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Volumn 9, Issue , 2015, Pages

Repurposing Drugs in Oncology (ReDO) - Itraconazole as an anti-cancer agent

Author keywords

Drug repurposing; Hedgehog pathway inhibition; Itraconazole; ReDO project

Indexed keywords

ITRACONAZOLE; SONIC HEDGEHOG PROTEIN;

EID: 84934940315     PISSN: None     EISSN: 17546605     Source Type: Journal    
DOI: 10.3332/ecancer.2015.521     Document Type: Article
Times cited : (70)

References (47)
  • 1
    • 84879237440 scopus 로고    scopus 로고
    • Itraconazole: An update on pharmacology and clinical use for treatment of invasive and allergic fungal infections
    • Lestner J and Hope WW (2013) Itraconazole: an update on pharmacology and clinical use for treatment of invasive and allergic fungal infections Expert opinion on drug metabolism & toxicology 9(7) pp 911-26
    • (2013) Expert Opinion on Drug Metabolism & Toxicology , vol.9 , Issue.7 , pp. 911-926
    • Lestner, J.1    Hope, W.W.2
  • 2
    • 25844453682 scopus 로고    scopus 로고
    • BMJ Group and Pharmaceutical Press
    • Joint-Formulary-Committee (2015) British National Formulary 69th ed., BMJ Group and Pharmaceutical Press
    • (2015) British National Formulary 69th Ed.
  • 3
    • 0043015915 scopus 로고    scopus 로고
    • Efficacy and safety of itraconazole use in children
    • Gupta AK, Cooper EA and Ginter G (2003) Efficacy and safety of itraconazole use in children Dermatologic Clinics 21(3) pp 521-535
    • (2003) Dermatologic Clinics , vol.21 , Issue.3 , pp. 521-535
    • Gupta, A.K.1    Cooper, E.A.2    Ginter, G.3
  • 4
    • 0031919504 scopus 로고
    • Food interaction and steady-state pharmacokinetics of itraconazole oral solution in healthy volunteers
    • Barone JA et al (1993) Food interaction and steady-state pharmacokinetics of itraconazole oral solution in healthy volunteers Pharmacotherapy 18(4) pp 295-301
    • (1993) Pharmacotherapy , vol.18 , Issue.4 , pp. 295-301
    • Barone, J.A.1
  • 5
    • 0031808362 scopus 로고    scopus 로고
    • Enhanced bioavailability of itraconazole in hydroxypropyl-beta- cyclodextrin solution versus capsules in healthy volunteers
    • PMID: 9661037 PMCID: 105699
    • Barone JA et al (1998) Enhanced bioavailability of itraconazole in hydroxypropyl-beta- cyclodextrin solution versus capsules in healthy volunteers Antimicrob Agents Chemother 42(7) pp 1862-5 PMID: 9661037 PMCID: 105699
    • (1998) Antimicrob Agents Chemother , vol.42 , Issue.7 , pp. 1862-1865
    • Barone, J.A.1
  • 6
    • 0032438509 scopus 로고    scopus 로고
    • Optimisation of itraconazole therapy using target drug concentrations
    • Poirier JM and Cheymol G (1998) Optimisation of itraconazole therapy using target drug concentrations Clin Pharmacokinet 35(6) pp 461-73 DOI: 10.2165/00003088-199835060-00004
    • (1998) Clin Pharmacokinet , vol.35 , Issue.6 , pp. 461-473
    • Poirier, J.M.1    Cheymol, G.2
  • 7
    • 84891711945 scopus 로고    scopus 로고
    • Tissue penetration of antifungal agents
    • PMID: 24396137 PMCID: 3910906
    • Felton T, Troke PF and Hope WW (2014) Tissue penetration of antifungal agents Clin Microbiol Rev 27(1) pp 68-88 DOI: 10.1128/CMR.00046-13 PMID: 24396137 PMCID: 3910906
    • (2014) Clin Microbiol Rev , vol.27 , Issue.1 , pp. 68-88
    • Felton, T.1    Troke, P.F.2    Hope, W.W.3
  • 8
    • 0034094331 scopus 로고    scopus 로고
    • Antifungal activity of itraconazole compared with hydroxy-itraconazole in vitro
    • PMID: 10702560
