메뉴 건너뛰기




Volumn 72, Issue 14, 2015, Pages 2677-2695

Lipid droplet dynamics in budding yeast

Author keywords

Endoplasmic reticulum; Membrane; Metabolism; Phospholipid; Sterol ester; Triacylglycerol

Indexed keywords

FAT DROPLET; PROTEOME; SACCHAROMYCES CEREVISIAE PROTEIN;

EID: 84933277490     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-015-1903-5     Document Type: Review
Times cited : (55)

References (145)
  • 1
    • 84895735915 scopus 로고    scopus 로고
    • Review: Biogenesis of the multifunctional lipid droplet: Lipids, proteins, and sites
    • 10.1083/jcb.201311051 1:CAS:528:DC%2BC2cXkt1eit7w%3D 3941045 24590170
    • Pol A, Gross SP, Parton RG (2014) Review: biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites. J Cell Biol 204(5):635-646. doi: 10.1083/jcb.201311051
    • (2014) J Cell Biol , vol.204 , Issue.5 , pp. 635-646
    • Pol, A.1    Gross, S.P.2    Parton, R.G.3
  • 2
    • 84861913952 scopus 로고    scopus 로고
    • Lipid droplets and cellular lipid metabolism
    • 10.1146/annurev-biochem-061009-102430 1:CAS:528:DC%2BC38XhtVGlsL7P 3767414 22524315
    • Walther TC, Farese RV Jr (2012) Lipid droplets and cellular lipid metabolism. Annu Rev Biochem 81:687-714. doi: 10.1146/annurev-biochem-061009-102430
    • (2012) Annu Rev Biochem , vol.81 , pp. 687-714
    • Walther, T.C.1    Farese, Jr.R.V.2
  • 3
    • 84871820511 scopus 로고    scopus 로고
    • Lipid droplets and peroxisomes: Key players in cellular lipid homeostasis or a matter of fat-store 'em up or burn 'em down
    • 10.1534/genetics.112.143362 1:CAS:528:DC%2BC3sXjt1eqs7g%3D 3527239 23275493
    • Kohlwein SD, Veenhuis M, van der Klei IJ (2013) Lipid droplets and peroxisomes: key players in cellular lipid homeostasis or a matter of fat-store 'em up or burn 'em down. Genetics 193(1):1-50. doi: 10.1534/genetics.112.143362
    • (2013) Genetics , vol.193 , Issue.1 , pp. 1-50
    • Kohlwein, S.D.1    Veenhuis, M.2    Van Der Klei, I.J.3
  • 5
    • 34147152663 scopus 로고    scopus 로고
    • Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic
    • 10.1194/jlr.M600413-JLR200 1:CAS:528:DC%2BD2sXktFGhu70%3D 17210984
    • Bartz R, Li WH, Venables B, Zehmer JK, Roth MR, Welti R, Anderson RG, Liu P, Chapman KD (2007) Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic. J Lipid Res 48(4):837-847. doi: 10.1194/jlr.M600413-JLR200
    • (2007) J Lipid Res , vol.48 , Issue.4 , pp. 837-847
    • Bartz, R.1    Li, W.H.2    Venables, B.3    Zehmer, J.K.4    Roth, M.R.5    Welti, R.6    Anderson, R.G.7    Liu, P.8    Chapman, K.D.9
  • 6
    • 84857673481 scopus 로고
    • Daum G (2012) Influence of squalene on lipid particle/droplet and membrane organization in the yeast Saccharomyces cerevisiae
    • 10.1016/j.bbalip.2012.01.015
    • Spanova M, Zweytick D, Lohner K, Klug L, Leitner E, Hermetter A (1821) Daum G (2012) Influence of squalene on lipid particle/droplet and membrane organization in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta 4:647-653. doi: 10.1016/j.bbalip.2012.01.015
    • (1821) Biochim Biophys Acta , vol.4 , pp. 647-653
    • Spanova, M.1    Zweytick, D.2    Lohner, K.3    Klug, L.4    Leitner, E.5    Hermetter, A.6
  • 7
    • 47749150637 scopus 로고    scopus 로고
    • Structural and biochemical properties of lipid particles from the yeast Saccharomyces cerevisiae
    • 10.1074/jbc.M800401200 1:CAS:528:DC%2BD1cXntFSntrs%3D 18430725
    • Czabany T, Wagner A, Zweytick D, Lohner K, Leitner E, Ingolic E, Daum G (2008) Structural and biochemical properties of lipid particles from the yeast Saccharomyces cerevisiae. J Biol Chem 283(25):17065-17074. doi: 10.1074/jbc.M800401200
    • (2008) J Biol Chem , vol.283 , Issue.25 , pp. 17065-17074
    • Czabany, T.1    Wagner, A.2    Zweytick, D.3    Lohner, K.4    Leitner, E.5    Ingolic, E.6    Daum, G.7
  • 8
    • 0345363228 scopus 로고    scopus 로고
    • Electrospray ionization tandem mass spectrometry (ESI-MS/MS) analysis of the lipid molecular species composition of yeast subcellular membranes reveals acyl chain-based sorting/remodeling of distinct molecular species en route to the plasma membrane
    • 1:CAS:528:DyaK1MXls1Srt70%3D 2156145 10459010
    • Schneiter R, Brugger B, Sandhoff R, Zellnig G, Leber A, Lampl M, Athenstaedt K, Hrastnik C, Eder S, Daum G, Paltauf F, Wieland FT, Kohlwein SD (1999) Electrospray ionization tandem mass spectrometry (ESI-MS/MS) analysis of the lipid molecular species composition of yeast subcellular membranes reveals acyl chain-based sorting/remodeling of distinct molecular species en route to the plasma membrane. J Cell Biol 146(4):741-754
    • (1999) J Cell Biol , vol.146 , Issue.4 , pp. 741-754
    • Schneiter, R.1    Brugger, B.2    Sandhoff, R.3    Zellnig, G.4    Leber, A.5    Lampl, M.6    Athenstaedt, K.7    Hrastnik, C.8    Eder, S.9    Daum, G.10    Paltauf, F.11    Wieland, F.T.12    Kohlwein, S.D.13
  • 9
    • 81755161505 scopus 로고    scopus 로고
    • Lipid particles/droplets of the yeast Saccharomyces cerevisiae revisited: Lipidome meets proteome
    • 10.1016/j.bbalip.2011.07.015 1:CAS:528:DC%2BC3MXhsV2msr7M 3229976 21820081
    • Grillitsch K, Connerth M, Kofeler H, Arrey TN, Rietschel B, Wagner B, Karas M, Daum G (2011) Lipid particles/droplets of the yeast Saccharomyces cerevisiae revisited: lipidome meets proteome. Biochim Biophys Acta 1811(12):1165-1176. doi: 10.1016/j.bbalip.2011.07.015
    • (2011) Biochim Biophys Acta , vol.1811 , Issue.12 , pp. 1165-1176
    • Grillitsch, K.1    Connerth, M.2    Kofeler, H.3    Arrey, T.N.4    Rietschel, B.5    Wagner, B.6    Karas, M.7    Daum, G.8
  • 10
    • 84886814081 scopus 로고    scopus 로고
    • The emergence of lipid droplets in yeast: Current status and experimental approaches
    • 10.1007/s00294-013-0407-9 1:CAS:528:DC%2BC3sXhsVylurnM 3824194 24057105
    • Radulovic M, Knittelfelder O, Cristobal-Sarramian A, Kolb D, Wolinski H, Kohlwein SD (2013) The emergence of lipid droplets in yeast: current status and experimental approaches. Curr Genet 59(4):231-242. doi: 10.1007/s00294-013-0407-9
    • (2013) Curr Genet , vol.59 , Issue.4 , pp. 231-242
    • Radulovic, M.1    Knittelfelder, O.2    Cristobal-Sarramian, A.3    Kolb, D.4    Wolinski, H.5    Kohlwein, S.D.6
  • 11
    • 84888367601 scopus 로고    scopus 로고
    • The biophysics and cell biology of lipid droplets
    • 10.1038/nrm3699 1:CAS:528:DC%2BC3sXhslGntLrK 24220094
    • Thiam AR, Farese RV Jr, Walther TC (2013) The biophysics and cell biology of lipid droplets. Nat Rev Mol Cell Biol 14(12):775-786. doi: 10.1038/nrm3699
    • (2013) Nat Rev Mol Cell Biol , vol.14 , Issue.12 , pp. 775-786
    • Thiam, A.R.1    Farese, Jr.R.V.2    Walther, T.C.3
  • 12
    • 39049151385 scopus 로고    scopus 로고
    • Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast
    • 10.1083/jcb.200711136 1:CAS:528:DC%2BD1cXitFajur4%3D 2234226 18250201
    • Fei W, Shui G, Gaeta B, Du X, Kuerschner L, Li P, Brown AJ, Wenk MR, Parton RG, Yang H (2008) Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast. J Cell Biol 180(3):473-482. doi: 10.1083/jcb.200711136
    • (2008) J Cell Biol , vol.180 , Issue.3 , pp. 473-482
    • Fei, W.1    Shui, G.2    Gaeta, B.3    Du, X.4    Kuerschner, L.5    Li, P.6    Brown, A.J.7    Wenk, M.R.8    Parton, R.G.9    Yang, H.10
  • 14
    • 84903362768 scopus 로고    scopus 로고
    • Control of lipid droplet size in budding yeast requires the collaboration between Fld1 and Ldb16
    • 10.1242/jcs.137737 24434579
    • Wang CW, Miao YH, Chang YS (2014) Control of lipid droplet size in budding yeast requires the collaboration between Fld1 and Ldb16. J Cell Sci 127(Pt 6):1214-1228. doi: 10.1242/jcs.137737
    • (2014) J Cell Sci , vol.127 , pp. 1214-1228
    • Wang, C.W.1    Miao, Y.H.2    Chang, Y.S.3
  • 15
    • 84905981861 scopus 로고    scopus 로고
    • A sterol-enriched vacuolar microdomain mediates stationary phase lipophagy in budding yeast
    • 10.1083/jcb.201404115 1:CAS:528:DC%2BC2cXhtlejtrvK 4121974 25070953
    • Wang CW, Miao YH, Chang YS (2014) A sterol-enriched vacuolar microdomain mediates stationary phase lipophagy in budding yeast. J Cell Biol 206(3):357-366. doi: 10.1083/jcb.201404115
    • (2014) J Cell Biol , vol.206 , Issue.3 , pp. 357-366
    • Wang, C.W.1    Miao, Y.H.2    Chang, Y.S.3
  • 16
    • 77956246711 scopus 로고    scopus 로고
    • Oleate inhibits steryl ester synthesis and causes liposensitivity in yeast
    • 10.1074/jbc.M110.122085 1:CAS:528:DC%2BC3cXhtVKhs7%2FE 2930682 20571028
    • Connerth M, Czabany T, Wagner A, Zellnig G, Leitner E, Steyrer E, Daum G (2010) Oleate inhibits steryl ester synthesis and causes liposensitivity in yeast. J Biol Chem 285(35):26832-26841. doi: 10.1074/jbc.M110.122085
    • (2010) J Biol Chem , vol.285 , Issue.35 , pp. 26832-26841
    • Connerth, M.1    Czabany, T.2    Wagner, A.3    Zellnig, G.4    Leitner, E.5    Steyrer, E.6    Daum, G.7
  • 18
    • 0036135597 scopus 로고    scopus 로고
    • Synthesis of triacylglycerols by the acyl-coenzyme A:diacyl-glycerol acyltransferase Dga1p in lipid particles of the yeast Saccharomyces cerevisiae
    • 1:CAS:528:DC%2BD38XjtVyruw%3D%3D 139573 11751830
