPERTY; TOPICAL DRUG ADMINISTRATION; VISUAL SYSTEM PARAMETERS; ANIMAL; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; CHICKEN; DRUG DELIVERY SYSTEM; DRUG EFFECTS; EYE; FLOW KINETICS; HUMAN; KERATINOCYTE; METABOLISM; PATHOLOGY; PHYSICAL CHEMISTRY; PROCEDURES; SCANNING ELECTRON MICROSCOPY; SPRAGUE DAWLEY RAT;

ADMINISTRATION, OPHTHALMIC; ANIMALS; CARRAGEENAN; CELL SURVIVAL; CELLS, CULTURED; CHICKENS; DRUG DELIVERY SYSTEMS; EYE; HUMANS; HYDROGELS; KERATINOCYTES; MAGNETIC RESONANCE IMAGING; MALE; MICROSCOPY, ELECTRON, SCANNING; PHASE TRANSITION; PHYSICOCHEMICAL PHENOMENA; POLYSACCHARIDES, BACTERIAL; RATS, SPRAGUE-DAWLEY; RHEOLOGY; SURFACE PROPERTIES; TEARS;

EID: 84935028253     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2015.06.003     Document Type: Article

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