In situ gelling Gelrite/alginate formulations as vehicles for ophthalmic drug delivery

AAPS PharmSciTech

Volumn 11, Issue 2, 2010, Pages 610-620

  Liu, Yuejiang ^a   Liu, Jinpeng ^a   Zhang, Xiaolin ^a   Zhang, Ruodan ^a   Huang, Yongliang ^a   Wu, Chunjie ^a  

^a CHENGDU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Alginate; Gelrite ; In situ gelling; Matrine; Ophthalmic delivery

Indexed keywords

ALGINIC ACID; DRUG VEHICLE; GELLING AGENT; GELRITE; MATRINE; POLYMER; ALKALOID; ANTHELMINTIC AGENT; BACTERIAL POLYSACCHARIDE; EYE DROPS; GEL; GELLAN; QUINOLIZINE DERIVATIVE;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SOLUTION; FLOW KINETICS; IN VITRO STUDY; IN VIVO STUDY; LACRIMAL FLUID; PRIORITY JOURNAL; ANIMAL; CHEMISTRY; DRUG SCREENING; GEL; PROCEDURES; RABBIT; SYNTHESIS;

ALKALOIDS; ANIMALS; ANTHELMINTICS; DRUG COMPOUNDING; DRUG EVALUATION, PRECLINICAL; GELS; OPHTHALMIC SOLUTIONS; POLYSACCHARIDES, BACTERIAL; QUINOLIZINES; RABBITS; VEHICLES; PHARMACEUTICAL VEHICLES;

EID: 77954819693     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-010-9413-0     Document Type: Article

References (46)