    • Sorger D, Daum G (2002) Synthesis of triacylglycerols by the acyl-coenzyme A:diacyl-glycerol acyltransferase Dga1p in lipid particles of the yeast Saccharomyces cerevisiae. J Bacteriol 184(2):519-524
    • (2002) J Bacteriol , vol.184 , Issue.2 , pp. 519-524
    • Sorger, D.1    Daum, G.2
  • 19
    • 0034612345 scopus 로고    scopus 로고
    • Phospholipid:diacylglycerol acyltransferase: An enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants
    • 10.1073/pnas.120067297 1:CAS:528:DC%2BD3cXktFajtrk%3D 18631 10829075
    • Dahlqvist A, Stahl U, Lenman M, Banas A, Lee M, Sandager L, Ronne H, Stymne S (2000) Phospholipid:diacylglycerol acyltransferase: an enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants. Proc Natl Acad Sci USA 97(12):6487-6492. doi: 10.1073/pnas.120067297
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.12 , pp. 6487-6492
    • Dahlqvist, A.1    Stahl, U.2    Lenman, M.3    Banas, A.4    Lee, M.5    Sandager, L.6    Ronne, H.7    Stymne, S.8
  • 20
    • 0034717265 scopus 로고    scopus 로고
    • A lecithin cholesterol acyltransferase-like gene mediates diacylglycerol esterification in yeast
    • 10.1074/jbc.C000144200 1:CAS:528:DC%2BD3cXjvFajurs%3D 10747858
    • Oelkers P, Tinkelenberg A, Erdeniz N, Cromley D, Billheimer JT, Sturley SL (2000) A lecithin cholesterol acyltransferase-like gene mediates diacylglycerol esterification in yeast. J Biol Chem 275(21):15609-15612. doi: 10.1074/jbc.C000144200
    • (2000) J Biol Chem , vol.275 , Issue.21 , pp. 15609-15612
    • Oelkers, P.1    Tinkelenberg, A.2    Erdeniz, N.3    Cromley, D.4    Billheimer, J.T.5    Sturley, S.L.6
  • 21
    • 0029835340 scopus 로고    scopus 로고
    • Molecular cloning and characterization of two isoforms of Saccharomyces cerevisiae acyl-CoA:sterol acyltransferase
    • 1:CAS:528:DyaK28XlvFSqu74%3D 8798656
    • Yu C, Kennedy NJ, Chang CC, Rothblatt JA (1996) Molecular cloning and characterization of two isoforms of Saccharomyces cerevisiae acyl-CoA:sterol acyltransferase. J Biol Chem 271(39):24157-24163
    • (1996) J Biol Chem , vol.271 , Issue.39 , pp. 24157-24163
    • Yu, C.1    Kennedy, N.J.2    Chang, C.C.3    Rothblatt, J.A.4
  • 22
    • 77952331856 scopus 로고    scopus 로고
    • Triacylglycerol homeostasis: Insights from yeast
    • 10.1074/jbc.R110.118356 1:CAS:528:DC%2BC3cXmtVyksrc%3D 2871431 20231294
    • Kohlwein SD (2010) Triacylglycerol homeostasis: insights from yeast. J Biol Chem 285(21):15663-15667. doi: 10.1074/jbc.R110.118356
    • (2010) J Biol Chem , vol.285 , Issue.21 , pp. 15663-15667
    • Kohlwein, S.D.1
  • 23
    • 0037088637 scopus 로고    scopus 로고
    • The DGA1 gene determines a second triglyceride synthetic pathway in yeast
    • 10.1074/jbc.M111646200 1:CAS:528:DC%2BD38Xitl2ltbg%3D 11751875
    • Oelkers P, Cromley D, Padamsee M, Billheimer JT, Sturley SL (2002) The DGA1 gene determines a second triglyceride synthetic pathway in yeast. J Biol Chem 277(11):8877-8881. doi: 10.1074/jbc.M111646200
    • (2002) J Biol Chem , vol.277 , Issue.11 , pp. 8877-8881
    • Oelkers, P.1    Cromley, D.2    Padamsee, M.3    Billheimer, J.T.4    Sturley, S.L.5
  • 25
    • 0033974053 scopus 로고    scopus 로고
    • Contribution of Are1p and Are2p to steryl ester synthesis in the yeast Saccharomyces cerevisiae
    • 1:CAS:528:DC%2BD3cXhsFGjt7w%3D
    • Zweytick D, Leitner E, Kohlwein SD, Yu C, Rothblatt J, Daum G (2000) Contribution of Are1p and Are2p to steryl ester synthesis in the yeast Saccharomyces cerevisiae. Eur J Biochem FEBS 267(4):1075-1082
    • (2000) Eur J Biochem FEBS , vol.267 , Issue.4 , pp. 1075-1082
    • Zweytick, D.1    Leitner, E.2    Kohlwein, S.D.3    Yu, C.4    Rothblatt, J.5    Daum, G.6
  • 26
    • 40849116174 scopus 로고    scopus 로고
    • Synthesis and turnover of non-polar lipids in yeast
    • 1:CAS:528:DC%2BD1cXjs1SktLg%3D 18258205
    • Rajakumari S, Grillitsch K, Daum G (2008) Synthesis and turnover of non-polar lipids in yeast. Prog Lipid Res 47(3):157-171
    • (2008) Prog Lipid Res , vol.47 , Issue.3 , pp. 157-171
    • Rajakumari, S.1    Grillitsch, K.2    Daum, G.3
  • 27
    • 0027289677 scopus 로고
    • Acetyl-CoA carboxylase from yeast is an essential enzyme and is regulated by factors that control phospholipid metabolism
    • 1:CAS:528:DyaK3sXkvVyjtbw%3D 8098706
    • Hasslacher M, Ivessa AS, Paltauf F, Kohlwein SD (1993) Acetyl-CoA carboxylase from yeast is an essential enzyme and is regulated by factors that control phospholipid metabolism. J Biol Chem 268(15):10946-10952
    • (1993) J Biol Chem , vol.268 , Issue.15 , pp. 10946-10952
    • Hasslacher, M.1    Ivessa, A.S.2    Paltauf, F.3    Kohlwein, S.D.4
  • 28
    • 0034898311 scopus 로고    scopus 로고
    • Inhibition of acetyl coenzyme A carboxylase activity restores expression of the INO1 gene in a snf1 mutant strain of Saccharomyces cerevisiae
    • 1:CAS:528:DC%2BD3MXlvF2hsbY%3D 87291 11486011
    • Shirra MK, Patton-Vogt J, Ulrich A, Liuta-Tehlivets O, Kohlwein SD, Henry SA, Arndt KM (2001) Inhibition of acetyl coenzyme A carboxylase activity restores expression of the INO1 gene in a snf1 mutant strain of Saccharomyces cerevisiae. Mol Cell Biol 21(17):5710-5722
    • (2001) Mol Cell Biol , vol.21 , Issue.17 , pp. 5710-5722
    • Shirra, M.K.1    Patton-Vogt, J.2    Ulrich, A.3    Liuta-Tehlivets, O.4    Kohlwein, S.D.5    Henry, S.A.6    Arndt, K.M.7
  • 30
    • 54849422418 scopus 로고    scopus 로고
    • Quantitative modeling of triacylglycerol homeostasis in yeast-metabolic requirement for lipolysis to promote membrane lipid synthesis and cellular growth
    • 10.1111/j.1742-4658.2008.06681.x 1:CAS:528:DC%2BD1cXhsVWkt77P 18959743
    • Zanghellini J, Natter K, Jungreuthmayer C, Thalhammer A, Kurat CF, Gogg-Fassolter G, Kohlwein SD, von Grunberg HH (2008) Quantitative modeling of triacylglycerol homeostasis in yeast-metabolic requirement for lipolysis to promote membrane lipid synthesis and cellular growth. The FEBS journal 275(22):5552-5563. doi: 10.1111/j.1742-4658.2008.06681.x
    • (2008) The FEBS journal , vol.275 , Issue.22 , pp. 5552-5563
    • Zanghellini, J.1    Natter, K.2    Jungreuthmayer, C.3    Thalhammer, A.4    Kurat, C.F.5    Gogg-Fassolter, G.6    Kohlwein, S.D.7    Von Grunberg, H.H.8
  • 31
    • 0033571069 scopus 로고    scopus 로고
    • Phosphatidic acid, a key intermediate in lipid metabolism
    • 1:CAS:528:DyaK1MXnsVantr8%3D
    • Athenstaedt K, Daum G (1999) Phosphatidic acid, a key intermediate in lipid metabolism. Eur J Biochem FEBS 266(1):1-16
    • (1999) Eur J Biochem FEBS , vol.266 , Issue.1 , pp. 1-16
    • Athenstaedt, K.1    Daum, G.2
  • 32
    • 0035834657 scopus 로고    scopus 로고
    • The initial step of the glycerolipid pathway: Identification of glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate acyltransferases in Saccharomyces cerevisiae
    • 10.1074/jbc.M104749200 1:CAS:528:DC%2BD3MXosVGnsbk%3D 11544256
    • Zheng Z, Zou J (2001) The initial step of the glycerolipid pathway: identification of glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate acyltransferases in Saccharomyces cerevisiae. J Biol Chem 276(45):41710-41716. doi: 10.1074/jbc.M104749200
    • (2001) J Biol Chem , vol.276 , Issue.45 , pp. 41710-41716
    • Zheng, Z.1    Zou, J.2
  • 33
    • 0037064024 scopus 로고    scopus 로고
    • Differential partitioning of lipids metabolized by separate yeast glycerol-3-phosphate acyltransferases reveals that phospholipase D generation of phosphatidic acid mediates sensitivity to choline-containing lysolipids and drugs
    • 10.1074/jbc.M207753200 1:CAS:528:DC%2BD38Xns1Cnu7c%3D 12167660
    • Zaremberg V, McMaster CR (2002) Differential partitioning of lipids metabolized by separate yeast glycerol-3-phosphate acyltransferases reveals that phospholipase D generation of phosphatidic acid mediates sensitivity to choline-containing lysolipids and drugs. J Biol Chem 277(41):39035-39044. doi: 10.1074/jbc.M207753200
    • (2002) J Biol Chem , vol.277 , Issue.41 , pp. 39035-39044
    • Zaremberg, V.1    McMaster, C.R.2
  • 34
    • 84858992869 scopus 로고    scopus 로고
    • Controlling lipid fluxes at glycerol-3-phosphate acyltransferase step in yeast: Unique contribution of Gat1p to oleic acid-induced lipid particle formation
    • 10.1074/jbc.M111.314112 1:CAS:528:DC%2BC38XktlKrsrY%3D 3323052 22267742
    • Marr N, Foglia J, Terebiznik M, Athenstaedt K, Zaremberg V (2012) Controlling lipid fluxes at glycerol-3-phosphate acyltransferase step in yeast: unique contribution of Gat1p to oleic acid-induced lipid particle formation. J Biol Chem 287(13):10251-10264. doi: 10.1074/jbc.M111.314112
    • (2012) J Biol Chem , vol.287 , Issue.13 , pp. 10251-10264
    • Marr, N.1    Foglia, J.2    Terebiznik, M.3    Athenstaedt, K.4    Zaremberg, V.5
  • 35
    • 35648995880 scopus 로고    scopus 로고
    • SLC1 and SLC4 encode partially redundant acyl-coenzyme A 1-acylglycerol-3-phosphate O-acyltransferases of budding yeast
    • 10.1074/jbc.M702719200 1:CAS:528:DC%2BD2sXhtFGgs7%2FI 17675291
    • Benghezal M, Roubaty C, Veepuri V, Knudsen J, Conzelmann A (2007) SLC1 and SLC4 encode partially redundant acyl-coenzyme A 1-acylglycerol-3-phosphate O-acyltransferases of budding yeast. J Biol Chem 282(42):30845-30855. doi: 10.1074/jbc.M702719200
