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Volumn 914, Issue , 2012, Pages 237-254

Structure prediction of g protein-coupled receptors and their ensemble of functionally important conformations

Author keywords

Activation; BiHelix; GPCR; GPCR conformations; Helix kinks; Hydrophobicity; Protein structure prediction; Transmembrane helix; Transmembrane signaling

Indexed keywords

BETA ARRESTIN; G PROTEIN COUPLED RECEPTOR;

EID: 84934443930     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-23-6_14     Document Type: Article
Times cited : (24)

References (42)
  • 1
    • 40349093189 scopus 로고    scopus 로고
    • B-arrestins: Multifunctional cellular mediators
    • Barki-Harrington L, Rockman HA (2008) B-arrestins: Multifunctional cellular mediators. Physiology 23(1):17-22
    • (2008) Physiology , vol.23 , Issue.1 , pp. 17-22
    • Barki-Harrington, L.1    Rockman, H.A.2
  • 2
    • 77952354490 scopus 로고    scopus 로고
    • Seven transmembrane receptors as shapeshifting proteins: The impact of allosteric modulation and functional selectivity on New drug discovery
    • Kenakin T, Miller LJ (2010) Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on New drug discovery. Pharmacol Rev 62(2):265-304
    • (2010) Pharmacol Rev , vol.62 , Issue.2 , pp. 265-304
    • Kenakin, T.1    Miller, L.J.2
  • 3
    • 42149181885 scopus 로고    scopus 로고
    • Structural diversity of G protein-coupled receptors and significance for drug discovery
    • Lagerstrom MC, Schioth HB (2008) Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat Rev Drug Discov 7(4):339-357
    • (2008) Nat Rev Drug Discov , vol.7 , Issue.4 , pp. 339-357
    • Lagerstrom, M.C.1    Schioth, H.B.2
  • 4
    • 0034604451 scopus 로고    scopus 로고
    • Crystal structure of rhodopsin: A G protein-coupled receptor
    • Palczewski K et al (2000) Crystal structure of rhodopsin: a G protein-coupled receptor. Science 289(5480):739-745
    • (2000) Science , vol.289 , Issue.5480 , pp. 739-745
    • Palczewski, K.1
  • 5
    • 36448995359 scopus 로고    scopus 로고
    • High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor
    • Cherezov V et al (2007) High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science 318(5854):1258-1265
    • (2007) Science , vol.318 , Issue.5854 , pp. 1258-1265
    • Cherezov, V.1
  • 6
    • 56749103466 scopus 로고    scopus 로고
    • The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist
    • Jaakola VP et al (2008) The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science 322(5905):1211-1217
    • (2008) Science , vol.322 , Issue.5905 , pp. 1211-1217
    • Jaakola, V.P.1
  • 7
    • 47949129742 scopus 로고    scopus 로고
    • Structure of a beta1-adrenergic G-protein-coupled receptor
    • Warne T et al (2008) Structure of a beta1-adrenergic G-protein-coupled receptor. Nature 454(7203):486-491
    • (2008) Nature , vol.454 , Issue.7203 , pp. 486-491
    • Warne, T.1
  • 8
    • 43749109187 scopus 로고    scopus 로고
    • Crystal structure of squid rhodopsin
    • Murakami M, Kouyama T (2008) Crystal structure of squid rhodopsin. Nature 453(7193):363-U33
    • (2008) Nature , vol.453 , Issue.7193
    • Murakami, M.1    Kouyama, T.2
  • 9
    • 47049130668 scopus 로고    scopus 로고
    • Crystal structure of the ligand-free G-protein-coupled receptor opsin
    • Park JH et al (2008) Crystal structure of the ligand-free G-protein-coupled receptor opsin. Nature 454(7201):183-187
    • (2008) Nature , vol.454 , Issue.7201 , pp. 183-187
    • Park, J.H.1
  • 10
    • 78449305788 scopus 로고    scopus 로고
    • Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist
    • Chien EYT et al (2010) Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist. Science 330(6007):1091-1095
    • (2010) Science , vol.330 , Issue.6007 , pp. 1091-1095
    • Eyt, C.1
  • 11
    • 85027927015 scopus 로고    scopus 로고
    • Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists
    • Wu BL et al (2010) Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists. Science 330 (6007):1066-1071
    • (2010) Science , vol.330 , Issue.6007 , pp. 1066-1071
    • Wu, B.L.1
  • 12
    • 78651411166 scopus 로고    scopus 로고
    • Structure of a nanobody-stabilized active state of the beta(2) adrenoceptor
    • Rasmussen SG et al (2011) Structure of a nanobody-stabilized active state of the beta(2) adrenoceptor. Nature 469(7329):175-180
    • (2011) Nature , vol.469 , Issue.7329 , pp. 175-180
    • Rasmussen, S.G.1
  • 13
    • 78651399683 scopus 로고    scopus 로고
    • Structure and function of an irreversible agonist-beta(2) adrenoceptor complex
    • Rosenbaum DM et al (2011) Structure and function of an irreversible agonist-beta(2) adrenoceptor complex. Nature 469(7329):236-240
    • (2011) Nature , vol.469 , Issue.7329 , pp. 236-240
    • Rosenbaum, D.M.1
  • 14
    • 4344581120 scopus 로고    scopus 로고
    • The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure
    • Okada T et al (2004) The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure. J Mol Biol 342(2):571-583
    • (2004) J Mol Biol , vol.342 , Issue.2 , pp. 571-583
    • Okada, T.1
  • 15
    • 52949102889 scopus 로고    scopus 로고
    • Crystal structure of opsin in its G-protein-interacting conformation
    • Scheerer P et al (2008) Crystal structure of opsin in its G-protein-interacting conformation. Nature 455(7212):497-U30
    • (2008) Nature , vol.455 , Issue.7212
    • Scheerer, P.1
  • 16
    • 67650090499 scopus 로고    scopus 로고
    • G-protein-coupled receptor structures were not built in a day
    • Blois TM, Bowie JU (2009) G-protein-coupled receptor structures were not built in a day. Protein Sci 18(7):1335-1342
    • (2009) Protein Sci , vol.18 , Issue.7 , pp. 1335-1342
    • Blois, T.M.1    Bowie, J.U.2
  • 17
    • 38749131545 scopus 로고    scopus 로고
    • New G-protein-coupled receptor crystal structures: Insights and limitations
    • Kobilka B, Schertler GFX (2008) New G-protein-coupled receptor crystal structures: insights and limitations. Trends Pharmacol Sci 29(2):79-83
    • (2008) Trends Pharmacol Sci , vol.29 , Issue.2 , pp. 79-83
    • Kobilka, B.1    Gfx, S.2
  • 18
    • 58849094130 scopus 로고    scopus 로고
    • Topology of class a G protein-coupled receptors: Insights gained from crystal structures of rhodopsins, adrenergic and adenosine receptors
    • MustafiD, Palczewski K (2009) Topology of class a G protein-coupled receptors: insights gained from crystal structures of rhodopsins, adrenergic and adenosine receptors. Mol Pharmacol 75(1):1-12
    • (2009) Mol Pharmacol , vol.75 , Issue.1 , pp. 1-12
    • Mustafi, D.1    Palczewski, K.2
  • 19
    • 66249144426 scopus 로고    scopus 로고
    • The structure and function of G-proteincoupled receptors
    • Rosenbaum DM, Rasmussen SG, Kobilka BK (2009) The structure and function of G-proteincoupled receptors. Nature 459(7245):356-363
    • (2009) Nature , vol.459 , Issue.7245 , pp. 356-363
    • Rosenbaum, D.M.1    Rasmussen, S.G.2    Kobilka, B.K.3
  • 20
    • 58149203324 scopus 로고    scopus 로고
    • Discovery of New GPCR biology: One receptor structure at a time
    • Hanson MA, Stevens RC (2009) Discovery of New GPCR biology: one receptor structure at a time. Structure 17(1):8-14
    • (2009) Structure , vol.17 , Issue.1 , pp. 8-14
    • Hanson, M.A.1    Stevens, R.C.2
  • 21
    • 70349513038 scopus 로고    scopus 로고
    • Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models
    • Worth CL, Kleinau G, Krause G (2009) Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models. PLoS One 4(9):e7011
    • (2009) PLoS One , vol.4 , Issue.9
    • Worth, C.L.1    Kleinau, G.2    Krause, G.3
  • 22
    • 33947356279 scopus 로고    scopus 로고
    • G protein coupled receptor structure and activation
