Finding behavioral and network indicators of brain vulnerability

Frontiers in Human Neuroscience

Volumn , Issue FEBRUARY 2012, 2012, Pages

  Levit Binnun, Nava ^a   Golland, Yulia ^a  

^a INTERDISCIPLINARY CENTER   (Israel)

Author keywords

Psychopathology; Resilience; Secondary symptoms; Soft neurological signs; Systems neuroscience; Vulnerability; Vulnerability indicators; Vulnerability markers

Indexed keywords

ARTICLE; BEHAVIOR DISORDER; COPING BEHAVIOR; DISEASE ASSOCIATION; HUMAN; MENTAL DISEASE; MOTOR DYSFUNCTION; NERVE CELL NETWORK; NEUROSCIENCE; SENSORY DYSFUNCTION; SYMPTOMATOLOGY;

EID: 84933674945     PISSN: 16625161     EISSN: 16625161     Source Type: Journal    
DOI: 10.3389/fnhum.2012.00010     Document Type: Article

References (139)

1. Achard, S., Salvador, R., Whitcher, B., Suckling, J., and Bullmore, E. (2006). A resilient, low-frequency, small-world human brain functional network with highly connected association cortical hubs. J. Neurosci. 26, 63-72.
2. Admon, R., Lubin, G., Stern, O., Rosenberg, K., Sela, L., Ben-Ami, H., and Hendler, T. (2009). Human vulnerability to stress depends on amygdala's predisposition and hippocampal plasticity. Proc. Natl. Acad. Sci. U.S.A. 16, 14120-14125.
3. Alfano, C. A., and Kim, K. L. (2011). Objective sleep patterns and severity of symptoms in pediatric obsessive compulsive disorder: a pilot investigation. J. Anxiety Disord. 25, 835-839.
4. Amstadter, A. B. (2008). Emotion regulation and anxiety disorders. J. AnxietyDisord. 22,211-221.
5. Annoni, J. M., Beer, S., and Kesselring, J. (1992). Severe traumatic brain injury-epidemiology and outcome after 3 years. Disabil. Rehabil. 14, 23-26.
6. Arango, C., Kirkpatrick, B., and Buchanan, R. W. (2000). Neurological signs and the heterogeneity of schizophrenia. Am. J. Psychiatry 157, 560-565.
7. Asarnow, R. F., Brown, W., and Strandburg, R. (1995). Children with a schizophrenic disorder: neurobehavioral studies. Eur. Arch. Psychiatry Clin. Neurosci. 245, 70-79.
8. Ayres, A. J. (1978). Learning disabilities and the vestibular system. J. Learn. Disabil. 11, 30-41.
9. Balaban, C. D. (2002). Neural substrates linking balance control and anxiety. Physiol. Behav. 77, 469-475.
10. Baranek, G. T. (1999). Autism during infancy: a retrospective video analysis of sensory-motor and social behaviors at 9-12 months of age. J. Autism Dev. Disord. 29, 213-224.
11. Bassett, D. S., and Bullmore, E. (2006). Small-world brain networks. Neuroscientist 12, 512-523.
12. Bassett, D. S., Bullmore, E., Verchinski, B.A., Mattay, V. S., Weinberger, D. R., and Meyer-Lindenberg, A. (2008). Hierarchical organization of human cortical networks in health and schizophrenia. J. Neurosci. 28, 9239-9248.
13. Belmonte, M. K., Allen, K., Beckel-Mitchener, A., Boulanger, L. M., Carper, R. A., and Webb, S. J. (2004). Autism and abnormal development ofbrain connectivity. J. Neurosci. 24, 9228-9231.
14. Ben-Sasson, A., Carter, A. S., and Briggs-Gowan, M. J. (2009). Sensory over-responsivity in elementary school: prevalence and social-emotional correlates. J. Abnorm. Child Psychol. 37, 705-716.
15. Ben-Sasson, A., Cermak, S. A., Orsmond, G. I., Carter, A. S., Kadles, M. B., and Dunn, W. (2007). Extreme sensory modulation behaviors in toddlers with autism. Am. J. Occup. Ther. 61, 584-592.
