Significance of long-chain polyunsaturated fatty acids (PUFAs) for the development and behaviour of children

European Journal of Pediatrics

Volumn 169, Issue 2, 2010, Pages 149-164

  Schuchardt, Jan Philipp ^a   Huss, Michael ^b   Stauss Grabo, Manuela ^c   Hahn, Andreas ^a  

^a LEIBNIZ UNIVERSITY HANNOVER   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c Engelhard Arzneimittel GmbH and Co KG   (Germany)

Author keywords

Attention deficit hyperactivity disorder (ADHD); Childhood developmental disorders; DHA; EPA; Fatty acid metabolism; Omega 3 fatty acids

Indexed keywords

ARACHIDONIC ACID; DEXAMPHETAMINE; DOCOSAHEXAENOIC ACID; GAMMA LINOLENIC ACID; ICOSAPENTAENOIC ACID; LINOLEIC ACID; METHYLPHENIDATE; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; POLYUNSATURATED FATTY ACID; PRIMROSE OIL;

ADD ON THERAPY; ADOLESCENT; ATTENTION DEFICIT DISORDER; AUTISM; BRAIN FUNCTION; CENTRAL NERVOUS SYSTEM; CHILD; CHILD BEHAVIOR; CHILD DEVELOPMENT; CLINICAL PRACTICE; DEVELOPMENTAL DISORDER; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DYSLEXIA; DYSPRAXIA; ESSENTIAL FATTY ACID DEFICIENCY; FAT INTAKE; FATTY ACID METABOLISM; GENE EXPRESSION REGULATION; HUMAN; LIFESPAN; MEMBRANE FLUIDITY; MONOTHERAPY; NEUROTRANSMISSION; NUTRITIONAL DEFICIENCY; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REVIEW; RISK FACTOR; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADOLESCENT; ADOLESCENT BEHAVIOR; ADOLESCENT DEVELOPMENT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; CHILD BEHAVIOR; CHILD DEVELOPMENT; COGNITION DISORDERS; DIETARY SUPPLEMENTS; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; HUMANS;

EID: 77949423995     PISSN: 03406199     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00431-009-1035-8     Document Type: Review

References (143)

1. Ahmad SO, Park JH, Radel JD et al (2008) Reduced numbers of dopamine neurons in the substantia nigra pars compacta and ventral tegmental area of rats fed an n-3 polyunsaturated fatty acid-deficient diet: a stereological study. Neurosci Lett 438 (3):303-307.
2. Alessandri JM, Guesnet P, Vancassel S (2004) Polyunsaturated fatty acids in the central nervous system: evolution of concepts and nutritional implications throughout life. Reprod Nutr Dev 44 (6):509-538.
3. Aman MG, Mitchell EA, Turbott SH (1987) The effects of essential fatty acid supplementation by Efamol in hyperactive children. J Abnorm Child Psychol 15(1):75-90.
4. Amminger GP, Berger GE, Schafer MR et al (2007) Omega-3 fatty acids supplementation in children with autism: a doubleblind randomized, placebo-controlled pilot study. Biol Psychiatry 61(4):551-553.
5. Antalis CJ, Stevens LJ, Campbell M et al (2006) Omega-3 fatty acid status in attention-deficit/hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids 75(4-5):299-308.
6. Arnold LE, Kleykamp D, Votolato NA et al (1989) Gammalinolenic acid for attention-deficit hyperactivity disorder: placebo-controlled comparison to D-amphetamine. Biol Psychiatry 25(2):222-228.
7. Arnold LE, Kleykamp D, Votolato N et al (1994) Potential link between dietary intake of fatty acids and behavior: pilot exploration of serum-lipids in attention-deficit hyperactivity disorder. J Child Adolesc Psychopharmacol 4:171-182.
8. Arnold LE, DiSilvestro RA (2005) Zinc in attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 15 (4):619-627.
9. Barcelo-Coblijn G, Hogyes E, Kitajka K et al (2003) Modification by docosahexaenoic acid of age-induced alterations in gene expression and molecular composition of rat brain phospholipids. Proc Natl Acad Sci USA 100(20):11321-11326.
10. Bell JG, MacKinlay EE, Dick JR et al (2004) Essential fatty acids and phospholipase A2 in autistic spectrum disorders. Prostaglandins Leukot Essent Fatty Acids 71(4):201-204.