    • (2007) J Biol Chem , vol.282 , Issue.42 , pp. 30845-30855
    • Benghezal, M.1    Roubaty, C.2    Veepuri, V.3    Knudsen, J.4    Conzelmann, A.5
  • 37
    • 33646920976 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae Lipin homolog is a Mg2+ -dependent phosphatidate phosphatase enzyme
    • 10.1074/jbc.M600425200 1:CAS:528:DC%2BD28XjtVSrsrc%3D 1424669 16467296
    • Han GS, Wu WI, Carman GM (2006) The Saccharomyces cerevisiae Lipin homolog is a Mg2+ -dependent phosphatidate phosphatase enzyme. J Biol Chem 281(14):9210-9218. doi: 10.1074/jbc.M600425200
    • (2006) J Biol Chem , vol.281 , Issue.14 , pp. 9210-9218
    • Han, G.S.1    Wu, W.I.2    Carman, G.M.3
  • 38
    • 33751256342 scopus 로고    scopus 로고
    • Control of phospholipid synthesis by phosphorylation of the yeast lipin Pah1p/Smp2p Mg2+ -dependent phosphatidate phosphatase
    • 10.1074/jbc.M606654200 1769310 16968695
    • O'Hara L, Han GS, Peak-Chew S, Grimsey N, Carman GM, Siniossoglou S (2006) Control of phospholipid synthesis by phosphorylation of the yeast lipin Pah1p/Smp2p Mg2+ -dependent phosphatidate phosphatase. J Biol Chem 281(45):34537-34548. doi: 10.1074/jbc.M606654200
    • (2006) J Biol Chem , vol.281 , Issue.45 , pp. 34537-34548
    • O'Hara, L.1    Han, G.S.2    Peak-Chew, S.3    Grimsey, N.4    Carman, G.M.5    Siniossoglou, S.6
  • 39
    • 33751216445 scopus 로고    scopus 로고
    • Roles of phosphatidate phosphatase enzymes in lipid metabolism
    • 10.1016/j.tibs.2006.10.003 1:CAS:528:DC%2BD28Xht1Cls77N 1769311 17079146
    • Carman GM, Han GS (2006) Roles of phosphatidate phosphatase enzymes in lipid metabolism. Trends Biochem Sci 31(12):694-699. doi: 10.1016/j.tibs.2006.10.003
    • (2006) Trends Biochem Sci , vol.31 , Issue.12 , pp. 694-699
    • Carman, G.M.1    Han, G.S.2
  • 40
    • 0029920267 scopus 로고    scopus 로고
    • Regulation of phospholipid biosynthesis in the yeast Saccharomyces cerevisiae
    • 1:CAS:528:DyaK28XjsVKqtrw%3D 8663192
    • Carman GM, Zeimetz GM (1996) Regulation of phospholipid biosynthesis in the yeast Saccharomyces cerevisiae. J Biol Chem 271(23):13293-13296
    • (1996) J Biol Chem , vol.271 , Issue.23 , pp. 13293-13296
    • Carman, G.M.1    Zeimetz, G.M.2
  • 41
    • 0032730257 scopus 로고    scopus 로고
    • Phospholipid biosynthesis in the yeast Saccharomyces cerevisiae and interrelationship with other metabolic processes
    • 1:CAS:528:DC%2BD3cXjslKmsg%3D%3D 10793889
    • Carman GM, Henry SA (1999) Phospholipid biosynthesis in the yeast Saccharomyces cerevisiae and interrelationship with other metabolic processes. Prog Lipid Res 38(5-6):361-399
    • (1999) Prog Lipid Res , vol.38 , Issue.5-6 , pp. 361-399
    • Carman, G.M.1    Henry, S.A.2
  • 42
    • 0022799260 scopus 로고
    • Expression of the Saccharomyces cerevisiae inositol-1-phosphate synthase (INO1) gene is regulated by factors that affect phospholipid synthesis
    • 1:CAS:528:DyaL28XlvVGiu78%3D 367077 3025587
    • Hirsch JP, Henry SA (1986) Expression of the Saccharomyces cerevisiae inositol-1-phosphate synthase (INO1) gene is regulated by factors that affect phospholipid synthesis. Mol Cell Biol 6(10):3320-3328
    • (1986) Mol Cell Biol , vol.6 , Issue.10 , pp. 3320-3328
    • Hirsch, J.P.1    Henry, S.A.2
  • 43
    • 2942677427 scopus 로고    scopus 로고
    • Phospholipid metabolism regulated by a transcription factor sensing phosphatidic acid
    • 10.1126/science.1096083 1:CAS:528:DC%2BD2cXks1Chu7w%3D 15192221
    • Loewen CJ, Gaspar ML, Jesch SA, Delon C, Ktistakis NT, Henry SA, Levine TP (2004) Phospholipid metabolism regulated by a transcription factor sensing phosphatidic acid. Science 304(5677):1644-1647. doi: 10.1126/science.1096083
    • (2004) Science , vol.304 , Issue.5677 , pp. 1644-1647
    • Loewen, C.J.1    Gaspar, M.L.2    Jesch, S.A.3    Delon, C.4    Ktistakis, N.T.5    Henry, S.A.6    Levine, T.P.7
  • 44
    • 50649106881 scopus 로고    scopus 로고
    • Characterization of the yeast DGK1-encoded CTP-dependent diacylglycerol kinase
    • 10.1074/jbc.M802866200 1:CAS:528:DC%2BD1cXotlOhsrs%3D 2459283 18458076
    • Han GS, O'Hara L, Siniossoglou S, Carman GM (2008) Characterization of the yeast DGK1-encoded CTP-dependent diacylglycerol kinase. J Biol Chem 283(29):20443-20453. doi: 10.1074/jbc.M802866200
    • (2008) J Biol Chem , vol.283 , Issue.29 , pp. 20443-20453
    • Han, G.S.1    O'Hara, L.2    Siniossoglou, S.3    Carman, G.M.4
  • 45
    • 80051695513 scopus 로고    scopus 로고
    • Phosphatidate phosphatase activity plays key role in protection against fatty acid-induced toxicity in yeast
    • 10.1074/jbc.M111.258798 1:CAS:528:DC%2BC3MXhtVWgsbvL 3190715 21708942
    • Fakas S, Qiu Y, Dixon JL, Han GS, Ruggles KV, Garbarino J, Sturley SL, Carman GM (2011) Phosphatidate phosphatase activity plays key role in protection against fatty acid-induced toxicity in yeast. J Biol Chem 286(33):29074-29085. doi: 10.1074/jbc.M111.258798
    • (2011) J Biol Chem , vol.286 , Issue.33 , pp. 29074-29085
    • Fakas, S.1    Qiu, Y.2    Dixon, J.L.3    Han, G.S.4    Ruggles, K.V.5    Garbarino, J.6    Sturley, S.L.7    Carman, G.M.8
  • 46
    • 18944406929 scopus 로고    scopus 로고
    • The spatial organization of lipid synthesis in the yeast Saccharomyces cerevisiae derived from large scale green fluorescent protein tagging and high resolution microscopy
    • 10.1074/mcp.M400123-MCP200 1:CAS:528:DC%2BD2MXktlSms78%3D
    • Natter K, Leitner P, Faschinger A, Wolinski H, McCraith S, Fields S, Kohlwein SD (2005) The spatial organization of lipid synthesis in the yeast Saccharomyces cerevisiae derived from large scale green fluorescent protein tagging and high resolution microscopy. Mol Cell Proteomics MCP 4(5):662-672. doi: 10.1074/mcp.M400123-MCP200
    • (2005) Mol Cell Proteomics MCP , vol.4 , Issue.5 , pp. 662-672
    • Natter, K.1    Leitner, P.2    Faschinger, A.3    Wolinski, H.4    McCraith, S.5    Fields, S.6    Kohlwein, S.D.7
  • 47
    • 77953591461 scopus 로고    scopus 로고
    • The Kennedy pathway-De novo synthesis of phosphatidylethanolamine and phosphatidylcholine
    • 10.1002/iub.337 1:CAS:528:DC%2BC3cXmsVGhtLk%3D 20503434
    • Gibellini F, Smith TK (2010) The Kennedy pathway-De novo synthesis of phosphatidylethanolamine and phosphatidylcholine. IUBMB Life 62(6):414-428. doi: 10.1002/iub.337
    • (2010) IUBMB Life , vol.62 , Issue.6 , pp. 414-428
    • Gibellini, F.1    Smith, T.K.2
  • 48
    • 84857424979 scopus 로고    scopus 로고
    • Metabolism and regulation of glycerolipids in the yeast Saccharomyces cerevisiae
    • 10.1534/genetics.111.130286 1:CAS:528:DC%2BC38XnsVSmsbo%3D 3276621 22345606
    • Henry SA, Kohlwein SD, Carman GM (2012) Metabolism and regulation of glycerolipids in the yeast Saccharomyces cerevisiae. Genetics 190(2):317-349. doi: 10.1534/genetics.111.130286
    • (2012) Genetics , vol.190 , Issue.2 , pp. 317-349
    • Henry, S.A.1    Kohlwein, S.D.2    Carman, G.M.3
  • 49
    • 0027231368 scopus 로고
    • Sterol composition of yeast organelle membranes and subcellular distribution of enzymes involved in sterol metabolism
    • 1:CAS:528:DyaK3sXks1Omt7Y%3D 204601 8491706
    • Zinser E, Paltauf F, Daum G (1993) Sterol composition of yeast organelle membranes and subcellular distribution of enzymes involved in sterol metabolism. J Bacteriol 175(10):2853-2858
    • (1993) J Bacteriol , vol.175 , Issue.10 , pp. 2853-2858
    • Zinser, E.1    Paltauf, F.2    Daum, G.3
  • 50
    • 0026041521 scopus 로고
    • The gene encoding squalene epoxidase from Saccharomyces cerevisiae: Cloning and characterization
    • 1:CAS:528:DyaK3sXjsFSgtg%3D%3D 1743514
    • Jandrositz A, Turnowsky F, Hogenauer G (1991) The gene encoding squalene epoxidase from Saccharomyces cerevisiae: cloning and characterization. Gene 107(1):155-160
    • (1991) Gene , vol.107 , Issue.1 , pp. 155-160
    • Jandrositz, A.1    Turnowsky, F.2    Hogenauer, G.3
  • 51
    • 0031931498 scopus 로고    scopus 로고
    • Dual localization of squalene epoxidase, Erg1p, in yeast reflects a relationship between the endoplasmic reticulum and lipid particles
    • 1:CAS:528:DyaK1cXhtVWgtLc%3D 25265 9450962
    • Leber R, Landl K, Zinser E, Ahorn H, Spok A, Kohlwein SD, Turnowsky F, Daum G (1998) Dual localization of squalene epoxidase, Erg1p, in yeast reflects a relationship between the endoplasmic reticulum and lipid particles. Mol Biol Cell 9(2):375-386
    • (1998) Mol Biol Cell , vol.9 , Issue.2 , pp. 375-386
    • Leber, R.1    Landl, K.2    Zinser, E.3    Ahorn, H.4    Spok, A.5    Kohlwein, S.D.6    Turnowsky, F.7    Daum, G.8
  • 52
    • 0028283156 scopus 로고
    • Isolation and characterization of the gene encoding 2,3-oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae
    • 1:CAS:528:DyaK2cXmt1Crurc%3D 44401 8041797
    • Shi Z, Buntel CJ, Griffin JH (1994) Isolation and characterization of the gene encoding 2,3-oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae. Proc Natl Acad Sci USA 91(15):7370-7374
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.15 , pp. 7370-7374
    • Shi, Z.1    Buntel, C.J.2    Griffin, J.H.3
  • 53