16. Bhat, A. N., Landa, R. J., and Galloway, J. C. (2011). Current perspectives on motor functioning in infants, children, and adults with autism spectrum disorders. Phys. Ther. 91, 1116-1129.
17. Bombin, I., Arango, C., and Buchanan, R. W. (2005). Significance and meaning of neurological signs in schizophrenia: two decades later. Schizophr. Bull. 31, 962-977.
18. Bonanno, G. A. (2004). Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? Am. Psychol. 59, 20-28.
19. Breslau, N., Roth, T., Rosenthal, L., and Andreski, P. (1996). Sleep disturbance and psychiatric disorders: a longitudinal epidemiological study of young adults. Biol. Psychiatry 39, 411-418.
20. Brookes, R. L., Tinkler, S., Nicolson, R. I. and Fawcett, A. J. (2010). Striking the right balance: motor difficulties in children and adults with dyslexia. Dyslexia 16, 358-373.
21. Brown, C., Cromwell, R. L., Filion, D., Dunn, W., and Tollefson, N. (2002). Sensory processing in schizophrenia: missing and avoiding information. Schizophr. Res. 55, 187-195.
22. Brown, S., Shankar, R., and Smith, K. (2009). Borderline personality disorder and sensory processing impairment. Prog. Neurol. Psychiatry 13, 10-16.
23. Bryson, S. E., Zwaigenbaum, L., Brian, J., Roberts, W., Szatmari, P., Rombough, V., and McDermott, C. (2007). A prospective case series of high-risk infants who developed autism. J. Autism Dev. Disord. 37, 12-24.
24. Carton, S., Morand, P., Bungenera, C., and Jouvent, R. (1995). Sensation seeking and emotional disturbances in depression: relationship and evolution. J. Affect. Disord. 34, 219-225.
25. Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., and Poulton, R. (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301, 386-389.
26. Castellanos, F. X., Margulies, D. S., Kelly, A. M. C., Uddin, L. Q., Ghaffari, M., Kirsch, A., Shaw, D., Shehzad, Z., Martino, A. D., Biswal, B., Sonuga-Barke, E. J., Rotrosen, J., Adler, L. A., and Milham, M. P. (2008). Cingulate- precuneus interactions: a new locus of dysfunction in adult attention- deficit/hyperactivity disorder. Biol. Psychiatry 63, 332-337.
27. Chan, R. C. K., Wang, Y., Wang, L., Chen, E. Y. H., Manschreck, T.C., Li, Z. J., Yu, X., and Gong, Q. Y. (2009). Neurological soft signs and their relationships to neurocognitive functions: a revisit with the structural equation modeling design. PLoS One 4, e8469. doi: 10.1371/journal.pone. 0008469
28. Chan, R. C. K., Xu, T., Heinrichs, R. W., Yu, Y., and Wang, Y. (2010a). Neurological soft signs in schizophrenia: a meta-analysis. Schizophr. Bull. 36, 1089-1104.
29. Chan, R. C., Xu, T., Heinrichs, R. W., Yu, Y., and Gong, Q. Y. (2010b). Neurological soft signs in non- psychotic first-degree relatives of patients with schizophrenia: a systematic review and metaanalysis. Neurosci. Biobehav. Rev. 34, 889-896.
30. Chan, R. C., Xu, T., Li, H. J., Zhao, Q., Liu, H. H., Wang, Y., Yan, C., Cao, X. Y., Wang, Y. N., and Shi, Y. F.(2011). Neurological abnormalities and neurocognitive functions in healthy elder people: a structural equation modeling analysis. Behav. Brain Funct. 10, 7-32.
31. Charney, D. S. (2004). Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress. Am. J. Psychiatry 161, 195-216.
32. Cicchetti, D. (2010). Resilience under conditions of extreme stress: a multilevel perspective. World Psychiatry 9, 145-154.
33. Dar, R., Kahn, D. T., and Carmeli, R. (2012). The relationship between sensory processing, childhood rituals and obsessive compulsive symptoms. J. Behav. Ther. Exp. Psychiatry 43, 679-684.
34. Davidson, R. J. (2000). Affective style, psychopathology, and resilience: brain mechanisms and plasticity. Am. Psychol. 55, 1196-1214.