    • Kobilka BK (2007) G protein coupled receptor structure and activation. Biochimica Et Biophysica Acta-Biomembranes 1768(4):794-807
    • (2007) Biochimica et Biophysica Acta-Biomembranes , vol.1768 , Issue.4 , pp. 794-807
    • Kobilka, B.K.1
  • 23
    • 73849149844 scopus 로고    scopus 로고
    • Ligand-specific regulation of the extracellular surface of a G-proteincoupled receptor
    • Bokoch MP et al (2010) Ligand-specific regulation of the extracellular surface of a G-proteincoupled receptor. Nature 463(7277):108-U121
    • (2010) Nature , vol.463 , Issue.7277
    • Bokoch, M.P.1
  • 24
    • 32344450353 scopus 로고    scopus 로고
    • Transmembrane protein structures without X-rays
    • Fleishman SJ, Unger VM, Ben-Tal N (2006) Transmembrane protein structures without X-rays. Trends Biochem Sci 31(2):106-113
    • (2006) Trends Biochem Sci , vol.31 , Issue.2 , pp. 106-113
    • Fleishman, S.J.1    Unger, V.M.2    Ben-Tal, N.3
  • 25
    • 84934436854 scopus 로고    scopus 로고
    • Experimentally determined hydrophobicity scales for membrane proteins
    • Wimley WC, Creamer TP, White SH (1996) Experimentally determined hydrophobicity scales for membrane proteins. Biophys J 70(2):Tuam1-Tuam1
    • (1996) Biophys J , vol.70 , Issue.2
    • Wimley, W.C.1    Creamer, T.P.2    White, S.H.3
  • 26
    • 37249037182 scopus 로고    scopus 로고
    • Molecular code for transmembrane-helix recognition by the Sec61 translocon
    • Hessa T et al (2007) Molecular code for transmembrane-helix recognition by the Sec61 translocon. Nature 450(7172):1026-U2
    • (2007) Nature , vol.450 , Issue.7172
    • Hessa, T.1
  • 27
    • 33645883232 scopus 로고    scopus 로고
    • How hydrogen bonds shape membrane protein structure
    • White SH (2006) How hydrogen bonds shape membrane protein structure. Peptide Solvation H-Bonds 72:157-172
    • (2006) Peptide Solvation H-Bonds , vol.72 , pp. 157-172
    • White, S.H.1
  • 28
    • 25444444202 scopus 로고    scopus 로고
    • Computational Modeling approaches to structure-function analysis of G protein-coupled receptors
    • Fanelli F, De Benedetti PG (2005) Computational Modeling approaches to structure-function analysis of G protein-coupled receptors. Chem Rev 105(9):3297-3351
    • (2005) Chem Rev , vol.105 , Issue.9 , pp. 3297-3351
    • Fanelli, F.1    De Benedetti, P.G.2
  • 30
    • 50149116588 scopus 로고    scopus 로고
    • Agonist-induced conformational changes in bovine rhodopsin: Insight into activation of G-protein-coupled receptors
    • Bhattacharya S, Hall SE, Vaidehi N (2008) Agonist-induced conformational changes in bovine rhodopsin: Insight into activation of G-protein-coupled receptors. J Mol Biol 382(2):539-555
    • (2008) J Mol Biol , vol.382 , Issue.2 , pp. 539-555
    • Bhattacharya, S.1    Hall, S.E.2    Vaidehi, N.3
  • 31
    • 44049086134 scopus 로고    scopus 로고
    • Ligand-stabilized conformational states of human beta(2) adrenergic receptor: Insight into G-proteincoupled receptor activation
    • Bhattacharya S et al (2008) Ligand-stabilized conformational states of human beta(2) adrenergic receptor: Insight into G-proteincoupled receptor activation. Biophys J 94(6): 2027-2042
    • (2008) Biophys J , vol.94 , Issue.6 , pp. 2027-2042
    • Bhattacharya, S.1
  • 32
    • 0036790954 scopus 로고    scopus 로고
    • Prediction of structure and function of G protein-coupled receptors
    • Vaidehi N et al (2002) Prediction of structure and function of G protein-coupled receptors. Proc Natl Acad Sci USA 99(20):12622-12627
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.20 , pp. 12622-12627
    • Vaidehi, N.1
  • 33
    • 1642410853 scopus 로고    scopus 로고
    • The predicted 3D structure of the human D2 dopamine receptor and the binding site and binding affinities for agonists and antagonists