11. Bennett CN, Horrobin DF (2000) Gene targets related to phospholipid and fatty acid metabolism in schizophrenia and other psychiatric disorders: an update. Prostaglandins Leukot Essent Fatty Acids 63(1-2):47-59.
12. Berger A, Mutch DM, German JB (2002) Dietary effects of arachidonate-rich fungal oil and fish oil on murine hepatic and hippocampal gene expression. Lipids Health Dis 1:2.
13. Biederman J, Munir K, Knee D et al (1987) High rate of affective disorders in probands with attention deficit disorder and in their relatives: a controlled family study. Am J Psychiatry 144 (3):330-333.
14. Birch EE, Garfield S, Hoffman DR (2000) A randomized controlled trial of early dietary supply of long-chain polyunsaturated fatty acids and mental development in term infants. Dev Med Child Neurol 42(3):174-181.
15. Birch EE, Hoffman DR, Castañeda YS (2002) A randomized controlled trial of long-chain polyunsaturated fatty acid supplementation of formula in term infants after weaning at 6 wk of age. Am J Clin Nutr 75(3):570-580.
16. Bourre JM, Pascal G, Durand G et al (1984) Alterations in the fatty acid composition of rat brain cells (neurons, astrocytes, and oligodendrocytes) and of subcellular fractions (myelin and synaptosomes) induced by a diet devoid of n-3 fatty acids. J Neurochem 43(2):342-348.
17. Bourre JM, Dumont O, Piciotti M et al (1991) Essentiality of omega 3 fatty acids for brain structure and function. World Rev Nutr Diet 66:103-117.
18. Bourre JM, Dumont O, Durand G (1993) Brain phospholipids as dietary source of (n-3) polyunsaturated fatty acids for nervous tissue in the rat. J Neurochem 60(6):2018-2028.
19. Brenna JT (2002) Efficiency of conversion of alpha-linolenic acid to long chain n-3 fatty acids in man. Curr Opin Clin Nutr Metab Care 5(2):127-132.
20. British Nutrition Foundation (BNF) (1995) n-3 fatty acids and health. Briefing paper. BNF, London.
21. Brookes KJ, Chen W, Xu X et al (2006) Association of fatty acid desaturase genes with attention-deficit/hyperactivity disorder. Biol Psychiatry 60(10):1053-1061.
22. Brue AW, Oakland TD, Evans RA (2001) The use of a dietary supplement combination and an essential fatty acid as an alternative and complementary treatment for children with attention-deficit/hyperactivity disorder. Sci Rev Altern Med 5 (4):187-194.
23. Burdge GC, Wootton SA (2002) Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br J Nutr 88(4):411-420.
24. Burdge GC, Jones AE, Wootton SA (2002) Eicosapentaenoic and docosapentaenoic acids are the principal products of alphalinolenic acid metabolism in young men. Br J Nutr 88(4):355-363.
25. Burdge GC, Calder PC (2005) Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. Reprod Nutr Dev 45:581-597.
26. Busch B (2007) Polyunsaturated fatty acid supplementation for ADHD? Fishy, fascinating, and far from clear. J Dev Behav Pediatr 28(2):139-144.
27. Calderon F, Kim HY (2004) Docosahexaenoic acid promotes neurite growth in hippocampal neurons. J Neurochem 90 (4):979-988.
28. Castellanos FX (1997) Toward a pathophysiology of attentiondeficit/ hyperactivity disorder. Clin Pediatr (Phila) 36(7):381-393.
29. Chalon S, Delion-Vancassel S, Belzung C (1998) Dietary fish oil affects monoaminergic neurotransmission and behavior in rats. J Nutr 128(12):2512-2519.
30. Chalon S, Vancassel S, Zimmer L (2001) Polyunsaturated fatty acids and cerebral function: focus on monoaminergic neurotransmission. Lipids 36(9):937-944.
31. Chalon S (2006) Omega-3 fatty acids and monoamine neurotransmission. Prostaglandins Leukot Essent Fatty Acids 75(4-5): 259-269.
32. Chen JR, Hsu SF, Hsu CD et al (2004) Dietary patterns and blood fatty acid composition in children with attention-deficit hyperactivity disorder in Taiwan. J Nutr Biochem 15(8):467-472.