35. Davis, A. S., Pass, L. A., Finch, W. H., Dean, R. S., and Woodcock, R. W. (2009). The canonical relationship between sensory-motor functioning and cognitive processing in children with attention-deficit/hyperactivity disorder. Arch. Clin. Neuropsychol. 24, 273-286.
36. Dazzan, P., Morgan, K. D., Chitnis, X., Suckling, J., Morgan, C., Fearon, P., McGuire, P. K., Jones, P. B., Leff, J., and Murray, R. M. (2006). The structural brain correlates of neurological soft signs in healthy individuals. Cereb. Cortex 16, 1225-1231.
37. Dazzan, P., Morgan, K. D., Orr, K.G., Hutchinson, G., Chitnis, X., Suckling, J., Fearon, P., Salvo, J., McGuire, P. K., Mallett, R. M., Jones, P. B., Leff, J., and Murray, R.M. (2004). The structural brain correlates of neurological soft signs in ^SOP first-episode psychoses study. Brain 127, 143-153.
38. Dazzan, P., Soulsby, B., Mechelli, A., Wood, S. J., Velakoulis, D., Phillips, L. J., Yung, A. R., Chitnis, X., Lin, A., Murray, R. M., McGorry, P., McGuire, P. K., and Pantelis, C. (2011).Volumetric abnormalities predating the onset of schizophrenia and affective psychoses: an MRI study in D. subjects at ultrahigh risk of psychosis. Schizophr. Bull. (Epub ahead of print).
39. DeGangi, G. A., Breinbauer, C., Doussard-Roosevelt, J., Porges, S., and Greenspan, S. I. (2000). Prediction of childhood problems at three years in children experiencing disorders of regulation during infancy. Infant Ment. Health J. 21, 156-175.
40. DeGangi, G. A., Porges, S. W., Sickel, R. Z., and Greenspan, S. T. (1993). Four year follow up of a sample of regulatory disordered infants. Infant Ment. Health J. 14, 330-343.
41. DeGangi, G. A., and Greenspan, S. I. (1988). The development of sensory functions in infants. Phys. Occup. Ther. Pediatr. 8, 21-33.
42. DeSantis, A. M., Coster, W. J., Bigsby, R., and Lester, B. M. (2004). Colic and fussing in infancy and sensory processing at 3-8 years of age. Infant Ment. Health J. 25, 522-539.
43. DeYoung, C. G., Cicchetti, D., and Rogosch, F. A. (2011). Moderation of the association between childhood maltreatment and neuroticism by the corticotropin-releasing hormone receptor 1 gene. J. Child Psychol. Psychiatry 52, 898-906.
44. Dosenbach, N. U. F., Fair, D. A., Cohen, A. L., Schlaggar, B. L., and Petersen, S. E. (2008). A dual-networks architecture of top-down control. Trends Cogn. Sci. 12, 99-105.
45. Emck, C., Bosscher, R., Beek, P., and Doreleijers, T. (2009). Gross motor performance and self-perceived motor competence in children with emotional, behavioral, and pervasive developmental disorders: a review. Dev. Med. Child Neurol. 51, 501-517.
46. Engel-Yeger, B., and Dunn, W. (2011). The relationship between sensory processing difficulties and anxiety level of healthy adults. Br. J. Occup. Ther. 74,210-216.
47. Erez, O., Gordon, C. R., Sever, J., Sadeh, A., and Mintz, M. (2004). Balance dysfunction in childhood anxiety: findings and theoretical approach. J. Anxiety Disord. 18,341-356.
48. Fellick, J. M., Thomson, A. P., Sills, J., and Hart, C. A. (2001). Neurological soft signs in mainstream pupils. Arch. Dis. Child. 85, 371-374.
49. Fish, B., and Dixon, W. J. (1978). Vestibular hyporeactivity in infants at risk for schizophrenia: association with critical developmental disorders. Arch. Gen. Psychiatry 5, 963-971.
50. Fournier, K. A., Hass, C. J., Naik, S. K., Lodha, N., and Cauraugh, J. H. (2010). Motor coordination in autism spectrum disorders: a synthesis and meta-analysis. J. Autism Dev. Disord. 40, 1227-1240.
51. Galvin, J., Froude, E. H., and Imms, C. (2009). Sensory processing abilities of children who have sustained traumatic brain injuries. Am. J. Occup. Ther. 63,701-709.
