Design and synthesis of dimethylaminomethyl-substituted curcumin derivatives/analogues: Potent antitumor and antioxidant activity, improved stability and aqueous solubility compared with curcumin

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 5, 2013, Pages 1297-1301

  Fang, Xubin ^a   Fang, Lei ^a,b   Gou, Shaohua ^a   Cheng, Lin ^a  

^a SOUTHEAST UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Antioxidant activity; Antitumor; Aqueous solubility; Curcumin derivatives

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIOXIDANT; CURCUMIN; DIMETHYLAMINOMETHYL SUBSTITUTED CURCUMIN DERIVATIVE; SCAVENGER; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; TUMOR CELL LINE;

ANTIOXIDANTS; CELL LINE, TUMOR; CURCUMIN; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG STABILITY; HCT116 CELLS; HEP G2 CELLS; HUMANS; OXIDATION-REDUCTION; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

EID: 84873705754     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.12.098     Document Type: Article

References (18)

1. J. Kim, H.J. Lee, and K.W. Lee J. Neurochem. 112 2010 1415
2. A.L. Cheng, C.H. Hsu, J.K. Lin, M.M. Hsu, Y.F. Ho, T.S. Shen, J.Y. Ko, J.T. Lin, B.R. Lin, M.S. Wu, H.S. Yu, S.H. Jee, G.S. Chen, T.M. Chen, C.A. Chen, M.K. Lai, Y.S. Pu, M.H. Pan, Y.J. Wang, C.C. Tsai, and C.Y. Hsieh Anticancer Res. 21 2001 2895
3. R.A. Sharma, S.A. Euden, S.L. Platton, D.N. Cooke, A. Shafayat, H.R. Hewitt, T.H. Marczylo, B. Morgan, D. Hemingway, S.M. Plummer, M. Pirmohamed, A.J. Gescher, and W.P. Steward Clin. Cancer Res. 10 2004 6847
4. R.P. Sahu, S. Batra, and S.K. Srivastava Br. J. Cancer 100 2009 1425
5. B.B. Aggarwal, A. Kumar, and A.C. Bharti Anticancer Res. 23 2003 363
6. R.K. Srivastava, Q. Chen, I. Siddiqui, K. Sarva, and S. Shankar Cell Cycle 6 2007 2953
7. P. Anand, A.B. Kunnumakkara, R.A. Newman, and B.B. Aggarwal Mol. Pharm. 4 2007 807
8. R. Blasius, A. Duvoix, F. Morceau, M. Schnekenburger, S. Delhalle, E. Henry, M. Dicato, and M. Diederich Ann. N.Y. Acad. Sci. 1030 2004 442
9. A.P. Zambre, V.M. Kulkarni, S. Padhye, S.K. Sandur, and B.B. Aggarwal Bioorg. Med. Chem. 14 2006 7196
10. R.J. Anto, G. Kuttan, K.V.D. Babu, K.N. Rajasekharan, and R. Kuttan Int. J. Pharm. 131 1996 1
11. J.S. Shim, D.H. Kim, H.J. Jung, J.H. Kim, D. Lim, S.K. Lee, K.W. Kim, J.W. Ahn, J.S. Yoo, J.R. Rho, J. Shin, and H.J. Kwon Bioorg. Med. Chem. 10 2002 2987
12. A. Safavy, K.P. Raisch, S. Mantena, L.L. Sanford, S.W. Sham, N.R. Krishna, and J.A. Bonner J. Med. Chem. 50 2007 6284
13. E. Ferrari, S. Lazzari, G. Marverti, F. Pignedoli, F. Spagnolo, and M. Saladini Bioorg. Med. Chem. 17 2009 3043
14. Z.Y. Du, R.R. Liu, W.Y. Shao, X.P. Mao, L. Ma, L.Q. Gu, Z.S. Huang, and A.S.C. Chan Eur. J. Med. Chem. 41 2006 213
15. Y. Song, P. Wang, J.J. Wu, X. Zhou, X.L. Zhang, L.H. Weng, X.P. Cao, and F. Liang Bioorg. Med. Chem. Lett. 16 2006 1660
16. A. Mazumder, N. Neamati, S. Sunder, J. Schulz, H. Pertz, E. Eich, and Y. Pommier J. Med. Chem. 40 1997 3057
17. Y. Sun, S. Gou, F. Liu, R. Yin, and L. Fang ChemMedChem 7 2012 642
18. J.-Y. Feng, and Z.-Q. Liu J. Agric. Food Chem. 57 2009 11041