-
1
-
-
84871036375
-
Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the global burden of disease study 2010
-
Lozano R., et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380, 2095-2128 (2012
-
(2010)
Lancet
, vol.380
, pp. 2095-2128
-
-
Lozano, R.1
-
2
-
-
84918815964
-
Cancer incidence and mortality worldwide: Sources, methods and major patterns in globocan 2012
-
Ferlay J., et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int. J. Cancer 136, 359-386 (2015
-
(2015)
Int. J. Cancer
, vol.136
, pp. 359-386
-
-
Ferlay, J.1
-
3
-
-
84887101903
-
Aacr cancer progress report 2013
-
AACR Cancer Progress Report Writing Committee
-
AACR Cancer Progress Report Writing Committee. AACR Cancer Progress Report 2013. Clin. Cancer Res. 19, S4-S98 (2013
-
(2013)
Clin. Cancer Res
, vol.19
, pp. S4-S98
-
-
-
4
-
-
84858658381
-
Easl-eortc clinical practice guidelines: Management of hepatocellular carcinoma
-
European Association for the Study of the Liver & European Organisation for Research and Treatment of Cancer
-
European Association for the Study of the Liver & European Organisation for Research and Treatment of Cancer. EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. J. Hepatol. 56, 908-943 (2012
-
(2012)
J. Hepatol
, vol.56
, pp. 908-943
-
-
-
5
-
-
79952231921
-
Management of hepatocellular carcinoma: An update
-
The American Association for the Study of Liver Diseases
-
Bruix J., Sherman M. & The American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma: an update. Hepatology 53, 1020-1022 (2011
-
(2011)
Hepatology
, vol.53
, pp. 1020-1022
-
-
Bruix, J.1
Sherman, M.2
-
6
-
-
0037129704
-
Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: A randomised controlled trial
-
Llovet J. M., et al. Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial. Lancet 359, 1734-1739 (2002
-
(2002)
Lancet
, vol.359
, pp. 1734-1739
-
-
Llovet, J.M.1
-
7
-
-
0036237822
-
Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma
-
Lo C. Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma. Hepatology 35, 1164-1171 (2002
-
(2002)
Hepatology
, vol.35
, pp. 1164-1171
-
-
Lo, C.1
-
8
-
-
0037308133
-
Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival
-
Llovet J. M. Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. Hepatology 37, 429-442 (2003
-
(2003)
Hepatology
, vol.37
, pp. 429-442
-
-
Llovet, J.M.1
-
9
-
-
84922252607
-
Brivanib as adjuvant therapy to transarterial chemoembolization in patients with hepatocellular carcinoma: A randomized phase III trial
-
Kudo M., et al. Brivanib as adjuvant therapy to transarterial chemoembolization in patients with hepatocellular carcinoma: a randomized phase III trial. Hepatology 60, 1697-1707 (2014
-
(2014)
Hepatology
, vol.60
, pp. 1697-1707
-
-
Kudo, M.1
-
10
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet J. M., et al. Sorafenib in advanced hepatocellular carcinoma. N. Engl. J. Med. 359, 378-390 (2008
-
(2008)
N. Engl. J. Med
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
-
11
-
-
77349092851
-
Molecular classification and novel targets in hepatocellular carcinoma: Recent advancements
-
Hoshida Y., et al. Molecular classification and novel targets in hepatocellular carcinoma: recent advancements. Semin. Liver Dis. 30, 35-51 (2010
-
(2010)
Semin. Liver Dis
, vol.30
, pp. 35-51
-
-
Hoshida, Y.1
-
12
-
-
53049086329
-
Focal gains of vegfa and molecular classification of hepatocellular carcinoma
-
Chiang D. Y., et al. Focal gains of VEGFA and molecular classification of hepatocellular carcinoma. Cancer Res. 68, 6779-6788 (2008
-
(2008)
Cancer Res
, vol.68
, pp. 6779-6788
-
-
Chiang, D.Y.1
-
13
-
-
33846463379
-
Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets
-
Boyault S., et al. Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets. Hepatology 45, 42-52 (2007
-
(2007)
Hepatology
, vol.45
, pp. 42-52
-
-
Boyault, S.1
-
14
-
-
4544273428
-
Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling
-
Lee J. S., et al. Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling. Hepatology 40, 667-676 (2004
-
(2004)
Hepatology
, vol.40
, pp. 667-676
-
-
Lee, J.S.1
-
15
-
-
33645742425
-
A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells
-
Lee J. S., et al. A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nat. Med. 12, 410-416 (2006
-
(2006)
Nat. Med
, vol.12
, pp. 410-416
-
-
Lee, J.S.1
-
16
-
-
70349739285
-
Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma
-
Hoshida Y., et al. Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma. Cancer Res. 69, 7385-7392 (2009
-
(2009)
Cancer Res
, vol.69
, pp. 7385-7392
-
-
Hoshida, Y.1
-
17
-
-
40449099255
-
Epcam and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma
-
Yamashita T., et al. EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. Cancer Res. 68, 1451-1461 (2008
-
(2008)
Cancer Res
, vol.68
, pp. 1451-1461
-
-
Yamashita, T.1
-
18
-
-
84866532501
-
Wnt-pathway activation in two molecular classes of hepatocellular carcinoma and experimental modulation by sorafenib
-
Lachenmayer A., et al. Wnt-pathway activation in two molecular classes of hepatocellular carcinoma and experimental modulation by sorafenib. Clin. Cancer Res. 18, 4997-5007 (2012
-
(2012)
Clin. Cancer Res
, vol.18
, pp. 4997-5007
-
-
Lachenmayer, A.1
-
19
-
-
79955401037
-
Combining clinical, pathology, and gene expression data to predict recurrence of hepatocellular carcinoma
-
Villanueva A., et al. Combining clinical, pathology, and gene expression data to predict recurrence of hepatocellular carcinoma. Gastroenterology 140, 1501-1512.e2 (2011
-
(2011)
Gastroenterology
, vol.140
, pp. 1501-1501e2
-
-
Villanueva, A.1
-
20
-
-
0034746832
-
Expression of mutant nuclear β catenin correlates with non-invasive hepatocellular carcinoma, absence of portal vein spread, and good prognosis
-
Mao T. L., Chu J. S., Jeng Y. M., Lai P. L. & Hsu H. C. Expression of mutant nuclear β catenin correlates with non-invasive hepatocellular carcinoma, absence of portal vein spread, and good prognosis. J. Pathol. 193, 95-101 (2001
-
(2001)
J. Pathol
, vol.193
, pp. 95-101
-
-
Mao, T.L.1
Chu, J.S.2
Jeng, Y.M.3
Lai, P.L.4
Hsu, H.C.5
-
21
-
-
84864455290
-
Gene signatures in the management of hepatocellular carcinoma
-