    • Kalani MYS et al (2004) The predicted 3D structure of the human D2 dopamine receptor and the binding site and binding affinities for agonists and antagonists. Proc Natl Acad Sci USA 101(11):3815-3820
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.11 , pp. 3815-3820
    • Mys, K.1
  • 34
    • 1542267836 scopus 로고    scopus 로고
    • Predicted 3D structure for the human beta 2 adrenergic receptor and its binding site for agonists and antagonists
    • Freddolino PL et al (2004) Predicted 3D structure for the human beta 2 adrenergic receptor and its binding site for agonists and antagonists. Proc Natl Acad Sci USA 101(9):2736-2741
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.9 , pp. 2736-2741
    • Freddolino, P.L.1
  • 35
    • 33748643600 scopus 로고    scopus 로고
    • The predicted 3D structures of the human M1 muscarinic acetylcholine receptor with agonist or antagonist bound
    • Peng JY et al (2006) The predicted 3D structures of the human M1 muscarinic acetylcholine receptor with agonist or antagonist bound. ChemMedChem 1(8):878-890
    • (2006) ChemMedChem , vol.1 , Issue.8 , pp. 878-890
    • Peng, J.Y.1
  • 36
    • 33748747498 scopus 로고    scopus 로고
    • Predictions of CCR1 chemokine receptor structure and BX 471 antagonist binding followed by experimental validation
    • Vaidehi N et al (2006) Predictions of CCR1 chemokine receptor structure and BX 471 antagonist binding followed by experimental validation. J Biol Chem 281(37):27613-27620
    • (2006) J Biol Chem , vol.281 , Issue.37 , pp. 27613-27620
    • Vaidehi, N.1
  • 37
    • 34848928184 scopus 로고    scopus 로고
    • Prediction of the 3D structure and dynamics of human DP G-protein coupled receptor bound to an agonist and an antagonist
    • Li Y et al (2007) Prediction of the 3D structure and dynamics of human DP G-protein coupled receptor bound to an agonist and an antagonist. J Am Chem Soc 129(35):10720-10731
    • (2007) J Am Chem Soc , vol.129 , Issue.35 , pp. 10720-10731
    • Li, Y.1
  • 38
    • 49649120129 scopus 로고    scopus 로고
    • The structure of human serotonin 2c G-protein-coupled receptor bound to agonists and antagonists
    • Bray JK, Goddard WA 3rd (2008) The structure of human serotonin 2c G-protein-coupled receptor bound to agonists and antagonists. J Mol Graph Model 27(1):66-81
    • (2008) J Mol Graph Model , vol.27 , Issue.1 , pp. 66-81
    • Bray, J.K.1    Goddard III, W.A.2
  • 39
    • 58149267930 scopus 로고    scopus 로고
    • Flat-bottom strategy for improved accuracy in protein sidechain placements
    • Kam VWT, Goddard WA (2008) Flat-bottom strategy for improved accuracy in protein sidechain placements. J Chem Theor Comput 4(12):2160-2169
    • (2008) J Chem Theor Comput , vol.4 , Issue.12 , pp. 2160-2169
    • Kam, V.W.T.1    Goddard, W.A.2
  • 40
    • 0347949636 scopus 로고    scopus 로고
    • Ser and Thr residues modulate the conformation of pro-kinked transmembrane alpha-helices
    • Deupi X et al (2004) Ser and Thr residues modulate the conformation of pro-kinked transmembrane alpha-helices. Biophys J 86(1 Pt 1):105-115
    • (2004) Biophys J , vol.86 , Issue.1 PART 1 , pp. 105-115
    • Deupi, X.1
  • 41
    • 0031847518 scopus 로고    scopus 로고
    • Structure of rhodopsin
    • Schertler GF (1998) Structure of rhodopsin. Eye (Lond) 12(Pt 3b):504-510
    • (1998) Eye (Lond) , vol.12 , Issue.PART 3B , pp. 504-510
    • Schertler, G.F.1
  • 42
    • 35448975187 scopus 로고    scopus 로고
    • Prediction of the 3-D structure of rat MrgA G protein-coupled receptor and identification of its binding site
    • Heo J et al (2007) Prediction of the 3-D structure of rat MrgA G protein-coupled receptor and identification of its binding site. J Mol Graph Model 26(4):800-812
    • (2007) J Mol Graph Model , vol.26 , Issue.4 , pp. 800-812
    • Heo, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.