-
1
-
-
0037699955
-
Angiogenesis in health and disease
-
Carmeliet P, (2003) Angiogenesis in health and disease. Nat Med 9 (6): 653-660.
-
(2003)
Nat Med
, vol.9
, Issue.6
, pp. 653-660
-
-
Carmeliet, P.1
-
2
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, et al. (2006) Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 355 (24): 2542-2550.
-
(2006)
N Engl J Med
, vol.355
, Issue.24
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
Brahmer, J.4
Schiller, J.H.5
-
3
-
-
0037374498
-
The price of innovation: New estimates of drug development costs
-
DiMasi JA, Hansen RW, Grabowski HG, (2003) The price of innovation: New estimates of drug development costs. J Health Econ 22 (2): 151-185.
-
(2003)
J Health Econ
, vol.22
, Issue.2
, pp. 151-185
-
-
DiMasi, J.A.1
Hansen, R.W.2
Grabowski, H.G.3
-
4
-
-
34547770279
-
New uses for old drugs
-
Chong CR, Sullivan DJ Jr, (2007) New uses for old drugs. Nature 448 (7154): 645-646.
-
(2007)
Nature
, vol.448
, Issue.7154
, pp. 645-646
-
-
Chong, C.R.1
Sullivan Jr., D.J.2
-
5
-
-
34248598317
-
Inhibition of angiogenesis by the antifungal drug itraconazole
-
Chong CR, Xu J, Lu J, Bhat S, Sullivan DJ Jr, et al. (2007) Inhibition of angiogenesis by the antifungal drug itraconazole. ACS Chem Biol 2 (4): 263-270.
-
(2007)
ACS Chem Biol
, vol.2
, Issue.4
, pp. 263-270
-
-
Chong, C.R.1
Xu, J.2
Lu, J.3
Bhat, S.4
Sullivan Jr., D.J.5
-
6
-
-
33646439982
-
Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target
-
Chong CR, Qian DZ, Pan F, Wei Y, Pili R, et al. (2006) Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target. J Med Chem 49 (9): 2677-2680.
-
(2006)
J Med Chem
, vol.49
, Issue.9
, pp. 2677-2680
-
-
Chong, C.R.1
Qian, D.Z.2
Pan, F.3
Wei, Y.4
Pili, R.5
-
7
-
-
58149374576
-
Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth
-
Zhang H, Qian DZ, Tan YS, Lee K, Gao P, et al. (2008) Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth. Proc Natl Acad Sci U S A 105 (50): 19579-19586.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.50
, pp. 19579-19586
-
-
Zhang, H.1
Qian, D.Z.2
Tan, Y.S.3
Lee, K.4
Gao, P.5
-
8
-
-
58049211941
-
Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes
-
Ren YR, Pan F, Parvez S, Fleig A, Chong CR, et al. (2008) Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes. PLoS One 3 (12): e4009.
-
(2008)
PLoS One
, vol.3
, Issue.12
-
-
Ren, Y.R.1
Pan, F.2
Parvez, S.3
Fleig, A.4
Chong, C.R.5
-
9
-
-
78650350269
-
Effect of nitroxoline on angiogenesis and growth of human bladder cancer
-
Shim JS, Matsui Y, Bhat S, Nacev BA, Xu J, et al. (2010) Effect of nitroxoline on angiogenesis and growth of human bladder cancer. J Natl Cancer Inst 102 (24): 1855-1873.
-
(2010)
J Natl Cancer Inst
, vol.102
, Issue.24
, pp. 1855-1873
-
-
Shim, J.S.1
Matsui, Y.2
Bhat, S.3
Nacev, B.A.4
Xu, J.5
-
10
-
-
48949097660
-
Antiretroviral treatment of adult HIV infection: 2008 recommendations of the international AIDS society-USA panel
-
Hammer SM, Eron JJ Jr, Reiss P, Schooley RT, Thompson MA, et al. (2008) Antiretroviral treatment of adult HIV infection: 2008 recommendations of the international AIDS society-USA panel. JAMA 300 (5): 555-570.
-
(2008)
JAMA
, vol.300
, Issue.5
, pp. 555-570
-
-
Hammer, S.M.1
Eron Jr., J.J.2
Reiss, P.3
Schooley, R.T.4
Thompson, M.A.5
-
11
-
-
0035313488
-
FGF and VEGF function in angiogenesis: Signalling pathways, biological responses and therapeutic inhibition
-
Cross MJ, Claesson-Welsh L, (2001) FGF and VEGF function in angiogenesis: Signalling pathways, biological responses and therapeutic inhibition. Trends Pharmacol Sci 22 (4): 201-207.
