Potent fluorinated agelastatin analogues for chronic lymphocytic leukemia: Design, synthesis, and pharmacokinetic studies

Journal of Medicinal Chemistry

Volumn 57, Issue 12, 2014, Pages 5085-5093

  Stout, E Paige ^a   Choi, Michael Y ^c,d   Castro, Januario E ^c,d   Molinski, Tadeusz F ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

13 DEBROMO 13 TRIFLUOROMETHYL AGELASTATIN A; AGELASTATIN A; AGELASTATIN DERIVATIVE; ALKALOID DERIVATIVE; ANTILEUKEMIC AGENT; FLUORINE DERIVATIVE; IMIDAZOLE DERIVATIVE; NATURAL PRODUCT; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL LINE; MOUSE; NONHUMAN; SINGLE DRUG DOSE; SPONGE (PORIFERA); STRUCTURE ACTIVITY RELATION;

ALKALOIDS; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MICE, INBRED BALB C; OXAZOLIDINONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84903523658     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm4016922     Document Type: Article

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