-
1
-
-
0037686295
-
Killing the messenger: Short RNAs that silence gene expression
-
Dykxhoorn, D.M. et al. (2005). Killing the messenger: short RNAs that silence gene expression. Nat Rev Mol Cell Biol. 4, 457-467.
-
(2005)
Nat Rev Mol Cell Biol
, vol.4
, pp. 457-467
-
-
Dykxhoorn, D.M.1
-
2
-
-
0141613693
-
siRNA-mediated antitumorigenesis for drug target validation and therapeutics
-
Lu, P.Y. et al. (2003). siRNA-mediated antitumorigenesis for drug target validation and therapeutics. Curr Opin Mol Ther. 5, 225-234.
-
(2003)
Curr Opin Mol Ther
, vol.5
, pp. 225-234
-
-
Lu, P.Y.1
-
3
-
-
25144498128
-
In vivo application of RNA interference: From functional genomics to therapeutics
-
Lu, P.Y. et al. (2005). In vivo application of RNA interference: from functional genomics to therapeutics. Adv Genet. 54:117-142.
-
(2005)
Adv Genet
, vol.54
, pp. 117-142
-
-
Lu, P.Y.1
-
4
-
-
85069133765
-
-
Xie, P.Y. et al. (2004). Delivering siRNA to animal disease models for validation of novel drug targets in vivo. PharmaGenomics, July/August, 28-38.
-
Xie, P.Y. et al. (2004). Delivering siRNA to animal disease models for validation of novel drug targets in vivo. PharmaGenomics, July/August, 28-38.
-
-
-
-
5
-
-
9644275599
-
Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: Therapeutic strategy for herpetic stromal keratitis
-
Kim, B. et al. (2004). Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: therapeutic strategy for herpetic stromal keratitis. Am J Pathol. 165, 2177-2185.
-
(2004)
Am J Pathol
, vol.165
, pp. 2177-2185
-
-
Kim, B.1
-
6
-
-
23844474160
-
Antibody mediated in vivo delivery of small interfering RNAs via cellsurface receptors
-
Song, E. et al. (2005). Antibody mediated in vivo delivery of small interfering RNAs via cellsurface receptors. Nat Biotechnol. 23(6), 709-717.
-
(2005)
Nat Biotechnol
, vol.23
, Issue.6
, pp. 709-717
-
-
Song, E.1
-
7
-
-
84927053253
-
Delivering siRNA in vivo for functional genomics and novel therapeutics
-
Appasani, K ed, Cambridge University Press, London
-
Lu, RY, and Woodle, M.C. (2005). Delivering siRNA in vivo for functional genomics and novel therapeutics. In: Appasani, K (ed.) RNA interference technology. Cambridge University Press, London.
-
(2005)
RNA interference technology
-
-
Lu, R.Y.1
Woodle, M.C.2
-
8
-
-
9144247189
-
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
-
Soutschek, J. et al. (2004). Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature. 432, 173-178.
-
(2004)
Nature
, vol.432
, pp. 173-178
-
-
Soutschek, J.1
-
9
-
-
32444445649
-
Harnessing in vivo siRNA delivery for drug discovery and therapeutic development
-
Xie, et al. (2006). Harnessing in vivo siRNA delivery for drug discovery and therapeutic development. Drug Discov Today. 11(1/2), 67-73.
-
(2006)
Drug Discov Today
, vol.11
, Issue.1-2
, pp. 67-73
-
-
Xie1
-
10
-
-
0141552295
-
Gene silencing by systemic delivery of synthetic siRNAs in adult mice
-
Sorensen, D.R. et al. (2003). Gene silencing by systemic delivery of synthetic siRNAs in adult mice. J Mol Biol. 327, 761-766.
-
(2003)
J Mol Biol
, vol.327
, pp. 761-766
-
-
Sorensen, D.R.1
-
11
-
-
14644413531
-
Novel cationic cardiolipin analogue-based liposome for efficient DNA and small interfering RNA delivery in vitro and in vivo
-
Chien, P.Y. et al. (2004). Novel cationic cardiolipin analogue-based liposome for efficient DNA and small interfering RNA delivery in vitro and in vivo. Cancer Gene Ther. 12, 321-328.