    • Odds FC and Bossche HV (2000) Antifungal activity of itraconazole compared with hydroxy-itraconazole in vitro J Antimicrob Chemother 45(3) pp 371-3 DOI: 10.1093/jac/45.3.371 PMID: 10702560
    • (2000) J Antimicrob Chemother , vol.45 , Issue.3 , pp. 371-373
    • Odds, F.C.1    Bossche, H.V.2
  • 9
    • 84873473085 scopus 로고    scopus 로고
    • Bethesda MD American Society of Health-System Pharmacists
    • Mc Evoy GK and Snow EK (2008) AHFS: Drug Information Bethesda MD American Society of Health-System Pharmacists
    • (2008) AHFS: Drug Information
    • Mc Evoy, G.K.1    Snow, E.K.2
  • 10
    • 23044459978 scopus 로고    scopus 로고
    • Itraconazole-related increased vincristine neurotoxicity: Case report and review of literature
    • PMID: 16012330
    • Bermúdez M et al (2005) Itraconazole-related increased vincristine neurotoxicity: case report and review of literature J Pediatr Hematol Oncol 27(7) 389-92 DOI: 10.1097/01.mph.0000172751.06286.5b PMID: 16012330
    • (2005) J Pediatr Hematol Oncol , vol.27 , Issue.7 , pp. 389-392
    • Bermúdez, M.1
  • 11
    • 44849130124 scopus 로고    scopus 로고
    • Itraconazole oral solution enhanced vincristine neurotoxicity in five patients with malignant lymphoma
    • PMID: 18379154
    • Takahashi N et al (2008) Itraconazole oral solution enhanced vincristine neurotoxicity in five patients with malignant lymphoma Intern Med 47(7) 651-3 DOI: 10.2169/internalmedicine.47.0701 PMID: 18379154
    • (2008) Intern Med , vol.47 , Issue.7 , pp. 651-653
    • Takahashi, N.1
  • 12
    • 0031464480 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of systemic antifungal therapy
    • Summers KK et al (1997) Therapeutic drug monitoring of systemic antifungal therapy J Antimicrob Chemother 40(6) pp 753-64 DOI: 10.1093/jac/40.6.753
    • (1997) J Antimicrob Chemother , vol.40 , Issue.6 , pp. 753-764
    • Summers, K.K.1
  • 13
    • 84891844859 scopus 로고    scopus 로고
    • The relationship between the success rate of empirical antifungal therapy with intravenous itraconazole and clinical parameters, including plasma levels of itraconazole, in immunocompromised patients receiving itraconazole oral solution as prophylaxis: A
    • Kim JS et al (2014) The relationship between the success rate of empirical antifungal therapy with intravenous itraconazole and clinical parameters, including plasma levels of itraconazole, in immunocompromised patients receiving itraconazole oral solution as prophylaxis: a Ann Hematol 93(1) pp 33-42 DOI: 10.1007/s00277-013-1826-x
    • (2014) Ann Hematol , vol.93 , Issue.1 , pp. 33-42
    • Kim, J.S.1
  • 14
    • 0025782262 scopus 로고
    • Reversal of daunorubicin resistance in P388/ADR cells by itraconazole
    • PMID: 1849151 PMCID: 295200
    • Gupta S, Kim J and Gollapudi S (1991) Reversal of daunorubicin resistance in P388/ADR cells by itraconazole J Clin Invest 87(4) pp 1467-9 DOI: 10.1172/JCI115154 PMID: 1849151 PMCID: 295200
    • (1991) J Clin Invest , vol.87 , Issue.4 , pp. 1467-1469
    • Gupta, S.1    Kim, J.2    Gollapudi, S.3
  • 15
    • 0030030061 scopus 로고    scopus 로고
    • Reversal effect of itraconazole on adriamycin and etoposide resistance in human leukemia cells
    • PMID: 8605275
    • Kurosawa M et al (1996) Reversal effect of itraconazole on adriamycin and etoposide resistance in human leukemia cells Ann Hematol 72(1) pp 17-21 DOI: 10.1007/BF00663011 PMID: 8605275
    • (1996) Ann Hematol , vol.72 , Issue.1 , pp. 17-21
    • Kurosawa, M.1
