The c-Jun/RHOB/AKT pathway confers resistance of BRAF-mutant melanoma cells to MAPK inhibitors

Oncotarget

Volumn 6, Issue 17, 2015, Pages 15250-15264

  Delmas, Audrey ^a,b,c   Cherier, Julia ^a,c   Pohorecka, Magdalena ^a,b,c   Medale Giamarchi, Claire ^a,b,c   Meyer, Nicolas ^a,b,d   Casanova, Anne ^c   Sordet, Olivier ^a,c   Lamant, Laurence ^a,d   Savina, Ariel ^e   Pradines, Anne ^a,b,c   Favre, Gilles ^a,b,c  

^a CANCER RESEARCH CENTER OF TOULOUSE   (France)

^b UNIVERSITÉ PAUL SABATIER   (France)

^c INSTITUT CLAUDIUS REGAUD   (France)

^d TOULOUSE UNIVERSITY HOSPITAL   (France)

^e Roche   (France)

Author keywords

AKT; Melanoma; Resistance; RHOB; Vemurafenib

Indexed keywords

B RAF KINASE; BRAF PROTEIN, HUMAN; INDOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN C JUN; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; RHOB GUANINE NUCLEOTIDE BINDING PROTEIN; SULFONAMIDE; VEMURAFENIB;

ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; CELL SURVIVAL; DISEASE FREE SURVIVAL; DRUG EFFECTS; DRUG RESISTANCE; FEMALE; GENETICS; HUMAN; MELANOMA; METABOLISM; MOUSE; NUDE MOUSE; SIGNAL TRANSDUCTION; TUMOR CELL LINE; TUMOR RECURRENCE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; DISEASE-FREE SURVIVAL; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; INDOLES; MAP KINASE SIGNALING SYSTEM; MELANOMA; MICE; MICE, NUDE; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM RECURRENCE, LOCAL; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-JUN; RHOB GTP-BINDING PROTEIN; SULFONAMIDES;

EID: 84934311631     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3888     Document Type: Article

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