Hoshida Y., Moeini A., Alsinet C., Kojima K. & Villanueva A. Gene signatures in the management of hepatocellular carcinoma. Semin. Oncol. 39, 473-485 (2012
-
(2012)
Semin. Oncol
, vol.39
, pp. 473-485
-
-
Hoshida, Y.1
Moeini, A.2
Alsinet, C.3
Kojima, K.4
Villanueva, A.5
-
22
-
-
84879465430
-
A hepatocellular carcinoma 5 gene score associated with survival of patients after liver resection
-
Nault J. C., et al. A hepatocellular carcinoma 5 gene score associated with survival of patients after liver resection. Gastroenterology 145, 176-187 (2013
-
(2013)
Gastroenterology
, vol.145
, pp. 176-187
-
-
Nault, J.C.1
-
23
-
-
70349871321
-
Microrna expression, survival, and response to interferon in liver cancer
-
Ji J., et al. MicroRNA expression, survival, and response to interferon in liver cancer. N. Engl. J. Med. 361, 1437-1447 (2009
-
(2009)
N. Engl. J. Med
, vol.361
, pp. 1437-1447
-
-
Ji, J.1
-
24
-
-
57349090407
-
Gene expression in fixed tissues and outcome in hepatocellular carcinoma
-
Hoshida Y., et al. Gene expression in fixed tissues and outcome in hepatocellular carcinoma. N. Engl. J. Med. 359, 1995-2004 (2008
-
(2008)
N. Engl. J. Med
, vol.359
, pp. 1995-2004
-
-
Hoshida, Y.1
-
25
-
-
0037025173
-
Cancer addiction to oncogenes-the achilles heal of cancer
-
Weinstein I. B. Cancer. Addiction to oncogenes-the Achilles heal of cancer. Science 297, 63-64 (2002
-
(2002)
Science
, vol.297
, pp. 63-64
-
-
Weinstein, I.B.1
-
26
-
-
84904054856
-
Human and mouse vegfa-amplified hepatocellular carcinomas are highly sensitive to sorafenib treatment
-
Horwitz E., et al. Human and mouse VEGFA-amplified hepatocellular carcinomas are highly sensitive to sorafenib treatment. Cancer Discov. 4, 730-743 (2014
-
(2014)
Cancer Discov
, vol.4
, pp. 730-743
-
-
Horwitz, E.1
-
27
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman P. B., et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N. Engl. J. Med. 364, 2507-2516 (2011
-
(2011)
N. Engl. J. Med
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
-
28
-
-
84911372597
-
Crizotinib in ros1-rearranged non small cell lung cancer
-
Shaw A. T., et al. Crizotinib in ROS1-rearranged non small cell lung cancer. N. Engl. J. Med. 371, 1963-1971 (2014
-
(2014)
N. Engl. J. Med
, vol.371
, pp. 1963-1971
-
-
Shaw, A.T.1
-
29
-
-
4043181214
-
Cancer genes and the pathways they control
-
Vogelstein B. & Kinzler K. W. Cancer genes and the pathways they control. Nat. Med. 10, 789-799 (2004
-
(2004)
Nat. Med
, vol.10
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
30
-
-
70350435633
-
Shifting paradigms: The seeds of oncogene addiction
-
Sawyers C. L. Shifting paradigms: the seeds of oncogene addiction. Nat. Med. 15, 1158-1161 (2009
-
(2009)
Nat. Med
, vol.15
, pp. 1158-1161
-
-
Sawyers, C.L.1
-
31
-
-
79955433548
-
Targeted therapies for hepatocellular carcinoma
-
Villanueva A. & Llovet J. M. Targeted therapies for hepatocellular carcinoma. Gastroenterology 140, 1410-1426 (2011
-
(2011)
Gastroenterology
, vol.140
, pp. 1410-1426
-
-
Villanueva, A.1
Llovet, J.M.2
-
32
-
-
80054775320
-
Maintenance of adenomatous polyposis coli (apc)-mutant colorectal cancer is dependent on wnt/β-catenin signaling
-
Scholer-Dahirel A. & Schlabach M. R. Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/β-catenin signaling. Proc. Natl Acad. Sci. USA 108, 17135-17140 (2011
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 17135-17140
-
-
Scholer-Dahirel, A.1
Schlabach, M.R.2
-
33
-
-
84901472677
-
Genomic portrait of resectable hepatocellular carcinomas: Implications of RB1 and FGF19 aberrations for patient stratification
-
Ahn S. M., et al. Genomic portrait of resectable hepatocellular carcinomas: Implications of RB1 and FGF19 aberrations for patient stratification. Hepatology 60, 1972-1982 (2014
-
(2014)
Hepatology
, vol.60
, pp. 1972-1982
-
-
Ahn, S.M.1
-
34
-
-
84861625981
-
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma
-
Guichard C., et al. Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma. Nat. Genet. 44, 694-698 (2012
-
(2012)
Nat. Genet
, vol.44
, pp. 694-698
-
-
Guichard, C.1
-
35
-
-
84883718528
-
Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma
-
Kan Z., et al. Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma. Genome Res. 23, 1422-1433 (2013
-
(2013)
Genome Res
, vol.23
, pp. 1422-1433
-
-
Kan, Z.1
-
36
-
-
79952497178
-
Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by oncogenomic screening
-
Sawey E. T., et al. Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by oncogenomic screening. Cancer Cell 19, 347-358 (2011
-
(2011)
Cancer Cell
, vol.19
, pp. 347-358
-
-
Sawey, E.T.1
-
37
-
-
84895901513
-
Mutational landscape of HCC-the end of the beginning
-
Villanueva A. & Llovet J. M. Mutational landscape of HCC-the end of the beginning. Nat. Rev. Clin. Oncol. 11, 73-74 (2014
-
(2014)
Nat. Rev. Clin. Oncol
, vol.11
, pp. 73-74
-
-
Villanueva, A.1
Llovet, J.M.2
-
38
-
-
84922551107
-
Trans-ancestry mutational landscape of hepatocellular carcinoma genomes
-
Totoki Y., et al. Trans-ancestry mutational landscape of hepatocellular carcinoma genomes. Nat. Genet. 46, 1267-1273 (2014
-
(2014)
Nat. Genet
, vol.46
, pp. 1267-1273
-
-
Totoki, Y.1
-
39
-
-
33747830764
-
Hepatocellular carcinoma pathogenesis: From genes to environment
-
Farazi P. A. & Depinho R. A. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat. Rev. Cancer 6, 674-687 (2006
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 674-687
-
-
Farazi, P.A.1
Depinho, R.A.2
-
40
-
-
33847069207
-
Genomics and signaling pathways in hepatocellular carcinoma
-
Villanueva A., Newell P., Chiang D., Friedman S. L. & Llovet J. M. Genomics and signaling pathways in hepatocellular carcinoma. Semin. Liver Dis. 27, 55-76 (2007
-
(2007)
Semin. Liver Dis
, vol.27
, pp. 55-76
-
-
Villanueva, A.1
Newell, P.2
Chiang, D.3
Friedman, S.L.4
Llovet, J.M.5
-
41
-
-
33845790499
-
A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in hcv cirrhosis
-
Llovet J. M., et al. A Molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis. Gastroenterology 131, 1758-1767 (2006
-
(2006)
Gastroenterology
, vol.131
, pp. 1758-1767
-
-
Llovet, J.M.1
-
42
-
-
84869774410
-
Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice
-