-
(2001)
Trends Pharmacol Sci
, vol.22
, Issue.4
, pp. 201-207
-
-
Cross, M.J.1
Claesson-Welsh, L.2
-
12
-
-
0037906432
-
Distinct role of fibroblast growth factor-2 and vascular endothelial growth factor on tumor growth and angiogenesis
-
Giavazzi R, Sennino B, Coltrini D, Garofalo A, Dossi R, et al. (2003) Distinct role of fibroblast growth factor-2 and vascular endothelial growth factor on tumor growth and angiogenesis. Am J Pathol 162 (6): 1913-1926.
-
(2003)
Am J Pathol
, vol.162
, Issue.6
, pp. 1913-1926
-
-
Giavazzi, R.1
Sennino, B.2
Coltrini, D.3
Garofalo, A.4
Dossi, R.5
-
13
-
-
43249095919
-
Tumor angiogenesis
-
Kerbel RS, (2008) Tumor angiogenesis. N Engl J Med 358 (19): 2039-2049.
-
(2008)
N Engl J Med
, vol.358
, Issue.19
, pp. 2039-2049
-
-
Kerbel, R.S.1
-
14
-
-
68449090011
-
Spheroid-based human endothelial cell microvessel formation in vivo
-
Laib AM, Bartol A, Alajati A, Korff T, Weber H, et al. (2009) Spheroid-based human endothelial cell microvessel formation in vivo. Nat Protoc 4 (8): 1202-1215.
-
(2009)
Nat Protoc
, vol.4
, Issue.8
, pp. 1202-1215
-
-
Laib, A.M.1
Bartol, A.2
Alajati, A.3
Korff, T.4
Weber, H.5
-
15
-
-
17444432282
-
Robust quantification of in vitro angiogenesis through image analysis
-
Niemisto A, Dunmire V, Yli-Harja O, Zhang W, Shmulevich I, (2005) Robust quantification of in vitro angiogenesis through image analysis. IEEE Trans Med Imaging 24 (4): 549-553.
-
(2005)
IEEE Trans Med Imaging
, vol.24
, Issue.4
, pp. 549-553
-
-
Niemisto, A.1
Dunmire, V.2
Yli-Harja, O.3
Zhang, W.4
Shmulevich, I.5
-
16
-
-
0032748089
-
Tensional forces in fibrillar extracellular matrices control directional capillary sprouting
-
Korff T, Augustin HG, (1999) Tensional forces in fibrillar extracellular matrices control directional capillary sprouting. J Cell Sci 112 (Pt 19): 3249-3258.
-
(1999)
J Cell Sci
, vol.112
, Issue.Pt 19
, pp. 3249-3258
-
-
Korff, T.1
Augustin, H.G.2
-
17
-
-
33748794547
-
Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
-
Chou TC, (2006) Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev 58 (3): 621-681.
-
(2006)
Pharmacol Rev
, vol.58
, Issue.3
, pp. 621-681
-
-
Chou, T.C.1
-
18
-
-
0021118703
-
Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
-
Chou TC, Talalay P, (1984) Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22: 27-55.
-
(1984)
Adv Enzyme Regul
, vol.22
, pp. 27-55
-
-
Chou, T.C.1
Talalay, P.2
-
19
-
-
34548316976
-
Molecular basis for sunitinib efficacy and future clinical development
-
Faivre S, Demetri G, Sargent W, Raymond E, (2007) Molecular basis for sunitinib efficacy and future clinical development. Nat Rev Drug Discov 6 (9): 734-745.
-
(2007)
Nat Rev Drug Discov
, vol.6
, Issue.9
, pp. 734-745
-
-
Faivre, S.1
Demetri, G.2
Sargent, W.3
Raymond, E.4
-
20
-
-
12244301581
-
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
-
Mendel DB, Laird AD, Xin X, Louie SG, Christensen JG, et al. (2003) In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 9 (1): 327-337.
-
(2003)
Clin Cancer Res
, vol.9
, Issue.1
, pp. 327-337
-
-
Mendel, D.B.1
Laird, A.D.2
Xin, X.3
Louie, S.G.4
Christensen, J.G.5
-
21
-
-
79952538238
-
Fibroblast growth factor 2 regulates endothelial cell sensitivity to sunitinib
-
Welti JC, Gourlaouen M, Powles T, Kudahetti SC, Wilson P, et al. (2011) Fibroblast growth factor 2 regulates endothelial cell sensitivity to sunitinib. Oncogene 30 (10): 1183-1193.