  • 16
    • 38149037869 scopus 로고    scopus 로고
    • Interactions of azole antifungal agents with the human breast cancer resistance protein (BCRP)
    • PMID: 17518356
    • Gupta A, Unadkat JD and Mao Q (2007) Interactions of azole antifungal agents with the human breast cancer resistance protein (BCRP) J Pharm Sci 96(12) pp 3226-35 DOI: 10.1002/jps.20963 PMID: 17518356
    • (2007) J Pharm Sci , vol.96 , Issue.12 , pp. 3226-3235
    • Gupta, A.1    Unadkat, J.D.2    Mao, Q.3
  • 17
    • 34248598317 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by the antifungal drug itraconazole
    • PMID: 17432820
    • Chong CR et al (2007) Inhibition of angiogenesis by the antifungal drug itraconazole ACS Chem Biol 2(4) pp 263-70 DOI: 10.1021/cb600362d PMID: 17432820
    • (2007) ACS Chem Biol , vol.2 , Issue.4 , pp. 263-270
    • Chong, C.R.1
  • 18
    • 80053238983 scopus 로고    scopus 로고
    • Synergistic inhibition of endothelial cell proliferation, tube formation, and sprouting by cyclosporin A and itraconazole
    • PMID: 21969860 PMCID: 3182171
    • Nacev BA and Liu JO (2011) Synergistic inhibition of endothelial cell proliferation, tube formation, and sprouting by cyclosporin A and itraconazole PloS One 6(9) p e24793 DOI: 10.1371/journal.pone.0024793 PMID: 21969860 PMCID: 3182171
    • (2011) PloS One , vol.6 , Issue.9
    • Nacev, B.A.1    Liu, J.O.2
  • 19
    • 80054888464 scopus 로고    scopus 로고
    • Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer
    • PMID: 21896639 PMCID: 3206167
    • Aftab BT et al (2011) Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer Cancer Res 71(21) pp 6764-72 DOI: 10.1158/0008-5472.CAN-11-0691 PMID: 21896639 PMCID: 3206167
    • (2011) Cancer Res , vol.71 , Issue.21 , pp. 6764-6772
    • Aftab, B.T.1
  • 20
    • 77950492233 scopus 로고    scopus 로고
    • Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth
    • PMID: 20385363 PMCID: 4039177
    • Kim J et al (2010) Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth Cancer Cell 17(4) pp 388-99 DOI: 10.1016/j.ccr.2010.02.027 PMID: 20385363 PMCID: 4039177
    • (2010) Cancer Cell , vol.17 , Issue.4 , pp. 388-399
    • Kim, J.1
  • 21
    • 0029583907 scopus 로고
    • Treatment of cerebral Aspergillosis with itraconazole: Do high doses improve the prognosis?
    • PMID: 8749640
    • Sánchez C et al (1995) Treatment of cerebral Aspergillosis with itraconazole: do high doses improve the prognosis? Clin Infect Dis 21(6) pp 1485-7 DOI: 10.1093/clinids/21.6.1485 PMID: 8749640
    • (1995) Clin Infect Dis , vol.21 , Issue.6 , pp. 1485-1487
    • Sánchez, C.1
  • 22
    • 84872417679 scopus 로고    scopus 로고
    • Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists
    • PMID: 23291299 PMCID: 3548977
    • Kim J et al (2013) Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists Cancer Cell 23(1) pp 23-34 DOI: 10.1016/j.ccr.2012.11.017 PMID: 23291299 PMCID: 3548977
    • (2013) Cancer Cell , vol.23 , Issue.1 , pp. 23-34
    • Kim, J.1
  • 23
    • 84890547769 scopus 로고    scopus 로고
    • Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro
    • You M et al (2014) Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro J Thorac Cardiovasc Surg 147(1) pp 508-16 DOI: 10.1016/j.jtcvs.2013.08.035
    • (2014) J Thorac Cardiovasc Surg , vol.147 , Issue.1 , pp. 508-516
    • You, M.1
  • 24
    • 84903842393 scopus 로고    scopus 로고
    • Itraconazole suppresses the growth of glioblastoma through induction of autophagy: Involvement of abnormal cholesterol trafficking