Villanueva A., et al. Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice. Gastroenterology 143, 1660-1669 (2012
-
(2012)
Gastroenterology
, vol.143
, pp. 1660-1669
-
-
Villanueva, A.1
-
43
-
-
84878985394
-
A critical role for notch signaling in the formation of cholangiocellular carcinomas
-
Zender S., et al. A critical role for notch signaling in the formation of cholangiocellular carcinomas. Cancer Cell 23, 784-795 (2013
-
(2013)
Cancer Cell
, vol.23
, pp. 784-795
-
-
Zender, S.1
-
44
-
-
68549115658
-
Notch signaling controls liver development by regulating biliary differentiation
-
Zong Y., et al. Notch signaling controls liver development by regulating biliary differentiation. Development 136, 1727-1739 (2009
-
(2009)
Development
, vol.136
, pp. 1727-1739
-
-
Zong, Y.1
-
45
-
-
70350502865
-
Mst1 and mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the yap1 oncogene
-
Zhou D., et al. Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell 16, 425-438 (2009
-
(2009)
Cancer Cell
, vol.16
, pp. 425-438
-
-
Zhou, D.1
-
46
-
-
84925103805
-
Yap inhibition restores hepatocyte differentiation in advanced hcc, leading to tumor regression
-
Fitamant J., et al. YAP inhibition restores hepatocyte differentiation in advanced HCC, leading to tumor regression. Cell Rep. 10, 1692-1707 (2015
-
(2015)
Cell Rep
, vol.10
, pp. 1692-1707
-
-
Fitamant, J.1
-
47
-
-
79959653996
-
SWI/SNF nucleosome remodellers and cancer
-
Wilson B. G. & Roberts C. W. M. SWI/SNF nucleosome remodellers and cancer. Nat. Rev. Cancer 11, 481-492 (2011
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 481-492
-
-
Wilson, B.G.1
Roberts, C.W.M.2
-
48
-
-
33645976174
-
Ubiquitous activation of ras and jak/stat pathways in human hcc
-
Calvisi D., et al. Ubiquitous activation of Ras and Jak/Stat pathways in human HCC. Gastroenterology 130, 1117-1128 (2006
-
(2006)
Gastroenterology
, vol.130
, pp. 1117-1128
-
-
Calvisi, D.1
-
49
-
-
69949129964
-
Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo
-
Newell P., et al. Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo. J. Hepatol. 51, 725-733 (2009
-
(2009)
J. Hepatol
, vol.51
, pp. 725-733
-
-
Newell, P.1
-
50
-
-
55749088393
-
Preclinical overview of sorafenib, a multikinase inhibitor that targets both raf and vegf and pdgf receptor tyrosine kinase signaling
-
Wilhelm S. M., et al. Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol. Cancer Ther. 7, 3129-3140 (2008
-
(2008)
Mol. Cancer Ther
, vol.7
, pp. 3129-3140
-
-
Wilhelm, S.M.1
-
51
-
-
84906349046
-
The preclinical development of regorafenib for the treatment of colorectal cancer
-
Miura K., et al. The preclinical development of regorafenib for the treatment of colorectal cancer. Expert Opin. Drug Discov. 9, 1087-1101 (2014
-
(2014)
Expert Opin. Drug Discov
, vol.9
, pp. 1087-1101
-
-
Miura, K.1
-
52
-
-
57349087153
-
Pivotal role of mtor signaling in hepatocellular carcinoma
-
Villanueva A., et al. Pivotal role of mTOR signaling in hepatocellular carcinoma. Gastroenterology 135, 1972-1983 (2008
-
(2008)
Gastroenterology
, vol.135
, pp. 1972-1983
-
-
Villanueva, A.1
-
53
-
-
77949875878
-
Igf activation in a molecular subclass of hepatocellular carcinoma and pre clinical efficacy of igf-1r blockage
-
Tovar V., et al. IGF activation in a molecular subclass of hepatocellular carcinoma and pre clinical efficacy of IGF-1R blockage. J. Hepatol. 52, 550-559 (2010
-
(2010)
J. Hepatol
, vol.52
, pp. 550-559
-
-
Tovar, V.1
-
54
-
-
84892493984
-
A phase ii study of cixutumumab (imc a12, nsc742460) in advanced hepatocellular carcinoma
-
Abou-Alfa G. K., et al. A phase II study of cixutumumab (IMC A12, NSC742460) in advanced hepatocellular carcinoma. J. Hepatol. 60, 319-324 (2014
-
(2014)
J. Hepatol
, vol.60
, pp. 319-324
-
-
Abou-Alfa, G.K.1
-
55
-
-
33745220780
-
Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype
-
Kaposi-Novak P. Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype. J. Clin. Invest. 116, 1582-1595 (2006
-
(2006)
J. Clin. Invest
, vol.116
, pp. 1582-1595
-
-
Kaposi-Novak, P.1
-
56
-
-
84875552108
-
Targeting the HGF/c-MET pathway in hepatocellular carcinoma
-
Goyal L., Muzumdar M. D. & Zhu A. X. Targeting the HGF/c-MET pathway in hepatocellular carcinoma. Clin. Cancer Res. 19, 2310-2318 (2013
-
(2013)
Clin. Cancer Res
, vol.19
, pp. 2310-2318
-
-
Goyal, L.1
Muzumdar, M.D.2
Zhu, A.X.3
-
59
-
-
0034856294
-
Clinical management of hepatocellular carcinoma conclusions of the Barcelona 2000 easl conference european association for the study of the liver
-
Bruix J., et al. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona 2000 EASL conference. European Association for the Study of the Liver. J. Hepatol. 35, 421-430 (2001
-
(2001)
J. Hepatol
, vol.35
, pp. 421-430
-
-
Bruix, J.1
-
61
-
-
57749189578
-
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial
-
Cheng A. L., et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 10, 25-34 (2009
-
(2009)
Lancet Oncol
, vol.10
, pp. 25-34
-
-
Cheng, A.L.1
-
62
-
-
84859880607
-
Plasma biomarkers as predictors of outcome in patients with advanced hepatocellular carcinoma
-
Llovet J. M., et al. Plasma biomarkers as predictors of outcome in patients with advanced hepatocellular carcinoma. Clin. Cancer Res. 18, 2290-2300 (2012
-
(2012)
Clin. Cancer Res
, vol.18
, pp. 2290-2300
-
-
Llovet, J.M.1
-
63
-
-
84866391058
-
Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: Subanalyses of a phase III trial
-
Bruix J., et al. Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: Subanalyses of a phase III trial. J. Hepatol. 57, 821-829 (2012
-
(2012)
J. Hepatol
, vol.57
, pp. 821-829
-
-
Bruix, J.1
-
64
-
-
84904751197
-
Early dermatologic adverse events predict better outcome in HCC patients treated with sorafenib
-
Reig M., et al. Early dermatologic adverse events predict better outcome in HCC patients treated with sorafenib. J. Hepatol. 61, 318-324 (2014
-
(2014)
J. Hepatol
, vol.61
, pp. 318-324
-
-
Reig, M.1
-
65
-
-
84874463179
-
Cost-effectiveness of sorafenib treatment in field practice for patients with hepatocellular carcinoma
-
Cammà C., et al. Cost-effectiveness of sorafenib treatment in field practice for patients with hepatocellular carcinoma. Hepatology 57, 1046-1054 (2013
-
(2013)
Hepatology
, vol.57
, pp. 1046-1054