-
(2004)
Cancer Gene Ther
, vol.12
, pp. 321-328
-
-
Chien, P.Y.1
-
12
-
-
22544476560
-
Highly branched HK peptides are effective carriers of siRNA
-
Leng, Q. et al. (2005). Highly branched HK peptides are effective carriers of siRNA. J Gene Med. 7(7), 977-986.
-
(2005)
J Gene Med
, vol.7
, Issue.7
, pp. 977-986
-
-
Leng, Q.1
-
13
-
-
22944469778
-
Small interfering RNA targeting Raf-1 inhibits tumor growth in vitro and in vivo
-
Advance online publication, April 1, doi:10.1038/sj. cgt.7700831
-
Leng, Q. et al. (2005). Small interfering RNA targeting Raf-1 inhibits tumor growth in vitro and in vivo. Cancer Gene Ther. Advance online publication, April 1, 2005; doi:10.1038/sj. cgt.7700831
-
(2005)
Cancer Gene Ther
-
-
Leng, Q.1
-
14
-
-
15444373116
-
RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo
-
Urban-Klein, B. et al. (2005). RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo. Gene Ther. 12, 461-466.
-
(2005)
Gene Ther
, vol.12
, pp. 461-466
-
-
Urban-Klein, B.1
-
15
-
-
0042173218
-
SiRNA-mediated inhibition of vascular endothelial growth factor severely limits tumor resistance to antiangiogenic thrombospondin-1 and slows tumor vascularization and growth
-
Filleur, S. et al. (2003). SiRNA-mediated inhibition of vascular endothelial growth factor severely limits tumor resistance to antiangiogenic thrombospondin-1 and slows tumor vascularization and growth. Cancer Res. 63, 3919-3922.
-
(2003)
Cancer Res
, vol.63
, pp. 3919-3922
-
-
Filleur, S.1
-
16
-
-
2942530436
-
Inhibition of influenza virus production in virus-infected mice by RNA interference
-
Ge, Q. et al. (2004). Inhibition of influenza virus production in virus-infected mice by RNA interference. Proc Natl Acad Sci USA. 101, 8676-8681.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 8676-8681
-
-
Ge, Q.1
-
17
-
-
0035816174
-
Sterically stabilized polyplex: Ligand-mediated activity
-
Woodle, M.C. et al. (2001). Sterically stabilized polyplex: ligand-mediated activity. J Control Release. 74, 309-311.
-
(2001)
J Control Release
, vol.74
, pp. 309-311
-
-
Woodle, M.C.1
-
18
-
-
23844474160
-
Antibody mediated in vivo delivery of small interfering RNAs via cellsurface receptors
-
Song, E. et al. (2005). Antibody mediated in vivo delivery of small interfering RNAs via cellsurface receptors. Nat Biotechnol. 23(6), 709-717.
-
(2005)
Nat Biotechnol
, vol.23
, Issue.6
, pp. 709-717
-
-
Song, E.1
-
19
-
-
23444445660
-
Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
-
Morrissey, D.V. et al. (2005). Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nat Biotechnol. 23(8), 1002-1007.
-
(2005)
Nat Biotechnol
, vol.23
, Issue.8
, pp. 1002-1007
-
-
Morrissey, D.V.1
-
20
-
-
14544298301
-
Cancer siRNA therapy by tumor selective delivery with ligandtargeted sterically stabilized nanoparticle
-
Schiffelers, R.M. et al. (2004). Cancer siRNA therapy by tumor selective delivery with ligandtargeted sterically stabilized nanoparticle. Nucleic Acids Res. 32, e149.
-
(2004)
Nucleic Acids Res
, vol.32
-
-
Schiffelers, R.M.1
-
21
-
-
11144282529
-
Antisense and siRNA as agonists of toll-like receptors
-
Agrawal, S., and Kandimalla, E.R. (2004). Antisense and siRNA as agonists of toll-like receptors. Nat Biotechnol. 22, 1533-1537.
-
(2004)
Nat Biotechnol
, vol.22
, pp. 1533-1537
-
-
Agrawal, S.1
Kandimalla, E.R.2
-
22
-
-
0037685280
-
Expression profiling reveals off-target gene regulation by RNAi
-
Jackson, A. et al. (2003). Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol. 21, 635-637.
-
(2003)
Nat Biotechnol
, vol.21
, pp. 635-637
-
-
Jackson, A.1
-
23
-
-
2442705429
-
Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3
-
Kariko, K. et al. (2004). Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3. J Immunol. 172, 6545-6549.
