-
1
-
-
40349093189
-
B-arrestins: Multifunctional cellular mediators
-
Barki-Harrington L, Rockman HA (2008) B-arrestins: Multifunctional cellular mediators. Physiology 23(1):17-22
-
(2008)
Physiology
, vol.23
, Issue.1
, pp. 17-22
-
-
Barki-Harrington, L.1
Rockman, H.A.2
-
2
-
-
77952354490
-
Seven transmembrane receptors as shapeshifting proteins: The impact of allosteric modulation and functional selectivity on New drug discovery
-
Kenakin T, Miller LJ (2010) Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on New drug discovery. Pharmacol Rev 62(2):265-304
-
(2010)
Pharmacol Rev
, vol.62
, Issue.2
, pp. 265-304
-
-
Kenakin, T.1
Miller, L.J.2
-
3
-
-
42149181885
-
Structural diversity of G protein-coupled receptors and significance for drug discovery
-
Lagerstrom MC, Schioth HB (2008) Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat Rev Drug Discov 7(4):339-357
-
(2008)
Nat Rev Drug Discov
, vol.7
, Issue.4
, pp. 339-357
-
-
Lagerstrom, M.C.1
Schioth, H.B.2
-
4
-
-
0034604451
-
Crystal structure of rhodopsin: A G protein-coupled receptor
-
Palczewski K et al (2000) Crystal structure of rhodopsin: a G protein-coupled receptor. Science 289(5480):739-745
-
(2000)
Science
, vol.289
, Issue.5480
, pp. 739-745
-
-
Palczewski, K.1
-
5
-
-
36448995359
-
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor
-
Cherezov V et al (2007) High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science 318(5854):1258-1265
-
(2007)
Science
, vol.318
, Issue.5854
, pp. 1258-1265
-
-
Cherezov, V.1
-
6
-
-
56749103466
-
The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist
-
Jaakola VP et al (2008) The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science 322(5905):1211-1217
-
(2008)
Science
, vol.322
, Issue.5905
, pp. 1211-1217
-
-
Jaakola, V.P.1
-
7
-
-
47949129742
-
Structure of a beta1-adrenergic G-protein-coupled receptor
-
Warne T et al (2008) Structure of a beta1-adrenergic G-protein-coupled receptor. Nature 454(7203):486-491
-
(2008)
Nature
, vol.454
, Issue.7203
, pp. 486-491
-
-
Warne, T.1
-
8
-
-
43749109187
-
Crystal structure of squid rhodopsin
-
Murakami M, Kouyama T (2008) Crystal structure of squid rhodopsin. Nature 453(7193):363-U33
-
(2008)
Nature
, vol.453
, Issue.7193
-
-
Murakami, M.1
Kouyama, T.2
-
9
-
-
47049130668
-
Crystal structure of the ligand-free G-protein-coupled receptor opsin
-
Park JH et al (2008) Crystal structure of the ligand-free G-protein-coupled receptor opsin. Nature 454(7201):183-187
-
(2008)
Nature
, vol.454
, Issue.7201
, pp. 183-187
-
-
Park, J.H.1
-
10
-
-
78449305788
-
Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist
-
Chien EYT et al (2010) Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist. Science 330(6007):1091-1095
-
(2010)
Science
, vol.330
, Issue.6007
, pp. 1091-1095
-
-
Eyt, C.1
-
11
-
-
85027927015
-
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists
-
Wu BL et al (2010) Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists. Science 330 (6007):1066-1071
-
(2010)
Science
, vol.330
, Issue.6007
, pp. 1066-1071
-
-
Wu, B.L.1
-
12
-
-
78651411166
-
Structure of a nanobody-stabilized active state of the beta(2) adrenoceptor
-
Rasmussen SG et al (2011) Structure of a nanobody-stabilized active state of the beta(2) adrenoceptor. Nature 469(7329):175-180
-
(2011)
Nature
, vol.469
, Issue.7329
, pp. 175-180
-
-
Rasmussen, S.G.1
-
13
-
-
78651399683
-
Structure and function of an irreversible agonist-beta(2) adrenoceptor complex
-
Rosenbaum DM et al (2011) Structure and function of an irreversible agonist-beta(2) adrenoceptor complex. Nature 469(7329):236-240
-
(2011)
Nature
, vol.469
, Issue.7329
, pp. 236-240
-
-
Rosenbaum, D.M.1
-
14
-
-
4344581120
-
The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure
-
Okada T et al (2004) The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure. J Mol Biol 342(2):571-583
-
(2004)
J Mol Biol
, vol.342
, Issue.2
, pp. 571-583
-
-
Okada, T.1
-
15
-
-
52949102889
-
Crystal structure of opsin in its G-protein-interacting conformation
-
Scheerer P et al (2008) Crystal structure of opsin in its G-protein-interacting conformation. Nature 455(7212):497-U30
-
(2008)
Nature
, vol.455
, Issue.7212
-
-
Scheerer, P.1
-
16
-
-
67650090499
-