-
-
Cammà, C.1
-
66
-
-
84890274647
-
Brivanib versus sorafenib as first-line therapy in patients with unresectable, advanced hepatocellular carcinoma: Results from the randomized phase III brisk-fl study
-
Johnson P. J., et al. Brivanib versus sorafenib as first-line therapy in patients with unresectable, advanced hepatocellular carcinoma: results from the randomized phase III BRISK-FL study. J. Clin. Oncol. 31, 3517-3524 (2013
-
(2013)
J. Clin. Oncol
, vol.31
, pp. 3517-3524
-
-
Johnson, P.J.1
-
67
-
-
84891915708
-
Sunitinib versus sorafenib in advanced hepatocellular cancer: Results of a randomized phase III trial
-
Cheng A. L., et al. Sunitinib versus sorafenib in advanced hepatocellular cancer: results of a randomized phase III trial. J. Clin. Oncol. 31, 4067-4075 (2013
-
(2013)
J. Clin. Oncol
, vol.31
, pp. 4067-4075
-
-
Cheng, A.L.1
-
68
-
-
84920993186
-
Linifanib versus sorafenib in patients with advanced hepatocellular carcinoma: Results of a randomized phase III trial
-
Cainap C., et al. Linifanib versus sorafenib in patients with advanced hepatocellular carcinoma: results of a randomized phase III trial. J. Clin. Oncol. 33, 172-179 (2015
-
(2015)
J. Clin. Oncol
, vol.33
, pp. 172-179
-
-
Cainap, C.1
-
69
-
-
84984589185
-
Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma
-
Tai W. T., et al. Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma. J. Hepatol. 55, 1041-1048 (2011
-
(2011)
J. Hepatol
, vol.55
, pp. 1041-1048
-
-
Tai, W.T.1
-
70
-
-
44449085884
-
Design and endpoints of clinical trials in hepatocellular carcinoma
-
Llovet J. M., et al. Design and endpoints of clinical trials in hepatocellular carcinoma. J. Natl Cancer Inst. 100, 698-711 (2008
-
(2008)
J. Natl Cancer Inst
, vol.100
, pp. 698-711
-
-
Llovet, J.M.1
-
71
-
-
84859212951
-
Hepatocellular carcinoma
-
Forner A., Llovet J. M. & Bruix J. Hepatocellular carcinoma. Lancet 379, 1245-1255 (2012
-
(2012)
Lancet
, vol.379
, pp. 1245-1255
-
-
Forner, A.1
Llovet, J.M.2
Bruix, J.3
-
72
-
-
16244369103
-
Prognosis of hepatocellular carcinoma: Comparison of 7 staging systems in an American cohort
-
Marrero J. A., et al. Prognosis of hepatocellular carcinoma: comparison of 7 staging systems in an American cohort. Hepatology 41, 707-716 (2005
-
(2005)
Hepatology
, vol.41
, pp. 707-716
-
-
Marrero, J.A.1
-
73
-
-
84885587718
-
Brivanib in patients with advanced hepatocellular carcinoma who were intolerant to sorafenib or for whom sorafenib failed: Results from the randomized phase III brisk-ps study
-
Llovet J. M., et al. Brivanib in patients with advanced hepatocellular carcinoma who were intolerant to sorafenib or for whom sorafenib failed: results from the randomized phase III BRISK-PS study. J. Clin. Oncol. 31, 3509-3516 (2013
-
(2013)
J. Clin. Oncol
, vol.31
, pp. 3509-3516
-
-
Llovet, J.M.1
-
74
-
-
84923144891
-
Search: A phase III, randomized, double-blind, placebo-controlled trial of sorafenib plus erlotinib in patients with hepatocellular carcinoma (hcc
-
Zhu A. X., Rosmorduc O., Evans J., Ross P. & Santoro A. SEARCH: a phase III, randomized, double-blind, placebo-controlled trial of sorafenib plus erlotinib in patients with hepatocellular carcinoma (HCC). J. Clin. Oncol. 33, 559-566 (2015
-
(2015)
J. Clin. Oncol
, vol.33
, pp. 559-566
-
-
Zhu, A.X.1
Rosmorduc, O.2
Evans, J.3
Ross, P.4
Santoro, A.5
-
75
-
-
84903593280
-
Effect of everolimus on survival in advanced hepatocellular carcinoma after failure of sorafenib
-
Zhu A. X., et al. Effect of everolimus on survival in advanced hepatocellular carcinoma after failure of sorafenib. JAMA 312, 57-67 (2014
-
(2014)
Jama
, vol.312
, pp. 57-67
-
-
Zhu, A.X.1
-
76
-
-
84923605516
-
Ramucirumab as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib: Results from the randomized phase III reach study
-
Zhu A. X., et al. Ramucirumab as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib: results from the randomized phase III reach study. Ann. Oncol. 25, 1-41 (2014
-
(2014)
Ann. Oncol
, vol.25
, pp. 1-41
-
-
Zhu, A.X.1
-
77
-
-
84891587587
-
Randomized, multicenter, open-label study of oxaliplatin plus fluorouracil/leucovorin versus doxorubicin as palliative chemotherapy in patients with advanced hepatocellular carcinoma from Asia
-
Qin S., et al. Randomized, multicenter, open-label study of oxaliplatin plus fluorouracil/leucovorin versus doxorubicin as palliative chemotherapy in patients with advanced hepatocellular carcinoma from Asia. J. Clin. Oncol. 31, 3501-3508 (2013
-
(2013)
J. Clin. Oncol
, vol.31
, pp. 3501-3508
-
-
Qin, S.1
-
78
-
-
84898989382
-
Hepatocellular carcinoma: Reasons for phase III failure and novel perspectives on trial design
-
Llovet J. M. & Hernandez-Gea V. Hepatocellular carcinoma: reasons for phase III failure and novel perspectives on trial design. Clin. Cancer Res. 20, 2072-2079 (2014
-
(2014)
Clin. Cancer Res
, vol.20
, pp. 2072-2079
-
-
Llovet, J.M.1
Hernandez-Gea, V.2
-
79
-
-
0032898237
-
Natural history of untreated nonsurgical hepatocellular carcinoma: Rationale for the design and evaluation of therapeutic trials
-
Llovet J. M., et al. Natural history of untreated nonsurgical hepatocellular carcinoma: rationale for the design and evaluation of therapeutic trials. Hepatology 29, 62-67 (1999
-
(1999)
Hepatology
, vol.29
, pp. 62-67
-
-
Llovet, J.M.1
-
80
-
-
67651165187
-
Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: An open-label, multicentre, phase II study
-
Faivre S., et al. Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: an open-label, multicentre, phase II study. Lancet Oncol. 10, 794-800 (2009
-
(2009)
Lancet Oncol
, vol.10
, pp. 794-800
-
-
Faivre, S.1
-
81
-
-
67649946279
-
Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: A phase II study
-
Zhu A. X., et al. Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study. J. Clin. Oncol. 27, 3027-3035 (2009
-
(2009)
J. Clin. Oncol
, vol.27
, pp. 3027-3035
-
-
Zhu, A.X.1
-
82
-
-
27244447373
-
Phase ii study of erlotinib (osi 774) in patients with advanced hepatocellular cancer
-
Philip P. A. Phase II study of erlotinib (OSI 774) in patients with advanced hepatocellular cancer. J. Clin. Oncol. 23, 6657-6663 (2005
-
(2005)
J. Clin. Oncol
, vol.23
, pp. 6657-6663
-
-
Philip, P.A.1
-
83
-
-
