The Saccharomyces cerevisiae YLL012/YEH1, YLR020/YEH2, and TGL1 genes encode a novel family of membrane-anchored lipases that are required for steryl ester hydrolysis

Molecular and Cellular Biology

Volumn 25, Issue 5, 2005, Pages 1655-1668

  Köffel, René ^a   Tiwari, Rashi ^a   Falquet, Laurent ^b   Schneiter, Roger ^a  

^a UNIVERSITY OF FRIBOURG   (Switzerland)

^b SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACID LIPASE; ESTER; GENE PRODUCT; LYSOZYME; STEROL; TRIACYLGLYCEROL LIPASE;

ARTICLE; CELL MUTANT; CELLULAR DISTRIBUTION; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC CODE; HYDROLYSIS; IN VIVO STUDY; MAMMAL; MOBILIZATION; MULTIGENE FAMILY; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; STEADY STATE; YEAST CELL;

AMINO ACID SEQUENCE; CARBOXYLIC ESTER HYDROLASES; CELL MEMBRANE; ESTERS; GENES, FUNGAL; HUMANS; HYDROLYSIS; MEMBRANE LIPIDS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; STEROLS; TRIGLYCERIDES;

EID: 14044272811     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.25.5.1655-1668.2005     Document Type: Article

References (54)