    • 0037169489 scopus 로고    scopus 로고
    • Yeast oxidosqualene cyclase (Erg7p) is a major component of lipid particles
    • 10.1074/jbc.M104195200 1:CAS:528:DC%2BD38XhtVShu7g%3D 11706015
    • Milla P, Athenstaedt K, Viola F, Oliaro-Bosso S, Kohlwein SD, Daum G, Balliano G (2002) Yeast oxidosqualene cyclase (Erg7p) is a major component of lipid particles. J Biol Chem 277(4):2406-2412. doi: 10.1074/jbc.M104195200
    • (2002) J Biol Chem , vol.277 , Issue.4 , pp. 2406-2412
    • Milla, P.1    Athenstaedt, K.2    Viola, F.3    Oliaro-Bosso, S.4    Kohlwein, S.D.5    Daum, G.6    Balliano, G.7
  • 54
    • 84880707873 scopus 로고    scopus 로고
    • Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4
    • 10.7554/eLife.00953 3721249 23898401
    • Foresti O, Ruggiano A, Hannibal-Bach HK, Ejsing CS, Carvalho P (2013) Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4. eLife 2:e00953. doi: 10.7554/eLife.00953
    • (2013) ELife , vol.2 , pp. 00953
    • Foresti, O.1    Ruggiano, A.2    Hannibal-Bach, H.K.3    Ejsing, C.S.4    Carvalho, P.5
  • 55
    • 79960398841 scopus 로고    scopus 로고
    • Lipid droplets are functionally connected to the endoplasmic reticulum in Saccharomyces cerevisiae
    • 10.1242/jcs.076836 1:CAS:528:DC%2BC3MXhtVOktr%2FL 21693588
    • Jacquier N, Choudhary V, Mari M, Toulmay A, Reggiori F, Schneiter R (2011) Lipid droplets are functionally connected to the endoplasmic reticulum in Saccharomyces cerevisiae. J Cell Sci 124(Pt 14):2424-2437. doi: 10.1242/jcs.076836
    • (2011) J Cell Sci , vol.124 , pp. 2424-2437
    • Jacquier, N.1    Choudhary, V.2    Mari, M.3    Toulmay, A.4    Reggiori, F.5    Schneiter, R.6
  • 56
    • 66949160825 scopus 로고    scopus 로고
    • Lipid droplets at a glance
    • 10.1242/jcs.037630 1:CAS:528:DC%2BD1MXksFWru7c%3D 2714424 19261844
    • Guo Y, Cordes KR, Farese RV Jr, Walther TC (2009) Lipid droplets at a glance. J Cell Sci 122(Pt 6):749-752. doi: 10.1242/jcs.037630
    • (2009) J Cell Sci , vol.122 , pp. 749-752
    • Guo, Y.1    Cordes, K.R.2    Farese, Jr.R.V.3    Walther, T.C.4
  • 57
    • 77952674796 scopus 로고    scopus 로고
    • Phospholipid demixing and the birth of a lipid droplet
    • 10.1016/j.jtbi.2010.02.025 1:CAS:528:DC%2BC3cXlslyrsL4%3D 20184900
    • Zanghellini J, Wodlei F, von Grunberg HH (2010) Phospholipid demixing and the birth of a lipid droplet. J Theor Biol 264(3):952-961. doi: 10.1016/j.jtbi.2010.02.025
    • (2010) J Theor Biol , vol.264 , Issue.3 , pp. 952-961
    • Zanghellini, J.1    Wodlei, F.2    Von Grunberg, H.H.3
  • 58
    • 0033991176 scopus 로고    scopus 로고
    • A proposed model for the assembly of chylomicrons
    • 1:STN:280:DC%2BD3c%2FkslKqsA%3D%3D 10580165
    • Hussain MM (2000) A proposed model for the assembly of chylomicrons. Atherosclerosis 148(1):1-15
    • (2000) Atherosclerosis , vol.148 , Issue.1 , pp. 1-15
    • Hussain, M.M.1
  • 59
    • 3843131947 scopus 로고    scopus 로고
    • A yeast strain lacking lipid particles bears a defect in ergosterol formation
    • 10.1074/jbc.M403251200 1:CAS:528:DC%2BD2cXlslOku7s%3D 15155725
    • Sorger D, Athenstaedt K, Hrastnik C, Daum G (2004) A yeast strain lacking lipid particles bears a defect in ergosterol formation. J Biol Chem 279(30):31190-31196. doi: 10.1074/jbc.M403251200
    • (2004) J Biol Chem , vol.279 , Issue.30 , pp. 31190-31196
    • Sorger, D.1    Athenstaedt, K.2    Hrastnik, C.3    Daum, G.4
  • 60
    • 84867426217 scopus 로고    scopus 로고
    • The ubiquitin-like (UBX)-domain-containing protein Ubx2/Ubxd8 regulates lipid droplet homeostasis
    • 10.1242/jcs.100230 1:CAS:528:DC%2BC38Xhtlyltb3O 22454508
    • Wang CW, Lee SC (2012) The ubiquitin-like (UBX)-domain-containing protein Ubx2/Ubxd8 regulates lipid droplet homeostasis. J Cell Sci 125(Pt 12):2930-2939. doi: 10.1242/jcs.100230
    • (2012) J Cell Sci , vol.125 , pp. 2930-2939
    • Wang, C.W.1    Lee, S.C.2
  • 61
    • 84864863755 scopus 로고    scopus 로고
    • The topology of the triacylglycerol synthesizing enzyme Lro1 indicates that neutral lipids can be produced within the luminal compartment of the endoplasmatic reticulum: Implications for the biogenesis of lipid droplets
    • 1:CAS:528:DC%2BC3MXhs1WrsLzK 3306359 22446555
    • Choudhary V, Jacquier N, Schneiter R (2011) The topology of the triacylglycerol synthesizing enzyme Lro1 indicates that neutral lipids can be produced within the luminal compartment of the endoplasmatic reticulum: implications for the biogenesis of lipid droplets. Commun Integr Biol 4(6):781-784
    • (2011) Commun Integr Biol , vol.4 , Issue.6 , pp. 781-784
    • Choudhary, V.1    Jacquier, N.2    Schneiter, R.3
  • 62
    • 80054685861 scopus 로고    scopus 로고
    • Topology of 1-acyl-sn-glycerol-3-phosphate acyltransferases SLC1 and ALE1 and related membrane-bound O-acyltransferases (MBOATs) of Saccharomyces cerevisiae
    • 10.1074/jbc.M111.256511 1:CAS:528:DC%2BC3MXhtlSqtL7L 3196135 21849510
    • Pagac M, de la Mora HV, Duperrex C, Roubaty C, Vionnet C, Conzelmann A (2011) Topology of 1-acyl-sn-glycerol-3-phosphate acyltransferases SLC1 and ALE1 and related membrane-bound O-acyltransferases (MBOATs) of Saccharomyces cerevisiae. J Biol Chem 286(42):36438-36447. doi: 10.1074/jbc.M111.256511
    • (2011) J Biol Chem , vol.286 , Issue.42 , pp. 36438-36447
    • Pagac, M.1    De La Mora, H.V.2    Duperrex, C.3    Roubaty, C.4    Vionnet, C.5    Conzelmann, A.6
  • 64
    • 79955486102 scopus 로고    scopus 로고
    • The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets
    • 10.1083/jcb.201010111 1:CAS:528:DC%2BC3MXktVKjtLw%3D 3063132 21422231
    • Adeyo O, Horn PJ, Lee S, Binns DD, Chandrahas A, Chapman KD, Goodman JM (2011) The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets. J Cell Biol 192(6):1043-1055. doi: 10.1083/jcb.201010111
    • (2011) J Cell Biol , vol.192 , Issue.6 , pp. 1043-1055
    • Adeyo, O.1    Horn, P.J.2    Lee, S.3    Binns, D.D.4    Chandrahas, A.5    Chapman, K.D.6    Goodman, J.M.7
  • 65
    • 71449118409 scopus 로고    scopus 로고
    • Diacylglycerol enrichment of endoplasmic reticulum or lipid droplets recruits perilipin 3/TIP47 during lipid storage and mobilization
    • 10.1074/jbc.M109.013995 1:CAS:528:DC%2BD1MXhtlequ7nN 2781494 19748893
    • Skinner JR, Shew TM, Schwartz DM, Tzekov A, Lepus CM, Abumrad NA, Wolins NE (2009) Diacylglycerol enrichment of endoplasmic reticulum or lipid droplets recruits perilipin 3/TIP47 during lipid storage and mobilization. J Biol Chem 284(45):30941-30948. doi: 10.1074/jbc.M109.013995
    • (2009) J Biol Chem , vol.284 , Issue.45 , pp. 30941-30948
    • Skinner, J.R.1    Shew, T.M.2    Schwartz, D.M.3    Tzekov, A.4    Lepus, C.M.5    Abumrad, N.A.6    Wolins, N.E.7
  • 66
    • 80053927108 scopus 로고    scopus 로고
    • Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase
    • 10.1016/j.cmet.2011.07.013 1:CAS:528:DC%2BC3MXht12rtLvN 3735358 21982710
    • Krahmer N, Guo Y, Wilfling F, Hilger M, Lingrell S, Heger K, Newman HW, Schmidt-Supprian M, Vance DE, Mann M, Farese RV Jr, Walther TC (2011) Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase. Cell Metab 14(4):504-515. doi: 10.1016/j.cmet.2011.07.013
    • (2011) Cell Metab , vol.14 , Issue.4 , pp. 504-515
    • Krahmer, N.1    Guo, Y.2    Wilfling, F.3    Hilger, M.4    Lingrell, S.5    Heger, K.6    Newman, H.W.7    Schmidt-Supprian, M.8    Vance, D.E.9    Mann, M.10    Farese, Jr.R.V.11    Walther, T.C.12
  • 67
    • 79958712557 scopus 로고    scopus 로고
    • Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine
    • 10.1074/jbc.M110.202424 1:CAS:528:DC%2BC3MXntlOkurY%3D 3122193 21498505
    • Moessinger C, Kuerschner L, Spandl J, Shevchenko A, Thiele C (2011) Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine. J Biol Chem 286(24):21330-21339. doi: 10.1074/jbc.M110.202424
    • (2011) J Biol Chem , vol.286 , Issue.24 , pp. 21330-21339
    • Moessinger, C.1    Kuerschner, L.2    Spandl, J.3    Shevchenko, A.4    Thiele, C.5
  • 68
    • 0034614454 scopus 로고    scopus 로고
    • 1-Acyldihydroxyacetone-phosphate reductase (Ayr1p) of the yeast Saccharomyces cerevisiae encoded by the open reading frame YIL124w is a major component of lipid particles
    • 1:CAS:528:DC%2BD3cXjvVGrug%3D%3D 10617610
    • Athenstaedt K, Daum G (2000) 1-Acyldihydroxyacetone-phosphate reductase (Ayr1p) of the yeast Saccharomyces cerevisiae encoded by the open reading frame YIL124w is a major component of lipid particles. J Biol Chem 275(1):235-240
    • (2000) J Biol Chem , vol.275 , Issue.1 , pp. 235-240
    • Athenstaedt, K.1    Daum, G.2
  • 69
    • 38049184643 scopus 로고    scopus 로고
    • The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology
    • 10.1073/pnas.0704154104 1:CAS:528:DC%2BD1cXkt1Kjsg%3D%3D 2409237 18093937
    • Szymanski KM, Binns D, Bartz R, Grishin NV, Li WP, Agarwal AK, Garg A, Anderson RG, Goodman JM (2007) The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology. Proc Natl Acad Sci USA 104(52):20890-20895. doi: 10.1073/pnas.0704154104
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.52 , pp. 20890-20895
    • Szymanski, K.M.1    Binns, D.2    Bartz, R.3    Grishin, N.V.4    Li, W.P.5    Agarwal, A.K.6    Garg, A.7    Anderson, R.G.8    Goodman, J.M.9