34548150925
-
Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma
-
Thomas M. B., et al. Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma. Cancer 110, 1059-1067 (2007
-
(2007)
Cancer
, vol.110
, pp. 1059-1067
-
-
Thomas, M.B.1
-
84
-
-
84984559340
-
Phase 2 trial of linifanib (abt 869) in patients with unresectable or metastatic hepatocellular carcinoma
-
Toh H. C., et al. Phase 2 trial of linifanib (ABT 869) in patients with unresectable or metastatic hepatocellular carcinoma. Cancer 119, 380-387 (2012
-
(2012)
Cancer
, vol.119
, pp. 380-387
-
-
Toh, H.C.1
-
85
-
-
79953325932
-
Phase II, open-label study of brivanib as first-line therapy in patients with advanced hepatocellular carcinoma
-
Finn R. S., et al. Phase II, open-label study of brivanib as first-line therapy in patients with advanced hepatocellular carcinoma. Clin. Cancer Res. 17, 1973-1983 (2011
-
(2011)
Clin. Cancer Res
, vol.17
, pp. 1973-1983
-
-
Finn, R.S.1
-
86
-
-
84857008164
-
Phase II open-label study of brivanib as second line therapy in patients with advanced hepatocellular carcinoma
-
Finn R. S., Kang Y. K., Mulcahy M. & Lim H. Y. Phase II, open-label study of brivanib as second line therapy in patients with advanced hepatocellular carcinoma. Clin. Cancer Res. 18, 2090-2098 (2012
-
(2012)
Clin. Cancer Res
, vol.18
, pp. 2090-2098
-
-
Finn, R.S.1
Kang, Y.K.2
Mulcahy, M.3
Lim, H.Y.4
-
87
-
-
84859383549
-
Second-line therapies in hepatocellular carcinoma: Emergence of resistance to sorafenib
-
Villanueva A. & Llovet J. M. Second-line therapies in hepatocellular carcinoma: emergence of resistance to sorafenib. Clin. Cancer Res. 18, 1824-1826 (2012
-
(2012)
Clin. Cancer Res
, vol.18
, pp. 1824-1826
-
-
Villanueva, A.1
Llovet, J.M.2
-
88
-
-
84890287907
-
A phase ii and biomarker study of ramucirumab, a human monoclonal antibody targeting the vegf receptor 2, as first-line monotherapy in patients with advanced hepatocellular cancer
-
Zhu A. X., et al. A phase II and biomarker study of ramucirumab, a human monoclonal antibody targeting the VEGF receptor 2, as first-line monotherapy in patients with advanced hepatocellular cancer. Clin. Cancer Res. 19, 6614-6623 (2013
-
(2013)
Clin. Cancer Res
, vol.19
, pp. 6614-6623
-
-
Zhu, A.X.1
-
89
-
-
20344367769
-
Resection and liver transplantation for hepatocellular carcinoma
-
Llovet J. M., Schwartz M. & Mazzaferro V. Resection and liver transplantation for hepatocellular carcinoma. Semin. Liver Dis. 25, 181-200 (2005
-
(2005)
Semin. Liver Dis
, vol.25
, pp. 181-200
-
-
Llovet, J.M.1
Schwartz, M.2
Mazzaferro, V.3
-
90
-
-
0034596475
-
Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: A randomised trial
-
Takayama T., et al. Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trial. Lancet 356, 802-807 (2000
-
(2000)
Lancet
, vol.356
, pp. 802-807
-
-
Takayama, T.1
-
91
-
-
5844370499
-
Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma hepatoma prevention study group
-
Muto Y., et al. Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. Hepatoma Prevention Study Group. N. Engl. J. Med. 334, 1561-1567 (1996
-
(1996)
N. Engl. J. Med
, vol.334
, pp. 1561-1567
-
-
Muto, Y.1
-
92
-
-
84907023733
-
Storm: A phase III randomized double-blind placebo-controlled trial of adjuvant sorafenib after resection or ablation to prevent recurrence of hepatocellular carcinoma [abstract
-
Bruix J., Takayama T., Mazzaferro V., Chau G. Y. & Yang J. STORM: A phase III randomized, double-blind, placebo-controlled trial of adjuvant sorafenib after resection or ablation to prevent recurrence of hepatocellular carcinoma [abstract]. J. Clin. Oncol. 32, a4006 (2014
-
(2014)
J. Clin. Oncol
, vol.32
, pp. a4006
-
-
Bruix, J.1
Takayama, T.2
Mazzaferro, V.3
Chau, G.Y.4
Yang, J.5
-
93
-
-
0028226376
-
New designs for the selection of treatments to be tested in randomized clinical trials
-
Simon R., Thall P. F. & Ellenberg S. S. New designs for the selection of treatments to be tested in randomized clinical trials. Stat. Med. 13, 417-429 (1994
-
(1994)
Stat. Med
, vol.13
, pp. 417-429
-
-
Simon, R.1
Thall, P.F.2
Ellenberg, S.S.3
-
94
-
-
33749017926
-
Phase II study of sorafenib in patients with advanced hepatocellular carcinoma
-
Abou-Alfa G. K., et al. Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J. Clin. Oncol. 24, 4293-4300 (2006
-
(2006)
J. Clin. Oncol
, vol.24
, pp. 4293-4300
-
-
Abou-Alfa, G.K.1
-
95
-
-
84888292557
-
Postprogression survival of patients with advanced hepatocellular carcinoma: Rationale for second-line trial design
-
Reig M., et al. Postprogression survival of patients with advanced hepatocellular carcinoma: rationale for second-line trial design. Hepatology 58, 2023-2031 (2013
-
(2013)
Hepatology
, vol.58
, pp. 2023-2031
-
-
Reig, M.1
-
96
-
-
77349102071
-
Modified recist (mrecist assessment for hepatocellular carcinoma
-
Lencioni R. & Llovet J. M. Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Semin. Liver Dis. 30, 52-60 (2010
-
(2010)
Semin. Liver Dis
, vol.30
, pp. 52-60
-
-
Lencioni, R.1
Llovet, J.M.2
-
97
-
-
54949085398
-
K ras mutations and benefit from cetuximab in advanced colorectal cancer
-
Karapetis C. S., et al. K ras mutations and benefit from cetuximab in advanced colorectal cancer. N. Engl. J. Med. 359, 1757-1765 (2008
-
(2008)
N. Engl. J. Med
, vol.359
, pp. 1757-1765
-
-
Karapetis, C.S.1
-
98
-
-
76949086699
-
-
US National Library of Medicine online
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01755767 (2015
-
(2015)
Clinical Trials.gov
-
-
-
99
-
-
76949086699
-
-
US National Library of Medicine online
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01915602 (2015
-
(2015)
Clinical Trials.gov
-
-
-
100
-
-
0242499448
-
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer
-
Siegel P. M. & Massagué J. Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat. Rev. Cancer 3, 807-821 (2003
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 807-821
-
-
Siegel, P.M.1
Massagué, J.2
-
101
-
-
84893867951
-
TGF β: Duality of function between tumor prevention and carcinogenesis
-
Principe D. R., et al. TGF β: duality of function between tumor prevention and carcinogenesis. J. Natl Cancer Inst. 106, djt369-djt369 (2014
-
(2014)
J. Natl Cancer Inst
, vol.106
, pp. djt369-djt369
