Salbutamol up-regulates matrix metalloproteinase-9 in the alveolar space in the acute respiratory distress syndrome

Critical Care Medicine

Volumn 37, Issue 7, 2009, Pages 2242-2249

  O'Kane, Cecilia M ^a   McKeown, Scott W ^a   Perkins, Gavin D ^b   Bassford, Chris R ^c   Gao, Fang ^d   Thickett, David R ^c   McAuley, Danny F ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d BIRMINGHAM HEARTLANDS HOSPITAL   (United Kingdom)

Author keywords

Acute Respiratory distress syndrome; Epithelium; Matrix metalloproteinase; Neutrophil; Repair

Indexed keywords

COLLAGENASE 3; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; MACROPHAGE ELASTASE; MATRILYSIN; NEUTROPHIL COLLAGENASE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; PLACEBO; SALBUTAMOL; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; METALLOPROTEINASE;

ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; CELL CULTURE; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; LUNG EXTRAVASCULAR FLUID; LUNG LAVAGE; PRIORITY JOURNAL; PROTEIN SECRETION; SUPERNATANT; WOUND HEALING; ZYMOGRAPHY; CHEMISTRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CULTURE TECHNIQUE; CYTOLOGY; ENZYMOLOGY; EPITHELIUM CELL; LUNG ALVEOLUS; METABOLISM; PATHOLOGY; RANDOMIZED CONTROLLED TRIAL;

ADRENERGIC BETA-AGONISTS; ALBUTEROL; BRONCHOALVEOLAR LAVAGE FLUID; CELL CULTURE TECHNIQUES; EPITHELIAL CELLS; EXTRAVASCULAR LUNG WATER; HUMANS; METALLOPROTEASES; PULMONARY ALVEOLI; RESPIRATORY DISTRESS SYNDROME, ADULT; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

EID: 67649766886     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181a5506c     Document Type: Article

References (35)

