Regulation of β-adrenergic receptor trafficking and lung microvascular endothelial cell permeability by Rab5 GTPase

International Journal of Biological Sciences

Volumn 11, Issue 8, 2015, Pages 868-878

  Yang, Junjun ^a   Sun, Huan ^a,c   Zhang, Jihang ^a   Hu, Mingdong ^a   Wang, Jianchun ^a   Wu, Guangyu ^b   Wang, Guansong ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c MIANYANG CENTRAL HOSPITAL   (China)

Author keywords

Internalization; Lipopolysaccharide; Lung; Microvascular endothelial cell; Permeability; Rab5; Small interfering RNA; Trafficking; adrenergic receptor

Indexed keywords

BETA ADRENERGIC RECEPTOR; LIPOPOLYSACCHARIDE; RAB PROTEIN;

ANIMAL; CELL CULTURE; CYTOLOGY; LUNG; MALE; METABOLISM; PROTEIN TRANSPORT; RAT; SPRAGUE DAWLEY RAT; VASCULAR ENDOTHELIUM; VASCULARIZATION;

ANIMALS; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; LIPOPOLYSACCHARIDES; LUNG; MALE; PROTEIN TRANSPORT; RAB5 GTP-BINDING PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA;

EID: 84933533779     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.12045     Document Type: Article

References (41)

