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Volumn 6, Issue 9, 2011, Pages

Synergistic inhibition of endothelial cell proliferation, tube formation, and sprouting by cyclosporin A and itraconazole

Author keywords

[No Author keywords available]

Indexed keywords

ALBENDAZOLE; AMPHOTERICIN B; ATORVASTATIN; AURANOFIN; BROMOCRIPTINE; CHLORTETRACYCLINE; CLOMIFENE; CYCLOSPORIN A; DIGOXIN; DIIODOHYDROXYQUIN; ERGOSTEROL; ESTRADIOL; FELODIPINE; FLOXURIDINE; FLUINDOSTATIN; HYPERICIN; IDOXURIDINE; ITRACONAZOLE; MEVINOLIN; MICONAZOLE; MYCOPHENOLIC ACID; NIMODIPINE; PENTAMIDINE; PIMECROLIMUS; PROGESTERONE; RALOXIFENE; SERTRALINE; SIMVASTATIN; SUNITINIB; UNINDEXED DRUG; ANTIFUNGAL AGENT; COLLAGEN; CYCLOSPORIN; LAMININ; MATRIGEL; PROTEOGLYCAN;

EID: 80053238983     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024793     Document Type: Article
Times cited : (26)

References (37)
  • 1
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P, (2003) Angiogenesis in health and disease. Nat Med 9 (6): 653-660.
    • (2003) Nat Med , vol.9 , Issue.6 , pp. 653-660
    • Carmeliet, P.1
  • 2
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, et al. (2006) Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 355 (24): 2542-2550.
    • (2006) N Engl J Med , vol.355 , Issue.24 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3    Brahmer, J.4    Schiller, J.H.5
  • 3
    • 0037374498 scopus 로고    scopus 로고
    • The price of innovation: New estimates of drug development costs
    • DiMasi JA, Hansen RW, Grabowski HG, (2003) The price of innovation: New estimates of drug development costs. J Health Econ 22 (2): 151-185.
    • (2003) J Health Econ , vol.22 , Issue.2 , pp. 151-185
    • DiMasi, J.A.1    Hansen, R.W.2    Grabowski, H.G.3
  • 4
    • 34547770279 scopus 로고    scopus 로고
    • New uses for old drugs
    • Chong CR, Sullivan DJ Jr, (2007) New uses for old drugs. Nature 448 (7154): 645-646.
    • (2007) Nature , vol.448 , Issue.7154 , pp. 645-646
    • Chong, C.R.1    Sullivan Jr., D.J.2
  • 5
    • 34248598317 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by the antifungal drug itraconazole
    • Chong CR, Xu J, Lu J, Bhat S, Sullivan DJ Jr, et al. (2007) Inhibition of angiogenesis by the antifungal drug itraconazole. ACS Chem Biol 2 (4): 263-270.
    • (2007) ACS Chem Biol , vol.2 , Issue.4 , pp. 263-270
    • Chong, C.R.1    Xu, J.2    Lu, J.3    Bhat, S.4    Sullivan Jr., D.J.5
  • 6
    • 33646439982 scopus 로고    scopus 로고
    • Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target
    • Chong CR, Qian DZ, Pan F, Wei Y, Pili R, et al. (2006) Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target. J Med Chem 49 (9): 2677-2680.
    • (2006) J Med Chem , vol.49 , Issue.9 , pp. 2677-2680
    • Chong, C.R.1    Qian, D.Z.2    Pan, F.3    Wei, Y.4    Pili, R.5
  • 7
    • 58149374576 scopus 로고    scopus 로고
    • Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth
    • Zhang H, Qian DZ, Tan YS, Lee K, Gao P, et al. (2008) Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth. Proc Natl Acad Sci U S A 105 (50): 19579-19586.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.50 , pp. 19579-19586
    • Zhang, H.1    Qian, D.Z.2    Tan, Y.S.3    Lee, K.4    Gao, P.5
  • 8
    • 58049211941 scopus 로고    scopus 로고
    • Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes
    • Ren YR, Pan F, Parvez S, Fleig A, Chong CR, et al. (2008) Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes. PLoS One 3 (12): e4009.
    • (2008) PLoS One , vol.3 , Issue.12
    • Ren, Y.R.1    Pan, F.2    Parvez, S.3    Fleig, A.4    Chong, C.R.5
  • 9
    • 78650350269 scopus 로고    scopus 로고
    • Effect of nitroxoline on angiogenesis and growth of human bladder cancer
    • Shim JS, Matsui Y, Bhat S, Nacev BA, Xu J, et al. (2010) Effect of nitroxoline on angiogenesis and growth of human bladder cancer. J Natl Cancer Inst 102 (24): 1855-1873.