33. Clandinin MT, Chappell JE, Leong S et al (1980) Extrauterine fatty acid accretion in infant brain: implications for fatty acid requirements. Early Hum Dev 4(2):131-138.
34. Colter AL, Cutler C, Meckling KA (2008) Fatty acid status and behavioural symptoms of attention deficit hyperactivity disorder in adolescents: a case-control study. Nutr J 7:8.
35. Crawford MA (1993) The role of essential fatty acids in neural development: implications for perinatal nutrition. Am J Clin Nutr 57(5 Suppl):703S-709S.
36. D-A-CH, Deutsche Gesellschaft für Ernährung (DGE), Österreichische Gesellschaft für Ernährung (ÖGE), Schweizerische Gesellschaft für Ernährung (SGE), Schweizerische Vereinigung für Ernährung (SVE), (2008) Referenzwerte für die Nährstoffzufuhr. Umschau/Braus, Frankfurt am Main.
37. Delion S, Chalon S, Herault J et al (1994) Chronic dietary alphalinolenic acid deficiency alters dopaminergic and serotoninergic neurotransmission in rats. J Nutr 124(12):2466-2476.
38. Delion S, Chalon S, Guilloteau D et al (1996) alpha-Linolenic acid dietary deficiency alters age-related changes of dopaminergic and serotoninergic neurotransmission in the rat frontal cortex. J Neurochem 66(4):1582-1591.
39. DGE, Deutsche Gesellschaft für Ernährung (2004) Ernährungsbericht 2004. Deutsche Gesellschaft für Ernährung e.V., Bonn.
40. Ernst E (1994) Effects of n-3 fatty acids on blood rheology. J Int Med 225:129-132.
41. Faraone SV, Biederman J (1998) Neurobiology of attention deficit hyperactivity disorder. Biol Psychiatry 44(10):951-958.
42. Freeman MP, Hibbeln JR, Wisner KL et al (2006) Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry. J Clin Psychiatry 67(12):1954-1967.
43. Galland L (1985) Impaired essential fatty acid metabolism in latent tetany. Magnesium 4(5-6):333-338.
44. Hahn A, Ströhle A (2004) Prävention degenerativer Erkrankungen, ω-3-Fettsäuren. Chem unserer Zeit 38:310-318.
45. Hahn A, Ströhle A, Wolters M (2006) Ernährung-Physiologische Grundlagen, Prävention, Therapie. 2. Auflage, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart.
46. Hahn A, Ströhle A, Wolters M (2007) Ernährung bei Erkrankungen des rheumatischen Formenkreises. Medizinische Monatsschrift für Pharmazeuten 30:138-146.
47. Hansen AE, Haggard ME, Boelsche AN et al (1958) Essential fatty acids in infant nutrition. III. Clinical manifestations of linoleic acid deficiency. J Nutr 66(4):565-576.
48. Harding KL, Judah RD, Gant C (2003) Outcome-based comparison of Ritalin versus food-supplement treated children with AD/HD. Altern Med Rev 8(3):319-330.
49. Hellgren L, Gillberg IC, Bagenholm A et al (1994) Children with deficits in attention, motor control and perception (DAMP) almost grown up: psychiatric and personality disorders at age 16 years. J Child Psychol Psychiatry 35(7):1255-1271.
50. Hibbeln JR, Bissette G, Umhau JC et al (2004) Omega-3 status and cerebrospinal fluid corticotrophin releasing hormone in perpetrators of domestic violence. Biol Psychiatry 56(11):895-897.
51. Hirayama S, Hamazaki T, Terasawa K (2004) Effect of docosahexaenoic acid-containing food administration on symptoms of attention-deficit/ hyperactivity disorder-a placebocontrolled double-blind study. Eur J Clin Nutr 58(3):467-473.
52. Holte LL, Separovic F, Gawrisch K (1996) Nuclear magnetic resonance investigation of hydrocarbon chain packing in bilayers of polyunsaturated phospholipids. Lipids 31:S199-S203.
53. Horrobin DF, Glen AI, Hudson CJ (1995) Possible relevance of phospholipid abnormalities and genetic interactions in psychiatric disorders: the relationship between dyslexia and schizophrenia. Med Hypotheses 45(6):605-613.
