Nonceliac gluten sensitivity or wheat intolerance syndrome?

Journal of Pediatrics

Volumn 166, Issue 4, 2015, Pages 805-811

  Guandalini, Stefano ^a   Polanco, Isabel ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b HOSPITAL INFANTIL LA PAZ   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DISACCHARIDE; GLUTEN; HLA DQ2 ANTIGEN; HLA DQ8 ANTIGEN; MONOSACCHARIDE; OLIGOSACCHARIDE; PLACEBO; POLYOL;

ARTICLE; CELIAC DISEASE; CLINICAL ASSESSMENT; CONTROLLED CLINICAL TRIAL (TOPIC); FOOD ALLERGY; HUMAN; NOCEBO EFFECT; NONCELIAC GLUTEN SENSITIVITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); WHEAT ALLERGY; ADVERSE EFFECTS; DIET THERAPY; GLUTEN FREE DIET; HEALTH; INCIDENCE; MEDITERRANEAN DIET; WHEAT;

CELIAC DISEASE; DIET, GLUTEN-FREE; DIET, MEDITERRANEAN; GLOBAL HEALTH; GLUTENS; HUMANS; INCIDENCE; TRITICUM;

EID: 84933279230     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2014.12.039     Document Type: Article

References (59)

1. Catassi C, Kryszak D, Bhatti B, Sturgeon C, Helzlsouer K, Clipp SL, et al. Natural history of celiac disease autoimmunity in a USA cohort followed since 1974. Ann Med 2010;42:530-8.
2. Troncone R, Jabri B. Coeliac disease and gluten sensitivity. J Intern Med 2011;269:582-90.
3. Wieser H. Chemistry of gluten proteins. Food Microbiol 2007;24:115-9.
4. Bizzaro N, Tozzoli R, Villalta D, Fabris M, Tonutti E. Cutting-edge issues in celiac disease and in gluten intolerance. Clin Rev Allergy Immunol 2012;42:279-87.
5. Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasano A, Green PH, et al. The Oslo definitions for coeliac disease and related terms. Gut 2013;62:43-52.
6. Sapone A, Bai JC, Ciacci C, Dolinsek J, Green PH, Hadjivassiliou M, et al. Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med 2012;10:13.
7. Ellis A, Linaker BD. Noncoeliac gluten sensitivity? Lancet 1978;1:1358-9.
8. Verdu EF, Armstrong D, Murray JA. Between celiac disease and irritable bowel syndrome: The "no man's land" of gluten sensitivity. Am J Gastroenterol 2009;104:1587-94.
9. Catassi C, Bai JC, Bonaz B, Bouma G, Calabro A, Carroccio A, et al. Nonceliac gluten sensitivity: The new frontier of gluten related disorders. Nutrients 2013;5:3839-53.
10. Volta U, De Giorgio R. New understanding of gluten sensitivity. Nat Rev Gastroenterol Hepatol 2012;9:295-9.
11. Volta U, Bardella MT, Calabro A, Troncone R, Corazza GR, Study Group for Non-Celiac Gluten Sensitivity. An Italian prospective multicenter survey on patients suspected of having non-celiac gluten sensitivity. BMC Med 2014;12:85.
12. Carroccio A, Mansueto P, Iacono G, Soresi M, D'Alcamo A, Cavataio F, et al. Non-celiac wheat sensitivity diagnosed by double-blind placebocontrolled challenge: exploring a new clinical entity. Am J Gastroenterol 2012;107:1898-906. quiz 907.
13. Biesiekierski JR, Newnham ED, Irving PM, Barrett JS, Haines M, Doecke JD, et al. Gluten causes gastrointestinal symptoms in subjects without celiac disease: A double-blind randomized placebo-controlled trial. Am J Gastroenterol 2011;106:508-14. quiz 15.
14. Ford RP. The gluten syndrome: A neurological disease. Med Hypotheses 2009;73:438-40.
15. Dickerson F, Stallings C, Origoni A, Vaughan C, Khushalani S, Alaedini A, et al. Markers of gluten sensitivity and celiac disease in bipolar disorder. Bipolar Disord 2011;13:52-8.
16. Dickerson F, Stallings C, Origoni A, Vaughan C, Khushalani S, Leister F, et al. Markers of gluten sensitivity and celiac disease in recent-onset psychosis and multi-episode schizophrenia. Biol Psychiatry 2010;68:100-4.
17. Hadjivassiliou M, Chattopadhyay AK, Grunewald RA, Jarratt JA, Kandler RH, Rao DG, et al. Myopathy associated with gluten sensitivity. Muscle Nerve 2007;35:443-50.
18. Jackson JR, Eaton WW, Cascella NG, Fasano A, Kelly DL. Neurologic and psychiatric manifestations of celiac disease and gluten sensitivity. Psychiatr Q 2012;83:91-102.