  • 70
    • 41449116419 scopus 로고    scopus 로고
    • Genome-wide analysis of sterol-lipid storage and trafficking in Saccharomyces cerevisiae
    • 10.1128/EC.00386-07 1:CAS:528:DC%2BD1cXkvVGjs7k%3D 2238164 18156287
    • Fei W, Alfaro G, Muthusamy BP, Klaassen Z, Graham TR, Yang H, Beh CT (2008) Genome-wide analysis of sterol-lipid storage and trafficking in Saccharomyces cerevisiae. Eukaryot Cell 7(2):401-414. doi: 10.1128/EC.00386-07
    • (2008) Eukaryot Cell , vol.7 , Issue.2 , pp. 401-414
    • Fei, W.1    Alfaro, G.2    Muthusamy, B.P.3    Klaassen, Z.4    Graham, T.R.5    Yang, H.6    Beh, C.T.7
  • 71
    • 84861432786 scopus 로고    scopus 로고
    • Seipin: from human disease to molecular mechanism
    • 10.1194/jlr.R023754 1:CAS:528:DC%2BC38Xns1emtbw%3D 3351812 22474068
    • Cartwright BR, Goodman JM (2012) Seipin: from human disease to molecular mechanism. J Lipid Res 53(6):1042-1055. doi: 10.1194/jlr.R023754
    • (2012) J Lipid Res , vol.53 , Issue.6 , pp. 1042-1055
    • Cartwright, B.R.1    Goodman, J.M.2
  • 72
    • 78650388357 scopus 로고    scopus 로고
    • Seipin is a discrete homooligomer
    • 10.1021/bi1013003 1:CAS:528:DC%2BC3cXhsVegu7%2FN 3086013 21062080
    • Binns D, Lee S, Hilton CL, Jiang QX, Goodman JM (2010) Seipin is a discrete homooligomer. Biochemistry 49(50):10747-10755. doi: 10.1021/bi1013003
    • (2010) Biochemistry , vol.49 , Issue.50 , pp. 10747-10755
    • Binns, D.1    Lee, S.2    Hilton, C.L.3    Jiang, Q.X.4    Goodman, J.M.5
  • 73
    • 84922780683 scopus 로고    scopus 로고
    • Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology
    • 10.1091/mbc.E14-08-1303 25540432
    • Cartwright BR, Binns DD, Hilton CL, Han S, Gao Q, Goodman JM (2014) Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology. Mol Biol Cell. doi: 10.1091/mbc.E14-08-1303
    • (2014) Mol Biol Cell
    • Cartwright, B.R.1    Binns, D.D.2    Hilton, C.L.3    Han, S.4    Gao, Q.5    Goodman, J.M.6
  • 74
    • 84924061517 scopus 로고    scopus 로고
    • Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis
    • 10.1016/j.molmet.2014.12.013 1:CAS:528:DC%2BC2MXmslGitQ%3D%3D 4338318 25737955
    • Talukder MM, Sim MF, O'Rahilly S, Edwardson JM, Rochford JJ (2015) Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis. Mol Metab 4(3):199-209. doi: 10.1016/j.molmet.2014.12.013
    • (2015) Mol Metab , vol.4 , Issue.3 , pp. 199-209
    • Talukder, M.M.1    Sim, M.F.2    O'Rahilly, S.3    Edwardson, J.M.4    Rochford, J.J.5
  • 75
    • 84899942026 scopus 로고    scopus 로고
    • Seipin promotes adipose tissue fat storage through the ER Ca(2)(+)-ATPase SERCA
    • 10.1016/j.cmet.2014.03.028 1:CAS:528:DC%2BC2cXotVejurc%3D 24807223
    • Bi J, Wang W, Liu Z, Huang X, Jiang Q, Liu G, Wang Y, Huang X (2014) Seipin promotes adipose tissue fat storage through the ER Ca(2)(+)-ATPase SERCA. Cell Metab 19(5):861-871. doi: 10.1016/j.cmet.2014.03.028
    • (2014) Cell Metab , vol.19 , Issue.5 , pp. 861-871
    • Bi, J.1    Wang, W.2    Liu, Z.3    Huang, X.4    Jiang, Q.5    Liu, G.6    Wang, Y.7    Huang, X.8
  • 77
    • 77956509037 scopus 로고    scopus 로고
    • Structural insights into triglyceride storage mediated by fat storage-inducing transmembrane (FIT) protein 2
    • 10.1371/journal.pone.0010796 2875400 20520733
    • Gross DA, Snapp EL, Silver DL (2010) Structural insights into triglyceride storage mediated by fat storage-inducing transmembrane (FIT) protein 2. PLoS One 5(5):e10796. doi: 10.1371/journal.pone.0010796
    • (2010) PLoS One , vol.5 , Issue.5 , pp. 10796
    • Gross, D.A.1    Snapp, E.L.2    Silver, D.L.3
  • 78
    • 84866182918 scopus 로고    scopus 로고
    • SCS3 and YFT2 link transcription of phospholipid biosynthetic genes to ER stress and the UPR
    • 10.1371/journal.pgen.1002890 1:CAS:528:DC%2BC38Xht1OitrrO 3426550 22927826
    • Moir RD, Gross DA, Silver DL, Willis IM (2012) SCS3 and YFT2 link transcription of phospholipid biosynthetic genes to ER stress and the UPR. PLoS Genet 8(8):e1002890. doi: 10.1371/journal.pgen.1002890
    • (2012) PLoS Genet , vol.8 , Issue.8 , pp. 1002890
    • Moir, R.D.1    Gross, D.A.2    Silver, D.L.3    Willis, I.M.4
  • 79
    • 44449095056 scopus 로고    scopus 로고
    • Functional genomic screen reveals genes involved in lipid-droplet formation and utilization
    • 10.1038/nature06928 1:CAS:528:DC%2BD1cXmsVKqtbw%3D 2734507 18408709
    • Guo Y, Walther TC, Rao M, Stuurman N, Goshima G, Terayama K, Wong JS, Vale RD, Walter P, Farese RV (2008) Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature 453(7195):657-661. doi: 10.1038/nature06928
    • (2008) Nature , vol.453 , Issue.7195 , pp. 657-661
    • Guo, Y.1    Walther, T.C.2    Rao, M.3    Stuurman, N.4    Goshima, G.5    Terayama, K.6    Wong, J.S.7    Vale, R.D.8    Walter, P.9    Farese, R.V.10
  • 80
    • 84862908504 scopus 로고    scopus 로고
    • Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites
    • 10.1083/jcb.201104142 1:CAS:528:DC%2BC3MXhs1ChurvK 3241734 22144693
    • Gong J, Sun Z, Wu L, Xu W, Schieber N, Xu D, Shui G, Yang H, Parton RG, Li P (2011) Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites. J Cell Biol 195(6):953-963. doi: 10.1083/jcb.201104142
    • (2011) J Cell Biol , vol.195 , Issue.6 , pp. 953-963
    • Gong, J.1    Sun, Z.2    Wu, L.3    Xu, W.4    Schieber, N.5    Xu, D.6    Shui, G.7    Yang, H.8    Parton, R.G.9    Li, P.10
  • 81
    • 84875871194 scopus 로고    scopus 로고
    • Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes
    • 10.1038/ncomms2581 3615468 23481402
    • Sun Z, Gong J, Wu H, Xu W, Wu L, Xu D, Gao J, Wu JW, Yang H, Yang M, Li P (2013) Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes. Nat Commun 4:1594. doi: 10.1038/ncomms2581
    • (2013) Nat Commun , vol.4 , pp. 1594
    • Sun, Z.1    Gong, J.2    Wu, H.3    Xu, W.4    Wu, L.5    Xu, D.6    Gao, J.7    Wu, J.W.8    Yang, H.9    Yang, M.10    Li, P.11
  • 84
    • 77951245602 scopus 로고    scopus 로고
    • The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase
    • 10.1074/jbc.M109.064469 1:CAS:528:DC%2BC3cXksVGktrc%3D 2852968 20164531
    • Gruber A, Cornaciu I, Lass A, Schweiger M, Poeschl M, Eder C, Kumari M, Schoiswohl G, Wolinski H, Kohlwein SD, Zechner R, Zimmermann R, Oberer M (2010) The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase. J Biol Chem 285(16):12289-12298. doi: 10.1074/jbc.M109.064469
    • (2010) J Biol Chem , vol.285 , Issue.16 , pp. 12289-12298
    • Gruber, A.1    Cornaciu, I.2    Lass, A.3    Schweiger, M.4    Poeschl, M.5    Eder, C.6    Kumari, M.7    Schoiswohl, G.8    Wolinski, H.9    Kohlwein, S.D.10    Zechner, R.11    Zimmermann, R.12    Oberer, M.13
  • 86
    • 33846029180 scopus 로고    scopus 로고
    • Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism
    • 10.1074/jbc.M608048200 1:CAS:528:DC%2BD28XhtlCrt7zE 17074755
    • Schweiger M, Schreiber R, Haemmerle G, Lass A, Fledelius C, Jacobsen P, Tornqvist H, Zechner R, Zimmermann R (2006) Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism. J Biol Chem 281(52):40236-40241. doi: 10.1074/jbc.M608048200
    • (2006) J Biol Chem , vol.281 , Issue.52 , pp. 40236-40241
    • Schweiger, M.1    Schreiber, R.2    Haemmerle, G.3    Lass, A.4    Fledelius, C.5    Jacobsen, P.6    Tornqvist, H.7    Zechner, R.8    Zimmermann, R.9
  • 88
    • 77954658402 scopus 로고    scopus 로고
    • Identification of Yju3p as functional orthologue of mammalian monoglyceride lipase in the yeast Saccharomyces cerevisiae
    • 10.1016/j.bbalip.2010.06.001 1:CAS:528:DC%2BC3cXovFymtLs%3D 2911655 20554061
    • Heier C, Taschler U, Rengachari S, Oberer M, Wolinski H, Natter K, Kohlwein SD, Leber R, Zimmermann R (2010) Identification of Yju3p as functional orthologue of mammalian monoglyceride lipase in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta 1801(9):1063-1071. doi: 10.1016/j.bbalip.2010.06.001
    • (2010) Biochim Biophys Acta , vol.1801 , Issue.9 , pp. 1063-1071
    • Heier, C.1    Taschler, U.2    Rengachari, S.3    Oberer, M.4    Wolinski, H.5    Natter, K.6    Kohlwein, S.D.7    Leber, R.8    Zimmermann, R.9
  • 89
    • 0037931415 scopus 로고    scopus 로고
    • YMR313c/TGL3 encodes a novel triacylglycerol lipase located in lipid particles of Saccharomyces cerevisiae
    • 10.1074/jbc.M302577200 1:CAS:528:DC%2BD3sXkslygs7o%3D 12682047
    • Athenstaedt K, Daum G (2003) YMR313c/TGL3 encodes a novel triacylglycerol lipase located in lipid particles of Saccharomyces cerevisiae. J Biol Chem 278(26):23317-23323. doi: 10.1074/jbc.M302577200
    • (2003) J Biol Chem , vol.278 , Issue.26 , pp. 23317-23323
    • Athenstaedt, K.1    Daum, G.2
  • 90
    • 27844486104 scopus 로고    scopus 로고
    • Tgl4p and Tgl5p, two triacylglycerol lipases of the yeast Saccharomyces cerevisiae are localized to lipid particles
    • 10.1074/jbc.M507261200 1:CAS:528:DC%2BD2MXhtF2isr%2FI 16135509
    • Athenstaedt K, Daum G (2005) Tgl4p and Tgl5p, two triacylglycerol lipases of the yeast Saccharomyces cerevisiae are localized to lipid particles. J Biol Chem 280(45):37301-37309. doi: 10.1074/jbc.M507261200
    • (2005) J Biol Chem , vol.280 , Issue.45 , pp. 37301-37309
