Binding of flavonoids from Sophora flavescens to the rat uterine estrogen receptor

Planta Medica

Volumn 71, Issue 11, 2005, Pages 1065-1068

  Hillerns, Pablo Ibieta ^a   Wink, Michael ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

8 PRENYLKAEMPFEROL; ESTROGEN RECEPTOR; FLAVONOID; KAEMPFEROL; KUSHENOL; LECHIANONE; MAACKIAIN; NORKURARINONE; PLANT EXTRACT; SOPHORA FLAVESCENS EXTRACT; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING AFFINITY; DRUG ISOLATION; ENZYME INHIBITION; ESTROGEN ACTIVITY; PLANT ROOT; PRENYLATION; RECEPTOR BINDING; SOPHORA;

ANIMALS; FEMALE; FLAVONOIDS; MOLECULAR STRUCTURE; PLANT EXTRACTS; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; SOPHORA; UTERUS;

FABACEAE; SOPHORA; SOPHORA FLAVESCENS;

EID: 29144455044     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-871302     Document Type: Article

References (18)

1. Chen X, Yi C, Yang X, Wang X. Liquid chromatography of active principles in Sophora flavescens root. J Chromatogr B 2004; 812: 149-63
2. Ryu S, Lee H, Kim Y, Kim S. Determination of isoprenyl and lavandulyl positions of flavonoids from Sophora flavescens by NMR experiment. Arch Pharmacol Res 1997; 20: 491-5
3. Kuroyanagi M, Arakawa T, Hirayama Y, Hayashi T. Antibacterial and antiandrogen flavonoids from Sophora flavescens. J Nat Prod 1999; 62: 1595-9
4. Son J, Park J, Kim J, Kim Y, Chung S, Lee S. Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity. Planta Med 2003; 69: 559-61
5. Lee H, Ko H, Ryu S, Oh W, Kim B, Ahn S et al. Inhibition of phospholipase C gamma 1 by the prenylated flavonoids from Sophora flavescens. Planta Med 1997; 63: 266-8
6. Chung M, Rho M, Ko J, Ryu S, Jeune K, Kim K et al. In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens. Planta Med 2004; 70: 258-60
7. Ko W, Kang T, Kim N, Lee S, Kim Y, Ko G et al. Lavandulylflavonoids: a new class of in vitro apoptogenic agents from Sophora flavescens. Toxicol In Vitro 2000; 14: 429-33
8. Kim Y, Min B, Bae K. A cytotoxic constituent from Sophora flavescens. Arch Pharm Res 1997; 20: 342-5
9. Liu J, Burdette J, Xu H, Gu C, van Breemen R, Bhat K et al. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem 2001; 49: 2472-9
10. Milligan S, Kalita J, Pocock V, Van De Kauter V, Stevens J, Deinzer M et al. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. J Clin Endocrinol Metab 2000; 85: 4912-5
11. Naeyer A, Berghe W, Pocock V, Milligan S, Haegeman G, Keukeleire D. Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens. J Nat Prod 2004; 67: 1829-32
12. Milligan S, Kalita J, Heyerick A, Rong H, De Cooman L, De Keukeleire D. Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer. J Clin Endocrinol Metab 1999; 84: 2249-52
13. Komatsu M, Tomimori T, Hatayama K, Mikuriya N. Studies on the constituents of Sophora species. IV. Constituents of Sophora angustifolia Sieb. et Zucc. Yakugaku Zasshi 1970; 90: 463-8
14. Woo E, Kwak J, Kim H, Park H. A new prenylated flavonol from the roots of Sophora flavescens. J Nat Prod 1998; 61: 1552-4
15. Iinuma M, Tanaka T, Mizuno M, Shirataki Y, Yokoe I, Komatsu M, Lang F. Two flavanones in Sophora leachiano and some related structures. Phytochemistry 1990; 29: 2667-9
16. Wu L, Miyase T, Akira U, Kuroyanagi M, Noro T, Fukushima S. Studies on the constituents of Sophora flavescens AITON. Chem Pharm Bull 1985; 33: 3231-6
17. Kinoshita T, Ichinose K, Takahashi C, Ho F, Wu J. Chemical studies on Sophora tomentosa: the isolation of a new class of isoflavonoid. Chem Pharm Bull 1990; 38: 2756-9
18. Hatayama K, Komatsu M. Studies on the constituents of Sophora species. V. Constituents of the root of Sophora angustifolia Sieb. et ZUCC. Chem Pharm Bull 1971; 19: 2126-31