    • PMID: 24905460 PMCID: 4203550
    • Liu R et al (2014) Itraconazole suppresses the growth of glioblastoma through induction of autophagy: involvement of abnormal cholesterol trafficking Autophagy 10(7) pp 1241-55 DOI: 10.4161/auto.28912 PMID: 24905460 PMCID: 4203550
    • (2014) Autophagy , vol.10 , Issue.7 , pp. 1241-1255
    • Liu, R.1
  • 25
    • 77953150792 scopus 로고    scopus 로고
    • Antifungal therapy with itraconazole impairs the anti-lymphoma effects of rituximab by inhibiting recruitment of CD20 to cell surface lipid rafts
    • PMID: 20460536
    • Ringshausen I et al (2010) Antifungal therapy with itraconazole impairs the anti-lymphoma effects of rituximab by inhibiting recruitment of CD20 to cell surface lipid rafts Cancer Res 70(11) pp 4292-6 DOI: 10.1158/0008-5472.CAN-10-0259 PMID: 20460536
    • (2010) Cancer Res , vol.70 , Issue.11 , pp. 4292-4296
    • Ringshausen, I.1
  • 26
    • 0027325684 scopus 로고
    • Itraconazole and multidrug resistance: Possible effects on remission rate and disease-free survival in acute leukemia
    • PMID: 8396989
    • Vreugdenhil G et al (1993) Itraconazole and multidrug resistance: possible effects on remission rate and disease-free survival in acute leukemia Ann Hematol 67(3) pp 107-9 DOI: 10.1007/BF01701730 PMID: 8396989
    • (1993) Ann Hematol , vol.67 , Issue.3 , pp. 107-109
    • Vreugdenhil, G.1
  • 27
    • 84874386385 scopus 로고    scopus 로고
    • Repurposing itraconazole as a treatment for advanced prostate cancer: A noncomparative randomized phase II trial in men with metastatic castration-resistant prostate cancer
    • PMID: 23340005 PMCID: 3579600
    • Antonarakis ES et al (2013) Repurposing itraconazole as a treatment for advanced prostate cancer: a noncomparative randomized phase II trial in men with metastatic castration-resistant prostate cancer Oncologist 18(2) pp 163-73 DOI: 10.1634/theoncologist.2012-314 PMID: 23340005 PMCID: 3579600
    • (2013) Oncologist , vol.18 , Issue.2 , pp. 163-173
    • Antonarakis, E.S.1
  • 28
    • 84896380125 scopus 로고    scopus 로고
    • High-dose itraconazole as a noncastrating therapy for a patient with biochemically recurrent prostate cancer
    • Suzman DL and Antonarakis ES (2014) High-dose itraconazole as a noncastrating therapy for a patient with biochemically recurrent prostate cancer Clin Genitourin Cancer 12(2) pp e51-3 DOI: 10.1016/j.clgc.2013.11.015
    • (2014) Clin Genitourin Cancer , vol.12 , Issue.2 , pp. e51-e53
    • Suzman, D.L.1    Antonarakis, E.S.2
  • 29
    • 84876411054 scopus 로고    scopus 로고
    • Phase 2 study of pemetrexed and itraconazole as second-line therapy for metastatic nonsquamous non-small-cell lung cancer
    • PMID: 23546045 PMCID: 3636564
    • Rudin CM et al (2013) Phase 2 study of pemetrexed and itraconazole as second-line therapy for metastatic nonsquamous non-small-cell lung cancer J Thorac Oncol 8(5) pp 619-23 PMID: 23546045 PMCID: 3636564
    • (2013) J Thorac Oncol , vol.8 , Issue.5 , pp. 619-623
    • Rudin, C.M.1
  • 30
    • 84897949607 scopus 로고    scopus 로고
    • Open-Label, Exploratory Phase II Trial of Oral Itraconazole for the Treatment of Basal Cell Carcinoma
    • Kim DJ et al (2014) Open-Label, Exploratory Phase II Trial of Oral Itraconazole for the Treatment of Basal Cell Carcinoma J Clinic Oncol 32(8) pp 745-51 DOI: 10.1200/JCO.2013.49.9525
    • (2014) J Clinic Oncol , vol.32 , Issue.8 , pp. 745-751
    • Kim, D.J.1
  • 31