1. Wang CY, Calfee CS, Paul DW, et al. One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome. Intensive Care Med. 2014; 40: 388-96.
2. Matthay MA, Zemans RL. The acute respiratory distress syndrome: pathogenesis and treatment. Annu Rev Pathol. 2011; 6: 147-63.
3. Gonzales JN, Gorshkov B, Varn MN, et al. Protective effect of adenosine receptors against lipopolysaccharide-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2014; 306: L497-507.
4. Calvert JW, Lefer DJ. Role of beta-adrenergic receptors and nitric oxide signaling in exercise-mediated cardioprotection. Physiology (Bethesda). 2013; 28: 216-24.
5. Roth Flach RJ, Matevossian A, Akie TE, et al. beta3-Adrenergic receptor stimulation induces E-selectin-mediated adipose tissue inflammation. J Biol Chem. 2013; 288: 2882-92.
6. Yu JT, Wang ND, Ma T, et al. Roles of beta-adrenergic receptors in Alzheimer's disease: implications for novel therapeutics. Brain Res Bull. 2011; 84: 111-7.
7. Guimaraes S, Moura D. Vascular adrenoceptors: an update. Pharmacol Rev. 2001; 53: 319-56.
8. Namiecinska M, Wiktorowska-Owczarek A, Loboda A, et al. Cyclic AMP generating system in human microvascular endothelium is highly responsive to adrenaline. Pharmacol Rep. 2006; 58: 884-9.
9. Stohl LL, Zang JB, Ding W, et al. Norepinephrine and adenosine-5'-triphosphate synergize in inducing IL-6 production by human dermal microvascular endothelial cells. Cytokine. 2013; 64: 605-12.
10. Li Y, Wang G, Lin K, et al. Rab1 GTPase promotes expression of beta-adrenergic receptors in rat pulmonary microvascular endothelial cells. Int J Biochem Cell Biol. 2010; 42: 1201-9.
11. Olkkonen VM, Stenmark H. Role of Rab GTPases in membrane traffic. Int Rev Cytol. 1997; 176: 1-85.
12. Mizuno-Yamasaki E, Rivera-Molina F, Novick P. GTPase networks in membrane traffic. Annu Rev Biochem. 2012; 81: 637-59.
13. Jiang X, Pan H, Nabhan JF, et al. A novel EST-derived RNAi screen reveals a critical role for farnesyl diphosphate synthase in beta2-adrenergic receptor internalization and down-regulation. FASEB J. 2012; 26: 1995-2007.
14. Seachrist JL, Anborgh PH, Ferguson SS. beta 2-adrenergic receptor internalization, endosomal sorting, and plasma membrane recycling are regulated by rab GTPases. J Biol Chem. 2000; 275: 27221-8.
15. Wang G, Wu G. Small GTPase regulation of GPCR anterograde trafficking. Trends Pharmacol Sci. 2012; 33: 28-34.
16. Choi S, Kim JA, Na HY, et al. Globotriaosylceramide induces lysosomal degradation of endothelial KCa3.1 in fabry disease. Arterioscler Thromb Vasc Biol. 2014; 34: 81-9.
17. Dudek SM, Munoz NM, Desai A, et al. Group V phospholipase A2 mediates barrier disruption of human pulmonary endothelial cells caused by LPS in vitro. Am J Respir Cell Mol Biol. 2011; 44: 361-8.
18. Wu G, Zhao G, He Y. Distinct pathways for the trafficking of angiotensin II and adrenergic receptors from the endoplasmic reticulum to the cell surface: Rab1-independent transport of a G protein-coupled receptor. J Biol Chem. 2003; 278: 47062-9.
19. Li C, Fan Y, Lan TH, et al. Rab26 Modulates the Cell Surface Transport of alpha2-Adrenergic Receptors from the Golgi. J Biol Chem. 2012; 287: 42784-94.
20. Duvernay MT, Dong C, Zhang X, et al. Anterograde trafficking of G protein-coupled receptors: function of the C-terminal F(X)6LL motif in export from the endoplasmic reticulum. Mol Pharmacol. 2009; 75: 751-61.
21. Duvernay MT, Dong C, Zhang X, et al. A single conserved leucine residue on the first intracellular loop regulates ER export of G protein-coupled receptors. Traffic. 2009; 10: 552-66.
22. Pan T, Huang B, Zhang W, et al. Cytotoxicity assessment based on the AUC50 using multi-concentration time-dependent cellular response curves. Anal Chim Acta. 2013; 764: 44-52.
23. Slanina H, Konig A, Claus H, et al. Real-time impedance analysis of host cell response to meningococcal infection. J Microbiol Methods. 2011; 84: 101-8.
24. Gong P, Angelini DJ, Yang S, et al. TLR4 signaling is coupled to SRC family kinase activation, tyrosine phosphorylation of zonula adherens proteins, and opening of the paracellular pathway in human lung microvascular endothelia. J Biol Chem. 2008; 283: 13437-49.
25. Sun C, Beard RS Jr., McLean DL, et al. ADAM15 deficiency attenuates pulmonary hyperpermeability and acute lung injury in lipopolysaccharide-treated mice. Am J Physiol Lung Cell Mol Physiol. 2013; 304: L135-42.
26. Rafikov R, Dimitropoulou C, Aggarwal S, et al. Lipopolysaccharide-induced lung injury involves the nitration-mediated activation of RhoA. J Biol Chem. 2014; 289: 4710-22.
27. Grinnell KL, Chichger H, Braza J, et al. Protection against LPS-induced pulmonary edema through the attenuation of protein tyrosine phosphatase-1B oxidation. Am J Respir Cell Mol Biol. 2012; 46: 623-32.
28. Ji Y, Chen S, Li K, et al. The role of beta-adrenergic receptor signaling in the proliferation of hemangioma-derived endothelial cells. Cell Div. 2013; 8: 1.
29. Panjala SR, Steinle JJ. Insulin and beta-adrenergic receptors inhibit retinal endothelial cell apoptosis through independent pathways. Neurochem Res. 2011; 36: 604-12.
30. Unwalla HJ, Horvath G, Roth FD, et al. Albuterol modulates its own transepithelial flux via changes in paracellular permeability. Am J Respir Cell Mol Biol. 2012; 46: 551-8.
31. Nayak RC, Keshava S, Esmon CT, et al. Rab GTPases regulate endothelial cell protein C receptor-mediated endocytosis and trafficking of factor VIIa. PLoS One. 2013; 8: e59304.
32. Park SY, Shi X, Pang J, et al. Thioredoxin-interacting protein mediates sustained VEGFR2 signaling in endothelial cells required for angiogenesis. Arterioscler Thromb Vasc Biol. 2013; 33: 737-43.
33. Spindler V, Waschke J. Beta-adrenergic stimulation contributes to maintenance of endothelial barrier functions under baseline conditions. Microcirculation. 2011; 18: 118-27.
34. Iaccarino G, Ciccarelli M, Sorriento D, et al. Ischemic neoangiogenesis enhanced by beta2-adrenergic receptor overexpression: a novel role for the endothelial adrenergic system. Circ Res. 2005; 97: 1182-9.
35. Evans BA, Hutchinson DS, Summers RJ. beta2-Adrenoceptor-mediated regulation of glucose uptake in skeletal muscle--ligand-directed signalling or a reflection of system complexity? Naunyn Schmiedebergs Arch Pharmacol. 2013; 386: 757-60.
36. Dong C, Yang L, Zhang X, et al. Rab8 interacts with distinct motifs in {alpha}2B- and {beta}2-adrenergic receptors and differentially modulates their transport. J Biol Chem. 2010; 285: 20369-80.
37. Pierce KL, Premont RT, Lefkowitz RJ. Seven-transmembrane receptors. Nat Rev Mol Cell Biol. 2002; 3: 639-50.
38. Sandri C, Caccavari F, Valdembri D, et al. The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling. Cell Res. 2012; 22: 1479-501.
39. O'Kane CM, McKeown SW, Perkins GD, et al. Salbutamol up-regulates matrix metalloproteinase-9 in the alveolar space in the acute respiratory distress syndrome. Crit Care Med. 2009; 37: 2242-9.
40. Perkins GD, Gates S, Park D, et al. The beta agonist lung injury trial prevention. A randomized controlled trial. Am J Respir Crit Care Med. 2014; 189: 674-83.
41. Asmussen S, Salter M, Prough DS, et al. Isoproternenol increases vascular volume expansion and urinary output after a large crystalloid bolus in healthy volunteers. Shock. 2014; 42: 407-14.