G-protein-coupled receptor structures were not built in a day
-
Blois TM, Bowie JU (2009) G-protein-coupled receptor structures were not built in a day. Protein Sci 18(7):1335-1342
-
(2009)
Protein Sci
, vol.18
, Issue.7
, pp. 1335-1342
-
-
Blois, T.M.1
Bowie, J.U.2
-
17
-
-
38749131545
-
New G-protein-coupled receptor crystal structures: Insights and limitations
-
Kobilka B, Schertler GFX (2008) New G-protein-coupled receptor crystal structures: insights and limitations. Trends Pharmacol Sci 29(2):79-83
-
(2008)
Trends Pharmacol Sci
, vol.29
, Issue.2
, pp. 79-83
-
-
Kobilka, B.1
Gfx, S.2
-
18
-
-
58849094130
-
Topology of class a G protein-coupled receptors: Insights gained from crystal structures of rhodopsins, adrenergic and adenosine receptors
-
MustafiD, Palczewski K (2009) Topology of class a G protein-coupled receptors: insights gained from crystal structures of rhodopsins, adrenergic and adenosine receptors. Mol Pharmacol 75(1):1-12
-
(2009)
Mol Pharmacol
, vol.75
, Issue.1
, pp. 1-12
-
-
Mustafi, D.1
Palczewski, K.2
-
19
-
-
66249144426
-
The structure and function of G-proteincoupled receptors
-
Rosenbaum DM, Rasmussen SG, Kobilka BK (2009) The structure and function of G-proteincoupled receptors. Nature 459(7245):356-363
-
(2009)
Nature
, vol.459
, Issue.7245
, pp. 356-363
-
-
Rosenbaum, D.M.1
Rasmussen, S.G.2
Kobilka, B.K.3
-
20
-
-
58149203324
-
Discovery of New GPCR biology: One receptor structure at a time
-
Hanson MA, Stevens RC (2009) Discovery of New GPCR biology: one receptor structure at a time. Structure 17(1):8-14
-
(2009)
Structure
, vol.17
, Issue.1
, pp. 8-14
-
-
Hanson, M.A.1
Stevens, R.C.2
-
21
-
-
70349513038
-
Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models
-
Worth CL, Kleinau G, Krause G (2009) Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models. PLoS One 4(9):e7011
-
(2009)
PLoS One
, vol.4
, Issue.9
-
-
Worth, C.L.1
Kleinau, G.2
Krause, G.3
-
22
-
-
33947356279
-
G protein coupled receptor structure and activation
-
Kobilka BK (2007) G protein coupled receptor structure and activation. Biochimica Et Biophysica Acta-Biomembranes 1768(4):794-807
-
(2007)
Biochimica et Biophysica Acta-Biomembranes
, vol.1768
, Issue.4
, pp. 794-807
-
-
Kobilka, B.K.1
-
23
-
-
73849149844
-
Ligand-specific regulation of the extracellular surface of a G-proteincoupled receptor
-
Bokoch MP et al (2010) Ligand-specific regulation of the extracellular surface of a G-proteincoupled receptor. Nature 463(7277):108-U121
-
(2010)
Nature
, vol.463
, Issue.7277
-
-
Bokoch, M.P.1
-
25
-
-
84934436854
-
Experimentally determined hydrophobicity scales for membrane proteins
-
Wimley WC, Creamer TP, White SH (1996) Experimentally determined hydrophobicity scales for membrane proteins. Biophys J 70(2):Tuam1-Tuam1
-
(1996)
Biophys J
, vol.70
, Issue.2
-
-
Wimley, W.C.1
Creamer, T.P.2
White, S.H.3
-
26
-
-
37249037182
-
Molecular code for transmembrane-helix recognition by the Sec61 translocon
-
Hessa T et al (2007) Molecular code for transmembrane-helix recognition by the Sec61 translocon. Nature 450(7172):1026-U2
-
(2007)
Nature
, vol.450
, Issue.7172
-
-
Hessa, T.1
-
27
-
-
33645883232
-
How hydrogen bonds shape membrane protein structure
-
White SH (2006) How hydrogen bonds shape membrane protein structure. Peptide Solvation H-Bonds 72:157-172
-
(2006)
Peptide Solvation H-Bonds
, vol.72
, pp. 157-172
-
-
White, S.H.1
-
28
-
-
25444444202
-
Computational Modeling approaches to structure-function analysis of G protein-coupled receptors
-
Fanelli F, De Benedetti PG (2005) Computational Modeling approaches to structure-function analysis of G protein-coupled receptors. Chem Rev 105(9):3297-3351
-
(2005)
Chem Rev
, vol.105
, Issue.9
, pp. 3297-3351
-
-
Fanelli, F.1
De Benedetti, P.G.2
-
30
-
-
50149116588
-
Agonist-induced conformational changes in bovine rhodopsin: Insight into activation of G-protein-coupled receptors
-
Bhattacharya S, Hall SE, Vaidehi N (2008) Agonist-induced conformational changes in bovine rhodopsin: Insight into activation of G-protein-coupled receptors. J Mol Biol 382(2):539-555
-
(2008)
J Mol Biol
, vol.382
, Issue.2
, pp. 539-555
-
-
Bhattacharya, S.1
Hall, S.E.2
Vaidehi, N.3
-
31
-
-
44049086134
-
Ligand-stabilized conformational states of human beta(2) adrenergic receptor: Insight into G-proteincoupled receptor activation