    • 84902245472 scopus 로고    scopus 로고
    • Impact of combination chemotherapy with itraconazole on survival for patients with recurrent or persistent ovarian clear cell carcinoma
    • PMID: 24692739
    • Tsubamoto H et al (2014) Impact of combination chemotherapy with itraconazole on survival for patients with recurrent or persistent ovarian clear cell carcinoma Anticancer Res 34(4) pp 2007-14 PMID: 24692739
    • (2014) Anticancer Res , vol.34 , Issue.4 , pp. 2007-2014
    • Tsubamoto, H.1
  • 32
    • 84902985388 scopus 로고    scopus 로고
    • Impact of combination chemotherapy with itraconazole on survival of patients with refractory ovarian cancer
    • PMID: 24778064
    • Tsubamoto H et al (2014) Impact of combination chemotherapy with itraconazole on survival of patients with refractory ovarian cancer Anticancer Res 34(5) pp 2481-7 PMID: 24778064
    • (2014) Anticancer Res , vol.34 , Issue.5 , pp. 2481-2487
    • Tsubamoto, H.1
  • 33
    • 84906318465 scopus 로고    scopus 로고
    • Impact of Itraconazole on the Survival of Heavily Pre-treated Patients with Triple-Negative Breast Cancer
    • PMID: 24982411
    • Tsubamoto H, Sonoda T and Inoue K (2014) Impact of Itraconazole on the Survival of Heavily Pre-treated Patients with Triple-Negative Breast Cancer Anticancer Res 34(7) pp 3839-44 PMID: 24982411
    • (2014) Anticancer Res , vol.34 , Issue.7 , pp. 3839-3844
    • Tsubamoto, H.1    Sonoda, T.2    Inoue, K.3
  • 34
    • 85026314475 scopus 로고    scopus 로고
    • A pilot trial of itraconazole pharmacokinetics in patients with metastatic breast cancer
    • pp abstr
    • Ademuyiwa FO et al (2011) A pilot trial of itraconazole pharmacokinetics in patients with metastatic breast cancer J Clin Oncol suppl pp abstr e13565
    • (2011) J Clin Oncol Suppl
    • Ademuyiwa, F.O.1
  • 35
    • 84964292661 scopus 로고    scopus 로고
    • Itraconazole therapy in a pancreatic adenocarcinoma patient: A case report
    • Lockhart NR, Waddell JA and Schrock NE (2015) Itraconazole therapy in a pancreatic adenocarcinoma patient: A case report J Oncol Pharm Pract DOI: 10.1177/1078155215572931 PMID: 25670260
    • (2015) J Oncol Pharm Pract
    • Lockhart, N.R.1    Waddell, J.A.2    Schrock, N.E.3
  • 37
    • 84907971362 scopus 로고    scopus 로고
    • CUSP9∗treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide
    • PMID: 25211298 PMCID: 4226667
    • Kast RE, Karpel-Massler G and Halatsch M (2014) CUSP9∗treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide Oncotarget 5(18) pp 8052-82 PMID: 25211298 PMCID: 4226667
    • (2014) Oncotarget , vol.5 , Issue.18 , pp. 8052-8082
    • Kast, R.E.1    Karpel-Massler, G.2    Halatsch, M.3
  • 38
    • 77949539205 scopus 로고    scopus 로고
    • Cholesterol trafficking is required for mTOR activation in endothelial cells
    • PMID: 20176935 PMCID: 2842052
    • Xu J et al (2010) Cholesterol trafficking is required for mTOR activation in endothelial cells Proc Nat Acad Sci USA 107(10) pp 4764-9 DOI: 10.1073/pnas.0910872107 PMID: 20176935 PMCID: 2842052
    • (2010) Proc Nat Acad Sci USA , vol.107 , Issue.10 , pp. 4764-4769
    • Xu, J.1
  • 39
    • 83755162608 scopus 로고    scopus 로고
    • The antifungal drug itraconazole inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells
    • PMID: 22025615 PMCID: 3243534
    • Nacev BA et al (2011) The antifungal drug itraconazole inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells J Biol Chem 286(51) pp 44045-56 DOI: 10.1074/jbc.M111.278754 PMID: 22025615 PMCID: 3243534