19. Michaelsson G, Gerden B, Hagforsen E, Nilsson B, Pihl-Lundin I, Kraaz W, et al. Psoriasis patients with antibodies to gliadin can be improved by a gluten-free diet. Br J Dermatol 2000;142:44-51.
20. Sapone A, Lammers KM, Casolaro V, Cammarota M, Giuliano MT, De Rosa M, et al. Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity. BMC Med 2011;9:23.
21. DiGiacomo DV, Tennyson CA, Green PH, Demmer RT. Prevalence of gluten-free diet adherence among individuals without celiac disease in the USA: results from the Continuous National Health and Nutrition Examination Survey 2009-2010. Scand J Gastroenterol 2013;48: 921-5.
22. Rubio-Tapia A, Ludvigsson JF, Brantner TL, Murray JA, Everhart JE. The prevalence of celiac disease in the United States. Am J Gastroenterol 2012;107:1538-44. quiz 7, 45.
23. Francavilla R, Cristofori F, Castellaneta S, Polloni C, Albano V, Dellatte S, et al. Clinical, serologic, and histologic features of gluten sensitivity in children. J Pediatr 2014;164:463-7.e1.
24. Bruni O, Dosi C, Luchetti A, Della Corte M, Riccioni A, Battaglia D, et al. An unusual case of drug-resistant epilepsy in a child with nonceliac gluten sensitivity. Seizure 2014;23:674-6.
25. Volta U, Tovoli F, Cicola R, Parisi C, Fabbri A, Piscaglia M, et al. Serological tests in gluten sensitivity (nonceliac gluten intolerance). J Clin Gastroenterol 2012;46:680-5.
26. Dezi R, Niveloni S, Sugai E, Pedreira S, Smecuol E, Vazquez H, et al. Gluten sensitivity in the rectal mucosa of first-degree relatives of celiac disease patients. Am J Gastroenterol 1997;92:1326-30.
27. Troncone R, Greco L, Mayer M, Mazzarella G, Maiuri L, Congia M, et al. In siblings of celiac children, rectal gluten challenge reveals gluten sensitization not restricted to celiac HLA. Gastroenterology 1996;111:318-24.
28. Lundin KE, Alaedini A. Non-celiac gluten sensitivity. Gastrointest Endosc Clin N Am 2012;22:723-34.
29. Biesiekierski JR, Newnham ED, Shepherd SJ, Muir JG, Gibson PR. Characterization of adults with a self-diagnosis of nonceliac gluten sensitivity. Nutr Clin Pract 2014;29:504-9.
30. Lundin KE. Nonceliac gluten sensitivity-why worry? BMC Med 2014; 12:86.
31. Brown I, Mino-Kenudson M, Deshpande V, Lauwers GY. Intraepithelial lymphocytosis in architecturally preserved proximal small intestinal mucosa: an increasing diagnostic problem with a wide differential diagnosis. Arch Pathol Lab Med 2006;130:1020-5.
32. Chang F, Mahadeva U, Deere H. Pathological and clinical significance of increased intraepithelial lymphocytes (IELs) in small bowel mucosa. APMIS 2005;113:385-99.
33. Guz-Mark A, Zevit N, Morgenstern S, Shamir R. Duodenal intraepithelial lymphocytosis is common in children without coeliac disease, and is not meaningfully influenced by Helicobacter pylori infection. Aliment Pharmacol Ther 2014;39:1314-20.
34. Kakar S, Nehra V, Murray JA, Dayharsh GA, Burgart LJ. Significance of intraepithelial lymphocytosis in small bowel biopsy samples with normal mucosal architecture. Am J Gastroenterol 2003;98:2027-33.
35. Husby S, Koletzko S, Korponay-Szabo IR, Mearin ML, Phillips A, Shamir R, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr 2012;54:136-60.
36. Fernandez-Banares F, Carrasco A, Garcia-Puig R, Rosinach M, Gonzalez C, Alsina M, et al. Intestinal intraepithelial lymphocyte cytometric pattern is more accurate than subepithelial deposits of anti-tissue transglutaminase IgA for the diagnosis of celiac disease in lymphocytic enteritis. PLoS One 2014;9:e101249.
37. Borghini R, Donato G, Di Tola M, Isonne C, Picarelli A. Mutatis mutandis: are we diagnosing too many people with non-celiac gluten sensitivity? Multiple case report. Turkish J Gastroenterol 2014;25: 319-22.
38. Sapone A, Lammers KM, Mazzarella G, Mikhailenko I, Carteni M, Casolaro V, et al. Differential mucosal IL-17 expression in two gliadininduced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease. Int Arch Allergy Immunol 2010;152:75-80.