1. Albertine KH: Ultrastructural abnormalities in increased-permeability pulmonary edema. Clin Chest Med 1985; 6:345-369
2. Delclaux C, d'Ortho MP, Delacourt C, et al: Gelatinases in epithelial lining fluid of patients with adult respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol 1997; 272:L442-L451
3. Chesnutt AN, Matthay MA, Tibayan FA, et al: Early detection of type III procollagen peptide in acute lung injury. Pathogenetic and prognostic significance. Am J Respir Crit Care Med 1997; 156(3 Pt 1):840-845
4. Armstrong L, Thickett DR, Mansell JP, et al: Changes in collagen turnover in early acute respiratory distress syndrome. Am J Respir Crit Care Med 1999; 160:1910-1915
5. Marshall RP, Bellinghan G, Webb S, et al: Fibroproliferation occurs early in the acute respiratory distress syndrome and impacts on outcome. Am J Respir Crit Care Med 2000; 162:1783-1788
6. O'Kane CM, Frank J, McAuley DF: Matrix metalloproteinases: A potential role in the pathogenesis of ARDS. In: Yearbook of Intensive Care and Emergency Medicine. Vincent JL (Ed). Springer, Heidelberg, Germany, 2004, pp 287-300
7. Torii K, Iida K, Miyazaki Y, et al: Higher concentrations of matrix metalloproteinases in bronchoalveolar lavage fluid of patients with adult respiratory distress syndrome. Am J Respir Crit Care Med 1997; 155:43-46
8. Pugin J, Verghese G, Widmer MC, et al: The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome. Crit Care Med 1999; 27:304-312
9. Lanchou J, Corbel M, Tanguy M, et al: Imbalance between matrix metalloproteinases (MMP-9 and MMP-2) and tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in acute respiratory distress syndrome patients. Crit Care Med 2003; 31:536-542
10. Fligiel SE, Standiford T, Fligiel HM, et al. Matrix metalloproteinases and matrix metalloproteinase inhibitors in acute lung injury. Hum Pathol 2006; 37:422-430
11. McAuley DF, Frank JA, Fang X, et al: Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury. Crit Care Med 2004; 32: 1470-1476
12. Perkins G, McAuley D, Thickett DR, et al: The beta-agonist lung injury trial (BALTI): a randomized placebo-controlled clinical trial. Am J Respir Crit Care Med 2006; 173: 281-287
13. Groshaus HE, Manocha S, Walley KR, et al: Mechanisms of beta-receptor stimulationinduced improvement of acute lung injury and pulmonary edema. Crit Care 2004; 8:234-242
14. Perkins GD, Nathani N, McAuley DF, et al: In vitro and in vivo effects of salbutamol on neutrophil function in acute lung injury. Thorax 2007; 62:36-42
15. McKeown ST, O'Kane CM, Perkins GD, et al: Salbutamol drives upregulated MMP-9 activity in the alveolar space in acute respiratory distress syndrome. Thorax 2007; 62(Suppl III):A63 S159
16. Elkington PT, Green JA, Emerson JE, et al: Synergistic up-regulation of epithelial cell matrix metalloproteinase-9 secretion in tuberculosis. Am J Respir Cell Mol Biol 2007; 37:431-437
17. Elkington PT, Emerson JE, Lopez-Pascua LDC, et al: Mycobacterium tuberculosis upregulates matrix metalloproteinase-1 secretion from human airway epithelial cells via a p38 MAPK switch. J Immunol 2005; 175: 5333-5340
18. Armstrong L, Medford AR, Uppington KM, et al: Expression of functional toll-like receptor-2 and -4 on alveolar epithelial cells. Am J Respir Cell Mol Biol 2004; 31:241-245
19. O'Kane CM, Boyle JJ, Horncastle DE, et al: Monocyte-dependent fibroblast CXCL8 secretion occurs in tuberculosis and limits survival of mycobacteria within macrophages. J Immunol 2007; 178:3767-3776
20. Cantin AM, Martel M, Drouin G, et al: Inhibition of gelatinase B (matrix metallopro-teinase-9) by dihydrolipoic acid. Can J Physiol Pharmacol 2005; 83:301-308
21. Folkesson M, Kazi M, Zhu C, et al: Presence of NGAL/MMP-9 complexes in human abdominal aortic aneurysms. Thromb Haemost 2007; 98:427-433
22. Cowland JB, Sorensen OE, Sehested M, et al: Neutrophil gelatinase-associated lipocalin is up-regulated in human epithelial cells by IL-1β, but not by TNF-α. J Immunol 2003; 171:6630-6639
23. Carney DE, Lutz CJ, Picone AL, et al: Matrix metalloproteinase inhibitor prevents acute lung injury after cardiopulmonary bypass. Circulation 1999; 100:400-406
24. Foda HD, Rollo EE, Drews M, et al: Ventilator-induced lung injury upregulates and activates gelatinases and EMMPRIN: Attenuation by the synthetic matrix metalloproteinase inhibitor, Prinomastat (AG3340). Am J Respir Cell Mol Biol 2001; 25: 717-724
25. Menon B, Singh M, Singh K: Matrix metalloproteinases mediate beta-adrenergic receptor-stimulated apoptosis in adult rat ventricular myocytes. Am J Physiol Cell Physiol 2005; 289:C168-C176
26. Hartog CM, Wermelt JA, Sommerfeld CO, et al: Pulmonary matrix metalloproteinase excess in hospital-acquired pneumonia. Am J Respir Crit Care Med 2003; 167:593-598
27. Martineau AR, Newton SM, Wilkinson KA, et al: Neutrophil-mediated innate immune resistance to mycobacteria. J Clin Invest 2007; 117:1988-1994
28. Gupta K, Shukla M, Cowland JB, et al. Neutrophil gelatinase-associated lipocalin is expressed in osteoarthritis and forms a complex with matrix metalloproteinase 9. Arthritis Rheum 2007; 56:3326-3335
29. Renckens R, Roelofs JJ, Florquin S, et al: Matrix metalloproteinase-9 deficiency impairs host defense against abdominal sepsis. J Immunol 2006; 176:3735-3741
30. Albaiceta GM, Gutierrez-Fernandez A, Parra D, et al: Lack of matrix metalloproteinase-9 worsens ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol 2008; 294: L535-L543
31. Perkins GD, Gao F, Thickett DR: In vivo and in vitro effects of salbutamol upon alveolar epithelial repair in acute lung injury. Thorax 2008; 63:215-220
32. Buckley S, Driscoll B, Shi W, et al: Migration and gelatinases in cultured fetal, adult, and hyperoxic alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 2001; 281: L427-L434
33. Buckley S, Warburton D: Dynamics of metalloproteinase-2 and -9, TGF-beta, and uPA activities during normoxic vs hyperoxic alveolarization. Am J Physiol Lung Cell Mol Physiol 2002; 283:L747-L754
34. Bove PF, Wesley UV, Greul A-K, et al: Nitric oxide promotes airway epithelial wound repair through enhanced activation of MMP-9. Am J Respir Cell Mol Biol 2007; 36:138-146
35. Duszyk M, Shu Y, Sawicki G, et al: Inhibition of matrix metalloproteinase MMP-2 activates chloride current in human airway epithelial cells. Can J Physiol Pharmacol 1999; 77: 529-535