-
(2011)
Oncogene
, vol.30
, Issue.10
, pp. 1183-1193
-
-
Welti, J.C.1
Gourlaouen, M.2
Powles, T.3
Kudahetti, S.C.4
Wilson, P.5
-
22
-
-
40749120515
-
Combining agents that target the tumor microenvironment improves the efficacy of anticancer therapy
-
Blansfield JA, Caragacianu D, Alexander HR 3rd, Tangrea MA, Morita SY, et al. (2008) Combining agents that target the tumor microenvironment improves the efficacy of anticancer therapy. Clin Cancer Res 14 (1): 270-280.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.1
, pp. 270-280
-
-
Blansfield, J.A.1
Caragacianu, D.2
Alexander 3rd, H.R.3
Tangrea, M.A.4
Morita, S.Y.5
-
23
-
-
76249126867
-
Sunitinib acts primarily on tumor endothelium rather than tumor cells to inhibit the growth of renal cell carcinoma
-
Huang D, Ding Y, Li Y, Luo WM, Zhang ZF, et al. (2010) Sunitinib acts primarily on tumor endothelium rather than tumor cells to inhibit the growth of renal cell carcinoma. Cancer Res 70 (3): 1053-1062.
-
(2010)
Cancer Res
, vol.70
, Issue.3
, pp. 1053-1062
-
-
Huang, D.1
Ding, Y.2
Li, Y.3
Luo, W.M.4
Zhang, Z.F.5
-
24
-
-
84946384873
-
Toxicity of poisons applied jointly
-
Bliss CL, (1939) Toxicity of poisons applied jointly. Ann Appl Biol 26: 585.
-
(1939)
Ann Appl Biol
, vol.26
, pp. 585
-
-
Bliss, C.L.1
-
25
-
-
0029036955
-
The search for synergy: A critical review from a response surface perspective
-
Greco WR, Bravo G, Parsons JC, (1995) The search for synergy: A critical review from a response surface perspective. Pharmacol Rev 47 (2): 331-385.
-
(1995)
Pharmacol Rev
, vol.47
, Issue.2
, pp. 331-385
-
-
Greco, W.R.1
Bravo, G.2
Parsons, J.C.3
-
26
-
-
0001458215
-
Effect of more than one inhibitor
-
New York, Academic Press
-
Webb JL, (1963) Effect of more than one inhibitor. Anonymous Enzyme and Metabolic Inibitors New York Academic Press pp. 66-79 & 487-512.
-
(1963)
Anonymous Enzyme and Metabolic Inibitors
-
-
Webb, J.L.1
-
27
-
-
0017157814
-
Biological effects of cyclosporin A: A new antilymphocytic agent
-
Borel JF, Feurer C, Gubler HU, Stahelin H, (1976) Biological effects of cyclosporin A: A new antilymphocytic agent. Agents Actions 6 (4): 468-475.
-
(1976)
Agents Actions
, vol.6
, Issue.4
, pp. 468-475
-
-
Borel, J.F.1
Feurer, C.2
Gubler, H.U.3
Stahelin, H.4
-
28
-
-
0024454699
-
Cyclosporine inhibits basic fibroblast growth factor-driven proliferation of human endothelial cells and keratinocytes
-
Sharpe RJ, Arndt KA, Bauer SI, Maione TE, (1989) Cyclosporine inhibits basic fibroblast growth factor-driven proliferation of human endothelial cells and keratinocytes. Arch Dermatol 125 (10): 1359-1362.
-
(1989)
Arch Dermatol
, vol.125
, Issue.10
, pp. 1359-1362
-
-
Sharpe, R.J.1
Arndt, K.A.2
Bauer, S.I.3
Maione, T.E.4
-
29
-
-
0031050060
-
Corneal neovascularization induced by xenografts or chemical cautery. Inhibition by Cyclosporin A
-
Benelli U, Ross JR, Nardi M, Klintworth GK, (1997) Corneal neovascularization induced by xenografts or chemical cautery. inhibition by cyclosporin A. Invest Ophthalmol Vis Sci 38 (2): 274-282.
