Contents of therapeutic metabolites in Swertia chirayita correlate with the expression profiles of multiple genes in corresponding biosynthesis pathways

Phytochemistry

Volumn 116, Issue 1, 2015, Pages 38-47

  Padhan, Jibesh Kumar ^a   Kumar, Varun ^a   Sood, Hemant ^a   Singh, Tiratha Raj ^a   Chauhan, Rajinder S ^a  

^a JAYPEE UNIVERSITY OF INFORMATION TECHNOLOGY   (India)

Author keywords

Amarogentin; Mangiferin; MEP; MVA; Phenylpropanoid; Secoiridoid; Swertia chirayita; Swertiamarin; Xanthone

Indexed keywords

SWERTIA;

AMAROGENTIN; IRIDOID; MANGIFERIN; PYRONE DERIVATIVE; SWERTIAMARIN; XANTHONE DERIVATIVE;

CHEMISTRY; GENETICS; MEDICINAL PLANT; PLANT ROOT; SWERTIA;

IRIDOID GLUCOSIDES; IRIDOIDS; PLANT ROOTS; PLANTS, MEDICINAL; PYRONES; SWERTIA; XANTHONES;

EID: 84934962059     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phytochem.2015.05.007     Document Type: Article

References (45)

1. Aharoni, A., De Vos, C.H., Wein, M., Sun, Z., Greco, R., Kroon, A., Mol, J.N., O'Connell, A.P., 2001. The strawberry FaMYB1 transcription factor suppresses anthocyanin and flavonol accumulation in transgenic tobacco. Plant J. 28, 319-332.
2. Alam, P., Abdin, M.Z., 2011. Over-expression of HMG-CoA reductase and amorpha-4,11-diene synthase genes in Artemisia annua L. and its influence on artemisinin content. Plant Cell Rep. 30, 1919-1928.
3. Badola, H.K., Pal, M., 2002. Endangered medicinal plant species in Himachal Pradesh. Curr. Sci. 83, 797-798.
4. Bhat, A.J., Kumar, M., Negi, A.K., Todaria, N.P., 2013. Informants' consensus on ethnomedicinal plants in Kedarnath Wildlife Sanctuary of Indian Himalayas. J. Med. Plants Res. 7, 148-154.
5. Cazzonelli, C.I., Pogson, B.J., 2010. Source to sink: regulation of carotenoid biosynthesis in plants. Trends Plant Sci. 15, 266-274.
6. Degenhardt, J., Gershenzon, J., Baldwin, I.T., Kessler, A., 2003. Attracting friends to feast on foes: engineering terpene emission to make crop plants more attractive to herbivore enemies. Curr. Opin. Biotechnol. 14, 169-176.
7. Fujita, M., Inoue, T., 1977. Biosynthesis of mangiferin in Anemarrhena asphodeloides: intact incorporation of C6-C3 precursor into xanthone. Tetrahedron Lett. 18, 4503-4506.
8. Grotewold, E., Chamberlin, M., Snook, M., Siame, B., Butler, L., Swenson, J., Maddock, S., St Clair, G., Bowen, B., 1998. Engineering secondary metabolism in maize cells by ectopic expression of transcription factors. Plant Cell 10, 721-740.
9. Guha, S., Ghosal, S., Chattopadhyay, U., 1996. Antitumor, immunomodulatory and anti-HIV effect of mangiferin, a naturally occurring glucosylxanthone. Chemotherapy 42, 443-451.
10. Hotelling, H., 1933. Analysis of a complex of statistical variables into principal components. J. Educ. Psychol. 24, 417-441.
11. Joshi, P., Dhawan, V., 2005. Swertia chirayita-an overview. Curr. Sci. 89, 635-640.
12. Kao, Y.Y., Harding, S.A., Tsai, C.J., 2002. Differential expression of two distinct phenylalanine ammonia-lyase genes in condensed tannin-accumulating and lignifying cells of quaking aspen. Plant Physiol. 130, 796-807.
13. Kavimani, S., Manisenthlkumar, K.T., 2000. Effect of methanolic extract of Enicostemma littorale on Dalton's ascitic lymphoma. J. Ethnopharmacol. 71, 349-352.
14. Kavitha, M., Nataraj, J., Essa, M.M., Memon, M.A., Manivasagam, T., 2013. Mangiferin attenuates MPTP induced dopaminergic neurodegeneration and improves motor impairment, redox balance and Bcl-2/Bax expression in experimental Parkinson's disease mice. Chem. Biol. Interact. 206, 239-247.
