The Shark Strikes Twice: Hypervariable Loop 2 of Shark IgNAR Antibody Variable Domains and Its Potential to Function as an Autonomous Paratope

Marine Biotechnology

Volumn 17, Issue 4, 2015, Pages 386-392

  Zielonka, Stefan ^a   Empting, Martin ^b   Könning, Doreen ^a   Grzeschik, Julius ^a   Krah, Simon ^c   Becker, Stefan ^c   Dickgießer, Stephan ^a   Kolmar, Harald ^a  

^a DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c Merck Serono GmbH   (Germany)

Author keywords

Antibody engineering; Antibody technology; Antigen binding site; Heavy chain antibody; IgNAR; Shark; Single chain binding domain; Yeast surface display

Indexed keywords

ANTIGENS; CELL ADHESION; CHAINS; MOLECULES; YEAST;

ANTIBODY ENGINEERING; ANTIGEN-BINDING SITES; BINDING DOMAIN; HEAVY-CHAIN ANTIBODIES; IGNAR; SHARK; YEAST SURFACE DISPLAYS;

ANTIBODIES;

ANTIBODY; ANTIGEN; BIOENGINEERING; CELL ORGANELLE; CLONAL ORGANISM; MOLECULAR ANALYSIS; SHARK; TECHNOLOGICAL CHANGE; YEAST;

CHONDRICHTHYES;

IMMUNOGLOBULIN HEAVY CHAIN;

ANIMAL; ANTIBODY COMBINING SITE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; FLOW CYTOMETRY; GENE LIBRARY; GENETICS; HUMAN; IMMUNOLOGY; PROTEIN TERTIARY STRUCTURE; SHARK;

ANIMALS; BINDING SITES; BINDING SITES, ANTIBODY; FLOW CYTOMETRY; GENE LIBRARY; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; SHARKS;

EID: 84933675534     PISSN: 14362228     EISSN: 14362236     Source Type: Journal    
DOI: 10.1007/s10126-015-9642-z     Document Type: Article

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