    • Athenstaedt, K.1    Daum, G.2
  • 91
    • 33846501577 scopus 로고    scopus 로고
    • Dynamics of neutral lipid storage and mobilization in yeast
    • 10.1016/j.biochi.2006.06.018 1:CAS:528:DC%2BD2sXhtlaqsL4%3D 16919863
    • Daum G, Wagner A, Czabany T, Athenstaedt K (2007) Dynamics of neutral lipid storage and mobilization in yeast. Biochimie 89(2):243-248. doi: 10.1016/j.biochi.2006.06.018
    • (2007) Biochimie , vol.89 , Issue.2 , pp. 243-248
    • Daum, G.1    Wagner, A.2    Czabany, T.3    Athenstaedt, K.4
  • 92
    • 84904184308 scopus 로고    scopus 로고
    • Modifications of the C terminus affect functionality and stability of yeast triacylglycerol lipase Tgl3p
    • 10.1074/jbc.M114.556944 1:CAS:528:DC%2BC2cXhtFCktLzP 24847060
    • Koch B, Schmidt C, Ploier B, Daum G (2014) Modifications of the C terminus affect functionality and stability of yeast triacylglycerol lipase Tgl3p. J Biol Chem 289(28):19306-19316. doi: 10.1074/jbc.M114.556944
    • (2014) J Biol Chem , vol.289 , Issue.28 , pp. 19306-19316
    • Koch, B.1    Schmidt, C.2    Ploier, B.3    Daum, G.4
  • 93
    • 58149308056 scopus 로고    scopus 로고
    • Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression
    • 10.1016/j.molcel.2008.12.019 1:CAS:528:DC%2BD1MXhtFOit74%3D 19150427
    • Kurat CF, Wolinski H, Petschnigg J, Kaluarachchi S, Andrews B, Natter K, Kohlwein SD (2009) Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression. Mol Cell 33(1):53-63. doi: 10.1016/j.molcel.2008.12.019
    • (2009) Mol Cell , vol.33 , Issue.1 , pp. 53-63
    • Kurat, C.F.1    Wolinski, H.2    Petschnigg, J.3    Kaluarachchi, S.4    Andrews, B.5    Natter, K.6    Kohlwein, S.D.7
  • 94
    • 77957971106 scopus 로고    scopus 로고
    • Triacylglycerol lipolysis is linked to sphingolipid and phospholipid metabolism of the yeast Saccharomyces cerevisiae
    • 10.1016/j.bbalip.2010.08.004 1:CAS:528:DC%2BC3cXhtlShtLzE 20727985
    • Rajakumari S, Rajasekharan R, Daum G (2010) Triacylglycerol lipolysis is linked to sphingolipid and phospholipid metabolism of the yeast Saccharomyces cerevisiae. Biochim Biophys Acta 1801(12):1314-1322. doi: 10.1016/j.bbalip.2010.08.004
    • (2010) Biochim Biophys Acta , vol.1801 , Issue.12 , pp. 1314-1322
    • Rajakumari, S.1    Rajasekharan, R.2    Daum, G.3
  • 95
    • 84890406779 scopus 로고    scopus 로고
    • Screening for hydrolytic enzymes reveals Ayr1p as a novel triacylglycerol lipase in Saccharomyces cerevisiae
    • 10.1074/jbc.M113.509927 1:CAS:528:DC%2BC3sXhvFaku7jN 3861654 24187129
    • Ploier B, Scharwey M, Koch B, Schmidt C, Schatte J, Rechberger G, Kollroser M, Hermetter A, Daum G (2013) Screening for hydrolytic enzymes reveals Ayr1p as a novel triacylglycerol lipase in Saccharomyces cerevisiae. J Biol Chem 288(50):36061-36072. doi: 10.1074/jbc.M113.509927
    • (2013) J Biol Chem , vol.288 , Issue.50 , pp. 36061-36072
    • Ploier, B.1    Scharwey, M.2    Koch, B.3    Schmidt, C.4    Schatte, J.5    Rechberger, G.6    Kollroser, M.7    Hermetter, A.8    Daum, G.9
  • 96
    • 79957966848 scopus 로고    scopus 로고
    • The putative Saccharomyces cerevisiae hydrolase Ldh1p is localized to lipid droplets
    • 10.1128/EC.05038-11 1:CAS:528:DC%2BC3MXnsFOnt7k%3D 3127662 21478430
    • Thoms S, Debelyy MO, Connerth M, Daum G, Erdmann R (2011) The putative Saccharomyces cerevisiae hydrolase Ldh1p is localized to lipid droplets. Eukaryot Cell 10(6):770-775. doi: 10.1128/EC.05038-11
    • (2011) Eukaryot Cell , vol.10 , Issue.6 , pp. 770-775
    • Thoms, S.1    Debelyy, M.O.2    Connerth, M.3    Daum, G.4    Erdmann, R.5
  • 97
    • 79957961147 scopus 로고    scopus 로고
    • Involvement of the Saccharomyces cerevisiae hydrolase Ldh1p in lipid homeostasis
    • 10.1128/EC.05040-11 1:CAS:528:DC%2BC3MXnsFOnt7c%3D 3127674 21478434
    • Debelyy MO, Thoms S, Connerth M, Daum G, Erdmann R (2011) Involvement of the Saccharomyces cerevisiae hydrolase Ldh1p in lipid homeostasis. Eukaryot Cell 10(6):776-781. doi: 10.1128/EC.05040-11
    • (2011) Eukaryot Cell , vol.10 , Issue.6 , pp. 776-781
    • Debelyy, M.O.1    Thoms, S.2    Connerth, M.3    Daum, G.4    Erdmann, R.5
  • 98
    • 14044272811 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae YLL012/YEH1, YLR020/YEH2, and TGL1 genes encode a novel family of membrane-anchored lipases that are required for steryl ester hydrolysis
    • 10.1128/MCB.25.5.1655-1668.2005 549362 15713625
    • Koffel R, Tiwari R, Falquet L, Schneiter R (2005) The Saccharomyces cerevisiae YLL012/YEH1, YLR020/YEH2, and TGL1 genes encode a novel family of membrane-anchored lipases that are required for steryl ester hydrolysis. Mol Cell Biol 25(5):1655-1668. doi: 10.1128/MCB.25.5.1655-1668.2005
    • (2005) Mol Cell Biol , vol.25 , Issue.5 , pp. 1655-1668
    • Koffel, R.1    Tiwari, R.2    Falquet, L.3    Schneiter, R.4
  • 99
    • 17144404154 scopus 로고    scopus 로고
    • YEH2/YLR020c encodes a novel steryl ester hydrolase of the yeast Saccharomyces cerevisiae
    • 10.1074/jbc.M409914200 15632184
    • Mullner H, Deutsch G, Leitner E, Ingolic E, Daum G (2005) YEH2/YLR020c encodes a novel steryl ester hydrolase of the yeast Saccharomyces cerevisiae. J Biol Chem 280(14):13321-13328. doi: 10.1074/jbc.M409914200
    • (2005) J Biol Chem , vol.280 , Issue.14 , pp. 13321-13328
    • Mullner, H.1    Deutsch, G.2    Leitner, E.3    Ingolic, E.4    Daum, G.5
  • 100
    • 33746268567 scopus 로고    scopus 로고
    • Yeh1 constitutes the major steryl ester hydrolase under heme-deficient conditions in Saccharomyces cerevisiae
    • 10.1128/EC.00002-06 1:CAS:528:DC%2BD28Xnt1OgsrY%3D 1489292 16835446
    • Koffel R, Schneiter R (2006) Yeh1 constitutes the major steryl ester hydrolase under heme-deficient conditions in Saccharomyces cerevisiae. Eukaryot Cell 5(7):1018-1025. doi: 10.1128/EC.00002-06
    • (2006) Eukaryot Cell , vol.5 , Issue.7 , pp. 1018-1025
    • Koffel, R.1    Schneiter, R.2
  • 101
    • 59049107663 scopus 로고    scopus 로고
    • Mobilization of steryl esters from lipid particles of the yeast Saccharomyces cerevisiae
    • 10.1016/j.bbalip.2008.11.004 1:CAS:528:DC%2BD1MXhsFOlu7c%3D 19111628
    • Wagner A, Grillitsch K, Leitner E, Daum G (2009) Mobilization of steryl esters from lipid particles of the yeast Saccharomyces cerevisiae. Biochim Biophys Acta 1791(2):118-124. doi: 10.1016/j.bbalip.2008.11.004
    • (2009) Biochim Biophys Acta , vol.1791 , Issue.2 , pp. 118-124
    • Wagner, A.1    Grillitsch, K.2    Leitner, E.3    Daum, G.4
  • 102
    • 84892543665 scopus 로고    scopus 로고
    • An ER protein functionally couples neutral lipid metabolism on lipid droplets to membrane lipid synthesis in the ER
    • 10.1016/j.celrep.2013.11.046 1:CAS:528:DC%2BC2cXls1yi 3947819 24373967
    • Markgraf DF, Klemm RW, Junker M, Hannibal-Bach HK, Ejsing CS, Rapoport TA (2014) An ER protein functionally couples neutral lipid metabolism on lipid droplets to membrane lipid synthesis in the ER. Cell Reports 6(1):44-55. doi: 10.1016/j.celrep.2013.11.046
    • (2014) Cell Reports , vol.6 , Issue.1 , pp. 44-55
    • Markgraf, D.F.1    Klemm, R.W.2    Junker, M.3    Hannibal-Bach, H.K.4    Ejsing, C.S.5    Rapoport, T.A.6
  • 103
    • 77950607704 scopus 로고    scopus 로고
    • Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins
    • 10.1194/jlr.R000034 1:CAS:528:DC%2BC3cXisVeksbY%3D 2817576 19638644
    • Kimmel AR, Brasaemle DL, McAndrews-Hill M, Sztalryd C, Londos C (2010) Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins. J Lipid Res 51(3):468-471. doi: 10.1194/jlr.R000034
    • (2010) J Lipid Res , vol.51 , Issue.3 , pp. 468-471
    • Kimmel, A.R.1    Brasaemle, D.L.2    McAndrews-Hill, M.3    Sztalryd, C.4    Londos, C.5
  • 105
    • 84904011588 scopus 로고    scopus 로고
    • High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation
    • 10.1194/jlr.M050229 1:CAS:528:DC%2BC2cXhtVylsL7N 4076087 24868093
    • Currie E, Guo X, Christiano R, Chitraju C, Kory N, Harrison K, Haas J, Walther TC, Farese RV Jr (2014) High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation. J Lipid Res 55(7):1465-1477. doi: 10.1194/jlr.M050229
    • (2014) J Lipid Res , vol.55 , Issue.7 , pp. 1465-1477
    • Currie, E.1    Guo, X.2    Christiano, R.3    Chitraju, C.4    Kory, N.5    Harrison, K.6    Haas, J.7    Walther, T.C.8    Farese, Jr.R.V.9
  • 106
    • 0032693609 scopus 로고    scopus 로고
    • Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae
    • 1:CAS:528:DyaK1MXmvVWqsrw%3D 103780 10515935
    • Athenstaedt K, Zweytick D, Jandrositz A, Kohlwein SD, Daum G (1999) Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae. J Bacteriol 181(20):6441-6448
    • (1999) J Bacteriol , vol.181 , Issue.20 , pp. 6441-6448
    • Athenstaedt, K.1    Zweytick, D.2    Jandrositz, A.3    Kohlwein, S.D.4    Daum, G.5
  • 107
    • 0032693609 scopus 로고    scopus 로고
    • Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae
    • 1:CAS:528:DyaK1MXmvVWqsrw%3D 103780 10515935
    • Athenstaedt K, Zweytick D, Jandrositz A, Kohlwein SD, Daum G (1999) Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae. J Bacteriol 181(20):6441-6448
    • (1999) J Bacteriol , vol.181 , Issue.20 , pp. 6441-6448