    • (2010) J Natl Cancer Inst , vol.102 , Issue.24 , pp. 1855-1873
    • Shim, J.S.1    Matsui, Y.2    Bhat, S.3    Nacev, B.A.4    Xu, J.5
  • 10
    • 48949097660 scopus 로고    scopus 로고
    • Antiretroviral treatment of adult HIV infection: 2008 recommendations of the international AIDS society-USA panel
    • Hammer SM, Eron JJ Jr, Reiss P, Schooley RT, Thompson MA, et al. (2008) Antiretroviral treatment of adult HIV infection: 2008 recommendations of the international AIDS society-USA panel. JAMA 300 (5): 555-570.
    • (2008) JAMA , vol.300 , Issue.5 , pp. 555-570
    • Hammer, S.M.1    Eron Jr., J.J.2    Reiss, P.3    Schooley, R.T.4    Thompson, M.A.5
  • 11
    • 0035313488 scopus 로고    scopus 로고
    • FGF and VEGF function in angiogenesis: Signalling pathways, biological responses and therapeutic inhibition
    • Cross MJ, Claesson-Welsh L, (2001) FGF and VEGF function in angiogenesis: Signalling pathways, biological responses and therapeutic inhibition. Trends Pharmacol Sci 22 (4): 201-207.
    • (2001) Trends Pharmacol Sci , vol.22 , Issue.4 , pp. 201-207
    • Cross, M.J.1    Claesson-Welsh, L.2
  • 12
    • 0037906432 scopus 로고    scopus 로고
    • Distinct role of fibroblast growth factor-2 and vascular endothelial growth factor on tumor growth and angiogenesis
    • Giavazzi R, Sennino B, Coltrini D, Garofalo A, Dossi R, et al. (2003) Distinct role of fibroblast growth factor-2 and vascular endothelial growth factor on tumor growth and angiogenesis. Am J Pathol 162 (6): 1913-1926.
    • (2003) Am J Pathol , vol.162 , Issue.6 , pp. 1913-1926
    • Giavazzi, R.1    Sennino, B.2    Coltrini, D.3    Garofalo, A.4    Dossi, R.5
  • 13
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel RS, (2008) Tumor angiogenesis. N Engl J Med 358 (19): 2039-2049.
    • (2008) N Engl J Med , vol.358 , Issue.19 , pp. 2039-2049
    • Kerbel, R.S.1
  • 14
    • 68449090011 scopus 로고    scopus 로고
    • Spheroid-based human endothelial cell microvessel formation in vivo
    • Laib AM, Bartol A, Alajati A, Korff T, Weber H, et al. (2009) Spheroid-based human endothelial cell microvessel formation in vivo. Nat Protoc 4 (8): 1202-1215.
    • (2009) Nat Protoc , vol.4 , Issue.8 , pp. 1202-1215
    • Laib, A.M.1    Bartol, A.2    Alajati, A.3    Korff, T.4    Weber, H.5
  • 16
    • 0032748089 scopus 로고    scopus 로고
    • Tensional forces in fibrillar extracellular matrices control directional capillary sprouting
    • Korff T, Augustin HG, (1999) Tensional forces in fibrillar extracellular matrices control directional capillary sprouting. J Cell Sci 112 (Pt 19): 3249-3258.
    • (1999) J Cell Sci , vol.112 , Issue.Pt 19 , pp. 3249-3258
    • Korff, T.1    Augustin, H.G.2
  • 17
    • 33748794547 scopus 로고    scopus 로고
    • Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
    • Chou TC, (2006) Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev 58 (3): 621-681.
    • (2006) Pharmacol Rev , vol.58 , Issue.3 , pp. 621-681
    • Chou, T.C.1
  • 18
    • 0021118703 scopus 로고
    • Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
    • Chou TC, Talalay P, (1984) Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22: 27-55.
    • (1984) Adv Enzyme Regul , vol.22 , pp. 27-55
    • Chou, T.C.1    Talalay, P.2
  • 19
    • 34548316976 scopus 로고    scopus 로고
    • Molecular basis for sunitinib efficacy and future clinical development
    • Faivre S, Demetri G, Sargent W, Raymond E, (2007) Molecular basis for sunitinib efficacy and future clinical development. Nat Rev Drug Discov 6 (9): 734-745.
    • (2007) Nat Rev Drug Discov , vol.6 , Issue.9 , pp. 734-745
    • Faivre, S.1    Demetri, G.2    Sargent, W.3    Raymond, E.4
  • 20
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
    • Mendel DB, Laird AD, Xin X, Louie SG, Christensen JG, et al. (2003) In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 9 (1): 327-337.