    • (2011) J Biol Chem , vol.286 , Issue.51 , pp. 44045-44056
    • Nacev, B.A.1
  • 40
    • 84922604990 scopus 로고    scopus 로고
    • Successful treatment of oral itraconazole for infantile hemangiomas: A case series
    • February
    • Ran Y et al (2015) Successful treatment of oral itraconazole for infantile hemangiomas: A case series J Dermatol (February) 42(2) pp 202-6 DOI: 10.1111/1346-8138.12724
    • (2015) J Dermatol , vol.42 , Issue.2 , pp. 202-206
    • Ran, Y.1
  • 41
    • 84866491082 scopus 로고    scopus 로고
    • Cancer stem cells
    • PMID: 22981632 PMCID: 3496019
    • Yu Z et al (2012) Cancer stem cells Int J Biochem Cell Biol 44(12) pp 2144-2151 DOI: 10.1016/j.biocel.2012.08.022 PMID: 22981632 PMCID: 3496019
    • (2012) Int J Biochem Cell Biol , vol.44 , Issue.12 , pp. 2144-2151
    • Yu, Z.1
  • 42
    • 84886819205 scopus 로고    scopus 로고
    • RARα2 expression confers myeloma stem cell features
    • PMID: 23847194 PMCID: 3750340
    • Yang Y et al (2013) RARα2 expression confers myeloma stem cell features Blood 122(8) pp 1437-47 DOI: 10.1182/blood-2013-02-482919 PMID: 23847194 PMCID: 3750340
    • (2013) Blood , vol.122 , Issue.8 , pp. 1437-1447
    • Yang, Y.1
  • 43
    • 84896131650 scopus 로고    scopus 로고
    • Inhibition of the multidrug resistance P-glycoprotein: Time for a change of strategy?
    • PMID: 24492893 PMCID: 3965902
    • Callaghan R, Luk F and Bebawy M (2014) Inhibition of the multidrug resistance P-glycoprotein: time for a change of strategy? Drug Metab Dispos 42(4) pp 623-31 DOI: 10.1124/dmd.113.056176 PMID: 24492893 PMCID: 3965902
    • (2014) Drug Metab Dispos , vol.42 , Issue.4 , pp. 623-631
    • Callaghan, R.1    Luk, F.2    Bebawy, M.3
  • 44
    • 0036135397 scopus 로고    scopus 로고
    • Interaction of common azole antifungals with P glycoprotein
    • Wang E et al (2002) Interaction of common azole antifungals with P glycoprotein Antimicrob Agents Chemother 46(1) pp 160-5 DOI: 10.1128/AAC.46.1.160-165.2002
    • (2002) Antimicrob Agents Chemother , vol.46 , Issue.1 , pp. 160-165
    • Wang, E.1
  • 45
    • 84893570326 scopus 로고    scopus 로고
    • Human ABC transporter ABCG2/BCRP expression in chemoresistance: basic and clinical perspectives for molecular cancer therapeutics
    • Noguchi K, Katayama K and Sugimoto Y (2014) Human ABC transporter ABCG2/BCRP expression in chemoresistance: basic and clinical perspectives for molecular cancer therapeutics Pharmacogenomics Pers Med 7 pp 53-64 DOI: 10.2147/PGPM.S38295
    • (2014) Pharmacogenomics Pers Med , vol.7 , pp. 53-64
    • Noguchi, K.1    Katayama, K.2    Sugimoto, Y.3
  • 46
    • 84921351430 scopus 로고    scopus 로고
    • Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma
    • PMID: 25306392
    • Pricl S et al (2014) Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma Mol Oncol 9(2) 389-97 DOI: 10.1016/j.molonc.2014.09.003 PMID: 25306392
    • (2014) Mol Oncol , vol.9 , Issue.2 , pp. 389-397
    • Pricl, S.1
  • 47
    • 84927030619 scopus 로고    scopus 로고
    • Hedgehog pathway inhibitors promote adaptive immune responses in basal cell carcinoma
    • PMID: 25593302
    • Otsuka A et al (2015) Hedgehog pathway inhibitors promote adaptive immune responses in basal cell carcinoma Clin Cancer Res 21(6) 1289-97 DOI: 10.1158/1078-0432.CCR-14-2110 PMID: 25593302
    • (2015) Clin Cancer Res , vol.21 , Issue.6 , pp. 1289-1297
    • Otsuka, A.1


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