54. Huang YS, Horrobin DF (1987) Sex differences in n-3 and n-6 fatty acid metabolism in EFA-depleted rats. Proc Soc Exp Biol Med 185(3):291-296.
55. Innis SM (2005) Essential fatty acid transfer and fetal development. Placenta 26:S70-S75.
56. Jensen PS (2000) ADHD: current concepts on etiology, pathophysiology, and neurobiology. Child Adolesc Psychiatr Clin N Am 9(3):557-572.
57. Johnson M, Östlund S, Fransson G et al (2008) Omega-3/omega-6 fatty acids for attention deficit hyperactivity disorder: a randomized placebo-controlled trial in children and adolescents. J Atten Disord. doi:10.1177/1087054708316261.
58. Joshi K, Lad S, Kale M et al (2006) Supplementation with flax oil and vitamin C improves the outcome of attention deficit hyperactivity disorder (ADHD). Prostagland Leukotri Essen Fatty Acids 74:17-21.
59. Judge MP, Harel O, Lammi-Keefe CJ (2007) A docosahexaenoic acid-functional food during pregnancy benefits infant visual acuity at four but not six months of age. Lipids 42(2):117-122.
60. Jump DB (2002) Dietary polyunsaturated fatty acids and regulation of gene transcription. Curr Opin Lipidol 13(2):155-164.
61. Kamada T, Yamashita T, Baba Y et al (1986) Dietary sardine oil increases erythrocyte membrane fluidity in diabetic patients. Diabetes 35:604-611.
62. Kelley DS, Taylor PC, Nelson GJ et al (1999) Docosahexaenoic acid ingestion inhibits natural killer cell activity and production of inflammatory mediators in young healthy men. Lipids 34 (4):317-24.
63. Kim HY, Akbar M, Kim KY (2001) Inhibition of neuronal apoptosis by polyunsaturated fatty acids. J Mol Neurosci 16(2-3): 223-227.
64. Kim HY, Akbar M, Lau A (2003) Effects of docosapentaenoic acid on neuronal apoptosis. Lipids 38(4):453-457.
65. Kitajka K, Puskas LG, Zvara A et al (2002) The role of n-3 polyunsaturated fatty acids in brain: modulation of rat brain gene expression by dietary n-3 fatty acids. Proc Natl Acad Sci USA 99(5):2619-2624.
66. Kitajka K, Sinclair AJ, Weisinger RS (2004) Effects of dietary omega-3 polyunsaturated fatty acids on brain gene expression. Proc Natl Acad Sci USA 101(30):10931-10936.
67. Knickmeyer R, Baron-Cohen S, Raggatt P et al (2005) Foetal testosterone, social relationships, and restricted interests in children. J Child Psychol Psychiatry 46(2):198-210.
68. Knickmeyer RC, Baron-Cohen S (2006) Fetal testosterone and sex differences in typical social development and in autism. J Child Neurol 21(10):825-845.
69. Kodas E, Galineau L, Bodard S et al (2004) Serotoninergic neurotransmission is affected by n-3 polyunsaturated fatty acids in the rat. J Neurochem 89(3):695-702.
70. Kohlmeier L (1995) Future of dietary exposure assessment. Am J Clin Nutr 61(3 Suppl):702S-709S.
71. Koletzko B, Cetin I, Brenna JT et al (2007) Dietary fat intakes for pregnant and lactating women. Br J Nutr 98(5):873-877.
72. Koletzko B, Demmelmair H, Schaeffer L et al (2008) Genetically determined variation in polyunsaturated fatty acid metabolism may result in different dietary requirements. Nestle Nutr Workshop Ser Pediatr Program 62:35-49.
73. Koletzko B, Lien E, Agostoni C et al (2008) The roles of longchain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations. J Perinat Med 36(1):5-14.
74. Lee A (2001) Membrane structure. Curr Biol 11(20):R811-R814.
75. Litman BJ, Niu SL, Polozova A (2001) The role of docosahexaenoic acid containing phospholipids in modulating G protein-coupled signaling pathways: visual transduction. J Mol Neurosci 16:237-242.
76. Marra CA, de Alaniz MJ (1989) Influence of testosterone administration on the biosynthesis of unsaturated fatty acids in male and female rats. Lipids 24(12):1014-1019.
77. Martinez M (1992) Tissue levels of polyunsaturated fatty acids during early human development. J Pediatr 120(4 Pt 2):S129-S138.
