A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells

Science

Volumn 348, Issue 6241, 2015, Pages

  Stary, Georg ^a   Olive, Andrew ^a   Radovic Moreno, Aleksandar F ^b,c   Gondek, David ^a   Alvarez, David ^a   Basto, Pamela A ^b,c   Perro, Mario ^a   Vrbanac, Vladimir D ^d   Tager, Andrew M ^d   Shi, Jinjun ^f   Yethon, Jeremy A ^e   Farokhzad, Omid C ^f,g   Langer, Robert ^b,c   Starnbach, Michael N ^a   Von Andrian, Ulrich H ^a,h  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^c Massachusetts Institute of Technology Cambridge   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e SANOFI PASTEUR   (France)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

^g KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^h MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL VACCINE; INACTIVATED VACCINE; INTERLEUKIN 12; ALPHA E INTEGRINS; ALPHA INTEGRIN; CD11 ANTIGEN; IMMUNOLOGICAL ADJUVANT; LEUKOCYTE ANTIGEN; NANOPARTICLE;

BACTERIUM; CYTOLOGY; IMMUNITY; IMMUNIZATION; INFECTIOUS DISEASE; MEMORY; VACCINATION; VACCINE;

ACIDIFICATION; ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL LOAD; BACTERIUM CONJUGATION; BACTERIUM DETECTION; CD4+ T LYMPHOCYTE; CHLAMYDIA TRACHOMATIS; CHLAMYDIASIS; CONTROLLED STUDY; DENDRITIC CELL; ENDOMETRIUM; FEMALE; IMMUNOGENICITY; INFECTION PREVENTION; MEMORY CELL; MEMORY T LYMPHOCYTE; MOUSE; MUCOSAL DRUG ADMINISTRATION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTON TRANSPORT; REGULATORY T LYMPHOCYTE; TH1 CELL; ULTRAVIOLET RADIATION; VACCINATION; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CD8+ T LYMPHOCYTE; CHLAMYDIA INFECTIONS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; MUCOSA; PROCEDURES; RADIATION RESPONSE; T LYMPHOCYTE SUBPOPULATION; UTERUS;

CHLAMYDIA TRACHOMATIS; MUS;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGENS, CD; ANTIGENS, CD11; BACTERIAL VACCINES; CD8-POSITIVE T-LYMPHOCYTES; CHLAMYDIA INFECTIONS; CHLAMYDIA TRACHOMATIS; DENDRITIC CELLS; FEMALE; IMMUNOLOGIC MEMORY; INTEGRIN ALPHA CHAINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MUCOUS MEMBRANE; NANOPARTICLES; T-LYMPHOCYTE SUBSETS; TH1 CELLS; ULTRAVIOLET RAYS; UTERUS; VACCINATION; VACCINES, INACTIVATED;

EID: 84933564632     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaa8205     Document Type: Article

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