39. Caio G, Volta U, Tovoli F, De Giorgio R. Effect of gluten free diet on immune response to gliadin in patients with non-celiac gluten sensitivity. BMC Gastroenterol 2014;14:26.
40. Biesiekierski JR, Peters SL, Newnham ED, Rosella O, Muir JG, Gibson PR. No effects of gluten in patients with self-reported nonceliac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates. Gastroenterology 2013;145:320-8. e1-3.
41. Biesiekierski JR, Rosella O, Rose R, Liels K, Barrett JS, Shepherd SJ, et al. Quantification of fructans, galacto-oligosacharides and other shortchain carbohydrates in processed grains and cereals. J Hum Nutr Diet 2011;24:154-76.
42. Peters SL, Biesiekierski JR, Yelland GW, Muir JG, Gibson PR. Randomised clinical trial: gluten may cause depression in subjects with noncoeliac gluten sensitivity-an exploratory clinical study. Aliment Pharmacol Ther 2014;39:1104-12.
43. Altenbach SB, Vensel WH, Dupont FM. The spectrum of low molecular weight alpha-amylase/protease inhibitor genes expressed in the US bread wheat cultivar Butte 86. BMC Res Notes 2011;4:242.
44. Silano V, Pocchiari F, Kasarda DD. Physical characterization of alphaamylase inhibitors from wheat. Biochimica et Biophysica Acta 1973; 317:139-48.
45. Junker Y, Zeissig S, Kim SJ, Barisani D, Wieser H, Leffler DA, et al. Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4. J Exp Med 2012;209:2395-408.
46. Brandtzaeg P. Food allergy: separating the science from the mythology. Nat Rev Gastroenterol Hepatol 2010;7:380-400.
47. Carroccio A, Mansueto P, D'Alcamo A, Iacono G. Nonceliac wheat sensitivity as an allergic condition: personal experience and narrative review. Am J Gastroenterol 2013;108:1845-52. quiz 53.
48. Carroccio A, Di Prima L, Pirrone G, Scalici C, Florena AM, Gasparin M, et al. Anti-transglutaminase antibody assay of the culture medium of intestinal biopsy specimens can improve the accuracy of celiac disease diagnosis. Clin Chem 2006;52:1175-80.
49. Carroccio A, Iacono G, D'Amico D, Cavataio F, Teresi S, Caruso C, et al. Production of anti-endomysial antibodies in cultured duodenal mucosa: usefulness in coeliac disease diagnosis. Scand J Ggastroenterol 2002;37: 32-8.
50. Picarelli A, Di Tola M, Marino M, Libanori V, Borghini R, Salvi E, et al. Usefulness of the organ culture system when villous height/crypt depth ratio, intraepithelial lymphocyte count, or serum antibody tests are not diagnostic for celiac disease. Translational Res 2013;161:172-80.
51. Koskinen O, Collin P, Lindfors K, Laurila K, Maki M, Kaukinen K. Usefulness of small-bowel mucosal transglutaminase-2 specific autoantibody deposits in the diagnosis and follow-up of celiac disease. J Clin Gastroenterol 2010;44:483-8.
52. Ford AC, Moayyedi P. Meta-analysis: factors affecting placebo response rate in the irritable bowel syndrome. Aliment Pharmacol Ther 2010;32: 144-58.
53. Shah E, Pimentel M. Placebo effect in clinical trial design for irritable bowel syndrome. J Neurogastroenterol Motility 2014;20:163-70.
54. FordAC, Luthra P,Hanauer SB, Travis SP,HarrisMS,ReinischW. Placebo Response rate in clinical trials of fistulizing Crohn's disease: systematic review and meta-analysis. Clin Gastroenterol Hepatol 2014;12:1981-90.
55. Jewett DL, Fein G, Greenberg MH. A double-blind study of symptom provocation to determine food sensitivity. N Engl J Med 1990;323: 429-33.
56. Suarez FL, Savaiano DA, Levitt MD. A comparison of symptoms after the consumption of milk or lactose-hydrolyzed milk by people with selfreported severe lactose intolerance. N Engl J Med 1995;333:1-4.
57. Godlee F. Gluten sensitivity: real or not. BMJ 2012;345:e8450.
58. Carroccio A, Brusca I, Mansueto P, Pirrone G, Barrale M, Di Prima L, et al. A cytologic assay for diagnosis of food hypersensitivity in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 2010;8:254-60.
59. Carroccio A, Rini G, Mansueto P. Nonceliac wheat sensitivity is a more appropriate label than nonceliac gluten sensitivity. Gastroenterology 2014;146:320-1.