52. Goldsmith, H. H., Van Hulle, C. A., Arneson, C. L., Schreiber, J. E., and Gernsbacher, M. A. (2006). A population-based twin study of parentally reported tactile and auditory defensiveness in young children. J. Abnorm. Child Psychol. 34, 393-407.
53. Gomez, C. R., and Baird, S. (2005). Identifying early indicators for autism in self-regulation difficulties. Focus Autism Other Dev. Disabl. 20, 106-116.
54. Gottesman, I. I., and Gould, T. D. (2003). The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry 160, 636-645.
55. Gouze, K. R., Hopkins, J., LeBailly, A., and Lavigne, J. V. (2009). Reexamining the epidemiology of sensory regulation dysfunction and comorbid psychopathology. J. Abnorm. Child Psychol. 37, 1077-1087.
56. Gregory, A. M., and O'Connor, T. G. (2002). Sleep problems in childhood: a longitudinal study of developmental change and association with behavioral problems. J. Am. Acad. Child Adolesc. Psychiatry 41, 964-971.
57. Gurvits, T. V., Metzger, L. J., Lasko, N. B., Cannistraro, P. A., Tarhan, A. S., Gilbertson, M. K., Orr, S. P., Charbonneau, A. M., Wedig, M. M., and Pitman, K. R. (2006). Subtle neurologic compromise as a vulnerability factor for combat- related posttraumatic stress disorder. Arch. Gen. Psychiatry 63, 571-576.
58. Haglund, M. E. M., Nestadt, P. S., Cooper, N. S., Southwick, S. M., and Charney, D. S. (2007). Psychobiological mechanisms of resilience: relevance to prevention and treatment of stress-related psychopathology. Dev. Psychopathol 19, 889-920.
59. Heinrichs, M., Wagner, D., Schoch, W., Soravia, L. M., Hellhammer, D. H., and Ehlert, U. (2005). Predicting posttraumatic stress symptoms from pretraumatic risk factors: a 2-year prospective follow-up study in firefighters. Am. J. Psychiatry 162, 2276-2286.
60. Heuser, M., Thomann, P. A., Essig, M., Bachmann, S., and Schroder, J. (2011). Neurological signs and morphological cerebral changes in schizophrenia: an analysis of NSS subscales in patients with first episode psychosis. Psychiatry Res. 192, 69-76.
61. Hofmann, S. G., and Bitran, S. (2007). Sensory-processing sensitivity in social anxiety disorder: relationship to harm avoidance and diagnostic subtype. J. Anxiety Disord. 21, 944-954.
62. Insel, T. R., Gillin, J. C., Moore, A., Mendelson, W. B., Loewenstein, R. J., and Murphy, D. L. (1982). The sleep of patients with obsessive- compulsive disorder. Arch. Gen. Psychiatry39, 1372-1377.
63. Ivanenko, A., and Johnson, K. (2008). Sleep disturbances in children with psychiatric disorders. Semin. Pediatr. Neurol. 15, 70-78.
64. Jaegermann, N., and Klein, P. S. (2010). Enhancing mothers' interactions with toddlers who have sensory- processing disorders. Infant Ment. Health J. 31,291-311.
65. Janssen, J., Diaz-Caneja, A., Reig, S., Bombin, I., Mayoral, M., Parellada, M., Graell, M., Moreno, D., Zabala, A., Vazquez, V. G., Desco, M., and Arango, C. (2009). Brain morphology and neurological soft signs in adolescents with first-episode psychosis. Br. J. Psychiatry 195, 227-233.
66. Javitt, D. C. (2009). Sensory processing in schizophrenia: neither simple nor intact. Schizophr. Bull. 35, 1059-1064.
67. Jones, V., and Prior, M. (1985). Motor imitation abilities and neurological signs in autistic children. J. Autism Dev. Disord. 15, 37-46.
68. Just, M. A., Cherkassky, V. L., Keller, T. A., Kana, R. K., and Minshew, N. J. (2007). Functional and anatomical cortical under connectivity in autism: evidence from an fMRI study of an executive function task and corpus callosum morphometry. Cereb. Cortex 17, 951-961.