    • Athenstaedt, K.1    Zweytick, D.2    Jandrositz, A.3    Kohlwein, S.D.4    Daum, G.5
  • 108
    • 27144535945 scopus 로고    scopus 로고
    • Ubx2 links the Cdc48 complex to ER-associated protein degradation
    • 10.1038/ncb1298 1:CAS:528:DC%2BD2MXhtVGjs7nP 16179953
    • Neuber O, Jarosch E, Volkwein C, Walter J, Sommer T (2005) Ubx2 links the Cdc48 complex to ER-associated protein degradation. Nat Cell Biol 7(10):993-998. doi: 10.1038/ncb1298
    • (2005) Nat Cell Biol , vol.7 , Issue.10 , pp. 993-998
    • Neuber, O.1    Jarosch, E.2    Volkwein, C.3    Walter, J.4    Sommer, T.5
  • 110
    • 84885112498 scopus 로고    scopus 로고
    • Perturbations to the ubiquitin conjugate proteome in yeast deltaubx mutants identify Ubx2 as a regulator of membrane lipid composition
    • 10.1074/mcp.M113.030163 1:CAS:528:DC%2BC3sXhsFensLjP
    • Kolawa N, Sweredoski MJ, Graham RL, Oania R, Hess S, Deshaies RJ (2013) Perturbations to the ubiquitin conjugate proteome in yeast deltaubx mutants identify Ubx2 as a regulator of membrane lipid composition. Mol Cell Proteomics MCP 12(10):2791-2803. doi: 10.1074/mcp.M113.030163
    • (2013) Mol Cell Proteomics MCP , vol.12 , Issue.10 , pp. 2791-2803
    • Kolawa, N.1    Sweredoski, M.J.2    Graham, R.L.3    Oania, R.4    Hess, S.5    Deshaies, R.J.6
  • 111
    • 80051540452 scopus 로고    scopus 로고
    • Lipid droplet formation is dispensable for endoplasmic reticulum-associated degradation
    • 10.1074/jbc.C111.266452 1:CAS:528:DC%2BC3MXpsl2ntbc%3D 3151032 21693705
    • Olzmann JA, Kopito RR (2011) Lipid droplet formation is dispensable for endoplasmic reticulum-associated degradation. J Biol Chem 286(32):27872-27874. doi: 10.1074/jbc.C111.266452
    • (2011) J Biol Chem , vol.286 , Issue.32 , pp. 27872-27874
    • Olzmann, J.A.1    Kopito, R.R.2
  • 112
    • 84856731141 scopus 로고    scopus 로고
    • A role for seipin in lipid droplet dynamics and inheritance in yeast
    • 10.1242/jcs.091454 1:CAS:528:DC%2BC38XpvFyntA%3D%3D 22100922
    • Wolinski H, Kolb D, Hermann S, Koning RI, Kohlwein SD (2011) A role for seipin in lipid droplet dynamics and inheritance in yeast. J Cell Sci 124(Pt 22):3894-3904. doi: 10.1242/jcs.091454
    • (2011) J Cell Sci , vol.124 , pp. 3894-3904
    • Wolinski, H.1    Kolb, D.2    Hermann, S.3    Koning, R.I.4    Kohlwein, S.D.5
  • 113
    • 0000942202 scopus 로고    scopus 로고
    • PDR16 and PDR17, two homologous genes of Saccharomyces cerevisiae, affect lipid biosynthesis and resistance to multiple drugs
    • 9890948
    • van den Hazel HB, Pichler H, do Valle Matta MA, Leitner E, Goffeau A, Daum G (1999) PDR16 and PDR17, two homologous genes of Saccharomyces cerevisiae, affect lipid biosynthesis and resistance to multiple drugs. J Biol Chem 274(4):1934-1941
    • (1999) J Biol Chem , vol.274 , Issue.4 , pp. 1934-1941
    • Van Den Hazel, H.B.1    Pichler, H.2    Do Valle Matta, M.A.3    Leitner, E.4    Goffeau, A.5    Daum, G.6
  • 115
    • 80053062569 scopus 로고    scopus 로고
    • Interactomic study on interaction between lipid droplets and mitochondria
    • 10.1007/s13238-011-1061-y 1:CAS:528:DC%2BC3MXovFehsLY%3D 21748599
    • Pu J, Ha CW, Zhang S, Jung JP, Huh WK, Liu P (2011) Interactomic study on interaction between lipid droplets and mitochondria. Protein Cell 2(6):487-496. doi: 10.1007/s13238-011-1061-y
    • (2011) Protein Cell , vol.2 , Issue.6 , pp. 487-496
    • Pu, J.1    Ha, C.W.2    Zhang, S.3    Jung, J.P.4    Huh, W.K.5    Liu, P.6
  • 116
    • 0026051770 scopus 로고
    • Isolation of a phosphatidylserine transfer protein from yeast cytosol
    • 1:CAS:528:DyaK38XisVWn 1657167
    • Lafer G, Szolderits G, Paltauf F, Daum G (1991) Isolation of a phosphatidylserine transfer protein from yeast cytosol. Biochim Biophys Acta 1069(2):139-144
    • (1991) Biochim Biophys Acta , vol.1069 , Issue.2 , pp. 139-144
    • Lafer, G.1    Szolderits, G.2    Paltauf, F.3    Daum, G.4
  • 118
    • 0031201009 scopus 로고    scopus 로고
    • Role of the proline knot motif in oleosin endoplasmic reticulum topology and oil body targeting
    • 10.1105/tpc.9.8.1481 1:CAS:528:DyaK2sXlvVKgsb0%3D 157013 9286116
    • Abell BM, Holbrook LA, Abenes M, Murphy DJ, Hills MJ, Moloney MM (1997) Role of the proline knot motif in oleosin endoplasmic reticulum topology and oil body targeting. Plant Cell 9(8):1481-1493. doi: 10.1105/tpc.9.8.1481
    • (1997) Plant Cell , vol.9 , Issue.8 , pp. 1481-1493
    • Abell, B.M.1    Holbrook, L.A.2    Abenes, M.3    Murphy, D.J.4    Hills, M.J.5    Moloney, M.M.6
  • 119
    • 0028998554 scopus 로고
    • VIP21-caveolin, a membrane protein constituent of the caveolar coat, oligomerizes in vivo and in vitro
    • 1:CAS:528:DyaK2MXmvFOmtb4%3D 301248 7579702
    • Monier S, Parton RG, Vogel F, Behlke J, Henske A, Kurzchalia TV (1995) VIP21-caveolin, a membrane protein constituent of the caveolar coat, oligomerizes in vivo and in vitro. Mol Biol Cell 6(7):911-927
    • (1995) Mol Biol Cell , vol.6 , Issue.7 , pp. 911-927
    • Monier, S.1    Parton, R.G.2    Vogel, F.3    Behlke, J.4    Henske, A.5    Kurzchalia, T.V.6
  • 120
    • 0035809931 scopus 로고    scopus 로고
    • Caveolin-2 is targeted to lipid droplets, a new "membrane domain" in the cell
    • 1:CAS:528:DC%2BD3MXhslGmu74%3D 2198803 11238462
    • Fujimoto T, Kogo H, Ishiguro K, Tauchi K, Nomura R (2001) Caveolin-2 is targeted to lipid droplets, a new "membrane domain" in the cell. J Cell Biol 152(5):1079-1085
    • (2001) J Cell Biol , vol.152 , Issue.5 , pp. 1079-1085
    • Fujimoto, T.1    Kogo, H.2    Ishiguro, K.3    Tauchi, K.4    Nomura, R.5
  • 121
    • 0035809923 scopus 로고    scopus 로고
    • Accumulation of caveolin in the endoplasmic reticulum redirects the protein to lipid storage droplets
    • 1:CAS:528:DC%2BD3MXhslGmurc%3D 2198801 11238461
    • Ostermeyer AG, Paci JM, Zeng Y, Lublin DM, Munro S, Brown DA (2001) Accumulation of caveolin in the endoplasmic reticulum redirects the protein to lipid storage droplets. J Cell Biol 152(5):1071-1078
    • (2001) J Cell Biol , vol.152 , Issue.5 , pp. 1071-1078
    • Ostermeyer, A.G.1    Paci, J.M.2    Zeng, Y.3    Lublin, D.M.4    Munro, S.5    Brown, D.A.6
  • 122
    • 70350400618 scopus 로고    scopus 로고
    • Targeting sequences of UBXD8 and AAM-B reveal that the ER has a direct role in the emergence and regression of lipid droplets
    • 10.1242/jcs.054700 1:CAS:528:DC%2BD1MXhsVKitrjJ 2758803 19773358
    • Zehmer JK, Bartz R, Bisel B, Liu P, Seemann J, Anderson RG (2009) Targeting sequences of UBXD8 and AAM-B reveal that the ER has a direct role in the emergence and regression of lipid droplets. J Cell Sci 122(pt 20):3694-3702. doi: 10.1242/jcs.054700
    • (2009) J Cell Sci , vol.122 , pp. 3694-3702
    • Zehmer, J.K.1    Bartz, R.2    Bisel, B.3    Liu, P.4    Seemann, J.5    Anderson, R.G.6
  • 123
    • 33746959419 scopus 로고    scopus 로고
    • Identification and characterization of associated with lipid droplet protein 1: A novel membrane-associated protein that resides on hepatic lipid droplets
    • 1:CAS:528:DC%2BD28XhtVSksL3P 17004324
    • Turro S, Ingelmo-Torres M, Estanyol JM, Tebar F, Fernandez MA, Albor CV, Gaus K, Grewal T, Enrich C, Pol A (2006) Identification and characterization of associated with lipid droplet protein 1: a novel membrane-associated protein that resides on hepatic lipid droplets. Traffic 7(9):1254-1269
    • (2006) Traffic , vol.7 , Issue.9 , pp. 1254-1269
    • Turro, S.1    Ingelmo-Torres, M.2    Estanyol, J.M.3    Tebar, F.4    Fernandez, M.A.5    Albor, C.V.6    Gaus, K.7    Grewal, T.8    Enrich, C.9    Pol, A.10
  • 124
    • 21644459401 scopus 로고    scopus 로고
    • Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane
    • 10.1242/jcs.02401 1:CAS:528:DC%2BD2MXmtF2ntLo%3D 15914536
    • Ozeki S, Cheng J, Tauchi-Sato K, Hatano N, Taniguchi H, Fujimoto T (2005) Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane. J Cell Sci 118(Pt 12):2601-2611. doi: 10.1242/jcs.02401
    • (2005) J Cell Sci , vol.118 , Issue.PT 12 , pp. 2601-2611
    • Ozeki, S.1    Cheng, J.2    Tauchi-Sato, K.3    Hatano, N.4    Taniguchi, H.5    Fujimoto, T.6
  • 125
    • 0037477829 scopus 로고    scopus 로고
    • Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation
    • 10.1083/jcb.200210169 1:CAS:528:DC%2BD3sXkvFCmsr0%3D 2172984 12810697
    • Sztalryd C, Xu G, Dorward H, Tansey JT, Contreras JA, Kimmel AR, Londos C (2003) Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation. J Cell Biol 161(6):1093-1103. doi: 10.1083/jcb.200210169
    • (2003) J Cell Biol , vol.161 , Issue.6 , pp. 1093-1103
    • Sztalryd, C.1    Xu, G.2    Dorward, H.3    Tansey, J.T.4    Contreras, J.A.5    Kimmel, A.R.6    Londos, C.7
  • 126
    • 27844526218 scopus 로고    scopus 로고
    • Homoeostatic systems for sterols and other lipids
    • 10.1042/BST20051182 1:CAS:528:DC%2BD2MXhtFCqs7fE 16246077
    • Garbarino J, Sturley SL (2005) Homoeostatic systems for sterols and other lipids. Biochem Soc Trans 33(Pt 5):1182-1185. doi: 10.1042/BST20051182
    • (2005) Biochem Soc Trans , vol.33 , pp. 1182-1185
    • Garbarino, J.1    Sturley, S.L.2
  • 127
    • 37549018969 scopus 로고    scopus 로고
