Contribution of Are1p and Are2p to steryl ester synthesis in the yeast Saccharomyces cerevisiae

European Journal of Biochemistry

Volumn 267, Issue 4, 2000, Pages 1075-1082

  Zweytick, Dagmar ^a   Leitner, Erich ^a   Kohlwein, Sepp D ^a   Yu, Chunjiang ^b   Rothblatt, Jonathan ^c,d   Daum, Günther ^a  

^a GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c Dartmouth College ^*  (United States)

^d Hoechst Marion Roussel   (Germany)

Author keywords

Endoplasmic reticulum; Ergosterol; Steryl ester synthase

Indexed keywords

ACYLTRANSFERASE; CHOLESTEROL ACYLTRANSFERASE; STEROL DERIVATIVE;

ARTICLE; CELL VIABILITY; ENDOPLASMIC RETICULUM; ENZYME LOCALIZATION; FLUORESCENCE MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; STEROL SYNTHESIS;

ACYLTRANSFERASES; CELL DIVISION; ENDOPLASMIC RETICULUM; ERGOSTEROL; ESTERS; FATTY ACIDS; FUNGAL PROTEINS; GENE DELETION; ISOENZYMES; LANOSTEROL; MICROSCOPY, FLUORESCENCE; NAPHTHALENES; PHENOTYPE; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SUBCELLULAR FRACTIONS; SUBSTRATE SPECIFICITY;

SACCHAROMYCES CEREVISIAE;

EID: 0033974053     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01103.x     Document Type: Article

References (37)

