Cloning of the human RHOB gene promoter: Characterization of a VNTR sequence that affects transcriptional activity

Genomics

Volumn 81, Issue 5, 2003, Pages 525-530

  Tovar, Daniel ^a   Faye, Jean Charles ^a   Favre, Gilles ^a  

^a INSTITUT CLAUDIUS REGAUD   (France)

Author keywords

5 Flanking region; ARHB promoter; RHOB gene; Transcriptional regulation; VNTR

Indexed keywords

GENOMIC DNA; GUANOSINE TRIPHOSPHATASE; PROTEIN RHOB; RHO FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; DNA FLANKING REGION; GENE ACTIVITY; GENE AMPLIFICATION; GENETIC TRANSCRIPTION; GENOME ANALYSIS; HUMAN; HUMAN CELL; HUMAN GENOME; MOLECULAR CLONING; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; SIMIAN VIRUS 40; VARIABLE NUMBER OF TANDEM REPEAT;

SIMIAE; SIMIAN VIRUS 40;

EID: 0037404124     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0888-7543(03)00044-2     Document Type: Article

References (21)

1. Aspenstrom P. Effectors for the RHO GTPases. Curr. Opin. Cell Biol. 11:1999;95-102.
2. Hall A. RHO GTPases and the actin cytoskeleton. Science. 279:1998;509-514.
3. Prendergast G.C., et al. Critical role of RHO in cell transformation by oncogenic Ras. Oncogene. 10:1995;2289-2296.
4. Adamson P., Paterson H.F., Hall A. Intracellular localization of the p21RHO proteins. J. Cell Biol. 119:1992;617-627.
5. Michaelson D., et al. Differential localization of RHO GTPases in live cells regulation by hypervariable regions and RHOGDI binding . J. Cell Biol. 152:2001;111-126.
6. Baron R., et al. RHOB prenylation is driven by the three carboxyl-terminal amino acids of the protein evidenced in vivo by an anti-farnesyl cysteine antibody . Proc. Natl. Acad. Sci. USA. 97:2000;11626-11631.
7. Jahner D., Hunter T. The ras-related gene ARHB is an immediate-early gene inducible by v-Fps, epidermal growth factor, and platelet-derived growth factor in rat fibroblasts. Mol. Cell Biol. 11:1991;3682-3690.
8. Fritz G., Kaina B., Aktories K. The ras-related small GTP-binding protein RHOB is immediate-early inducible by DNA damaging treatments. J. Biol. Chem. 270:1995;25172-25177.
9. Fritz G., Kaina B. ARHB encoding a UV-inducible Ras-related small GTP-binding protein is regulated by GTPases of the RHO family and independent of JNK, ERK, and p38 MAP kinase. J. Biol. Chem. 272:1997;30637-30644.
10. Chen Z., et al. Both famesylated and geranylgeranylated RHOB inhibit malignant transformation and suppress human tumor growth in nude mice. J. Biol. Chem. 275:2000;17974-17978.
11. Nakamura T., Asano M., Shindo-Okada N., Nishimura S., Monden Y. Cloning of the RHOB gene from the mouse genome and characterization of its promoter region. Biochem. Biophys. Res. Commun. 226:1996;688-694.
12. Ou X., Pollock J., Dinauer M.C., Gharehbaghi-Schnell E., Skalnik D.G. Identification and functional characterization of the murine RAC2 gene promoter. DNA Cell Biol. 18:1999;253-263.
13. Courjal F., Chuchana P., Theillet C., Fort P. Structure and chromosomal assignment to 22q12 and 17qter of the ras-related RAC2 and RAC3 human genes. Genomics. 44:1997;242-246.
14. Matos P., et al. Small GTPase RAC1 structure, localization, and expression of the human gene . Biochem. Biophys. Res. Commun. 277:2000;741-751.
15. Le Gallic L., Fort P. Structure of the human ARHG locus encoding the RHO/Rac-like RHOG GTPase. Genomics. 42:1997;157-160.
16. Sabol S.Z., Hu S., Hamer D. A functional polymorphism in the monoamine oxidase A gene promoter. Hum. Genet. 103:1998;273-279.
17. D. Chevalier, et al., Characterization of new mutations in the coding sequence and 5′-untranslated region of the human prostacyclin synthase gene (CYP8A1). Hum. Genet. 108 (2001) 148-155.
18. Boussif O., et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo polyethylenimine . Proc. Natl. Acad. Sci. USA. 92:1995;7297-7301.
19. Nakamura Y., Koyama K., Matsushima M. VNTR (variable number of tandem repeat) sequences as transcriptional, translational, or functional regulators. J. Hum. Genet. 43:1998;149-152.
20. Krontiris T.G. Minisatellites and human disease. Science. 269:1995;1682-1683.
21. Phelan C.M., et al. Ovarian cancer risk in BRCA1 carriers is modified by the HRAS1 variable number of tandem repeat (VNTR) locus. Nat. Genet. 12:1996;309-311.