-
-
Principe, D.R.1
-
102
-
-
84897450600
-
Transforming growth factor β as a therapeutic target in hepatocellular carcinoma
-
Giannelli G., Villa E. & Lahn M. Transforming growth factor β as a therapeutic target in hepatocellular carcinoma. Cancer Res. 74, 1890-1894 (2014
-
(2014)
Cancer Res
, vol.74
, pp. 1890-1894
-
-
Giannelli, G.1
Villa, E.2
Lahn, M.3
-
103
-
-
46249085489
-
Transforming growth factor β gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer
-
Coulouarn C., Factor V. M. & Thorgeirsson S. S. Transforming growth factor β gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer. Hepatology 47, 2059-2067 (2008
-
(2008)
Hepatology
, vol.47
, pp. 2059-2067
-
-
Coulouarn, C.1
Factor, V.M.2
Thorgeirsson, S.S.3
-
104
-
-
84879528782
-
Differential inhibition of the tgf β signaling pathway in hcc cells using the small molecule inhibitor ly2157299 and the d10 monoclonal antibody against tgf β receptor type ii
-
Dituri F., et al. Differential Inhibition of the TGF β signaling pathway in HCC cells using the small molecule inhibitor LY2157299 and the D10 monoclonal antibody against TGF β receptor type II. PLoS ONE 8, e67109 (2013
-
(2013)
Plos One
, vol.8
, pp. e67109
-
-
Dituri, F.1
-
105
-
-
84904426489
-
A phase 2 study of a novel transforming growth factor-beta (tgf-β 1) receptor i kinase inhibitor ly2157299 monohydrate (ly) in patients with advanced hepatocellular carcinoma [abstract
-
Faivre S. J., Santoro A. & Kelley R. K. A phase 2 study of a novel transforming growth factor-beta (TGF-β 1) receptor I kinase inhibitor, LY2157299 monohydrate (LY), in patients with advanced hepatocellular carcinoma [abstract]. J. Clin. Oncol. 32, LBA173 (2014
-
(2014)
J. Clin. Oncol
, vol.32
, pp. LBA173
-
-
Faivre, S.J.1
Santoro, A.2
Kelley, R.K.3
-
106
-
-
84896735285
-
Fibroblast growth factor signaling in liver carcinogenesis
-
Roberts L. R. Fibroblast growth factor signaling in liver carcinogenesis. Hepatology 59, 1166-1173 (2014
-
(2014)
Hepatology
, vol.59
, pp. 1166-1173
-
-
Roberts, L.R.1
-
107
-
-
26644471951
-
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
-
Casanovas O., Hicklin D. J., Bergers G. & Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 8, 299-309 (2005
-
(2005)
Cancer Cell
, vol.8
, pp. 299-309
-
-
Casanovas, O.1
Hicklin, D.J.2
Bergers, G.3
Hanahan, D.4
-
108
-
-
0036086285
-
A mouse model of hepatocellular carcinoma: Ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice
-
Nicholes K., et al. A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice. Am. J. Pathol. 160, 2295-2307 (2002
-
(2002)
Am. J. Pathol
, vol.160
, pp. 2295-2307
-
-
Nicholes, K.1
-
109
-
-
37849029159
-
Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models
-
Desnoyers L. R., et al. Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models. Oncogene 27, 85-97 (2008
-
(2008)
Oncogene
, vol.27
, pp. 85-97
-
-
Desnoyers, L.R.1
-
110
-
-
84933281820
-
Abstract 3858: Gains in fgf19 are predictive of response to the fibroblast growth factor receptor (fgfr) small molecule tyrosine kinase inhibitor bgj 398 in vitro
-
Finn R. S., et al. Abstract 3858: Gains in FGF19 are predictive of response to the fibroblast growth factor receptor (FGFR) small molecule tyrosine kinase inhibitor BGJ 398 in vitro. Cancer Res. 72, 3858-3858 (2012
-
(2012)
Cancer Res
, vol.72
, pp. 3858-3858
-
-
Finn, R.S.1
-
111
-
-
84871491773
-
Fgfr genetic alterations predict for sensitivity to nvp-bgj398, a selective pan-fgfr inhibitor
-
Guagnano V., et al. FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor. Cancer Discov. 2, 1118-1133 (2012
-
(2012)
Cancer Discov
, vol.2
, pp. 1118-1133
-
-
Guagnano, V.1
-
112
-
-
84933280522
-
First isoform selective inhibitor of FGFR4 for the treatment of genomically defined patients with hepatocellular carcinoma [abstract
-
LB
-
Hagel M., et al. First isoform selective inhibitor of FGFR4 for the treatment of genomically defined patients with hepatocellular carcinoma [abstract]. Cancer Res. 74, LB 324 (2014
-
(2014)
Cancer Res
, vol.74
, pp. 324
-
-
Hagel, M.1
-
114
-
-
84864285704
-
Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial
-
Hauschild A., et al. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 380, 358-365 (2012
-
(2012)
Lancet
, vol.380
, pp. 358-365
-
-
Hauschild, A.1
-
115
-
-
84868224906
-
Combined braf and mek inhibition in melanoma with braf v600 mutations
-
Flaherty K. T., et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N. Engl. J. Med. 367, 1694-1703 (2012
-
(2012)
N. Engl. J. Med
, vol.367
, pp. 1694-1703
-
-
Flaherty, K.T.1
-
116
-
-
79959214127
-
Phase II study of the mitogen-activated protein kinase 1/2 inhibitor selumetinib in patients with advanced hepatocellular carcinoma
-
O'Neil B. H., et al. Phase II study of the mitogen-activated protein kinase 1/2 inhibitor selumetinib in patients with advanced hepatocellular carcinoma. J. Clin. Oncol. 29, 2350-2356 (2011
-
(2011)
J. Clin. Oncol
, vol.29
, pp. 2350-2356
-
-
O'neil, B.H.1
-
117
-
-
84887093344
-
Allosteric mek1/2 inhibitor refametinib (bay 86-9766) in combination with sorafenib exhibits antitumor activity in preclinical murine and rat models of hepatocellular carcinoma
-
Schmieder R., et al. Allosteric MEK1/2 inhibitor refametinib (BAY 86-9766) in combination with sorafenib exhibits antitumor activity in preclinical murine and rat models of hepatocellular carcinoma. Neoplasia 15, 1161-1171 (2013
-
(2013)
Neoplasia
, vol.15
, pp. 1161-1171
-
-
Schmieder, R.1
-
118
-
-
84918777261
-
A phase ii study of the efficacy and safety of the combination therapy of the mek inhibitor refametinib (bay 86-9766) plus sorafenib for asian patients with unresectable hepatocellular carcinoma
-
Lim H. Y., et al. A Phase II study of the efficacy and safety of the combination therapy of the MEK inhibitor refametinib (BAY 86-9766) plus sorafenib for Asian patients with unresectable hepatocellular carcinoma. Clin. Cancer Res. 20, 5976-5985 (2014
-
(2014)
Clin. Cancer Res
, vol.20
, pp. 5976-5985
-
-
Lim, H.Y.1
-
119
-
-
76949086699
-
-
US National Library of Medicine online
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01915602?term=refametiniamp;b&rank=4 (2015
-
(2015)
Clinical Trials.gov
-
-
-
120
-
-
84858766182
-
