Developmental toxicity and neurotoxicity of two matrine-type alkaloids, matrine and sophocarpine, in zebrafish (Danio rerio) embryos/larvae

Reproductive Toxicology

Volumn 47, Issue , 2014, Pages 33-41

  Lu, Zhao Guang ^a   Li, Ming Hui ^a   Wang, Jun Song ^b   Wei, Dan Dan ^a   Liu, Qing Wang ^a   Kong, Ling Yi ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Developmental toxicity; Matrine; Neurotoxicity; Sophocarpine; Spontaneous movement; Swimming behavior; Zebrafish

Indexed keywords

ALKALOID; MATRINE; SOPHOCARPINE; UNCLASSIFIED DRUG; CARDIOTOXIN; NEUROTOXIN; QUINOLIZINE DERIVATIVE; TERATOGENIC AGENT;

ADULT; ARTICLE; BEHAVIOR CHANGE; BODY MOVEMENT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEVELOPMENTAL TOXICITY; EMBRYO; FEMALE; FERTILIZATION; GROWTH RETARDATION; HEART BEAT; HEART EDEMA; LARVA; LETHALITY; NEUROTOXICITY; NONHUMAN; SCOLIOSIS; SWIMMING; TERATOGENICITY; ZEBRA FISH; ANIMAL CELL; ANIMAL EMBRYO; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CHINESE MEDICINE; EC50; LC50; MOVEMENT (PHYSIOLOGY); PLANT ROOT; SOPHORA FLAVESCENS; TOXIN STRUCTURE; ANIMAL; ANIMAL BEHAVIOR; CONGENITAL MALFORMATION; DRUG EFFECTS; EMBRYO DEVELOPMENT; HEART MUSCLE; HEART RATE; MOTOR ACTIVITY; NOTOCHORD; PATHOLOGY; TAIL;

DANIO RERIO;

ALKALOIDS; ANIMALS; BEHAVIOR, ANIMAL; CARDIOTOXINS; EMBRYO, NONMAMMALIAN; EMBRYONIC DEVELOPMENT; HEART RATE; MOTOR ACTIVITY; MYOCARDIUM; NEUROTOXINS; NOTOCHORD; QUINOLIZINES; TAIL; TERATOGENS; ZEBRAFISH;

EID: 84902987419     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2014.05.015     Document Type: Article

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