Molecular mechanisms of anti-angiogenic effect of curcumin

Biochemical and Biophysical Research Communications

Volumn 297, Issue 4, 2002, Pages 934-942

  Gururaj, Anupama E ^a   Belakavadi, Madesh ^a   Venkatesh, Deepak A ^a   Marmé, Dieter ^b   Salimath, Bharathi P ^a  

^a UNIVERSITY OF MYSORE   (India)

^b TUMOR BIOLOGY CENTER   (Germany)

Author keywords

Angiogenic ligands receptors gene expression; Anti angiogenesis; Apoptosis; Curcumin

Indexed keywords

ANGIOGENESIS INHIBITOR; CELL DNA; CURCUMIN; RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ASCITES FLUID; CELL COUNT; CELL CULTURE; CELL FRACTIONATION; CELL GROWTH; CELL STRAIN 3T3; CHORIOALLANTOIS; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; EHRLICH ASCITES TUMOR CELL; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL;

3T3 CELLS; ANGIOGENESIS INHIBITORS; ANIMALS; CARCINOMA, EHRLICH TUMOR; CELL SURVIVAL; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HUMANS; MICE; NEOVASCULARIZATION, PATHOLOGIC; TUMOR CELLS, CULTURED; UMBILICAL VEINS;

CURCUMA LONGA;

EID: 0036033449     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)02306-9     Document Type: Article

References (53)