The blockade of immune checkpoints in cancer immunotherapy
-
Pardoll D. M. The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 12, 252-264 (2012
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 252-264
-
-
Pardoll, D.M.1
-
121
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi F. S., et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363, 711-723 (2010
-
(2010)
N. Engl. J. Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
-
122
-
-
84879759020
-
Safety and tumor responses with lambrolizumab (anti PD 1) in melanoma
-
Hamid O., et al. Safety and tumor responses with lambrolizumab (anti PD 1) in melanoma. N. Engl. J. Med. 369, 134-144 (2013
-
(2013)
N. Engl. J. Med
, vol.369
, pp. 134-144
-
-
Hamid, O.1
-
123
-
-
84887862839
-
A rheostat for immune responses: The unique properties of PD 1 and their advantages for clinical application
-
Okazaki T., Chikuma S., Iwai Y., Fagarasan S. & Honjo T. A rheostat for immune responses: the unique properties of PD 1 and their advantages for clinical application. Nat. Immunol. 14, 1212-1218 (2013
-
(2013)
Nat. Immunol
, vol.14
, pp. 1212-1218
-
-
Okazaki, T.1
Chikuma, S.2
Iwai, Y.3
Fagarasan, S.4
Honjo, T.5
-
124
-
-
33646729862
-
A phase I/II trial testing immunization of hepatocellular carcinoma patients with dendritic cells pulsed with four alpha-fetoprotein peptides
-
Butterfield L. H., et al. A phase I/II trial testing immunization of hepatocellular carcinoma patients with dendritic cells pulsed with four alpha-fetoprotein peptides. Clin. Cancer Res. 12, 2817-2825 (2006
-
(2006)
Clin. Cancer Res
, vol.12
, pp. 2817-2825
-
-
Butterfield, L.H.1
-
125
-
-
58949092553
-
A phase II study of adoptive immunotherapy using dendritic cells pulsed with tumor lysate in patients with hepatocellular carcinoma
-
Palmer D. H., et al. A phase II study of adoptive immunotherapy using dendritic cells pulsed with tumor lysate in patients with hepatocellular carcinoma. Hepatology 49, 124-132 (2009
-
(2009)
Hepatology
, vol.49
, pp. 124-132
-
-
Palmer, D.H.1
-
126
-
-
84879141840
-
A clinical trial of ctla 4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis c
-
A clinical trial of CTLA 4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C. Hepatology 59, 81-88 (2013
-
(2013)
Hepatology
, vol.59
, pp. 81-88
-
-
-
127
-
-
84925222119
-
Nivolumab in previously untreated melanoma without BRAF mutation
-
Robert C., et al. Nivolumab in previously untreated melanoma without BRAF mutation. N. Engl. J. Med. 372, 320-330 (2015
-
(2015)
N. Engl. J. Med
, vol.372
, pp. 320-330
-
-
Robert, C.1
-
128
-
-
84905674992
-
Mk 3475 monotherapy for previously treated non-small cell lung cancer (nsclc): Preliminary safety and clinical activity [abstract]
-
Garon E. B., et al. MK 3475 monotherapy for previously treated non-small cell lung cancer (NSCLC): preliminary safety and clinical activity [abstract]. Clin. Cancer Res. 20, A20 (2014
-
(2014)
Clin. Cancer Res
, vol.20
, pp. A20
-
-
Garon, E.B.1
-
129
-
-
84871721240
-
Tivantinib for second-line treatment of advanced hepatocellular carcinoma: A randomised, placebo-controlled phase 2 study
-
Santoro A., et al. Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study. Lancet Oncol. 14, 55-63 (2013
-
(2013)
Lancet Oncol
, vol.14
, pp. 55-63
-
-
Santoro, A.1
-
130
-
-
84901747256
-
Cabozantinib suppresses tumor growth and metastasis in hepatocellular carcinoma by a dual blockade of vegfr2 and met
-
Xiang Q., et al. Cabozantinib suppresses tumor growth and metastasis in hepatocellular carcinoma by a dual blockade of VEGFR2 and MET. Clin. Cancer Res. 20, 2959-2970 (2014
-
(2014)
Clin. Cancer Res
, vol.20
, pp. 2959-2970
-
-
Xiang, Q.1
-
131
-
-
84920424119
-
Tivantinib (arq 197) efficacy is independent of met inhibition in non small cell lung cancer cell lines
-
Calles A., et al. Tivantinib (ARQ 197) efficacy is independent of MET inhibition in non small cell lung cancer cell lines. Mol. Oncol. 9, 260-269 (2015
-
(2015)
Mol. Oncol
, vol.9
, pp. 260-269
-
-
Calles, A.1
-
132
-
-
84893758816
-
Uhrf1 overexpression drives dna hypomethylation and hepatocellular carcinoma
-
Mudbhary R., et al. UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma. Cancer Cell 25, 196-209 (2014
-
(2014)
Cancer Cell
, vol.25
, pp. 196-209
-
-
Mudbhary, R.1
-
133
-
-
84903579347
-
Clinical trials in hepatocellular carcinoma: An update
-
Shen Y. C., et al. Clinical trials in hepatocellular carcinoma: an update. Liver Cancer 2, 345-364 (2013
-
(2013)
Liver Cancer
, vol.2
, pp. 345-364
-
-
Shen, Y.C.1
-
134
-
-
84866758581
-
Epigenetic therapy using belinostat for patients with unresectable hepatocellular carcinoma: A multicenter phase i/ii study with biomarker and pharmacokinetic analysis of tumors from patients in the mayo phase ii consortium and the cancer therapeutics research group
-
Yeo W., et al. Epigenetic therapy using belinostat for patients with unresectable hepatocellular carcinoma: a multicenter phase I/II study with biomarker and pharmacokinetic analysis of tumors from patients in the Mayo phase II consortium and the cancer therapeutics research group. J. Clin. Oncol. 30, 3361-3367 (2012
-
(2012)
J. Clin. Oncol
, vol.30
, pp. 3361-3367
-
-
Yeo, W.1
-
135
-
-
77950877402
-
HR23B is a biomarker for tumor sensitivity to HDAC inhibitor-based therapy
-
Khan O., et al. HR23B is a biomarker for tumor sensitivity to HDAC inhibitor-based therapy. Proc. Natl Acad. Sci. USA 107, 6532-6537 (2010
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 6532-6537
-
-
Khan, O.1
-
136
-
-
84885911845
-
Efficacy safety tolerability and pk of the hdac inhibitor resminostat in sorafenib-refractory hepatocellular carcinoma (hcc): Phase ii shelter study [abstract
-
Bitzer M., Horger M., Ganten T., Lauer U. M. & Woerns M. A. Efficacy, safety, tolerability, and PK of the HDAC inhibitor resminostat in sorafenib-refractory hepatocellular carcinoma (HCC): phase II shelter study [abstract]. J. Clin. Oncol. 30, 4115 (2013
-
(2013)
J. Clin. Oncol
, vol.30
, pp. 4115
-
-
Bitzer, M.1
Horger, M.2
Ganten, T.3
Lauer, U.M.4
Woerns, M.A.5
-
137
-
-
84861183742
-
Combination therapy for hepatocellular carcinoma: Additive preclinical efficacy of the hdac inhibitor panobinostat with sorafenib
-