15. Kumar, V., Chauhan, R., Sood, H., 2013. In vitro production and efficient quantification of major phytopharmaceuticals in an endangered medicinal herb, Swertia chirata. Int. J. Biotechnol. Bioeng. Res. 4, 495-506.
16. Kuwajima, H., Hayashi, N., Takaishi, K., Inoue, K., Takeda, Y., Inouye, H., 1990. Studies on monoterpene glucosides and related compounds. LXV. Biosynthesis of the biphenylcarboxylic acid moiety of amarogentin and amaroswerin. J. Pharm. Soc. Jpn. 110, 484-489.
17. Malhotra, N., Kumar, V., Sood, H., Singh, T.R., Chauhan, R.S., 2014. Multiple genes of mevalonate and non-mevalonate pathways contribute to high aconites content in an endangered medicinal herb, Aconitum heterophyllum Wall. Phytochemistry 108C, 26-34.
18. Medda, S., Mukhopadhyay, S., Basu, M.K., 1999. Evaluation of the in-vivo activity and toxicity of amarogentin, an antileishmanial agent, in both liposomal and niosomal forms. J. Antimicrob. Chemother. 44, 791-794.
19. Miettinen, K., Dong, L., Navrot, N., Schneider, T., Burlat, V., Pollier, J., Woittiez, L., van der Krol, S., Lugan, R., Ilc, T., Verpoorte, R., Oksman-Caldentey, K.M., Martinoia, E., Bouwmeester, H., Goossens, A., Memelink, J., Werck-Reichhart, D., 2014. The seco-iridoid pathway from Catharanthus roseus. Nat. Commun. 5, 3606. http://dx.doi.org/10.1038/ncomms4606.
20. Murashige, T., Skoog, F., 1962. A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol. Plant 15, 473-497.
21. Nour-Eldin, H.H., Andersen, T.G., Burow, M., Madsen, S.R., Jørgensen, M.E., Olsen, C.E., Dreyer, I., Hedrich, R., Geiger, D., Halkier, B.A., 2012. NRT/PTR transporters are essential for translocation of glucosinolate defence compounds to seeds. Nature 488, 531-534.
22. Olofsson, L., Engström, A., Lundgren, A., Brodelius, P.E., 2011. Relative expression of genes of terpene metabolism in different tissues of Artemisia annua L. BMC Plant Biol. 11, 45.
23. Pal, D., Sur, S., Mandal, S., Das, A., Roy, A., Das, S., Panda, C.K., 2012. Prevention of liver carcinogenesis by amarogentin through modulation of G1/S cell cycle check point and induction of apoptosis. Carcinogenesis 33, 2424-2431.
24. Pandit, S., Shitiz, K., Sood, H., Naik, P.K., Chauhan, R.S., 2013. Expression pattern of fifteen genes of non-mevalonate (MEP) and mevalonate (MVA) pathways in different tissues of endangered medicinal herb Picrorhiza kurroa with respect to picrosides content. Mol. Biol. Rep. 40, 1053-1063.
25. Pardo-Andreu, G.L., Paim, B.A., Castilho, R.F., Velho, J.A., Delgado, R., Vercesi, A.E., Oliveira, H.C., 2008. Mangifera indica L. extract (Vimang®) and its main polyphenol mangiferin prevent mitochondrial oxidative stress in atherosclerosis-prone hypercholesterolemic mouse. Pharmacol. Res. 57, 332-338.
26. Patil, K., Dhande, S., Kadam, V., 2013. Therapeutic Swertia chirata-an overview. Res. J. Pharmacognosy Phytochem. 5, 199-207.
27. Peebles, C.A., Sander, G.W., Hughes, E.H., Peacock, R., Shanks, J.V., San, K.Y., 2011. The expression of 1-deoxy-D-xylulose synthase and geraniol-10-hydroxylase or anthranilate synthase increases terpenoid indole alkaloid accumulation in Catharanthus roseus hairy roots. Metab. Eng. 13, 234-240.
28. Pfaffl, M.W., Tichopad, A., Prgomet, C., Neuvians, T.P., 2004. Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper-Excel-based tool using pair-wise correlations. Biotechnol. Lett. 26, 509-515.
29. Phoboo, S., Pinto, M.D.S., Barbosa, A.C.L., Sarkar, D., Bhowmik, P.C., Jha, P.K., Shetty, K., 2013. Phenolic-linked biochemical rationale for the anti-diabetic properties of Swertia chirayita (Roxb. ex Flem.) Karst. Phytother. Res. 27, 227-235.