1. Abraham, P. R., A. Mulder, J. Van't Riet, R. J. Planta, and H. A. Raue. 1992. Molecular cloning and physical analysis of an 8.2 kb segment of chromosome XI of Saccharomyces cerevisiae reveals five tightly linked genes. Yeast 8:227-238.
2. Alani, E., L. Cao, and N. Kleckner. 1987. A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains. Genetics 116:541-545.
3. Ameis, D., M. Merkel, C. Eckerskorn, and H. Greten. 1994. Purification, characterization and molecular cloning of human hepatic lysosomal acid lipase. Eur. J. Biochem. 219:905-914.
4. Anderson, R. A., R. S. Byrum, P. M. Coates, and G. N. Sando. 1994. Mutations at the lysosomal acid cholesteryl ester hydrolase gene locus in Wolman disease. Proc. Natl. Acad. Sci. USA 91:2718-2722.
5. Anderson, R. A., and G. N. Sando. 1991. Cloning and expression of cDNA encoding human lysosomal acid lipase/cholesteryl ester hydrolase. Similarities to gastric and lingual lipases. J. Biol. Chem. 266:22479-22484.
6. Assmann, G., and U. Seedorf. 1995. Acid lipase deficiency: Wolman disease and cholesteryl ester storage disease, p. 2563-2587. In C. R. Scriver, A. L. Beaduet, W. S. Sly, and D. Valle (ed.), The metabolic and molecular bases of inherited disease. McGraw-Hill, New York, N.Y.
7. Athenstaedt, K., and G. Daum. 2003. YMR313c/TGL3 encodes a novel triacylglycerol lipase located in lipid particles of Saccharomyces cerevisiae. J. Biol. Chem. 278:23317-23323.
8. Athenstaedt, K., D. Zweytick, A. Jandrositz, S. D. Kohlwein, and G. Daum. 1999. Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae. J. Bacteriol. 181:6441-6448.
9. Bailey, R. B., and L. W. Parks. 1975. Yeast sterol esters and their relationship to the growth of yeast. J. Bacteriol. 124:606-612.
10. Brady, L., A. M. Brzozowski, Z. S. Derewenda, E. Dodson, G. Dodson, S. Tolley, J. P. Turkenburg, L. Christiansen, B. Huge-Jensen, L. Norskov, et al. 1990. A serine protease triad forms the catalytic centre of a triacylglycerol lipase. Nature 343:767-770.
11. Brown, M. S., and J. L. Goldstein. 1986. A receptor-mediated pathway for cholesterol homeostasis. Science 232:34-47.
12. Brown, M. S., Y. K. Ho, and J. L. Goldstein. 1980. The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters. J. Biol. Chem. 255:9344-9352.
13. Burke, J. A., and W. K. Schubert. 1972. Deficient activity of hepatic acid lipase in cholesterol ester storage disease. Science 176:309-310.
14. Chang, T. Y., C. C. Chang, and D. Cheng. 1997. Acyl-coenzyme A:cholesterol acyltransferase. Annu. Rev. Biochem. 66:613-638.
15. Corsi, A. K., and R. Schekman. 1997. The lumenal domain of Sec63p stimulates the ATPase activity of BiP and mediates BiP recruitment to the translocon in Saccharomyces cerevisiae. J. Cell Biol. 137:1483-1493.
16. Cowles, C. R., G. Odorizzi, G. S. Payne, and S. D. Emr. 1997. The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cell 91:109-118.
17. Derewenda, Z. S., and U. Derewenda. 1991. Relationships among serine hydrolases: evidence for a common structural motif in triacylglyceride lipases and esterases. Biochem. Cell. Biol. 69:842-851.
18. Dupree, P., R. G. Parton, G. Raposo, T. V. Kurzchalia, and K. Simons. 1993. Caveolae and sorting in the trans-Golgi network of epithelial cells. EMBO J. 12:1597-1605.
19. Goldstein, J. L., S. E. Dana, J. R. Faust, A. L. Beaudet, and M. S. Brown. 1975. Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease. J. Biol. Chem. 250:8487-8495.
20. Graham, T. R., and V. A. Krasnov. 1995. Sorting of yeast α1,3-mannosyltransferase is mediated by a lumenal domain interaction, and a transmembrane domain signal that can confer clathrin-dependent Golgi localization to a secreted protein. Mol. Biol. Cell 6:809-824.
21. Hardwick, K. G., and H. R. Pelham. 1992. SED5 encodes a 39-kD integral membrane protein required for vesicular transport between the ER and the Golgi complex. J. Cell Biol. 119:513-521.
22. Heim, R., D. C. Prasher, and R. Y. Tsien. 1994. Wavelength mutations and posttranslational autoxidation of green fluorescent protein. Proc. Natl. Acad. Sci. USA 91:12501-12504.
23. Holthuis, J. C., B. J. Nichols, S. Dhruvakumar, and H. R. Pelham. 1998. Two syntaxin homologues in the TGN/endosomal system of yeast. EMBO J. 17:113-126.
24. Huh, W. K., J. V. Falvo, L. C. Gerke, A. S. Carroll, R. W. Howson, J. S. Weissman, and E. K. O'Shea. 2003. Global analysis of protein localization in budding yeast. Nature 425:686-691.
25. Ito, H., Y. Fukada, K. Murata, and A. Kimura. 1983. Transformation of intact cells with alkali cations. J. Bacteriol. 153:163-168.
26. Jandrositz, A., F. Turnowsky, and G. Hogenauer. 1991. The gene encoding squalene epoxidase from Saccharomyces cerevisiae: cloning and characterization. Gene 107:155-160.
27. Lange, Y., M. H. Swaisgood, B. V. Ramos, and T. L. Steck. 1989. Plasma membranes contain half the phospholipid and 90% of the cholesterol and sphingomyelin in cultured human fibroblasts. J. Biol. Chem. 264:3786-3793.