1. S. Mesiano, N. Ferrara, R.B. Jaffe, Role of vascular endothelial growth factor in ovarian cancer: inhibition of ascites formation by immunoneutralization, Am. J. Pathol. 153 (1998) 1249-1256.
2. L. Xu, J. Yoneda, C. Herrera, J. Wood, J.J. Killion, I.J. Fidler, Inhibition of malignant ascites and growth of human ovarian carcinoma by oral administration of a potent inhibitor of the vascular endothelial growth factor receptor tyrosine kinases, Int. J. Oncol. 16 (2000) 445-454.
3. A. Yukita, M. Asano, T. Okamoto, S. Mizutani, H. Suzuki, Suppression of ascites formation and re-accumulation associated with human ovarian cancer by anti-VPF monoclonal antibody in vivo, Anticancer Res. 20 (2000) 155-160.
4. J. Folkman, Angiogenesis in cancer, vascular, rheumatoid and other diseases, Nat. Med. 1 (1995) 27-31.
5. R.S. Kerbel, Tumor angiogenesis: past, present, and the near future, Carcinogenesis 21 (2000) 505-515.
6. P. Carmeliet, Developmental biology. Controlling the cellular brakes, Nature (Lond.) 401 (1999) 657-658.
7. D. Hanahan, J. Folkman, Patterns and the emerging mechanisms of the angiogenic switch during tumorigenesis, Cell 86 (1996) 353-364.
8. N. Bouch, V. Stelmach, S.C. Hsu, How tumors become angiogenic?, Adv. Cancer Res. 69 (1996) 135-174.
9. D. Hanahan, R.A. Weinberg, The hallmarks of cancer, Cell 100 (2000) 57-70.
10. D. Marmé, Tumor angiogenesis: the pivotal role of vascular endothelial growth factor, World J. Urol. 14 (1996) 166-174.
11. B. Stoelcker, B. Echtenacher, H.A. Weich, H. Sztajer, D.J. Hicklin, D.N. Mannel, VEGF/Flk-1 interaction, a requirement for malignant ascites recurrence, J. Interferon Cytokine Res. 20 (2000) 511-517.
12. N.W. Gale, G.D. Yancopoulos, Growth factors acting via endothelial cell specific receptor tyrosine kinases: VEGFs, angio-poietins, and ephrins in vascular development, Genes Dev. 13 (1999) 1055-1066.
13. S. Davis, T.H. Aldrich, P.F. Jones, A. Acheson, D.L. Compton, V. Jain, T.E. Ryan, J. Bruno, C. Radziejewski, P.C. Maisonpierre, G.D. Yancopoulos, Isolation of angiopoietin-1, a ligand for the Tie2 receptor, by secretion-trap expression cloning, Cell 87 (1996) 1161-1169.
14. P.C. Maisonpierre, C. Suri, P.F. Jones, S. Bartunkova, S.J. Wiegand, C. Radziejewski, D. Compton, J. McClain, T.H. Aldrich, N. Papadopoulos, T.J. Daly, S. Davis, T.N. Sato, G.D. Yancopoulos, Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis, Science 277 (1997) 55-60.
15. T.N. Sato, Y. Tozawa, U. Deutsch, K. Wolburg-Buchholz, Y. Fujiwara, M. Gendron-Maguire, T. Gridley, H. Wolburg, W. Risau, Y. Qin, Distinct roles of the receptor tyrosine kinases Tie1 and Tie2 in blood vessel formation, Nature 376 (1995) 70-74.
16. V.S. Govindaraja, Turmeric: chemistry, technology, and quality, Crit. Rev. Food Sci. Nutr. 12 (1980) 199.
17. K.M. Nandkarni, Curcuma longa, Popular Prakashan, Bombay, 1976.
18. H.P. Ammon, M.A. Wahl, Pharmacology of Curcuma longa, Planta Medica 57 (1991) 1-7.
19. Y.P. Lu, R.L. Chang, Y.R. Lou, M.T. Huang, H.L. Newmark, K. Reuhl, A.H. Conney, Effect of curcumin on 12-O-tetradecanoyl-phorbol-13-acetate- and ultraviolet B light-induced expression of c-jun and c-fos in JB6 cells and in mouse epidermis, Carcinogenesis 15 (1994) 2363-2370.
20. S. Singh, B.B. Aggarwal, Activation of transcription factor NF-κB is suppressed by curcumin, J. Biol. Chem. 270 (1995) 24995-25000.
21. T.S. Huang, S.C. Lee, J.K. Lin, Suppression of c-jun/Ap-1 activation by an inhibitor of tumor promotion in mouse fibroblast cells, Proc. Natl. Acad. Sci. USA 88 (1991) 5292-5296.
22. L. Korutla, J.Y. Cheung, J. Mendelssohn, R. Kumar, Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin, Carcinogenesis 16 (1995) 1741-1745.
23. C.V. Rao, B. Simi, B.S. Reddy, Inhibition by dietary curcumin of azoxymethanol-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon, Carcinogenesis 14 (1993) 2219-2225.
24. M.T. Huang, W. Ma, Y.P. Lu, R.L. Chang, C. Fisher, P.S. Manchand, H.L. Newmark, A.H. Conney, Effects of curcumin, demethoxycurcumin, bisdemethoxycurcumin, and tetrahydrocurcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion, Carcinogenesis 16 (1995) 2493-2497.
25. M.T. Huang, E.E. Deschner, H.L. Newmark, Z.Y. Wang, T.A. Ferraro, A.H. Conney, Effect of dietary curcumin and ascorbyl palmitate on azoxymethanol-induced colonic epithelial cell proliferation and focal areas of dysplasia, Cancer Lett. 64 (1992) 117-121.
26. J.L. Arbiser, N. Klauber, R. Rohan, R. van Leeuwen, M.-T. Huang, C. Fisher, E. Flynn, H.R. Byers, Curcumin is an in vivo inhibitor of angiogenesis, Mol. Med. 4 (1998) 376-383.
27. D. Thaloor, A.K. Singh, G.S. Sidhu, P.V. Prasad, H.K. Kleinman, R.K. Maheshwari, Inhibition of angiogenic differentiation of human umbilical vein endothelial cells by curcumin, Cell Growth Differ. 9 (1998) 305-312.
28. R. Mohan, J. Sivak, P. Ashton, L.A. Russo, B.Q. Pham, N. Kasahara, M.B. Raizman, M.E. Fini, Curcuminoids inhibit the angiogenic response stimulated by fibroblast growth factor-2, including expression of matrix metalloproteinase, gelatinase B, J. Biol. Chem. 275 (2000) 10405-10412.
