Non-celiac gluten sensitivity - why worry?

BMC Medicine

Volumn 12, Issue 1, 2014, Pages

  Lundin, Knut E A ^a,b,c  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

Celiac disease; Diagnosis; FODMAP; Gluten; Gluten free diet; Irritable bowel syndrome; Multicenter study; Non celiac gluten sensitivity

Indexed keywords

GLUTEN;

ARTICLE; CELIAC DISEASE; GASTROENTEROLOGY; GLUTEN FREE DIET; HUMAN; IRRITABLE COLON; MEDICAL DECISION MAKING; NUTRITIONAL INTOLERANCE; FEMALE; MALE;

FEMALE; HUMANS; MALE;

EID: 84901355480     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/1741-7015-12-86     Document Type: Article

References (21)

1. Kasarda D. Can an increase in celiac disease be attributed to an increase in gluten content of wheat as a consequence of wheat breeding?. J Agric Food Chem 2013, 61:1155-1159. 10.1021/jf305122s, 3573730, 23311690.
2. Makharia G, Mulder CJJ, Goh KL, Ahuja V, Bai JC, Catassi C, Green PHR, Gupta SD, Lundin KEA, Ramakrishna BS, Rawat R, Sharma H, Sood A, Watanabe C, Gibson PR. Issues associated with the emergence of coeliac disease in the Asia-Pacific region: a working party report of the World Gastroenterology Organization and the Asian Pacific Association of Gastroenterology. J Gastroenterol Hepatol 2014, 29:666-677. 10.1111/jgh.12514, 24783246.
3. Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasano A, Green PH, Hadjivassiliou M, Kaukinen K, Kelly CP, Leonard JN, Lundin KE, Murray JA, Sanders DS, Walker MM, Zingone F, Ciacci C. The Oslo definitions for coeliac disease and related terms. Gut 2013, 62:43-52. 10.1136/gutjnl-2011-301346, 3440559, 22345659.
4. Sapone A, Bai JC, Ciacci C, Dolinsek J, Green PHR, Hadjivassiliou M, Kaukinen K, Rostami K, Sanders DS, Schumann M, Ullrich R, Villalta D, Volta U, Catassi C, Fasano S. Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med 2012, 10:13-25. 10.1186/1741-7015-10-13, 3292448, 22313950.
5. Halmos EP, Power VA, Shepherd SJ, Gibson PR, Muir JG. A diet low in FODMAPs reduces symptoms of irritable bowel syndrome. Gastroenterology 2014, 146:67-75. 10.1053/j.gastro.2013.09.046, 24076059.
6. Volta U, Bardella MT, Calobro A, Troncone R, Corazza GR. An Italian prospective multicentre survey on patients suspected of having non-gluten sensitivity. BMC Med 12:85.
7. Lundin KE, Alaedini A. Non-celiac gluten sensitivity. Gastrointest Endoscopy Clin N Am 2012, 22:723-734.
8. DiGiacomo DV, Tennyson CA, Green PH, Demmer RT. Prevalence of gluten-free diet adherence among individuals without celiac disease in the USA: results from the Continuous National Health and Nutrition Examination Survey 2009-2010. Scand J Gastroenterol 2013, 48:921-925.
9. Aziz I, Lewis NR, Hadjivassiliou M, Winfield SN, Rugg N, Kelsall A, Newrick L, Sanders DS. A UK study assessing the population prevalence of self-reported gluten sensitivity and referral characteristics to secondary care. Eur J Gastroentero Hepatol 2014, 26:33-39.
10. Tanpowpong P, Ingham TR, Lampshire PK, Kirchberg FF, Epton MJ, Crane J, Camargo CA. Coeliac disease and gluten avoidance in New Zealand children. Arch Dis Child 2012, 97:12-16. 10.1136/archdischild-2011-300248, 22075107.
11. Hallert C, Grant C, Grehn S, Grännö C, Hultén S, Midhagen G, Ström M, Svensson H, Valdimarsson T. Evidence of poor vitamin status in coeliac patients on a gluten-free diet for 10 years. Aliment Pharmacol Ther 2002, 16:1333-1339. 10.1046/j.1365-2036.2002.01283.x, 12144584.
12. Kaukinen K, Turjanmaa K, Mäki M, Partanen J, Venäläinen R, Reunala T, Collin P. Intolerance to cereals is not specific for coeliac disease. Scand J Gastroenterol 2000, 35:942-946. 10.1080/003655200750022995, 11063153.
13. Brottveit M, Ráki M, Bergseng E, Fallang LE, Simonsen B, Løvik A, Larsen S, Løberg EM, Jahnsen FL, Sollid LM, Lundin KEA. Assessing possible celiac disease by an HLA-DQ2-gliadin tetramer test. Am J Gastro 2011, 106:1318-1324.
14. Brottveit M, Vandvik PO, Wojniusz S, Løvik A, Lundin KEA, Boye B. Absence of somatization in non-coeliac gluten sensitivity. Scand J Gastroenterol 2012, 47:770-777.
15. Coburn JA, Voort JLV, Lahr BD, Van Dyke CT, Kroning CM, Wu TT, Gandhi MJ, Murray JA. Human leukocyte antigen genetics and clinical features of self-treated patients on a gluten-free diet. J Clin Gastroenterol 2013, 47:828-833. 10.1097/MCG.0b013e31828f531c, 23632357.
16. Kabbani TA, Vanga RR, Leffler DA, Villafuerte-Galvez J, Pallav K, Hansen J, Mukherjee R, Dennis M, Kelly CP. Celiac disease or non-celiac gluten sensitivity? An approach to clinical differential diagnosis. Am J Gasteroenterol in press. http://www.ncbi.nlm.nih.gov/pubmed/24619056.
17. Leffler D, Schuppan D, Pallav K, Najarian R, Goldsmith JD, Hansen J, Kabbani T, Dennis M, Kelly CP. Kinetics of the histological, serological and symptomatic response to gluten challenge in adults with coeliac disease. Gut 2013, 62:996-1004. 10.1136/gutjnl-2012-302196, 3525791, 22619366.
18. Lähdeaho ML, Mäki M, Laurila K, Huhtala H, Kaukinen K. Small-bowel mucosal changes and antibody responses after low- and moderate-dose gluten challenge in celiac disease. BMC Gastroenterol 2011, 11:129-138. 10.1186/1471-230X-11-129, 3240817, 22115041.
19. Biesiekierski JR, Newnham ED, Irving PM, Barrett JS, Haines M, Doecke JD, Shepherd SJ, Muir JG, Gibson PR. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. Am J Gastroenterol 2011, 106:508-514. 10.1038/ajg.2010.487, 21224837.
20. Biesiekierski JR, Peters SL, Newnham ED, Rosella O, Muir JG, Gibson PR. No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates. Gastroenterology 2013, 145:320-328. 10.1053/j.gastro.2013.04.051, 23648697.
21. Junker Y, Zeissig S, Kim SJ, Barisani D, Wieser H, Leffler DA, Zevallos V, Libermann TA, Dillon S, Freitag TL, Kelly CP, Schuppan D. Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4. J Exp Med 2012, 209:2395-2408. 10.1084/jem.20102660, 3526354, 23209313.