Lachenmayer A., et al. Combination therapy for hepatocellular carcinoma: additive preclinical efficacy of the HDAC inhibitor panobinostat with sorafenib. J. Hepatol. 56, 1343-1350 (2012
-
(2012)
J. Hepatol
, vol.56
, pp. 1343-1350
-
-
Lachenmayer, A.1
-
138
-
-
79955372708
-
MicroRNA-based classification of hepatocellular carcinoma and oncogenic role of miR 517a
-
e16
-
Toffanin S., et al. MicroRNA-based classification of hepatocellular carcinoma and oncogenic role of miR 517a. Gastroenterology 140, 1618-1628e16 (2011
-
(2011)
Gastroenterology
, vol.140
, pp. 1618-1628
-
-
Toffanin, S.1
-
139
-
-
84887101163
-
Micrornas and other non-coding rnas as targets for anticancer drug development
-
Ling H., Fabbri M. & Calin G. A. MicroRNAs and other non-coding RNAs as targets for anticancer drug development. Nat. Rev. Drug Discov. 12, 847-865 (2013
-
(2013)
Nat. Rev. Drug Discov
, vol.12
, pp. 847-865
-
-
Ling, H.1
Fabbri, M.2
Calin, G.A.3
-
140
-
-
84872128718
-
A functional screening identifies five microRNAs controlling glypican 3: Role of mir 1271 down-regulation in hepatocellular carcinoma
-
Maurel M., et al. A functional screening identifies five microRNAs controlling glypican 3: role of mir 1271 down-regulation in hepatocellular carcinoma. Hepatology 57, 195-204 (2013
-
(2013)
Hepatology
, vol.57
, pp. 195-204
-
-
Maurel, M.1
-
141
-
-
76949086699
-
-
US National Library of Medicine online
-
US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT01507168 (2015
-
(2015)
Clinical Trials.gov
-
-
-
142
-
-
66449136951
-
Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model
-
Kota J., et al. Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 137, 1005-1017 (2009
-
(2009)
Cell
, vol.137
, pp. 1005-1017
-
-
Kota, J.1
-
143
-
-
84881298446
-
European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013
-
Baccarani M., et al. European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013. Blood 122, 872-884 (2013
-
(2013)
Blood
, vol.122
, pp. 872-884
-
-
Baccarani, M.1
-
144
-
-
84921985051
-
RNAi screening identifies a mechanism of sorafenib resistance in liver cancer
-
Rudalska R., et al. RNAi screening identifies a mechanism of sorafenib resistance in liver cancer. Nat. Med. 20, 1138-1146 (2014
-
(2014)
Nat. Med
, vol.20
, pp. 1138-1146
-
-
Rudalska, R.1
-
145
-
-
0035874981
-
Trastuzumab (herceptin), a humanized anti-her2 receptor monoclonal antibody, inhibits basal and activated her2 ectodomain cleavage in breast cancer cells
-
Molina M. A., et al. Trastuzumab (Herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells. Cancer Res. 61, 4744-4749 (2001
-
(2001)
Cancer Res
, vol.61
, pp. 4744-4749
-
-
Molina, M.A.1
-
146
-
-
84879071011
-
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
-
Shaw A. T., et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N. Engl. J. Med. 368, 2385-2394 (2013
-
(2013)
N. Engl. J. Med
, vol.368
, pp. 2385-2394
-
-
Shaw, A.T.1
-
147
-
-
10744233716
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
-
O'Brien S. G., et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N. Engl. J. Med. 348, 994-1004 (2003
-
(2003)
N. Engl. J. Med
, vol.348
, pp. 994-1004
-
-
O'brien, S.G.1
-
148
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez J. G., et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304, 1497-1500 (2004
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
-
149
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against her2 for metastatic breast cancer that overexpresses her2
-
Slamon D. J., et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J. Med. 344, 783-792 (2001
-
(2001)
N. Engl. J. Med
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
-
150
-
-
78049425319
-
Anaplastic lymphoma kinase inhibition in non small cell lung cancer
-
Kwak E. L., et al. Anaplastic lymphoma kinase inhibition in non small cell lung cancer. N. Engl. J. Med. 363, 1693-1703 (2010
-
(2010)
N. Engl. J. Med
, vol.363
, pp. 1693-1703
-
-
Kwak, E.L.1
-
151
-
-
0032827938
-
The role of immunohistochemistry and fluorescence in situ hybridization for her2/neu in assessing the prognosis of breast cancer
-
Mitchell M. S. & Press M. F. The role of immunohistochemistry and fluorescence in situ hybridization for HER2/neu in assessing the prognosis of breast cancer. Semin. Oncol. 26, 108-116 (1999
-
(1999)
Semin. Oncol
, vol.26
, pp. 108-116
-
-
Mitchell, M.S.1
Press, M.F.2
-
152
-
-
84863393080
-
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
-
Gerlinger M., et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N. Engl. J. Med. 366, 883-892 (2012
-
(2012)
N. Engl. J. Med
, vol.366
, pp. 883-892
-
-
Gerlinger, M.1
-
153
-
-
84927596844
-
Intratumor heterogeneity in hepatocellular carcinoma
-
Friemel J., et al. Intratumor heterogeneity in hepatocellular carcinoma. Clin. Cancer Res. 21, 1951-1961 (2014
-
(2014)
Clin. Cancer Res
, vol.21
, pp. 1951-1961
-
-
Friemel, J.1
-
154
-
-
0033862041
-
Chromosomal changes and clonality relationship between primary and recurrent hepatocellular carcinoma
-
Chen Y. J., et al. Chromosomal changes and clonality relationship between primary and recurrent hepatocellular carcinoma. Gastroenterology 119, 431-440 (2000
-
(2000)
Gastroenterology
, vol.119
, pp. 431-440
-
-
Chen, Y.J.1
-
155
-
-
84983720414
-
Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data
-
Tao Y., et al. Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data. Proc. Natl Acad. Sci. USA 108, 12042-12047 (2011
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 12042-12047
-
-
Tao, Y.1
-
157
-
-
84862976633
-
Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators
-
Fujimoto A., et al. Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators. Nat. Genet. 44, 760-764 (2012
-
(2012)
Nat. Genet
, vol.44
, pp. 760-764
-
-
Fujimoto, A.1
-
158
-
-
80052271807
-
Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma
-
Li M., et al. Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma. Nat. Genet. 43, 828-829 (2011
-
(2011)
Nat. Genet
, vol.43
, pp. 828-829
-
-
Li, M.1
-
159
-
-
84859007967
-
How to obtain the P value from a confidence interval
-
Altman D. G. & Bland J. M. How to obtain the P value from a confidence interval. BMJ 343, d2304 (2011
-
(2011)
Bmj
, vol.343
, pp. d2304
-
-
Altman, D.G.1
Bland, J.M.2
|