The expression of 1-deoxy-d-xylulose synthase and geraniol-10-hydroxylase or anthranilate synthase increases terpenoid indole alkaloid accumulation in Catharanthus roseus hairy roots

Metabolic Engineering

Volumn 13, Issue 2, 2011, Pages 234-240

  Peebles, Christie A M ^a   Sander, Guy W ^b   Hughes, Erik H ^a   Peacock, Ryan ^a   Shanks, Jacqueline V ^b   San, Ka Yiu ^a  

^a Rice University   (United States)

^b IOWA STATE UNIVERSITY   (United States)

Author keywords

Madagascar periwinkle; Methyl erythritol phosphate pathway; Plant metabolic engineering; Terpenoid indole alkaloid; Tissue culture

Indexed keywords

AJMALICINE; ANTHRANILATE SYNTHASE; ANTICANCER DRUG; CATHARANTHUS ROSEUS; HAIRY ROOT CULTURE; HAIRY ROOTS; HYDROXYLASES; INDUCIBLE EXPRESSION; LOW-YIELD; MADAGASCAR; METHYL-ERYTHRITOL PHOSPHATE PATHWAY; MULTIPLE GENES; OVER-EXPRESSION; PLANT METABOLIC ENGINEERING; SYNTHASES; TABERSONINE; TERPENOID INDOLE ALKALOIDS; VINBLASTINE; XYLULOSE;

GENES; LIPIDS; METABOLISM; NITROGEN COMPOUNDS; PLANTS (BOTANY); SERPENTINE; SILICATE MINERALS; TISSUE CULTURE; TISSUE ENGINEERING;

METABOLITES;

1 DEOXY DEXTRO XYLULOSE SYNTHASE; AJMALICINE; ANTHRANILATE SYNTHASE; GERANIOL 10 HYDROXYLASE; HORHAMMERICINE; INDOLE ALKALOID; LOCHNERICINE; OXYGENASE; SERPENTINE; SYNTHETASE; TABERSONINE; TERPENOID; UNCLASSIFIED DRUG;

ARTICLE; CATHARANTHUS ROSEUS; CONTROLLED STUDY; GENE OVEREXPRESSION; PLANT ROOT; PRIORITY JOURNAL;

ANTHRANILATE SYNTHASE; CATHARANTHUS; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION REGULATION, PLANT; PLANT ROOTS; PLANTS, GENETICALLY MODIFIED; SECOLOGANIN TRYPTAMINE ALKALOIDS; TRANSFERASES; VINBLASTINE; VINCRISTINE;

CATHARANTHUS ROSEUS;

EID: 79952103915     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2010.11.005     Document Type: Article

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