Antifungal activity of itraconazole compared with hydroxy-itraconazole in vitro

Journal of Antimicrobial Chemotherapy

Volumn 45, Issue 3, 2000, Pages 371-373

  Odds, F C ^a   Bossche, H Vanden ^b  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b JANSSEN RESEARCH FOUNDATION   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ITRACONAZOLE;

ANTIFUNGAL ACTIVITY; ARTICLE; BIOASSAY; CANDIDA ALBICANS; CANDIDA GLABRATA; DRUG SENSITIVITY; IC 50; NONHUMAN; TRICHOPHYTON MENTAGROPHYTES;

EID: 0034094331     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/45.3.371     Document Type: Article

References (7)

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2. Hostetler, J. S., Heykants, J., Clemons, K. V., Woestenborghs, R., Hanson, L. H. & Stevens, D. A. (1993). Discrepancies in bioassay and chromatography determinations explained by metabolism of itraconazole to hydroxyitraconazole: studies of interpatient variations in concentrations. Antimicrobial Agents and Chemotherapy 37, 2224-7.
3. Mikami, Y., Sakamoto, T., Yazawa, K., Gonoi, T., Ueno, Y. & Hasegawa, S. (1994). Comparison of in vitro antifungal activity of itraconazole and hydroxy-itraconazole by colorimetric MTT assay. Mycoses 37, 27-33.
4. Odds, F. C., Vranckx, L. & Woestenborghs, F. (1995). Antifungal susceptibility testing of yeasts: evaluation of technical variables for test automation. Antimicrobial Agents and Chemotherapy 39, 2051-60.
5. National Committee for Clinical Laboratory Standards. (1997). Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts - Approved Standard M27-A. NCCLS, Wayne, PA.
6. Odds, F. C., Dupont, B., Rinaldi, M. G., Stevens, D. A., Warnock, D. W. & Woestenborghs, R. (1999). Bioassays for itraconazole blood levels: an interlaboratory collaborative study. Journal of Antimicrobial Chemotherapy 43, 723-7.
7. Law, D., Moore, C. B. & Denning, D. W. (1994). Bioassay for serum itraconazole concentrations using hydroxyitraconazole standards. Antimicrobial Agents and Chemotherapy 38, 1561-6.