-
Bhattacharya S et al (2008) Ligand-stabilized conformational states of human beta(2) adrenergic receptor: Insight into G-proteincoupled receptor activation. Biophys J 94(6): 2027-2042
-
(2008)
Biophys J
, vol.94
, Issue.6
, pp. 2027-2042
-
-
Bhattacharya, S.1
-
32
-
-
0036790954
-
Prediction of structure and function of G protein-coupled receptors
-
Vaidehi N et al (2002) Prediction of structure and function of G protein-coupled receptors. Proc Natl Acad Sci USA 99(20):12622-12627
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.20
, pp. 12622-12627
-
-
Vaidehi, N.1
-
33
-
-
1642410853
-
The predicted 3D structure of the human D2 dopamine receptor and the binding site and binding affinities for agonists and antagonists
-
Kalani MYS et al (2004) The predicted 3D structure of the human D2 dopamine receptor and the binding site and binding affinities for agonists and antagonists. Proc Natl Acad Sci USA 101(11):3815-3820
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.11
, pp. 3815-3820
-
-
Mys, K.1
-
34
-
-
1542267836
-
Predicted 3D structure for the human beta 2 adrenergic receptor and its binding site for agonists and antagonists
-
Freddolino PL et al (2004) Predicted 3D structure for the human beta 2 adrenergic receptor and its binding site for agonists and antagonists. Proc Natl Acad Sci USA 101(9):2736-2741
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.9
, pp. 2736-2741
-
-
Freddolino, P.L.1
-
35
-
-
33748643600
-
The predicted 3D structures of the human M1 muscarinic acetylcholine receptor with agonist or antagonist bound
-
Peng JY et al (2006) The predicted 3D structures of the human M1 muscarinic acetylcholine receptor with agonist or antagonist bound. ChemMedChem 1(8):878-890
-
(2006)
ChemMedChem
, vol.1
, Issue.8
, pp. 878-890
-
-
Peng, J.Y.1
-
36
-
-
33748747498
-
Predictions of CCR1 chemokine receptor structure and BX 471 antagonist binding followed by experimental validation
-
Vaidehi N et al (2006) Predictions of CCR1 chemokine receptor structure and BX 471 antagonist binding followed by experimental validation. J Biol Chem 281(37):27613-27620
-
(2006)
J Biol Chem
, vol.281
, Issue.37
, pp. 27613-27620
-
-
Vaidehi, N.1
-
37
-
-
34848928184
-
Prediction of the 3D structure and dynamics of human DP G-protein coupled receptor bound to an agonist and an antagonist
-
Li Y et al (2007) Prediction of the 3D structure and dynamics of human DP G-protein coupled receptor bound to an agonist and an antagonist. J Am Chem Soc 129(35):10720-10731
-
(2007)
J Am Chem Soc
, vol.129
, Issue.35
, pp. 10720-10731
-
-
Li, Y.1
-
38
-
-
49649120129
-
The structure of human serotonin 2c G-protein-coupled receptor bound to agonists and antagonists
-
Bray JK, Goddard WA 3rd (2008) The structure of human serotonin 2c G-protein-coupled receptor bound to agonists and antagonists. J Mol Graph Model 27(1):66-81
-
(2008)
J Mol Graph Model
, vol.27
, Issue.1
, pp. 66-81
-
-
Bray, J.K.1
Goddard III, W.A.2
-
39
-
-
58149267930
-
Flat-bottom strategy for improved accuracy in protein sidechain placements
-
Kam VWT, Goddard WA (2008) Flat-bottom strategy for improved accuracy in protein sidechain placements. J Chem Theor Comput 4(12):2160-2169
-
(2008)
J Chem Theor Comput
, vol.4
, Issue.12
, pp. 2160-2169
-
-
Kam, V.W.T.1
Goddard, W.A.2
-
40
-
-
0347949636
-
Ser and Thr residues modulate the conformation of pro-kinked transmembrane alpha-helices
-
Deupi X et al (2004) Ser and Thr residues modulate the conformation of pro-kinked transmembrane alpha-helices. Biophys J 86(1 Pt 1):105-115
-
(2004)
Biophys J
, vol.86
, Issue.1 PART 1
, pp. 105-115
-
-
Deupi, X.1
-
41
-
-
0031847518
-
Structure of rhodopsin
-
Schertler GF (1998) Structure of rhodopsin. Eye (Lond) 12(Pt 3b):504-510
-
(1998)
Eye (Lond)
, vol.12
, Issue.PART 3B
, pp. 504-510
-
-
Schertler, G.F.1
-
42
-
-
35448975187
-
Prediction of the 3-D structure of rat MrgA G protein-coupled receptor and identification of its binding site
-
Heo J et al (2007) Prediction of the 3-D structure of rat MrgA G protein-coupled receptor and identification of its binding site. J Mol Graph Model 26(4):800-812
-
(2007)
J Mol Graph Model
, vol.26
, Issue.4
, pp. 800-812
-
-
Heo, J.1
|