30. Ray, S., Majumder, H.K., Chakravarty, A.K., Mukhopadhyay, S., Gil, R.R., Cordell, G.A., 1996. Amarogentin, a naturally occurring secoiridoid glycoside and a newly recognized inhibitor of topoisomerase I from Leishmania donovani. J. Nat. Prod. 59, 27-29.
31. Rozen, S., Skaletsky, H., 2000. Primer3 on the WWW for general users and for biologist programmers. Methods Mol. Biol. 132, 365-386 (Clifton, N.J.).
32. Saha, P., Mandal, S., Das, A., Das, S., 2006. Amarogentin can reduce hyperproliferation by downregulation of Cox-II and upregulation of apoptosis in mouse skin carcinogenesis model. Cancer Lett. 244, 252-259.
33. Saravanan, S., Hairul Islam, V.I., Prakash Babu, N., Pandikumar, P., Thirugnanasambantham, K., Chellappandian, M., Simon Durai Raj, C., Gabriel Paulraj, M., Ignacimuthu, S., 2014. Swertiamarin attenuates inflammation mediators via modulating NF-κB/I κB and JAK2/STAT3 transcription factors in adjuvant induced arthritis. Eur. J. Pharm. Sci. 56, 70-86.
34. Schmittgen, T.D., Livak, K.J., 2008. Analyzing real-time PCR data by the comparative CT method. Nat. Protoc. 3, 1101-1108.
35. Shitan, N., Morita, M., Yazaki, K., 2009. Identification of a nicotine transporter in leaf vacuoles of Nicotiana tabacum. Plant Signal. Behav. 4, 530-532.
36. Singh, R.S., Gara, R.K., Bhardwaj, P.K., Kaachra, A., Malik, S., Kumar, R., Sharma, M., Ahuja, P.S., Kumar, S., 2010. Expression of 3-hydroxy-3-methylglutaryl-CoA reductase, p-hydroxybenzoate-m-geranyltransferase and genes of phenylpropanoid pathway exhibits positive correlation with shikonins content in arnebia [Arnebia euchroma (Royle) Johnston]. BMC Mol. Biol. 11, 88.
37. Singh, P., Batth, T.S., Juminaga, D., Dahl, R.H., Keasling, J.D., Adams, P.D., Petzold, C.J., 2012. Application of targeted proteomics to metabolically engineered Escherichia coli. Proteomics 12, 1289-1299.
38. Tian, Y.S., Xu, J., Han, J., Zhao, W., Fu, X.Y., Peng, R.H., Yao, Q.H., 2013. Complementary screening, identification and application of a novel class II 5-enopyruvylshikimate-3-phosphate synthase from Bacillus cereus. World J. Microbiol. Biotechnol. 29, 549-557.
39. Vaidya, H., Goyal, R.K., Cheema, S.K., 2013. Anti-diabetic activity of swertiamarin is due to an active metabolite, gentianine, that upregulates PPAR-γ gene expression in 3T3-L1 cells. Phytother. Res. 27, 624-627.
40. Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., Speleman, F., 2002. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 3 (research0034).
41. Vasilev, N., Schmitz, C., Grömping, U., Fischer, R., Schillberg, S., 2014. Assessment of cultivation factors that affect biomass and geraniol production in transgenic tobacco cell suspension cultures. PLoS ONE 9, e104620.
42. Wang, C.Z., Maier, Ulrich H., Eisenreich, W., Adam, P., Obersteiner, I., Keil, M., Bacher, A., Zenk, Meinhart, H., 2001. Unexpected biosynthetic precursors of amarogentin-a retrobiosynthetic 13C NMR study. Eur. J. Org. Chem. 2001, 1459-1465.
43. Wang, J., Zhao, C., Liu, C., Xia, G., Xiang, F., 2011. Introgression of Swertia mussotii gene into Bupleurum scorzonerifolium via somatic hybridization. BMC Plant Biol. 11, 71.
44. Williamson, E.M., 2002. Major Herbs of Ayurveda. Churchill Livingstone, New York.
45. Yamamura, Y., Sahin, F.P., Nagatsu, A., Mizukami, H., 2003. Molecular cloning and characterization of a cDNA encoding a novel apoplastic protein preferentially expressed in a shikonin-producing callus strain of Lithospermum erythrorhizon. Plant Cell Physiol. 44, 437-446.