1. Lee V H L, Robinson JR. Mechanistic and quantitative evaluation of precorneal pilocarpine disposition in albino rabbits. J Pharm Sci. 1979;68:673-84.
2. Higuchi WI. The analysis of data on the medicament release from ointments. J Pharm Sci. 1962;51:802-4.
3. McDonald MB, Protzko EE, Brunner LS, Morris TW, Haas W, Paterno MR et al. Efficacy and safety of besifloxacin ophthalmic suspension 0.6% compared with moxifloxacin ophthalmic solution 0.5% for treating bacterial conjunctivitis. Optometry. 2009;80:296-7.
4. Mundada AS, Shrikhande BK. Formulation and evaluation of ciprofloxacin hydrochloride soluble ocular drug insert. Curr Eye Res. 2008;33:469-75.
5. Sieg JW, Robinson JR. Vehicle effects on ocular drug bioavailability. I: Evaluation of fluorometholone. J Pharm Sci. 1975;64:931-6.
6. Nanjawade BK, Manvi FV, Manjappa AS. In situ-forming hydrogels for sustained ophthalmic drug delivery. J Contr Rel. 2007;122:119-34.
7. Ganguly S, Dash AK. A novel in situ gel for sustained drug delivery and targeting. Int J Pharm. 2004;276:83-92.
8. Miller SC, Donovan MD. Effect of Poloxamer 407 gel on the miotic activity of pilocarpine nitrate in rabbits. Int J Pharm. 1982;12:147-52.
9. Gurny R, Boye T, Ibrahim H. Ocular therapy with nanoparticulate systems for controlled drug delivery. J Contr Rel. 1985;2:353-61.
10. ®: a novel, ion-activated, in situ-gelling polymer for ophthalmic vehicles effect on bioavailability of timolol. Int J Pharm. 1989;57:163-8.
11. Lin HR, Sung KC. Carbopol/pluronic phase change solutions for ophthalmic drug delivery. J Contr Rel. 2000;69:379-88.
12. Hui HW, Robinson JR. Ocular delivery of progesterone using a bioadhesive polymer. Int J Pharm. 1985;26:203-13.
13. Sanzgiri YD, Maschi S, Crescenzi V, Calligaro L, Topp EM, Stella VJ. Gellan-based systems for ophthalmic sustained delivery of methyl prednisolone. J Contr Rel. 1993;26:195-201. (Pubitemid 23287364)
14. Meseguer G, Gurny R, Buri P, Rozier A, Plazonnet B. Gamma scintigraphic study of precorneal drainage and assessment of miotic response in rabbits of various ophthalmic formulations containing pilocarpine. Int J Pharm. 1993;95:229-34.
15. Carlfors J, Edsman K, Petersson R, Jornving K. Rheological evaluation of Gelrite in situ gels for ophthalmic use. Eur J Pharm Sci. 1998;6:113-9. (Pubitemid 28164281)
16. Cao YX, Zhang C, Shen WB, Cheng ZH, Yu LL, Ping Q. Poly (N-isopropylacrylamide)-chitosan as thermosensitive in situ gelforming system for ocular drug delivery. J Contr Rel. 2007;120:186-94.
17. Miyazaki S, Suzuki S, Kawasaki N, Endo K, Takahashi A, Attwood D. In situ gelling xyloglucan formulations for sustained release ocular delivery of pilocarpine hydrochloride. Int J Pharm. 2001;229:29-36.
18. Agnihotri SA, Jawalkar SS, Aminabhavi TM. Controlled release of cephalexin through gellan gum beads: effect of formulation parameters on entrapment efficiency, size, and drug release. Eur J Pharm Biopharm. 2006;63:249-61.
19. Balasubramaniam J, Kant S, Pandit JK. In vitro and in vivo evaluation of the Gelrite gellan gum-based ocular delivery system for indomethacin. Acta Pharm. 2003;53:251-61.
20. Balakrishnana BJ, Mohantyb M, Umashankar PR, Jayakrishnana A. Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin. Biomaterials. 2005;26:6335-42.
21. Liu Z, Li J, Nie S, Liu H, Ding P, Pan W. Study of an alginate/HPMC-based in situ gelling ophthalmic delivery system for gatifloxacin. Int J Pharm. 2006;315:12-7.
22. Joshi A, Ding S, Himmelstein. Reversible gelation compositions and methods of use. US Patent 5, 252, 318, 12 Oct. 1993
23. Lin HR, Sung KC, Vong WJ. In situ gelling of alginate/pluronic solutions for ophthalmic delivery of pilocarpine. Biomacromolecules. 2004;5:2358-65.
24. Pongjanyakul T, Puttipipatkhachorn S. Xanthan-alginate composite gel beads: molecular interaction and in vitro characterization. Int J Pharm. 2007;331:61-71. (Pubitemid 46176497)
25. Wu CJ, Qi HY, Chen W, Huang C, Su C, Li W et al. Preparation and evaluation of a Carbopol/HPMC-based in situ gelling ophthalmic system for puerarin. Yakugaku Zasshi. 2007;127:183-91. (Pubitemid 46089916)
26. Yang HF, Zhang F. Research progress of matrine and its preparations. Qilu Pharm Affairs. 2008;27:551-3.
27. Chuang CY, Xiao JG, Chiou G C Y. Ocular anti-inflammatory actions of matrine. J Ocul Pharmacol. 1987;3:129-34.
28. Li XT. The pharmacodynamics study of matrine gutta to cure bacterial keratitis and bacterial conjunctivitis. Master thesis, Jilin University; 2008. p. 19-30.
29. Hou ZH, Tan DM, Xie YT, Lu MH, Xie JP, Liu GZ et al. Therapeutic effect of matrine in patients with chronic hepatitis B. Pract Prev Med. 2005;12:824-6.
30. Liu JJ. Effect of matrine on the treatment of patient with chronic hepatitis B. China Med Abstr. 2006;27:43-5.
31. Cohen S, Lobel E, Trevgoda A, Peled Y. A novel in situ forming ophthalmic drug delivery system from alginates undergoing gelation in the eye. J Contr Rel. 1997;44:201-8.
32. Paulsson M, Hägerström H, Edsman K. Rheological studies of the gelation of deacetylated gellan gum (Gelrite) in physiological conditions. Eur J Pharm Sci. 1999;9:99-105.
33. Srividya B, Cardoza RM, Amin PD. Sustained ophthalmic delivery of ofloxacin from a pH triggered in situ gelling system. J Contr Rel. 2001;73:205-11.
34. Edsmana K, Carlforsa J, Harju K. Rheological evaluation and ocular contact time of some carbomer gels for ophthalmic use. Int J Pharm. 1996;137:233-41.
35. Draize JH, Woodard G, Calvery HO. Methods for the study of irritation and toxicity of substances. J Pharmacol Exp Ther. 1944;82:377-90.
36. Colo GD, Zambito Y, Burgalassi S, Nardini I, Saettone MF. Effect of chitosan and of N-carboxymethylchitosan on intraocular penetration of topically applied ofloxacin. Int J Pharm. 2004;273:37-44.
37. Deasy PB, Quigley KJ. Rheological evaluation of deacetylated gellan gum (Gelrite) for pharmaceutical use. Int J Pharm. 1991;73:117-23.
38. Manjappa AS, Nanjwade BK, Manvi FV, Murthy R S R. Sustained ophthalmic in situ gel of ketorolac tromethamine rheology and in vivo studies. Drug Dev Res. 2009;70:417-24.
39. Jansson PE, Lindberg B, Sandford PA. Structural studies of gellan gum an extracellular polysaccharide elaborated by Pseudomonas elodea. Carbohydr Res. 1983;124:135-9.
40. Grasdalen H, Smidsroed O. Gelation of gellan gum. Carbohydr Polym. 1987;7:371-93.
41. Moritaka H, Kimura S, Fukuba H. Rheological properties of matrix-particle gellan gum gel: effects of calcium chloride on the matrix. Food Hydrocolloids. 2003;17:653-60.
42. Yuguchi Y, Urakawab H, Kajiwarab K. The effect of potassium salt on the structural characteristics of gellan gum gel. Food Hydrocolloids. 2002;16:191-5.
43. Larsen B, Smidsrod O, Painter TJ, Haug A. Calculation of the nearest-neighbour frequencies in fragments of alginate from the yields of free monomers after partial hydrolysis. Acta Chem. 1970;24:726-8.
44. Haug A, Larsen B, Smidsrod O. A study of the constitution of alginic acid by partial hydrolysis. Acta Chem. 1966;20:183-90.
45. Funami T, Fang Y, Noda S, Ishihara S, Nakauma M, Draget KI et al. Rheological properties of sodium alginate in an aqueous system during gelation in relation to supermolecular structures and Ca2+ binding. Food Hydrocolloids. 2009;23:1746-55.
46. Morris VJ, Tsiami A, Brownsey GJ. Work hardening effects in gellan gum gels. J Carbohydrate Chem. 1995;14:667-75.