78. Martinez M (1994) Polyunsaturated fatty acids in the developing human brain, red cells and plasma: influence of nutrition and peroxisomal disease. World Rev Nutr Diet 75:70-78.
79. Mirnikjoo B, Brown SE, Kim HF et al (2001) Protein kinase inhibition by omega-3 fatty acids. J Biol Chem 276(14):10888-10896.
80. Mitchell DC, Straume M, Litman BJ (1992) Role of sn-1-saturated, sn-2-polyunsaturated phospholipids in control of membrane receptor conformational equilibrium: effects of cholesterol and acyl chain unsaturation on the metarhodopsin I/metarhodopsin II equilibrium. Biochemistry 31:662-670.
81. Mitchell DC, Litman BJ (1998) Molecular order and dynamics in bilayers consisting of highly polyunsaturated phospholipids. Biophys J 74:879-891.
82. Mitchell DC, Niu SL, Litman BJ (2003) DHA-rich phospholipids optimize G-protein-coupled signaling. J Pediatr 143(4 Suppl):S80-S86.
83. Mitchell EA, Lewis S, Cutler DR (1983) Essential fatty acids and maladjusted behaviour in children. Prostaglandins Leukot Med 12(3):281-287.
84. Mitchell EA, Aman MG, Turbott SH et al (1987) Clinical characteristics and serum essential fatty acid levels in hyperactive children. Clin Pediatr (Phila) 26(8):406-411.
85. Nemets H, Nemets B, Apter A et al (2006) Omega-3 treatment of childhood depression: a controlled, double-blind pilot study. Am J Psychiatry 163(6):1098-1100.
86. Neuringer M, Connor WE, Van Petten C et al (1984) Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys. J Clin Invest 73(1):272-276.
87. Neuringer M, Connor WE, Lin DS et al (1986) Biochemical and functional effects of prenatal and postnatal omega 3 fatty acid deficiency on retina and brain in rhesus monkeys. Proc Natl Acad Sci USA 83(11):4021-4025.
88. Neuringer M, Reisbick S, Janowsky J (1994) The role of n-3 fatty acids in visual and cognitive development: current evidence and methods of assessment. J Pediatr 125(5 Pt 2):S39-S47.
89. Olsen SF, Secher NJ (2002) Low consumption of seafood in early pregnancy as a risk factor for preterm delivery: prospective cohort study. BMJ 324(7335):7447.
90. Orr SK, Bazinet RP (2008) The emerging role of docosahexaenoic acid in neuroinflammation. Curr Opin Investig Drugs 9 (7):735-743.
91. Pawlosky RJ, Hibbeln JR, Novotny JA et al (2001) Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans. J Lipid Res 42(8):1257-1265.
92. Peet M, Stokes C (2005) Omega-3 fatty acids in the treatment of psychiatric disorders. Drugs 65(8):1051-1059.
93. Polancyk G, de Lima M, Horta B et al (2007) The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry 164(6):942-948.
94. Posey DJ, McDougle CJ (2001) Pharmacotherapeutic management of autism. Expert Opin Pharmacother 2(4):587-600.
95. Rasmussen P, Gillberg C (2000) Natural outcome of ADHD with developmental coordination disorder at age 22 years: a controlled, longitudinal, community-based study. J Am Acad Child Adolesc Psychiatry 39(11):1424-1431.
96. Richardson AJ, Ross MA (2000) Fatty acid metabolism in neurodevelopmental disorder: a new perspective on associations between attention-deficit/ hyperactivity disorder, dyslexia, dyspraxia and the autistic spectrum. Prostaglandins Leukot Essent Fatty Acids 63(1-2):1-9.
97. Richardson AJ, Puri BK (2000) The potential role of fatty acids in attention-deficit/hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids 63(1-2):79-87.
98. Richardson AJ, Puri BK (2002) A randomized double-blind, placebocontrolled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties. Prog Neuropsychopharm Biol Psychiatry 26:233-239.
99. Richardson AJ (2004) Long-chain polyunsaturated fatty acids in childhood developmental and psychiatric disorders. Lipids 39 (12):1215-1222.
100. Richardson AJ, Montgomery P (2005) The Oxford-Durham study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder. Pediatrics 115(5):1360-1366.