-
(2004)
J Immunol
, vol.172
, pp. 6545-6549
-
-
Kariko, K.1
-
24
-
-
0042972933
-
Activation of the interferon system by short-interfering RNAs
-
Sledz, C.A. et al. (2003). Activation of the interferon system by short-interfering RNAs. Nat Cell Biol. 5, 834-839.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 834-839
-
-
Sledz, C.A.1
-
25
-
-
0038798081
-
Genomewide view of gene silencing by small interfering RNAs
-
Chi, J.T. et al. (2003). Genomewide view of gene silencing by small interfering RNAs. Proc Natl Acad Sci USA. 100,6364-6369.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 6364-6369
-
-
Chi, J.T.1
-
26
-
-
0038121109
-
Specificity of short interfering RNA determined through gene expression signatures
-
Semizarov, D. et al. (2003). Specificity of short interfering RNA determined through gene expression signatures. Proc Natl Acad Sci USA. 100, 6347-6352.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 6347-6352
-
-
Semizarov, D.1
-
27
-
-
11144347529
-
Lack of interferon response in animals to naked siRNAs
-
Heidel, J.D. et al. (2004). Lack of interferon response in animals to naked siRNAs. Nat Biotech. 22, 1579-1582.
-
(2004)
Nat Biotech
, vol.22
, pp. 1579-1582
-
-
Heidel, J.D.1
-
28
-
-
20144389695
-
Sequence-specific potent induction of IFN-a by short interfering RNA in plasmacytoid dendritic cells through TLR7
-
Hornung, V et al. (2005). Sequence-specific potent induction of IFN-a by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med. 11, 263-270.
-
(2005)
Nat Med
, vol.11
, pp. 263-270
-
-
Hornung, V.1
-
29
-
-
22344454846
-
Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
-
Judge, A.D. et al. (2005). Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat Biotech. 23, 457-462.
-
(2005)
Nat Biotech
, vol.23
, pp. 457-462
-
-
Judge, A.D.1
-
30
-
-
4644302416
-
Noninvasive delivery of small inhibitory RNA and other reagents to pulmonary alveoli in mice
-
Massaro, D. et al. (2004). Noninvasive delivery of small inhibitory RNA and other reagents to pulmonary alveoli in mice. Am J Physiol Lung Cell Mol Physiol. 287, L1066-L1070.
-
(2004)
Am J Physiol Lung Cell Mol Physiol
, vol.287
-
-
Massaro, D.1
-
31
-
-
1642291631
-
Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis
-
Zhang, X. et al. (2003). Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis. J Biol Chem. 279, 10677-10684.
-
(2003)
J Biol Chem
, vol.279
, pp. 10677-10684
-
-
Zhang, X.1
-
32
-
-
2942620143
-
Protection against lethal influenza virus challenge by RNA interference in vivo
-
Tompkins, S.M. et al. (2004). Protection against lethal influenza virus challenge by RNA interference in vivo. Proc Natl Acad Sci USA. 101, 8682-8686.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 8682-8686
-
-
Tompkins, S.M.1
-
33
-
-
24744466699
-
Prophylactic and therapeutic efficacies of siRNA targeting SARS Coronavirus in rhesus macaque
-
Li, B.J. et al. (2005). Prophylactic and therapeutic efficacies of siRNA targeting SARS Coronavirus in rhesus macaque. Nat Med. 11(9), 944-951.
-
(2005)
Nat Med
, vol.11
, Issue.9
, pp. 944-951
-
-
Li, B.J.1
-
34
-
-
0038748037
-
Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model
-
Reich, SJ. et al. (2003). Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model. Mol Vis. 9, 210-216.
-
(2003)
Mol Vis
, vol.9
, pp. 210-216
-
-
Reich, S.J.1
-
35
-
-
14544297836
-
RNA interference targeting transforming growth factor-beta type II receptor suppresses ocular inflammation and fibrosis
-
Nakamura, H. et al. (2004). RNA interference targeting transforming growth factor-beta type II receptor suppresses ocular inflammation and fibrosis. Mol Vis. 10, 703-711.
-
(2004)
Mol Vis
, vol.10
, pp. 703-711
-
-
Nakamura, H.1
-
36
-
-
5444234179
-
RNA interference: From model organisms towards therapy for neural and neuromuscular disorders
-
Buckingham, S.D. et al. (2004). RNA interference: from model organisms towards therapy for neural and neuromuscular disorders. Hum Mol Genet Spec. 2, R275-R288.