69. Karadag, F., Tumkaya, S., Kirtas, D., Efe, M., Alacam, H., and Oguzhanoglu, N. K. (2011). Neurological soft signs in obsessive compulsive disorder with good and poor insight. Prog. Neuropsychopharmacol. Biol. Psychiatry 35, 1074-1079.
70. Kempton, M. J., Haldane, M., Jogia, J., Grasby, P. M., Collier, D., and Frangou, S. (2009). Dissociable brain structural changes associated with predisposition, resilience, and disease expression in bipolar disorder. J. Neurosci. 29, 10863-10868.
71. Kinnealey, M., and Fuiek, M. (1999). The relationship between sensory defensiveness, anxiety, depression and perception of pain in adults. Occup. Ther. Int. 6, 195-206.
72. Kitano, H. (2004). Biological robustness. Nat. Rev. Genet. 5, 826-837.
73. Klein, P. S., Laish-Mishali, R., and Jaegermann, N. (2008). Differential treatment of toddlers with sensory processing disorders in relation to their temperament and sensorypro- file. J. Dev. Process. 3, 52-29.
74. Koenen, K. C. (2006). Developmental epidemiology of PTSD self regulation as a central mechanism. Ann. N.Y. Acad. Sci. 1071, 255-266.
75. Kremen, W. S., Koenen, K. C., Afari, N., and Lyons, M. J. (2012). Twin studies of posttraumatic stress disorder: differentiating vulnerability factors from sequelae. Neuropharmacology 62, 647-653.
76. Kroes, M., Kessels, A. G. H., Kalff, A.C., Feron, F. J. M., Vissers, Y. L. J., Jolles, J., and Vles, J. S. H. (2002). Quality of movement as predictor of ADHD: results from a prospective population study in 5- and 6- year old children. Dev. Med. Child Neurol. 44, 753-760.
77. Lauer, C. J., Schreiber, W., Holsboer, F., and Krieg, J. C. (1995). In quest of identifying vulnerability markers for psychiatric disorders by allnight polysomnography. Arch. Gen. Psychiatry 52, 145-153.
78. Leekam, S. R., Nieto, N., Libby, S. J., Wing, L., and Gould, J. (2007). Describing the sensory abnormalities of children and adults with autism. J. Autism Dev. Disord. 37, 894-910.
79. Levinson, H. N. (1988). The cerebellar- vestibular basis of learning disabilities in children, adolescents and adults: hypothesis and study. Percept. Mot. Skills 67, 983-1006.
80. Levit-Binnun, N., Handzy, N. Z., Moses, E., Modai, I., and Peled, A. (2007). Transcranial magnetic stimulation at M1 disrupts cognitive networks in schizophrenia. Schizophr. Res. 93, 334-344.
81. Lewis, M. D., Granic, I., LAmm, C., Zelazo, P. D., Stieben, J., Todd, R. M., Moadab, I., and Pepler, D. (2008). Changes in neural bases of emotion regulation associated with clinical improvement in children with behavior problems. Dev. Psychopathol. 20, 913-939.
82. Liss, M., Mailloux, J., and Erchull, M. J. (2008). The relationships between sensory processing sensitivity, alexithymia, autism, depression and anxiety. Pers. Individ. Dif. 45,255-259.
83. Liss, M., Saulnier, C., Fein, D., and Kinsbourne, M. (2006). Sensory and attention abnormalities in autistic spectrum disorders. Autism 10, 155-172.
84. Liss, M., Timmel, L., Baxley, K., and Killingsworth, P. (2005). Sensory processing sensitivity and its relation to parental bonding, anxiety, and depression. Pers. Individ. Dif. 39, 1429-1439.
85. Mangeot, S. D., Miller, L. I., Mclntosh, D. N., McGrath-Clarke, J., Simon, J., Hagerman, R. L., and Goldson, E.(2001). Sensory modulation dysfunction in children with attention deficit hyperactivity disorder. Dev. Med. Child Neurol. 43, 399-406.
86. Manschreck, T. C., Maher, B. A., Waller, N. G., Ames, D., and Latham, C. A. (1985). Deficient motor synchrony in schizophrenic disorder: clinical correlates. Biol. Psychiatry 20, 990-1002.