    • The cellular functions of the yeast lipin homolog PAH1p are dependent on its phosphatidate phosphatase activity
    • 10.1074/jbc.M705777200 1:CAS:528:DC%2BD2sXhsVamurrN 17971454
    • Han GS, Siniossoglou S, Carman GM (2007) The cellular functions of the yeast lipin homolog PAH1p are dependent on its phosphatidate phosphatase activity. J Biol Chem 282(51):37026-37035. doi: 10.1074/jbc.M705777200
    • (2007) J Biol Chem , vol.282 , Issue.51 , pp. 37026-37035
    • Han, G.S.1    Siniossoglou, S.2    Carman, G.M.3
  • 128
    • 71449102613 scopus 로고    scopus 로고
    • Good fat, essential cellular requirements for triacylglycerol synthesis to maintain membrane homeostasis in yeast
    • 10.1074/jbc.M109.024752 1:CAS:528:DC%2BD1MXhtlequ7nK 2781499 19608739
    • Petschnigg J, Wolinski H, Kolb D, Zellnig G, Kurat CF, Natter K, Kohlwein SD (2009) Good fat, essential cellular requirements for triacylglycerol synthesis to maintain membrane homeostasis in yeast. J Biol Chem 284(45):30981-30993. doi: 10.1074/jbc.M109.024752
    • (2009) J Biol Chem , vol.284 , Issue.45 , pp. 30981-30993
    • Petschnigg, J.1    Wolinski, H.2    Kolb, D.3    Zellnig, G.4    Kurat, C.F.5    Natter, K.6    Kohlwein, S.D.7
  • 130
    • 21244480972 scopus 로고    scopus 로고
    • The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth
    • 10.1038/sj.emboj.7600672 1:CAS:528:DC%2BD2MXks1Gnu70%3D 1142606 15889145
    • Santos-Rosa H, Leung J, Grimsey N, Peak-Chew S, Siniossoglou S (2005) The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth. EMBO J 24(11):1931-1941. doi: 10.1038/sj.emboj.7600672
    • (2005) EMBO J , vol.24 , Issue.11 , pp. 1931-1941
    • Santos-Rosa, H.1    Leung, J.2    Grimsey, N.3    Peak-Chew, S.4    Siniossoglou, S.5
  • 131
    • 59149106049 scopus 로고    scopus 로고
    • Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis
    • 10.1074/jbc.R800059200 1:CAS:528:DC%2BD1MXpsVyqtQ%3D%3D 2631973 18812320
    • Carman GM, Han GS (2009) Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis. J Biol Chem 284(5):2593-2597. doi: 10.1074/jbc.R800059200
    • (2009) J Biol Chem , vol.284 , Issue.5 , pp. 2593-2597
    • Carman, G.M.1    Han, G.S.2
  • 132
    • 78049319504 scopus 로고    scopus 로고
    • A phosphorylation-regulated amphipathic helix controls the membrane translocation and function of the yeast phosphatidate phosphatase
    • 10.1073/pnas.1007974107 1:CAS:528:DC%2BC3cXhtlartb3N 2955120 20876142
    • Karanasios E, Han GS, Xu Z, Carman GM, Siniossoglou S (2010) A phosphorylation-regulated amphipathic helix controls the membrane translocation and function of the yeast phosphatidate phosphatase. Proc Natl Acad Sci USA 107(41):17539-17544. doi: 10.1073/pnas.1007974107
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.41 , pp. 17539-17544
    • Karanasios, E.1    Han, G.S.2    Xu, Z.3    Carman, G.M.4    Siniossoglou, S.5
  • 133
    • 78651385378 scopus 로고    scopus 로고
    • Phosphorylation of phosphatidate phosphatase regulates its membrane association and physiological functions in Saccharomyces cerevisiae: Identification of SER(602), THR(723), AND SER(744) as the sites phosphorylated by CDC28 (CDK1)-encoded cyclin-dependent kinase
    • 10.1074/jbc.M110.155598 1:CAS:528:DC%2BC3MXjtFegtg%3D%3D 3020757 21081492
    • Choi HS, Su WM, Morgan JM, Han GS, Xu Z, Karanasios E, Siniossoglou S, Carman GM (2011) Phosphorylation of phosphatidate phosphatase regulates its membrane association and physiological functions in Saccharomyces cerevisiae: identification of SER(602), THR(723), AND SER(744) as the sites phosphorylated by CDC28 (CDK1)-encoded cyclin-dependent kinase. J Biol Chem 286(2):1486-1498. doi: 10.1074/jbc.M110.155598
    • (2011) J Biol Chem , vol.286 , Issue.2 , pp. 1486-1498
    • Choi, H.S.1    Su, W.M.2    Morgan, J.M.3    Han, G.S.4    Xu, Z.5    Karanasios, E.6    Siniossoglou, S.7    Carman, G.M.8
  • 136
    • 84880596969 scopus 로고    scopus 로고
    • Direct imaging reveals stable, micrometer-scale lipid domains that segregate proteins in live cells
    • 10.1083/jcb.201301039 1:CAS:528:DC%2BC3sXhtFaltbfE 3704982 23836928
    • Toulmay A, Prinz WA (2013) Direct imaging reveals stable, micrometer-scale lipid domains that segregate proteins in live cells. J Cell Biol 202(1):35-44. doi: 10.1083/jcb.201301039
    • (2013) J Cell Biol , vol.202 , Issue.1 , pp. 35-44
    • Toulmay, A.1    Prinz, W.A.2
  • 137
    • 81255176779 scopus 로고    scopus 로고
    • Sporulation in the budding yeast Saccharomyces cerevisiae
    • 10.1534/genetics.111.127126 1:CAS:528:DC%2BC38XitFKnsr8%3D 3213374 22084423
    • Neiman AM (2011) Sporulation in the budding yeast Saccharomyces cerevisiae. Genetics 189(3):737-765. doi: 10.1534/genetics.111.127126
    • (2011) Genetics , vol.189 , Issue.3 , pp. 737-765
    • Neiman, A.M.1
  • 138
    • 76649108895 scopus 로고    scopus 로고
    • Janus-faced enzymes yeast Tgl3p and Tgl5p catalyze lipase and acyltransferase reactions
    • 10.1091/mbc.E09-09-0775 1:CAS:528:DC%2BC3cXjtF2iu7w%3D 2820416 20016004
    • Rajakumari S, Daum G (2010) Janus-faced enzymes yeast Tgl3p and Tgl5p catalyze lipase and acyltransferase reactions. Mol Biol Cell 21(4):501-510. doi: 10.1091/mbc.E09-09-0775
    • (2010) Mol Biol Cell , vol.21 , Issue.4 , pp. 501-510
    • Rajakumari, S.1    Daum, G.2
  • 139
    • 84894696373 scopus 로고    scopus 로고
    • A visual screen of protein localization during sporulation identifies new components of prospore membrane-associated complexes in budding yeast
    • 10.1128/EC.00333-13 1:CAS:528:DC%2BC2cXmt1Whu7g%3D 3957589 24390141
    • Lam C, Santore E, Lavoie E, Needleman L, Fiacco N, Kim C, Neiman AM (2014) A visual screen of protein localization during sporulation identifies new components of prospore membrane-associated complexes in budding yeast. Eukaryot Cell 13(3):383-391. doi: 10.1128/EC.00333-13
    • (2014) Eukaryot Cell , vol.13 , Issue.3 , pp. 383-391
    • Lam, C.1    Santore, E.2    Lavoie, E.3    Needleman, L.4    Fiacco, N.5    Kim, C.6    Neiman, A.M.7
  • 140
    • 84884625856 scopus 로고    scopus 로고
    • A highly redundant gene network controls assembly of the outer spore wall in S. Cerevisiae
    • 10.1371/journal.pgen.1003700 1:CAS:528:DC%2BC3sXhsVagtLnK 3744438 23966878
    • Lin CP, Kim C, Smith SO, Neiman AM (2013) A highly redundant gene network controls assembly of the outer spore wall in S. cerevisiae. PLoS Genet 9(8):e1003700. doi: 10.1371/journal.pgen.1003700
    • (2013) PLoS Genet , vol.9 , Issue.8 , pp. 1003700
    • Lin, C.P.1    Kim, C.2    Smith, S.O.3    Neiman, A.M.4
  • 141
    • 0019069651 scopus 로고
    • Organelle relationships in cultured 3T3-L1 preadipocytes
    • 1:STN:280:DyaL3M%2Fis1Cgsg%3D%3D 7191426
    • Novikoff AB, Novikoff PM, Rosen OM, Rubin CS (1980) Organelle relationships in cultured 3T3-L1 preadipocytes. J Cell Biol 87(1):180-196
    • (1980) J Cell Biol , vol.87 , Issue.1 , pp. 180-196
    • Novikoff, A.B.1    Novikoff, P.M.2    Rosen, O.M.3    Rubin, C.S.4
  • 142
    • 84880036446 scopus 로고    scopus 로고
    • Balancing the fat: Lipid droplets and human disease
    • 10.1002/emmm.201100671 1:CAS:528:DC%2BC3sXhtVCgs7jN 3721468 23740690
    • Krahmer N, Farese RV Jr, Walther TC (2013) Balancing the fat: lipid droplets and human disease. EMBO Mol Med 5(7):905-915. doi: 10.1002/emmm.201100671
    • (2013) EMBO Mol Med , vol.5 , Issue.7 , pp. 905-915
    • Krahmer, N.1    Farese, Jr.R.V.2    Walther, T.C.3
  • 143
    • 68049092870 scopus 로고    scopus 로고
    • Neutral lipid storage disease: Genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5
    • 10.1152/ajpendo.00099.2009 1:CAS:528:DC%2BD1MXhtVahsbnO 19401457
    • Schweiger M, Lass A, Zimmermann R, Eichmann TO, Zechner R (2009) Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5. Am J Physiol Endocrinol Metab 297(2):E289-E296. doi: 10.1152/ajpendo.00099.2009
    • (2009) Am J Physiol Endocrinol Metab , vol.297 , Issue.2 , pp. 289-E296
    • Schweiger, M.1    Lass, A.2    Zimmermann, R.3    Eichmann, T.O.4    Zechner, R.5
  • 144
    • 79955907495 scopus 로고    scopus 로고
    • Molecular mechanisms of human lipodystrophies: from adipocyte lipid droplet to oxidative stress and lipotoxicity
    • 10.1016/j.biocel.2011.03.002 1:CAS:528:DC%2BC3MXmtFSltr4%3D 21392585
    • Vigouroux C, Caron-Debarle M, Le Dour C, Magre J, Capeau J (2011) Molecular mechanisms of human lipodystrophies: from adipocyte lipid droplet to oxidative stress and lipotoxicity. Int J Biochem Cell Biol 43(6):862-876. doi: 10.1016/j.biocel.2011.03.002
    • (2011) Int J Biochem Cell Biol , vol.43 , Issue.6 , pp. 862-876
    • Vigouroux, C.1    Caron-Debarle, M.2    Le Dour, C.3    Magre, J.4    Capeau, J.5
  • 145
    • 79958817996 scopus 로고    scopus 로고
    • Seipin, adipogenesis and lipid droplets
    • 10.1016/j.tem.2011.02.004 1:CAS:528:DC%2BC3MXnslOgtLo%3D
    • Fei W, Du X, Yang H (2011) Seipin, adipogenesis and lipid droplets. Trend Endocrinol Metab TEM 22(6):204-210. doi: 10.1016/j.tem.2011.02.004
    • (2011) Trend Endocrinol Metab TEM , vol.22 , Issue.6 , pp. 204-210
    • Fei, W.1    Du, X.2    Yang, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.