-
(2004)
Hum Mol Genet Spec
, vol.2
-
-
Buckingham, S.D.1
-
37
-
-
10344261343
-
siRNA relieves chronic neuropathic pain
-
Dorn, G. et al. (2004). siRNA relieves chronic neuropathic pain. Nucleic Acids Res. 32, e49.
-
(2004)
Nucleic Acids Res
, vol.32
-
-
Dorn, G.1
-
38
-
-
8444249644
-
Attenuation of alpha (2A)-adrenergic receptor expression in neonatal rat brain by RNA interference or antisense oligonucleotide reduced anxiety in adulthood
-
Shishkina, G.T. et al. (2004). Attenuation of alpha (2A)-adrenergic receptor expression in neonatal rat brain by RNA interference or antisense oligonucleotide reduced anxiety in adulthood. Neuroscience. 129, 521-528.
-
(2004)
Neuroscience
, vol.129
, pp. 521-528
-
-
Shishkina, G.T.1
-
39
-
-
10344228801
-
Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference
-
Thakker, D.R. et al. (2004). Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference. Proc Natl Acad Sci USA. 101, 17270-17275.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 17270-17275
-
-
Thakker, D.R.1
-
40
-
-
14844330061
-
Lipid-mediated siRNA delivery down-regulates exogenous gene expression in the mouse brain at picomolar levels
-
Hassani, Z. et al. (2004). Lipid-mediated siRNA delivery down-regulates exogenous gene expression in the mouse brain at picomolar levels. J Gene Med. 7, 198-207.
-
(2004)
J Gene Med
, vol.7
, pp. 198-207
-
-
Hassani, Z.1
-
41
-
-
15044354554
-
RNAi-induced gene silencing by local electroporation in targeting brain region
-
Akaneya, Y et al. (2005). RNAi-induced gene silencing by local electroporation in targeting brain region. J Neurophysiol. 93, 594-602.
-
(2005)
J Neurophysiol
, vol.93
, pp. 594-602
-
-
Akaneya, Y.1
-
42
-
-
13544265637
-
Inhibition of gene expression in mice muscle by in vivo electrically mediated siRNA delivery
-
Golzio, M. et al. (2004). Inhibition of gene expression in mice muscle by in vivo electrically mediated siRNA delivery. Gene Ther. 12, 246-251.
-
(2004)
Gene Ther
, vol.12
, pp. 246-251
-
-
Golzio, M.1
-
43
-
-
1942494048
-
Sequence-specific gene silencing in murine muscle induced by electroporation-mediated transfer of short interfering RNA
-
Kishida, T. et al. (2004). Sequence-specific gene silencing in murine muscle induced by electroporation-mediated transfer of short interfering RNA. J Gene Med. 6, 105-110.
-
(2004)
J Gene Med
, vol.6
, pp. 105-110
-
-
Kishida, T.1
-
44
-
-
4344715026
-
A facile nonviral method for delivering genes and siRNAs to skeletal muscle of mammalian limbs
-
Hagstrom, J.E. et al. (2004). A facile nonviral method for delivering genes and siRNAs to skeletal muscle of mammalian limbs. Mol Ther. 10(2), 386-398.
-
(2004)
Mol Ther
, vol.10
, Issue.2
, pp. 386-398
-
-
Hagstrom, J.E.1
-
45
-
-
33645921527
-
Tumor inhibition by RNAi-mediated VEGF and VEGFR2 down regulation in xenograft models
-
Lu, P.Y. et al. (2002). Tumor inhibition by RNAi-mediated VEGF and VEGFR2 down regulation in xenograft models. Cancer Gene Ther. 10 (Suppl.), S4.
-
(2002)
Cancer Gene Ther
, vol.10
, Issue.SUPPL.
-
-
Lu, P.Y.1
-
46
-
-
3242733298
-
Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo
-
Minakuchi, Y et al. (2004). Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo. Nucleic Acids Res. 32, e109.
-
(2004)
Nucleic Acids Res
, vol.32
-
-
Minakuchi, Y.1
-
47
-
-
2442668068
-
A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics
-
Takei, Y et al. (2004). A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics. Cancer Res. 64, 3365-3370.