87. Masten, A. S. (2001). Ordinary magic: resilience processes in development. Am. Psychol. 56, 227-238.
88. Masten, A. S. (2006). Developmental psychopathology: pathways to the future. Int. J. Behav. Dev. 30, 47-54.
89. McFarlane, A. C., Weber, D. L., and Clark, C. R. (1993). Abnormal stimulus processing in posttraumatic stress disorder. Biol. Psychiatry 34, 311-320.
90. Menon, V. (2011). Large-scale brain networks and psychopathology: a unifying triple network model. Trends Cogn. Sci. 15, 483-506.
91. Meyer, B., Ajchenbrenner, M., and Bowles, D. P. (2005). Sensory sensitivity, attachment experiences, and rejection responses among adults with borderline and avoidant features. J. Pers. Disord. 19, 641-658.
92. Meyer, B., and Caver, C. S. (2000). Negative childhood accounts, sensitivity, and pessimism: a study of avoidant personality disorder features in college students. J. Pers. Disord. 14, 233-248.
93. Mittal, V. A., Tessner, K. D., Trottman, H. D., Esterberg, M., Dhruv, S. H., Simeonova, D. I., McMillan, A. L., Murphy, E., Saczawa, M. E., and Walker, E. F. (2007). Movement abnormalities and the progression of prodromal symptomatology in adolescents at risk for psychotic disorder. J. Abnorm. Psychol. 2, 260-226.
94. Modell, S., Ising, M., Holsboer, F., and Lauer, C. J. (2005). The Munich vulnerability study on affective disorders: premorbid polysomnographic profile of affected high-risk probands. Biol. Psychiatry 58, 694-699.
95. Neal, J., Edelmann, R. J., and Glachan, M. (2002). Behavioral inhibition and symptoms of anxiety and depression: is there a specific relationship with social phobia? Br. J. Clin. Psychol. 41, 361-374.
96. Neelam, K., Garg, D., and Marshall, M. (2011). A systematic review and meta-analysis of neurological soft signs in relatives of people with schizophrenia. BMC Psychiatry 11, 139-146.
97. Negash, A., Kebede, D., Alem, A., Melaku, Z., Deyessa, N., Shibire, T., Fekadu, A., Fekadu, D., Jacobsson, L., and Kullgren, G. (2004). Neurological soft signs in bipolar I disorder patients. J. Affect. Disord. 80, 221-230.
98. Neumann, C. S., and Walker, E. F. (2003). Neuromotor functioning in adolescents with schizotypal personality disorder: associations with symptoms and neurocognition. Schizophr. Bull. 29, 285-298.
99. Ong, S. H., Wickramaratne, P., Tang, M., and Weissman, M. M. (2006). Early childhood sleep and eating problems as predictors of adolescent and adult mood and anxiety disorders. J. Affect. Disord. 96, 1-8.
100. Ornitz, E. M. (1974). The modulation of sensory input and motor output in autistic children. J. Autism Child. Schizophr. 4, 197-215.
101. Owens, J. A., Maxim, R., Nobile, C., McGuinn, M., and Msall, M. (2002). Parental and self-report of sleep in children with attention- deficit/hyperactivity disorder. Arch. Pediatr. Adolesc. Med. 154, 549-555.
102. Ozonoff, S., Young, G. S., Goldring, S., Greiss-Hess, L., Herrera, A. M., Steele, J., Macari, S., Hepburn, S. and Rogers, S. J. (2008). Gross motor development, movement abnormalities, and early identification of autism. J. Autism Dev. Disord. 38, 644-656.
103. Parush, S., Sohmer, H., Strinberg, A., and Kaitz, M. (2007). Somatosensory function in boys with ADHD and tactile defensiveness. Physiol. Behav. 90, 553-558.
104. Piazza, C. C., Fisher, W. F., and Kahng, S. W. (1996). Sleep patterns in children and young adults with mental retardation and severe behavior disorders. Dev. Med. Child Neurol. 38, 335-344.
105. Piek, J. P., Bradbury, G. S., Elsley, S. C., and Tate, L. (2008). Motor coordination and social-emotional behaviour in preschool aged children. Int. J. Disabil. Dev. Educ. 55, 143-151.