    • (2003) Clin Cancer Res , vol.9 , Issue.1 , pp. 327-337
    • Mendel, D.B.1    Laird, A.D.2    Xin, X.3    Louie, S.G.4    Christensen, J.G.5
  • 21
    • 79952538238 scopus 로고    scopus 로고
    • Fibroblast growth factor 2 regulates endothelial cell sensitivity to sunitinib
    • Welti JC, Gourlaouen M, Powles T, Kudahetti SC, Wilson P, et al. (2011) Fibroblast growth factor 2 regulates endothelial cell sensitivity to sunitinib. Oncogene 30 (10): 1183-1193.
    • (2011) Oncogene , vol.30 , Issue.10 , pp. 1183-1193
    • Welti, J.C.1    Gourlaouen, M.2    Powles, T.3    Kudahetti, S.C.4    Wilson, P.5
  • 22
    • 40749120515 scopus 로고    scopus 로고
    • Combining agents that target the tumor microenvironment improves the efficacy of anticancer therapy
    • Blansfield JA, Caragacianu D, Alexander HR 3rd, Tangrea MA, Morita SY, et al. (2008) Combining agents that target the tumor microenvironment improves the efficacy of anticancer therapy. Clin Cancer Res 14 (1): 270-280.
    • (2008) Clin Cancer Res , vol.14 , Issue.1 , pp. 270-280
    • Blansfield, J.A.1    Caragacianu, D.2    Alexander 3rd, H.R.3    Tangrea, M.A.4    Morita, S.Y.5
  • 23
    • 76249126867 scopus 로고    scopus 로고
    • Sunitinib acts primarily on tumor endothelium rather than tumor cells to inhibit the growth of renal cell carcinoma
    • Huang D, Ding Y, Li Y, Luo WM, Zhang ZF, et al. (2010) Sunitinib acts primarily on tumor endothelium rather than tumor cells to inhibit the growth of renal cell carcinoma. Cancer Res 70 (3): 1053-1062.
    • (2010) Cancer Res , vol.70 , Issue.3 , pp. 1053-1062
    • Huang, D.1    Ding, Y.2    Li, Y.3    Luo, W.M.4    Zhang, Z.F.5
  • 24
    • 84946384873 scopus 로고
    • Toxicity of poisons applied jointly
    • Bliss CL, (1939) Toxicity of poisons applied jointly. Ann Appl Biol 26: 585.
    • (1939) Ann Appl Biol , vol.26 , pp. 585
    • Bliss, C.L.1
  • 25
    • 0029036955 scopus 로고
    • The search for synergy: A critical review from a response surface perspective
    • Greco WR, Bravo G, Parsons JC, (1995) The search for synergy: A critical review from a response surface perspective. Pharmacol Rev 47 (2): 331-385.
    • (1995) Pharmacol Rev , vol.47 , Issue.2 , pp. 331-385
    • Greco, W.R.1    Bravo, G.2    Parsons, J.C.3
  • 26
    • 0001458215 scopus 로고
    • Effect of more than one inhibitor
    • New York, Academic Press
    • Webb JL, (1963) Effect of more than one inhibitor. Anonymous Enzyme and Metabolic Inibitors New York Academic Press pp. 66-79 & 487-512.
    • (1963) Anonymous Enzyme and Metabolic Inibitors
    • Webb, J.L.1
  • 27
    • 0017157814 scopus 로고
    • Biological effects of cyclosporin A: A new antilymphocytic agent
    • Borel JF, Feurer C, Gubler HU, Stahelin H, (1976) Biological effects of cyclosporin A: A new antilymphocytic agent. Agents Actions 6 (4): 468-475.
    • (1976) Agents Actions , vol.6 , Issue.4 , pp. 468-475
    • Borel, J.F.1    Feurer, C.2    Gubler, H.U.3    Stahelin, H.4
  • 28
    • 0024454699 scopus 로고
    • Cyclosporine inhibits basic fibroblast growth factor-driven proliferation of human endothelial cells and keratinocytes
    • Sharpe RJ, Arndt KA, Bauer SI, Maione TE, (1989) Cyclosporine inhibits basic fibroblast growth factor-driven proliferation of human endothelial cells and keratinocytes. Arch Dermatol 125 (10): 1359-1362.
    • (1989) Arch Dermatol , vol.125 , Issue.10 , pp. 1359-1362
    • Sharpe, R.J.1    Arndt, K.A.2    Bauer, S.I.3    Maione, T.E.4
  • 29
    • 0031050060 scopus 로고    scopus 로고
    • Corneal neovascularization induced by xenografts or chemical cautery. Inhibition by Cyclosporin A
    • Benelli U, Ross JR, Nardi M, Klintworth GK, (1997) Corneal neovascularization induced by xenografts or chemical cautery. inhibition by cyclosporin A. Invest Ophthalmol Vis Sci 38 (2): 274-282.
    • (1997) Invest Ophthalmol Vis Sci , vol.38 , Issue.2 , pp. 274-282