-
(2004)
Cancer Res
, vol.64
, pp. 3365-3370
-
-
Takei, Y.1
-
48
-
-
0036727416
-
Efficient delivery of siRNA for inhibition of gene expression in postnatal mice
-
Lewis, D.L. et al. (2002). Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. Nat Genet. 32, 107-108.
-
(2002)
Nat Genet
, vol.32
, pp. 107-108
-
-
Lewis, D.L.1
-
49
-
-
0037019339
-
RNA interference in adult mice
-
McCaffrey, A.P. et al. (2002). RNA interference in adult mice. Nature. 418, 38-39.
-
(2002)
Nature
, vol.418
, pp. 38-39
-
-
McCaffrey, A.P.1
-
50
-
-
0037348329
-
RNA interference targeting Fas protects mice from fulminant hepatitism
-
Song, E. et al. (2003). RNA interference targeting Fas protects mice from fulminant hepatitism. Nat Med. 9, 347-351.
-
(2003)
Nat Med
, vol.9
, pp. 347-351
-
-
Song, E.1
-
51
-
-
0038610713
-
Caspase 8 small interfering RNA prevents acute liver failure in mice
-
Zender, L. et al. (2003). Caspase 8 small interfering RNA prevents acute liver failure in mice. Proc Nat Acad Sci USA. 100, 7797-7802.
-
(2003)
Proc Nat Acad Sci USA
, vol.100
, pp. 7797-7802
-
-
Zender, L.1
-
52
-
-
1942533474
-
In vivo activity of nuclease-resistant siRNAs
-
Layzer, J.M. et al. (2004). In vivo activity of nuclease-resistant siRNAs. RNA 10, 766-771.
-
(2004)
RNA 10
, pp. 766-771
-
-
Layzer, J.M.1
-
53
-
-
0346873025
-
Small interfering RNA inhibits hepatitis B virus replication in mice
-
Giladi, H. et al. (2004). Small interfering RNA inhibits hepatitis B virus replication in mice. Mol Ther. 8, 769-776.
-
(2004)
Mol Ther
, vol.8
, pp. 769-776
-
-
Giladi, H.1
-
54
-
-
0142091755
-
Inhibition of hepatitis C virus protein expression by RNA interference
-
Sen, A. et al. (2003). Inhibition of hepatitis C virus protein expression by RNA interference. Virus Res. 96, 27-35.
-
(2003)
Virus Res
, vol.96
, pp. 27-35
-
-
Sen, A.1
-
55
-
-
4444220551
-
Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells
-
Lorenz, C. et al. (2004). Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells. Bioorg Med Chem Lett. 14, 4975-4977.
-
(2004)
Bioorg Med Chem Lett
, vol.14
, pp. 4975-4977
-
-
Lorenz, C.1
-
56
-
-
4644316534
-
Systemic siRNA-mediated gene silencing: A new approach to targeted therapy of cancer
-
Duxbury, M.S. (2004). Systemic siRNA-mediated gene silencing: a new approach to targeted therapy of cancer. Ann Surg. 240, 667-674.
-
(2004)
Ann Surg
, vol.240
, pp. 667-674
-
-
Duxbury, M.S.1
-
57
-
-
4644349816
-
Liposomes modified with cyclic RGD peptide for tumor targeting
-
Dubey, et al. (2004). Liposomes modified with cyclic RGD peptide for tumor targeting. J Drug Target. 12, 257-264.
-
(2004)
J Drug Target
, vol.12
, pp. 257-264
-
-
Dubey1
-
58
-
-
14844320045
-
Modulation of angiogenesis with siRNA inhibitors for novel therapeutics
-
Lu, P.Y. et al. (2005). Modulation of angiogenesis with siRNA inhibitors for novel therapeutics. Trend Mol Med. 11, 104-113.
-
(2005)
Trend Mol Med
, vol.11
, pp. 104-113
-
-
Lu, P.Y.1
-
59
-
-
22644446537
-
Nanoparticles deliver RNAi therapy
-
Woodle, M.C., and Lu, P.Y. (2005). Nanoparticles deliver RNAi therapy. Materials Today, 8 (suppl 1), 34-41.
-
(2005)
Materials Today
, vol.8
, Issue.SUPPL. 1
, pp. 34-41
-
-
Woodle, M.C.1
Lu, P.Y.2
|