106. Piek, J. P., Pitcher, T. M., and Hay, D. A. (1999). Motor coordination and kinaesthesis in boys with attention deficit hyperactivity disorder. Dev. Med. Child Neurol. 41, 159-165.
107. Pievani, M., de Haan, W., Wu, T., Seeley, W. W., and Frisoni, G. B. (2011). Functional network disruption in the degenerative dementias. Lancet Neurol. 10, 829-843.
108. Pine, D., Shaffer, D., and Schonfeld, I. S. (1993). Persistent emotional disorder in children with neurological soft signs. J. Am. Acad. Child Adolesc. Psychiatry 32, 1229-1236.
109. Quiros, J. B. (1976). Diagnosis of vestibular disorders in the learning disabled. J. Learn. Disabil. 9, 50-58.
110. Reynolds, S., and Lane, S. J. (2008). Diagnosis validity of sensory over- responsivity: a review of the literature and case reports. J. Autism Dev. Disord. 38, 516-529.
111. Richdale, A. L., and Schreck, K. A. (2009). Sleep problems in autism spectrum disorders: prevalence, nature and possible biopsychosocial aetiologies. Sleep Med. Rev. 13, 403-411.
112. Rogers, S. J. (2009). What are infant siblings teaching us about autism in infancy? Autism Res. 2, 125-137.
113. Sanders, R. E., and Keshavan, M. S. (1998). The neurologic examination in adult psychiatry: From soft signs to hard science. J. Neuropsychiatr. 10, 395-404.
114. Sakar, S., Katshu, M. Z., Nizamie, S. H., and Praharaj, S. K. (2010). Slow wave sleep deficits as a trait marker in patients with schizophrenia. Schizophr. Res. 124, 127-133.
115. Sanz-Arigita, E. J., Schoonheim, M. M., Damoiseaux, J. S., Rombouts, S. A. R. B., Maris, E., Barkhof, F., Scheltens, P., and Stam, C. J. (2010). Loss of "small-world" networks in Alzheimer's disease: graph analysis of fMRI resting-state functional connectivity. PLoS One 5, e13788. doi: 10.1371/journal.pone.0013788
116. Schiffman, J., Sorensen, H., Maeda, J., Mrtensen, E. L., Victoroff, J., Hayashi, K., Michelsen, N. M., Ekstorom, M., and Mednick, S. (2009). Childhood motor coordination and adult schizophrenia spectrum disorder. Am. J. Psychiatry 166, 1041-1047.
117. Schreck, K. A., Williams, K., and Smith, A. F. (2004). A comparison of eating behaviors between children with and without autism. J. Autism Dev. Disord. 34, 433-438.
118. Seidl, U., Thomann, P. A., and Schroder, J. (2009). Neurological soft signs in nursing home residents with Alzheimer's disease. J. Alzheimers Dis. 18, 525-532.
119. Shaffer, D., Schonfeld, I., O'Connor, P. A., Stokman, C., Trautman, P., Shafer, S., and Ng, S. (1985). Neurological soft signs: their relationship to psychiatric disorder and intelligence in childhood and adolescence. Arch. Gen. Psychiatry 42, 342-351.
120. Shefer, S., Gordon, C., Avraham, K. B., and Mintz, M. (2010). Progressive vestibular mutation lead to elevated anxiety. Brain Res. 1317, 157-164.
121. Shochat, T., Tzischinsky, O., and Engel- Yeger, B. (2009). Sensory hypersensitivity as a contributing factor in the relation between sleep and behavioral disorders in normal school children. Behav. Sleep Med. 7, 53-62.
122. Sporns, O. (2010). Networks of the Brain. Cambridge, MA: MIT Press.
123. Stam, C. J., de Haan, W., Daffertshofer, A., Jones, B. F., Manshanden, I., van Cappellen Walsum, A. M., Montez, T., Verbunt, J. P. A., de Munck, J. C., van Dijk, B. W., Berendse, H. W., and Scheltens, P.(2009). Graph theoretical analysis of magnetoencephalographic functional connectivity in Alzheimer's disease. Brain 132, 213-224.
124. Stam, C. J., Jones, B. F., Nolte, G., Breakspear, M., and Scheltens, P. (2007). Small-world networks and functional connectivity in Alzheimer's disease. Cereb. Cortex 17, 92-99.