1. 1. Chang, T.Y., Chang, C.C.Y. & Cheng, D. (1995) Acyl-CoenzymeA, cholesterol acyltransferase. Annu. Rev. Biochem. 66, 613-638.
2. 2. Suckling, K.E. & Stange, E.F. (1985) Role of acyl-CoA,cholesterol acyltransferase in cellular cholesterol metabolism. J. Lipid Res. 26, 647-671.
3. 3. Cases, S., Novak, S., Zheng, Y.W., Myers, H.M., Lear, S.R., Sande, E., Welch, C.B., Lusis, A.J., Spencer, T.A., Krause, B.R., Erickson, S.K. & Farese, R.V. Jr (1998) ACAT-2, a second mammalian acyl-CoA: cholesterol acyltransferase. J. Biol. Chem. 273, 26755-26764.
4. 4. Oelkers, P., Behari, A., Cromley, D., Billheimer, J.T. & Sturley, S.L. (1998) Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes. J. Biol. Chem. 273, 26765-26771.
5. 5. Anderson, R.A., Joyce, C., Davis, M., Reagan, J.W., Clark, M., Shelness, G.S. & Rudel, L.L. (1998) Identification of a form of acyl-CoA:cholesterol acyltransferase specific to liver and intestine in nonhuman primates. J. Biol. Chem. 273, 26747-26754.
6. 6. Ross, R. (1993) The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362, 801-809.
7. 7. Brown, M.S. & Goldstein, J.L. (1983) Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atheriosclerosis. Annu. Rev. Biochem. 52, 223-261.
8. 8. Bailey, R.B. & Parks, L.W. (1975) Yeast sterol esters and their relationship to the growth of yeast. J. Bacteriol. 124, 606-612.
9. 9. Clausen, M.K., Christiansen, K., Jensen, P.K. & Behnke, O. (1974) Isolation of lipid particles from baker's yeast. FEBS Lett. 43, 176-179.
10. 10. Christiansen, K. (1978) The biological role of dolichol. Biochim. Biophys. Acta 530, 78-90.
11. 11. Kostner, G.M. & Laggner, P. (1989) Chemical and physical properties of lipoproteins. In Clinical Biochemistry - Human Plasma Lipoproteins (Fruchart, J.C. & Sheperd, J., eds.), pp. 23-54. Walter de Gruyter, Berlin/New York.
12. 12. Leber, R., Zinser, E., Zellnig, G., Paltauf, F. & Daum, G. (1994) Characterization of lipid particles of the yeast, Saccharomyces cerevisiae. Yeast 10, 1421-1428.
13. 13. Yang, H., Bard, M., Bruner, D.A., Gleeson, A., Deckelbaum, R.J., Aljinovic, G., Pohl, T.M., Rothstein, R. & Sturley, S.L. (1996) Sterol esterification in yeast: a two-gene process. Science 272, 1353-1356.
14. 14. Yu, C., Kennedy, J., Chang, C.C.Y. & Rothblatt, J.A. (1996) Molecular cloning and characterization of two isoforms of Saccharomyces cerevisiae acyl-CoA:sterol acyltransferase. J. Biol. Chem. 271, 24157-24163.
15. 15. Zinser, E., Paltauf, F. & Daum, G. (1993) Sterol composition of yeast organelle membranes and subcellular distribution of enzymes involved in sterol metabolism. J. Bacteriol. 175, 2853-2858.
16. 16. Khelef, N., Buton, X., Beatini, N., Wang, H., Meiner, V., Chang, T., Farese, R.V. Jr, Maxfield, F.R. & Tabas, I. (1998) Immunolocalization of acyl-coenzyme A:cholesterol O-acyltransferase in macrophages. J. Biol. Chem. 273, 11218-11224.
17. 17. Chang, C.C.Y., Chen, J., Thomas, M.A., Cheng, D., Del Priore, V.A., Newton, R.S., Pape, M.E. & Chang, T. (1995) Regulation and immunolocalization of acyl-coenzymeA:cholesterol acyltransferase in mammalian cells as studied with specific antibodies. J. Biol. Chem. 270, 29532-29540.
18. 18. Meiner, V.L., Cases, S., Myers, H.M., Sande, E.R., Bellosta, S., Schambelan, M., Pitas, R.E., McGuire, J., Herz, J. & Farese, R.V. Jr (1996) Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice. Evidence suggesting multiple cholesterol esterification enzymes in mammals. Proc. Natl Acad. Sci. USA 273, 14041-14046.
19. 19. Yang, H., Cromley, D., Wang, H., Billheimer, J.T. & Sturley, S.T. (1997) Functional expression of a cDNA to human acyl-coenzymeA: cholesterol acyltransferase in yeast. J. Biol. Chem. 273, 3980-3985.
20. 20. Arthington-Skaggs, B.A., Crowell, D.N., Yang, H., Sturley, S.L. & Bard, M. (1996) Positive and negative regulation of a sterol biosynthetic gene (ERG3) in the post-squalene portion of the yeast ergosterol pathway. FEBS Lett. 392, 161-165.
21. 21. Leber, R., Zinser, E., Hrastnik, C., Paltauf, F. & Daum, G. (1995) Export of steryl esters from lipid particles and release of free sterols in the yeast, Saccharomyces cerevisiae. Biochim. Biophys. Acta 1234, 119-126.
22. 22. Hirsch, P.J. & Henry, S.A. (1986) Expression of the Saccharomyces cerevisiae inositol-1-phosphate synthase (INOI) gene is regulated by factors that affect phospholipid synthesis. Mol. Cell. Biol. 6, 3320-3328.
23. 23. Ito, H., Fukuda, Y., Murata, K. & Kimura, A. (1983) Transformation of intact yeast cells treated with alkali cations. J. Bacteriol. 153, 163-168.
24. 24. Maniatis, T., Fritsch, E.F. & Sambrook, J. (1982) Molecular Cloning: a Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
25. 25. Folch, J., Lees, M. & Sloane-Stanley, G.H. (1957) A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226, 497-509.
26. 26. Morrison, W.R. & Smith, L.M. (1964) Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol. J. Lipid. Res. 5, 600-608.
27. 27. Nes, W.D., Xu, S. & Haddon, W.F. (1989) Evidence for similarities and differences in the biosynthesis of fungal sterols. Steroids 53, 533-558.
28. 28. Xu, S., Norton, R.A., Crumley, F.G. & Nes, W.D. (1988) Comparison of the chromatographic properties of sterols, select additional steroids and triterpenoides, gravity-flow column liquid chromatography, thin-layer chromatography, gas-liquid chromatography and high-performance liquid chromatography. J. Chromatogr. 452, 377-398.
29. 29. Patterson, G.W. (1971) Relation between structure and retention time of sterols in gas chromatography. Anal. Chem. 43, 1165-1170.
30. 30. Zinser, E., Sperka-Gottlieb, C.D.M., Fasen, E.-V., Kohlwein, S.D., Paltauf, F. & Daum, G. (1991) Phospholipid synthesis and lipid composition of subcellular membranes in the unicellular eucaryote Saccharomyces cerevisiae. J. Bacteriol. 173, 2026-2034.
31. 31. Lowry, O.H., Rosebrough, N.J., Farr, A.L. & Randall, R.J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
32. 32. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227, 680-685.
33. 33. Haid, A. & Suissa, M. (1983) Immunochemical identification of membrane proteins after sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Methods Enzymol. 96, 192-205.
34. 34. Lewis, T.A., Rodriguez, R.J. & Parks, L.W. (1987) Relationship between intracellular sterol content and sterol esterification and hydrolysis in Saccharomyces cerevisiae. Biochim. Biophys. Acta 921, 205-212.
35. 35. Ryder, N.S. (1991) Squalene epoxidase as a target for the allylamines. Biochem. Soc. Trans. 19, 774-777.
36. 36. Leber, R., Landl, K., Zinser, E., Ahorn, H., Spök, A., Kohlwein, S.D., Turnowsky, F. & Daum, G. (1998) Dual localization of squalene epoxidase, Erglp, in yeast reflects a relationship between endoplasmic reticulum and lipid particles. Mol. Biol. Cell 9, 375-386.
37. 37. Lees, N.D., Bard, M. & Kirsch, D.R. (1997) Biochemistry and molecular biology of sterol synthesis in Saccharomyces cerevisiae. In Biochemistry and Function of Sterols (Parish, E.J. & Nes, W.D., eds.), pp. 85-99. CRC Press, Boca Raton, FL, USA.