101. Rojas CV, Martínez JI, Flores I et al (2003) Gene expression analysis in human fetal retinal explants treated with docosahexaenoic acid. Invest Ophthalmol Vis Sci 44(7):3170-3177.
102. Ross MA (2000) Could oxidative stress be a factor in neurodevelopmental disorders? Prostaglandins Leukot Essent Fatty Acids 63(1-2):61-63.
103. Ross BM, McKenzie I, Glen I et al (2003) Increased levels of ethane, a non-invasive marker of n-3 fatty acid oxidation, in breath of children with attention deficit hyperactivity disorder. Nutr Neurosci 6(5):277-281.
104. Rotstein NP, Politi LE, Aveldaño MI (1998) Docosahexaenoic acid promotes differentiation of developing photoreceptors in culture. Invest Ophthalmol Vis Sci 39(13):2750-2758.
105. Rowland AS, Lesesne CA, Abramowitz AJ (2002) The epidemiology of attention-deficit/hyperactivity disorder (ADHD): a public health view. Ment Retard Dev Disabil Res Rev 8(3):162-170.
106. Salem N Jr, Kim HY, Yergey JA (1986) Docosahexaenoic acid: membrane function and metabolism. In: Simopolous AP, Kifer RR, Martin RE (eds) Health effects of polyunsaturated fatty acids in seafoods. Academic, New York, pp 319-351.
107. Salem N Jr, Pawlosky R, Wegher B et al (1999) In vivo conversion of linoleic acid to arachidonic acid in human adults. Prostaglandins Leukot Essent Fatty Acids 60(5-6):407-410.
108. Salvati S, Natali F, Attorri L (2008) Eicosapentaenoic acid stimulates the expression of myelin proteins in rat brain. J Neurosci Res 86(4):776-784.
109. Scahill L, Schwab-Stone M (2000) Epidemiology of ADHD in school-age children. Child Adolesc Psychiatr ClinN Am 9 (3):541-555.
110. Schaeffer L, Gohlke H, Muller M et al (2006) Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Hum Mol Genet 15:1745-1756.
111. Schmitt B, Ströhle A, Watkinson BM et al (2002) Wirkstoffe funktioneller Lebensmittel in der Prävention der , Teil 2: ω-3-Fettsäuren-Versorgungssituation und Zufuhrempfehlung, Ernährungs-Umschau 49:223-229.
112. Schultz ST, Klonoff-Cohen HS, Wingard DL et al (2006) Breastfeeding, infant formula supplementation, and autistic disorder: the results of a patient survey. Int Breastfeed J 1:16.
113. Seung Kim HF, Weeber EJ, Sweatt JD et al (2001) Inhibitory effects of omega-3 fatty acids on protein kinase C activity in vitro. Mol Psychiatry 6(2):246-248.
114. Silver LB (2000) Attention-deficit/hyperactivity disorder in adult life. Child Adolesc Psychiatr Clin N Am 9(3):511-523.
115. Simopoulos AP (2002) The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother 56(8):365-379.
116. Sinclair HM (1990) Essential fatty acids: an historical perspective. Biochem Soc Trans 18:756-761.
117. Singer P (2000) Was sind, wie wirken ω-3-Fettsäuren? UZV-Verlag, Frankfurt am Main.
118. Sinn N, Bryan J (2007) Effect of supplementation with polyunsaturated fatty acids and micronutrients on learning and behaviour problems associated with child ADHD. J Dev Behav Pediatrics 28:82-91.
119. Song C, Manku MS, Horrobin DF (2008) Long-chain polyunsaturated fatty acids modulate interleukin-1beta-induced changes in behavior, monoaminergic neurotransmitters, and brain inflammation in rats. J Nutr 138(5):954-963.
120. Sorgi PJ, Hallowell EM, Hutchins HL et al (2007) Effects of an open-label pilot study with high-dose EPA/DHA concentrates on plasma phospholipids and behavior in children with attention deficit hyperactivity disorder. Nutr J 6:16.
121. Stevens LJ, Zentall SS, Deck JL et al (1995) Essential fatty acid metabolism in boys with attention-deficit hyperactivity disorder. Am J Clin Nutr 62(4):761-768.
122. Stevens LJ, Zentall SS, Abate ML et al (1996) Omega-3 fatty acids in boys with behavior, learning, and health problems. Physiol Behav 59(4-5):915-920.
