Evaluation of the in-vivo activity and toxicity of amarogentin, an antileishmanial agent, in both liposomal and niosomal forms

Journal of Antimicrobial Chemotherapy

Volumn 44, Issue 6, 1999, Pages 791-794

  Medda, Swapna ^a   Mukhopadhyay, Sibabrata ^a   Basu, Mukul Kumar ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMAROGENTIN; ANTILEISHMANIAL AGENT; ENZYME; LIPOSOME; NIOSOME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; HAMSTER; HISTOLOGY; LEISHMANIASIS; LIVER FUNCTION; MEMBRANE; NONHUMAN; PATHOLOGY; SUBCUTANEOUS DRUG ADMINISTRATION; VISCOSITY;

EID: 0032796277     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/44.6.791     Document Type: Article

References (18)

1. Chance, M. L. (1981). The six diseases of WHO: leishmaniasis. British Medical Journal, 283, 1245-7.
2. Antimonials: large scale failure in leishmaniasis 'alarming'. In TDR News, No. 34, UNDP/World Bank/WHO, Special Programme for Research and Training in Tropical Diseases, UNDP-World Bank-WHO, Geneva, 1990.
3. Das, N., Bachhawat, B. K., Mahato, S. B. & Basu, M. K. (1987). Plant glycosides in a liposomal drug delivery system. Biochemical Journal 247, 359-61.
4. Medda, S., Mukherjee, S., Das, N., Naskar, K., Mahato, S. B. & Basu, M. K. (1993). Sugar-coated liposomes: a novel delivery system for increased drug efficacy and reduced drug toxicity. Biotechnology and Applied Biochemistry 17, 37-47.
5. Ray, S., Majumder, H. K., Chakraborty, A. K., Mukhopadhyay, S., Gil, R. R. & Cordell, G. A. (1996). Amarogentin, a naturally occurring secoiridoid glycoside, and a newly recognised inhibitor of topoisomerase l from Leishmania donovani. Journal of Natural Products 59, 27-9.
6. Gregoriadis, G. & Ryman, B. E. (1972). Lysosomal localization of fructofuranosidase containing liposomes injected into rats. Biochemical Journal 129, 123-33.
7. Yoshioka, T., Sternberg, B. & Florence, A. T. (1994). Preparation and properties of vesicles (niosomes) of sorbitan monoesters (span 20, 40, 60 and 80) and a sorbitan triester (span 85). International Journal of Pharmaceutics 105, 1-6.
8. Shinitzky, M. & Berhenholz, Y. (1974). Dynamics of the hydrocarbon layer in liposomes of lecithin and sphingomyelin containing dicetylphosphate. Journal of Biological Chemistry 249, 2652-7.
9. Mukherjee, S., Ghosh, C. & Basu, M. K. (1988). Leishmania donovani. Role of microviscosity of macrophage membrane in the process of parasite attachment and internalization. Experimental Parasitology 66, 18-26.
10. 2+-ATPase activity in membrane from L. donovani promastigotes. Biochemical Journal 265, 923-6.
11. 0(D) antigen expression. Biochemical and Biophysical Research Communications 95, 887-93.
12. Schachter, D. & Shinitzky, M. (1977). Fluorescence polarization studies of rat intestinal microvillus membranes. Journal of Clinical Investigation 95, 536-48.
13. Looker, D. L., Bercus, R. L. & Marr, J. J. (1983). Purine metabolism in L. donovani amastigotes and promastigotes. Molecular and Biochemical Parasitology 9, 15-28.
14. Das, N., Mahato, S. B., Naskar, K., Ghosh, D. K. & Basu, M. K. (1990). Targeting of urea stibamine encapsulated in liposomes to reticuloendothelial system for the treatment of experimental leishmaniasis. Biochemical Medicine and Metabolic Biology 43, 133-9.
15. Gurr, E. (1962). Staining: Animal Tissues, Practical and Theoretical. Leonard Hill, London.
16. Reitman, S. & Frankel, S. (1957). A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminase. American Journal of Clinical Pathology 26, 56-63.
17. Kind, P. R. N. & King, E. J. (1954). Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine. Journal of Clinical Pathology 7, 322-6.
18. Singha, U. K., Guru, P. Y., Sen, A. B. & Tandon, T. S. (1992). Antileishmanial activity of traditional plants against Leishmania donovani in golden hamsters. International Journal of Pharmacology 30, 289-95.