-
(1997)
Invest Ophthalmol Vis Sci
, vol.38
, Issue.2
, pp. 274-282
-
-
Benelli, U.1
Ross, J.R.2
Nardi, M.3
Klintworth, G.K.4
-
30
-
-
0025893168
-
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
-
Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I, et al. (1991) Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66 (4): 807-815.
-
(1991)
Cell
, vol.66
, Issue.4
, pp. 807-815
-
-
Liu, J.1
Farmer Jr., J.D.2
Lane, W.S.3
Friedman, J.4
Weissman, I.5
-
31
-
-
79960475065
-
A calcineurin-independent mechanism of angiogenesis inhibition by a non-immunosuppressive cyclosporin A analog
-
Nacev B, Low WK, Huang Z, Su T, Su Z, et al. (2011) A calcineurin-independent mechanism of angiogenesis inhibition by a non-immunosuppressive cyclosporin A analog. J Pharmacol Exp Ther 338 (2): 466.
-
(2011)
J Pharmacol Exp Ther
, vol.338
, Issue.2
, pp. 466
-
-
Nacev, B.1
Low, W.K.2
Huang, Z.3
Su, T.4
Su, Z.5
-
32
-
-
0033618146
-
Characteristics of the heterologously expressed human lanosterol 14alpha-demethylase (other names: P45014DM, CYP51, P45051) and inhibition of the purified human and candida albicans CYP51 with azole antifungal agents
-
Lamb DC, Kelly DE, Waterman MR, Stromstedt M, Rozman D, et al. (1999) Characteristics of the heterologously expressed human lanosterol 14alpha-demethylase (other names: P45014DM, CYP51, P45051) and inhibition of the purified human and candida albicans CYP51 with azole antifungal agents. Yeast 15 (9): 755-763.
-
(1999)
Yeast
, vol.15
, Issue.9
, pp. 755-763
-
-
Lamb, D.C.1
Kelly, D.E.2
Waterman, M.R.3
Stromstedt, M.4
Rozman, D.5
-
33
-
-
33749667750
-
Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and candida albicans for inhibition by different antifungal azoles
-
Trosken ER, Adamska M, Arand M, Zarn JA, Patten C, et al. (2006) Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and candida albicans for inhibition by different antifungal azoles. Toxicology 228 (1): 24-32.
-
(2006)
Toxicology
, vol.228
, Issue.1
, pp. 24-32
-
-
Trosken, E.R.1
Adamska, M.2
Arand, M.3
Zarn, J.A.4
Patten, C.5
-
34
-
-
77949539205
-
Cholesterol trafficking is required for mTOR activation in endothelial cells
-
Xu J, Dang Y, Ren YR, Liu JO, (2010) Cholesterol trafficking is required for mTOR activation in endothelial cells. Proc Natl Acad Sci U S A 107 (10): 4764-4769.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.10
, pp. 4764-4769
-
-
Xu, J.1
Dang, Y.2
Ren, Y.R.3
Liu, J.O.4
-
35
-
-
77955905585
-
Imapct of absolute stereochemistry on the antiangiogenic and antifungal activities of itraconazole
-
Wei S, Nacev BA, Bhat S, Liu JO, (2010) Imapct of absolute stereochemistry on the antiangiogenic and antifungal activities of itraconazole. ACS Med Chem Lett 1 (4): 155.
-
(2010)
ACS Med Chem Lett
, vol.1
, Issue.4
, pp. 155
-
-
Wei, S.1
Nacev, B.A.2
Bhat, S.3
Liu, J.O.4
-
36
-
-
0037083792
-
Calcineurin is essential for survival during membrane stress in candida albicans
-
Cruz MC, Goldstein AL, Blankenship JR, Del Poeta M, Davis D, et al. (2002) Calcineurin is essential for survival during membrane stress in candida albicans. EMBO J 21 (4): 546-559.
-
(2002)
EMBO J
, vol.21
, Issue.4
, pp. 546-559
-
-
Cruz, M.C.1
Goldstein, A.L.2
Blankenship, J.R.3
Del Poeta, M.4
Davis, D.5
-
37
-
-
0035830860
-
Principles for the buffering of genetic variation
-
Hartman JL 4th, Garvik B, Hartwell L, (2001) Principles for the buffering of genetic variation. Science 291 (5506): 1001-1004.
-
(2001)
Science
, vol.291
, Issue.5506
, pp. 1001-1004
-
-
Hartman 4th, J.L.1
Garvik, B.2
Hartwell, L.3
|