    • Benelli, U.1    Ross, J.R.2    Nardi, M.3    Klintworth, G.K.4
  • 30
    • 0025893168 scopus 로고
    • Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
    • Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I, et al. (1991) Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66 (4): 807-815.
    • (1991) Cell , vol.66 , Issue.4 , pp. 807-815
    • Liu, J.1    Farmer Jr., J.D.2    Lane, W.S.3    Friedman, J.4    Weissman, I.5
  • 31
    • 79960475065 scopus 로고    scopus 로고
    • A calcineurin-independent mechanism of angiogenesis inhibition by a non-immunosuppressive cyclosporin A analog
    • Nacev B, Low WK, Huang Z, Su T, Su Z, et al. (2011) A calcineurin-independent mechanism of angiogenesis inhibition by a non-immunosuppressive cyclosporin A analog. J Pharmacol Exp Ther 338 (2): 466.
    • (2011) J Pharmacol Exp Ther , vol.338 , Issue.2 , pp. 466
    • Nacev, B.1    Low, W.K.2    Huang, Z.3    Su, T.4    Su, Z.5
  • 32
    • 0033618146 scopus 로고    scopus 로고
    • Characteristics of the heterologously expressed human lanosterol 14alpha-demethylase (other names: P45014DM, CYP51, P45051) and inhibition of the purified human and candida albicans CYP51 with azole antifungal agents
    • Lamb DC, Kelly DE, Waterman MR, Stromstedt M, Rozman D, et al. (1999) Characteristics of the heterologously expressed human lanosterol 14alpha-demethylase (other names: P45014DM, CYP51, P45051) and inhibition of the purified human and candida albicans CYP51 with azole antifungal agents. Yeast 15 (9): 755-763.
    • (1999) Yeast , vol.15 , Issue.9 , pp. 755-763
    • Lamb, D.C.1    Kelly, D.E.2    Waterman, M.R.3    Stromstedt, M.4    Rozman, D.5
  • 33
    • 33749667750 scopus 로고    scopus 로고
    • Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and candida albicans for inhibition by different antifungal azoles
    • Trosken ER, Adamska M, Arand M, Zarn JA, Patten C, et al. (2006) Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and candida albicans for inhibition by different antifungal azoles. Toxicology 228 (1): 24-32.
    • (2006) Toxicology , vol.228 , Issue.1 , pp. 24-32
    • Trosken, E.R.1    Adamska, M.2    Arand, M.3    Zarn, J.A.4    Patten, C.5
  • 34
    • 77949539205 scopus 로고    scopus 로고
    • Cholesterol trafficking is required for mTOR activation in endothelial cells
    • Xu J, Dang Y, Ren YR, Liu JO, (2010) Cholesterol trafficking is required for mTOR activation in endothelial cells. Proc Natl Acad Sci U S A 107 (10): 4764-4769.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.10 , pp. 4764-4769
    • Xu, J.1    Dang, Y.2    Ren, Y.R.3    Liu, J.O.4
  • 35
    • 77955905585 scopus 로고    scopus 로고
    • Imapct of absolute stereochemistry on the antiangiogenic and antifungal activities of itraconazole
    • Wei S, Nacev BA, Bhat S, Liu JO, (2010) Imapct of absolute stereochemistry on the antiangiogenic and antifungal activities of itraconazole. ACS Med Chem Lett 1 (4): 155.
    • (2010) ACS Med Chem Lett , vol.1 , Issue.4 , pp. 155
    • Wei, S.1    Nacev, B.A.2    Bhat, S.3    Liu, J.O.4
  • 36
    • 0037083792 scopus 로고    scopus 로고
    • Calcineurin is essential for survival during membrane stress in candida albicans
    • Cruz MC, Goldstein AL, Blankenship JR, Del Poeta M, Davis D, et al. (2002) Calcineurin is essential for survival during membrane stress in candida albicans. EMBO J 21 (4): 546-559.
    • (2002) EMBO J , vol.21 , Issue.4 , pp. 546-559
    • Cruz, M.C.1    Goldstein, A.L.2    Blankenship, J.R.3    Del Poeta, M.4    Davis, D.5
  • 37
    • 0035830860 scopus 로고    scopus 로고
    • Principles for the buffering of genetic variation
    • Hartman JL 4th, Garvik B, Hartwell L, (2001) Principles for the buffering of genetic variation. Science 291 (5506): 1001-1004.
    • (2001) Science , vol.291 , Issue.5506 , pp. 1001-1004
    • Hartman 4th, J.L.1    Garvik, B.2    Hartwell, L.3


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