29. G.J. Kelloff, J.A. Crowell, E.T. Hawk, V.E. Steele, R.A. Lubet, C.W. Bonne, J.M. Covey, L.A. Doody, G.S. Omenn, P. Greenwald, W.K. Hong, D.R. Parkinson, D. Bargheri, G.T. Baxter, M. Blunden, M.K. Doeltz, K.M. Eisenhauer, K. Johnson, G.G. Knapp, D.G. Longfellow, W.F. Malone, S.G. Nayfield, H.E. Scifried, L.M. Swall, C.C. Sigman, Strategy and planning for chemopreventive drug development: clinical development plans II, J. Cell. Biochem. 26 (Suppl.) (1996) 54-71.
30. P. Suman, C. Tathagata, C. Sreya, B. Arindam, K.D. Goutam, D. Tanya, S.A. Gaurisankar, Mechanisms of curcumin-induced apoptosis of Ehrlich's ascites carcinoma cells, Biochem. Biophys. Res. Commun. 288 (2001) 658-665.
31. C. Calaebresse, L. Venturini, R.P. Villa, L. Degos, D. Belpomme, C. Chomienne, Selective induction of apoptosis in myeloid leukemic cell lines by monoacetone glucose-3 butyrate, Biochem. Biophys. Res. Commun. 201 (1994) 266-268.
32. J. Sambrook, E.F. Fritsch, T. Maniatis, Molecular Cloning: A Laboratory Manual, second ed., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1989.
33. M.-C. Jiang, H.F. Yang-Yen, J.J. Yen, J.K. Lin, Curcumin induces apoptosis in immortalized NIH3T3 and malignant cancer cell lines, Nutr. Cancer 26 (1996) 111-120.
34. J.E. Nor, P.J. Polverini, Role of endothelial cell survival and death signals in angiogenesis, Angiogenesis 3 (1999) 101-116.
35. B.P. Salimath, A. Tabassum, E.G. Anupama, Bindumalini, G.B. Preeti, P.V. Salimath, Molecular mechanism of action of butyric acid in Ehrlich ascites tumor cells, Nutr. Res. 19 (1999) 589-600.
36. M.T. Huang, Y.R. Lou, W. Ma, H.L. Newmark, K.R. Reuhl, A.R. Conney, Inhibitory e+ects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice, Cancer Res. 54 (1994) 5841-5847.
37. C.V. Rao, A. Rivenson, B. Simi, B.S. Reddy, Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound, Cancer Res. 55 (1995) 259-266.
38. A.H. Conney, T. Lysz, T. Ferraro, T.F. Abidi, P.S. Manchand, J.D. Laskin, M.T. Huang, Inhibitory effect of curcumin and some related dietary components on tumor promotion and arachidonic acid metabolism in mouse skin, Adv. Enz. Regul. 31 (1991) 385-396.
39. Y.R. Chen, T.H. Tan, Inhibition of the c-jun N-terminal kinase (JNK) signaling pathway by curcumin, Oncogene 17 (1998) 173-178.
40. J.C. Luo, M. Toyoda, M. Shibuya, Differential inhibition of fluid accumulation and tumor growth in two mouse ascites tumors by an antivascular endothelial growth factor/permeability factor neutralizing antibody, Cancer Res. 58 (1998) 2594-2600.
41. G. Siemeister, M. Schirner, K. Weindel, P. Reusch, A. Menrad, D. Marmé, G. Martiny-Baron, Two independent mechanisms essential for tumor angiogenesis: inhibition of human melanoma xenograft growth by interfering with either the vascular endothe-lial growth factor receptor pathway or the Tie-2 pathway, Cancer Res. 59 (1999) 3185-3191.
42. P. Lin, J.A. Buxton, A. Acheson, C. Radziejewski, P.C. Maison-pierre, G.D. Yancopoulos, K.M. Channon, L.P. Hale, M.W. Dewhirst, S.E. George, K.G. Peters, Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie-2, Proc. Natl. Acad. Sci. USA 95 (1998) 8829-8834.
43. A. Mori, S. Arii, M. Furutani, M. Mizumoto, S. Uchida, H. Furuyama, Y. Kondo, M.J. Gorrin-Rivas, K. Furumoto, Y. Kaneda, M. Imamura, Soluble Flt-1 gene therapy for peritoneal metastases using HVJ-cationic liposomes, Gene Ther. 7 (2000) 1027-1033.
44. A. Menrad, K.H. Thierauch, G. Martiny-Baron, G. Siemeister, M. Schirner, M.R. Schneider, Novel antibodies directed against the extracellular domain of the human VEGF-receptor type II, Hybridoma 16 (1997) 465-471.
45. P. Lin, P. Polverini, M. Dewhirst, S. Shan, P.S. Rao, K. Peters, Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth, J. Clin. Invest. 100 (1997) 2072-2078.
46. T.N. Bhavani Shankar, N.V. Shantha, H.P. Ramesh, I.A.S. Murthy, V.S. Murthy, Toxicity studies on turmeric (Curcuma longa): acute toxicity studies in rats, guinea pigs, and monkeys, Indian J. Expt. Biol. 18 (1980) 73-75.
47. K. Krishnaswamy, N. Raghuramulu, Bioactive phytochemicals with emphasis on dietary practices, Indian J. Med. Res. 108 (1998) 167-181.
48. J.C. Luo, S. Yamaguchi, A. Shinkai, K. Shitara, M. Shibuya, Significant expression of vascular endothelial growth factor/vascular permeability factor in mouse ascites tumors, Cancer Res. 58 (1998) 2652-2660.
49. E. Tischer, R. Mitchell, T. Hartman, M. Silva, D. Gospadarowicz, J.C. Fiddes, J.A. Abraham, The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing, J. Biol. Chem. 266 (1991) 11947-11954.
50. B. Illi, P. Puri, L. Morgante, M.C. Capogrossi, C. Gaetano, Nuclear factor-κB and cAMP response element binding protein mediate opposite transcriptional effects on the Flk-1/KDR gene promoter, Circ. Res. 86 (2000) E110-117.
51. O. Hideyasu, H. Takagi, K. Suzuma, A. Otani, M. Matsumura, Y. Honda, Hypoxia and vascular endothelial growth factor selectively upregulate angiopoietin-2 in bovine microvascular endothelial cells, J. Biol. Chem. 274 (1999) 15732-15739.
52. Y. Cao, R. Cao, Angiogenesis inhibited by drinking tea, Nature 398 (1999) 381.
53. T. Fotsis, M. Pepper, H. AdlerCreutz, G. Fleischmann, T. Hase, R. Montesano, L. Schweigerer, Genistein, a dietary-derived inhibitor of in vitro angiogenesis, Proc. Natl. Acad. Sci. USA 90 (1993) 2690-2694.