123. Stevens L, Zhang W, Peck L et al (2003) EFA supplementation in children with inattention, hyperactivity, and other disruptive behaviors. Lipids 38(10):1007-1021.
124. Stillwell W, Wassall SR (2003) Docosahexaenoic acid: membrane properties of a unique fatty acid. Chem Phys Lipids 126 (1):1-27.
125. Ströhle A, Schmitt B, Hahn A (2002) Functional Foods-Eine übersicht zur aktuellen Situation. Journal für orthomolekulare Medizin 10:326-349.
126. Stubbs CD, Smith AD (1984) The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function. Biochim Biophys Acta 779 (1):89-137.
127. Tsukada H, Kakiuchi T, Fukumoto D et al (2000) Docosahexaenoic acid (DHA) improves the age-related impairment of the coupling mechanism between neuronal activation and functional cerebral blood flow response: a PETstudy in conscious monkeys. Brain Res 862(1-2):180-186.
128. Uauy R, Hoffman DR, Peirano P et al (2001) Essential fatty acids in visual and brain development. Lipids 36(9):885-895.
129. Uauy R, Dangour AD (2006) Nutrition in brain development and aging: role of essential fatty acids. Nutr Rev 64(5 Pt 2): S24-S33.
130. Vancassel S, Durand G, Barthelemy C et al (2001) Plasma fatty acid levels in autistic children. Prostaglandins Leukot Essent Fatty Acids 65(1):1-7.
131. Villa B, Calabresi L, Chiesa G et al (2002) Omega-3 fatty acid ethyl esters increase heart rate variability in patients with coronary disease. Pharmacol Res 45(6):475.
132. Voigt RG, Llorente AM, Jensen CL et al (2001) A randomized, double-blind, placebo-controlled trial of docosahexaenoic acid supplementation in children with attention-deficit/hyperactivity disorder. J Pediatr 139(2):189-196.
133. Wainwright PE (1997) Essential fatty acids and behaviour: is there a role for the eicosanoids? In: Yehuda S, Mostofsky DI (eds) Handbook of essential fatty acid biology: biochemistry, physiology and behavioral neurobiology. Humana, Totowa, NJ, pp 299-341.
134. Wainwright PE (2002) Dietary essential fatty acids and brain function: a developmental perspective on mechanisms. Proc Nutr Soc 61(1):61-69.
135. Wallis JG, Watts JL, Browse J (2002) Polyunsaturated fatty acid synthesis: what will they think of next? Trends Biochem Sci 27 (9):467.
136. Willatts P, Forsyth JS, DiModugno MK et al (1998) Effect of long-chain polyunsaturated fatty acids in infant formula on problem solving at 10 months of age. Lancet 352 (9129):688-691.
137. Ximenes da Silva SA, Lavialle F, Gendrot G et al (2002) Glucose transport and utilization are altered in the brain of rats deficient in n-3 polyunsaturated fatty acids. J Neurochem 81(6):1328-1337.
138. Yao J, Stanley JA, Reddy RD et al (2002) Correlations between peripheral polyunsaturated fatty acid content and in vivo membrane phospholipid metabolites. Biol Psychiatry 52(8):823-830.
139. Yehuda S, Rabinovitz S, Mostofsky DI (1999) Essential fatty acids are mediators of brain biochemistry and cognitive functions. J Neurosci Res 56(6):565-570.
140. Yoshida S, Sato A, Okuyama H (1998) Pathophysiological effects of dietary essential fatty acid balance on neural systems. Jpn J Pharmacol 77(1):11-22.
141. Young GS, Maharaj NJ, Conquer JA (2004) Blood phospholipid fatty acid analysis of adults with and without attention deficit/hyperactivity disorder. Lipids 39(2):117-123.
142. Zimmer L, Hembert S, Durand G et al (1998) Chronic n-3 polyunsaturated fatty acid diet-deficiency acts on dopamine metabolism in the rat frontal cortex: a microdialysis study. Neurosci Lett 240(3):177-181.
143. Zimmer L, Vancassel S, Cantagrel S et al (2002) The dopamine mesocorticolimbic pathway is affected by deficiency in n-3 polyunsaturated fatty acids. Am J Clin Nutr 75(4):662-667.