125. Steinberg, M., and Rendle-Short, J. (1977). Vestibular dysfunction in young children with minor neurological impairment. Dev. Med. Child Neurol. 19, 639-651.
126. Supekar, K., Menon, V., Rubin, D., Musen, M., and Greicius, M. D. (2008). Network analysis of intrinsic functional brain connectivity in Alzheimer's disease. PLoS Comput. Biol. 4, e1000100. doi: 10.1371/jour- nal.pcbi.1000100
127. Tani, P., Lindberg, N., appelberg, B., Nieninen-von Wendt, T., von- Wendt, L., and Porkka-Hieskanen, T. (2006). Clinical neurological abnormalities in young adults with Asperger. Psychiatry Clin. Neurosci. 60, 253-255.
128. Thomann, P. A., Wustenberg, T., Santos, V. D., Bachmann, S., Essig, M., and Schroder, J. (2009). Neurological soft signs and brain morphology in first-episode schizophrenia. Psychol. Med. 39, 371-379.
129. Udal, A. H., Malt, U. F., Lovdahl, H., Gjaerum, B., Pripp, A. H., and Groholt, B. (2009). Motor function may differentiate attention deficit hyperactivity disorder from early onset bipolar disorder. Behav. Brain Funct. 5, 47-57.
130. Van den Heuvel, M. P., Mandl, R. C. W., Stam, C. J., Kahn, R. S., and HulshoffPol, H. E. (2010).Aberrant frontal and temporal complex network structure in schizophrenia: a graph theoretical analysis. J. Neurosci. 30, 15915-15925.
131. Vialou, V., Robison, A. J., LaPlant, Q. C., Covington, H. E., Dietz, D. M., Ohnishi, Y. N., Mouzon, E., Rush, A. J., Watts, E. L., Wallace, DL., Iniguez, S. D., Ohnishi, Y. H., Steiner, M. A., Warren, B. L., Krishnan, V., Bolanos, C. A., Neve, R. L., Ghoes, S., Berton, O., Tamminga, C. A., and Nestler, E. J. (2010). AFosB in brain reward circuits mediates resilience to stress and antidepressant responses. Nat. Neurosci. 13, 745-752.
132. Viholainen, H., Ahonen, T., Lyytinen, P., Cantell, M., olvanen, A., and Lyytinen, H. (2006). Early motor development and later language and reading skills in children at risk of familial dyslexia. Dev. Med. Child Neurol. 48, 367-373.
133. Walker, E. F., Lewis, N., Loewy, R., and Palyo, S. (1999). Motor dysfunction and risk for schizophrenia. Dev. Psychopathol. 11, 509-523.
134. Wang, G., Grone, B., Colas, D., Appelbaum, L., and Mourrain, P. (2011). Synaptic plasticity in sleep: learning, homeostasis and disease. Trends Neurosci. 34, 452-463.
135. Wang, L., Zhu, C., He, Y., Zang, Y., Cao, Q., Zhang, H., Zhong, Q., and Wang, Y. (2009). Altered small-world brain functional networks in children with attention deficit/hyperactivity disorder. Hum. Brain Mapp. 30, 638-649.
136. Wen, W., He, Y., and Sachdev, P. (2011). Structural brain networks and neuropsychiatric disorders. Curr. Opin. Psychiatry 24, 219-225.
137. Yao, Z., Zhang, Y., Lin, L., Zhou, Y., Xu, C., and Jiang, T. (2010). Abnormal cortical networks in mild cognitive impairment and Alzheimer's disease. PLoS Comput. Biol. 6, e1001006. doi: 10.1371/journal.pcbi.1001006
138. Yesavage, J. A., Friedman, L., Kraemer, H, Tinklenberg, J. R., Salehi, A., Noda, A., Taylor, J. L., O'Hara, R., and Murphy, G. (2004). Sleep/wake disruption in Alzheimer's disease: APOE status and longitudinal course. J. Geriatr. Psychiatry Neurol. 17, 20-24.
139. Yochman, A., Parush, S., and Ornoy, A. (2004). Responses of preschool children with and without ADHD to sensory events in daily life. Am. J. Occup. Ther. 58, 294-302.