28. Leber, R., E. Zinser, C. Hrastnik, F. Paltauf, and G. Daum. 1995. Export of steryl esters from lipid particles and release of free sterols in the yeast, Saccharomyces cerevisiae. Biochim. Biophys. Acta 1234:119-126.
29. Leber, R., E. Zinser, G. Zellnig, F. Paltauf, and G. Daum. 1994. Characterization of lipid particles of the yeast, Saccharomyces cerevisiae. Yeast 10:1421-1428.
30. Lohse, P., S. Chahrokh-Zadeh, and D. Seidel. 1997. Human lysosomal acid lipase/cholesteryl ester hydrolase and human gastric lipase: identification of the catalytically active serine, aspartic acid, and histidine residues. J. Lipid Res. 38:892-903.
31. Longtine, M. S., A. McKenzie III, D. J. Demarini, N. G. Shah, A. Wach, A. Brachat, P. Philippsen, and J. R. Pringle. 1998. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14:953-961.
32. Lorenz, R. T., R. J. Rodriguez, T. A. Lewis, and L. W. Parks. 1986. Characteristics of sterol uptake in Saccharomyces cerevisiae. J. Bacteriol. 167:981-985.
33. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275.
34. Miled, N., S. Canaan, L. Dupuis, A. Roussel, M. Riviere, F. Carriere, A. de Caro, C. Cambillau, and R. Verger. 2000. Digestive lipases: from three-dimensional structure to physiology. Biochimie 82:973-986.
35. Mitra, P., Y. Zhang, L. E. Rameh, M. P. Ivshina, D. McCollum, J. J. Nunnari, G. M. Hendricks, M. L. Kerr, S. J. Field, L. C. Cantley, and A. H. Ross. 2004. A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast. J. Cell Biol. 166:205-211.
36. Odrorizzi, G., M. Babst, and S. D. Emr. 2000. Phosphoinositide signaling and the regulation of membrane trafficking in yeast. Trends Biochem. Sci. 25:229-235.
37. Ollis, D. L., E. Cheah, M. Cygler, B. Dijkstra, F. Frolow, S. M. Franken, M. Harel, S. J. Remington, I. Silman, J. Schrag, et al. 1992. The alpha/beta hydrolase fold. Protein Eng. 5:197-211.
38. Omura, S. 1981. Cerulenin. Methods Enzymol. 72:520-532.
39. Pagani, F., R. Pariyarath, R. Garcia, C. Stuani, A. B. Burlina, G. Ruotolo, M. Rabusin, and F. E. Baralle. 1998. New lysosomal acid lipase gene mutants explain the phenotype of Wolman disease and cholesteryl ester storage disease. J. Lipid Res. 39:1382-1388.
40. Pagani, F., R. Pariyarath, C. Stuani, R. Garcia, and F. E. Baralle. 1997. Cysteine residues in human lysosomal acid lipase are involved in selective cholesteryl esterase activity. Biochem. J. 326:265-269.
41. Patrick, A. D., and B. D. Lake. 1969. Deficiency of an acid lipase in Wolman's disease. Nature 222:1067-1068.
42. Schrag, J. D., and M. Cygler. 1997. Lipases and alpha/beta hydrolase fold. Methods Enzymol. 284:85-107.
43. +-ATPase from plasma membranes of Saccharomyces cerevisiae and Avena sativa roots: purification and reconstitution. Methods Enzymol. 157:533-544.
44. Sztalryd, C., G. Xu, H. Dorward, J. T. Tansey, J. A. Contreras, A. R. Kimmel, and C. Londos. 2003. Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation. J. Cell Biol. 161:1093-1103.
45. Taketani, S., T. Nishino, and H. Katsuki. 1981. Purification and properties of sterol-ester hydrolase from Saccharomyces cerevisiae. J. Biochem. (Tokyo) 89:1667-1673.
46. Taketani, S., T. Osumi, and H. Katsuki. 1978. Characterization of sterol-ester hydrolase in Saccharomyces cerevisiae. Biochim. Biophys. Acta 525:87-92.
47. Tatzer, V., G. Zellnig, S. D. Kohlwein, and R. Schneiter. 2002. Lipid-dependent subcellular relocalization of the acyl chain desaturase in yeast. Mol. Biol. Cell 13:4429-4442.
48. Taylor, F. R., and L. W. Parks. 1978. Metabolic interconversion of free sterols and steryl esters in Saccharomyces cerevisiae. J. Bacteriol. 136:531-537.
49. Van Heusden, G. P., M. Nebohacova, T. L. Overbeeke, and H. Y. Steensma. 1998. The Saccharomyces cerevisiae TGL2 gene encodes a protein with lipolytic activity and can complement an Escherichia coli diacylglycerol kinase disruptant. Yeast 14:225-232.
50. Winzeler, E. A., D. D. Shoemaker, A. Astromoff, H. Liang, K. Anderson, B. Andre, R. Bangham, R. Benito, J. D. Boeke, H. Bussey, A. M. Chu, C. Connelly, K. Davis, F. Dietrich, S. W. Dow, M. El Bakkoury, F. Foury, S. H. Friend, E. Gentalen, G. Giaever, J. H. Hegemann, T. Jones, M. Laub, H. Liao, R. W. Davis, et al. 1999. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 285:901-906.
51. Wong, H., and M. C. Schotz. 2002. The lipase gene family. J. Lipid Res. 43:993-999.
52. Yang, H., M. Bard, D. A. Bruner, A. Gleeson, R. J. Deckelbaum, G. Aljinovic, T. M. Pohl, R. Rothstein, and S. L. Sturley. 1996. Sterol esterification in yeast: a two-gene process. Science 272:1353-1356.
53. Yu, C., N. J. Kennedy, C. C. Chang, and J. A. Rothblatt. 1996. Molecular cloning and characterization of two isoforms of Saccharomyces cerevisiae acyl-CoA:sterol acyltransferase. J. Biol. Chem. 271:24157-24163.
54. Zhu, H., M. Bilgin, R. Bangham, D. Hall, A. Casamayor, P. Bertone, N. Lan, R. Jansen, S. Bidlingmaier, T. Houfek, T. Mitchell, P. Miller, R. A. Dean, M. Gerstein, and M. Snyder. 2001. Global analysis of protein activities with proteome chips. Science 293:2101-2115.